Diseases Of Infancy And Childhood

11 Questions

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Diseases Of Infancy And Childhood

Based on chapter 10 of Robbins and Cotran Pathologic Basis of Disease 7th edition.


Questions and Answers
  • 1. 
    Flattened facies, positional anomalies of the hands and feet, dislocated hips and hypoplastic lungs are features that can be caused by which of the following?
    • A. 

      Oligohydramnios sequence

    • B. 

      Holoprosencephaly

    • C. 

      Turner Syndrome

    • D. 

      Cystic Fibrosis

    • E. 

      Edward's Syndrome

    • F. 

      Down'd Syndrome

  • 2. 
    What does Agenesis mean?
    • A. 

      The complete absence of an organ and its associated primordium.

    • B. 

      The absence of an organ owing to the failure of development of the primordium.

    • C. 

      The absence of an opening - usually of a hollow, visceral organ.

    • D. 

      The incomplete development or underdevelopment of an organ with decreased numbers of cells

    • E. 

      An abnormal organisation of cells.

    • F. 

      An abnormality in an organ or tissue as a result of a decrease in the size of individual cells.

  • 3. 
    What does Aplasia mean?
    • A. 

      The complete absence of an organ and its associated primordium.

    • B. 

      The absence of an organ owing to the failure of development of the primordium.

    • C. 

      The absence of an opening - usually of a hollow, visceral organ.

    • D. 

      The incomplete development or underdevelopment of an organ with decreased numbers of cells

    • E. 

      An abnormal organisation of cells.

    • F. 

      An abnormality in an organ or tissue as a result of a decrease in the size of individual cells.

  • 4. 
    What does Atresia mean?
    • A. 

      The complete absence of an organ and its associated primordium.

    • B. 

      The absence of an organ owing to the failure of development of the primordium.

    • C. 

      The absence of an opening - usually of a hollow, visceral organ.

    • D. 

      The incomplete development or underdevelopment of an organ with decreased numbers of cells

    • E. 

      An abnormal organisation of cells.

    • F. 

      An abnormality in an organ or tissue as a result of a decrease in the size of individual cells.

  • 5. 
    What does Hypoplasia mean?
    • A. 

      The complete absence of an organ and its associated primordium.

    • B. 

      The absence of an organ owing to the failure of development of the primordium.

    • C. 

      The absence of an opening - usually of a hollow, visceral organ.

    • D. 

      The incomplete development or underdevelopment of an organ with decreased numbers of cells

    • E. 

      An abnormal organisation of cells.

    • F. 

      An abnormality in an organ or tissue as a result of a decrease in the size of individual cells.

  • 6. 
    What does Hypotrophy mean?
    • A. 

      The complete absence of an organ and its associated primordium.

    • B. 

      The absence of an organ owing to the failure of development of the primordium.

    • C. 

      The absence of an opening - usually of a hollow, visceral organ.

    • D. 

      The incomplete development or underdevelopment of an organ with decreased numbers of cells

    • E. 

      An abnormal organisation of cells.

    • F. 

      An abnormality in an organ or tissue as a result of a decrease in the size of individual cells.

  • 7. 
    • A. 

      The complete absence of an organ and its associated primordium.

    • B. 

      The absence of an organ owing to the failure of development of the primordium.

    • C. 

      The absence of an opening - usually of a hollow, visceral organ.

    • D. 

      The incomplete development or underdevelopment of an organ with decreased numbers of cells

    • E. 

      An abnormal organisation of cells.

    • F. 

      An abnormality in an organ or tissue as a result of a decrease in the size of individual cells.

  • 8. 
    Which of the following is the most common developmental defect of the forebrain and midface in humans?
    • A. 

      Oligohydramnios sequence

    • B. 

      Holoprosencephaly

    • C. 

      Patau Syndrome

    • D. 

      Klinefelter Syndrome

    • E. 

      Rubella Embryopathy

    • F. 

      Cystic Fibrosis

  • 9. 
    Cytomegalovirus infection in which trimester poses the greatest risk to the fetus?
    • A. 

      First

    • B. 

      Second

    • C. 

      Third

  • 10. 
    The _ _ _ _ _ _ _ _ is a highly conserved,180 nucleotide motif with DNA binding properties on HOX genes.  In vertebrates, these genes have been implicated in the patterning of limbs, vertebrae and craniofacial structures.
  • 11. 
    Which of the following is caused by a mutation in the PAX2 gene, which causes developmental defects of the eyes, kidneys ears and brain?
    • A. 

      Oligohydramnios sequence

    • B. 

      Holoprosencephaly

    • C. 

      Patau Syndrome

    • D. 

      Klinefelter Syndrome

    • E. 

      Renal-Coloboma Syndrome

    • F. 

      Cystic Fibrosis