Diseases Of Infancy And Childhood
Based on chapter 10 of Robbins and Cotran Pathologic Basis of Disease 7th edition.
- 1.Flattened facies, positional anomalies of the hands and feet, dislocated hips and hypoplastic lungs are features that can be caused by which of the following?
- A.
Oligohydramnios sequence
- B.
Holoprosencephaly
- C.
Turner Syndrome
- D.
Cystic Fibrosis
- E.
Edward's Syndrome
- F.
Down'd Syndrome
- 2.What does Agenesis mean?
- A.
The complete absence of an organ and its associated primordium.
- B.
The absence of an organ owing to the failure of development of the primordium.
- C.
The absence of an opening - usually of a hollow, visceral organ.
- D.
The incomplete development or underdevelopment of an organ with decreased numbers of cells
- E.
An abnormal organisation of cells.
- F.
An abnormality in an organ or tissue as a result of a decrease in the size of individual cells.
- 3.What does Aplasia mean?
- A.
The complete absence of an organ and its associated primordium.
- B.
The absence of an organ owing to the failure of development of the primordium.
- C.
The absence of an opening - usually of a hollow, visceral organ.
- D.
The incomplete development or underdevelopment of an organ with decreased numbers of cells
- E.
An abnormal organisation of cells.
- F.
An abnormality in an organ or tissue as a result of a decrease in the size of individual cells.
- 4.What does Atresia mean?
- A.
The complete absence of an organ and its associated primordium.
- B.
The absence of an organ owing to the failure of development of the primordium.
- C.
The absence of an opening - usually of a hollow, visceral organ.
- D.
The incomplete development or underdevelopment of an organ with decreased numbers of cells
- E.
An abnormal organisation of cells.
- F.
An abnormality in an organ or tissue as a result of a decrease in the size of individual cells.
- 5.What does Hypoplasia mean?
- A.
The complete absence of an organ and its associated primordium.
- B.
The absence of an organ owing to the failure of development of the primordium.
- C.
The absence of an opening - usually of a hollow, visceral organ.
- D.
The incomplete development or underdevelopment of an organ with decreased numbers of cells
- E.
An abnormal organisation of cells.
- F.
An abnormality in an organ or tissue as a result of a decrease in the size of individual cells.
- 6.What does Hypotrophy mean?
- A.
The complete absence of an organ and its associated primordium.
- B.
The absence of an organ owing to the failure of development of the primordium.
- C.
The absence of an opening - usually of a hollow, visceral organ.
- D.
The incomplete development or underdevelopment of an organ with decreased numbers of cells
- E.
An abnormal organisation of cells.
- F.
An abnormality in an organ or tissue as a result of a decrease in the size of individual cells.
- 7.What does Dysplasia in the context of malformations mean?
- A.
The complete absence of an organ and its associated primordium.
- B.
The absence of an organ owing to the failure of development of the primordium.
- C.
The absence of an opening - usually of a hollow, visceral organ.
- D.
The incomplete development or underdevelopment of an organ with decreased numbers of cells
- E.
An abnormal organisation of cells.
- F.
An abnormality in an organ or tissue as a result of a decrease in the size of individual cells.
- 8.Which of the following is the most common developmental defect of the forebrain and midface in humans?
- A.
Oligohydramnios sequence
- B.
Holoprosencephaly
- C.
Patau Syndrome
- D.
Klinefelter Syndrome
- E.
Rubella Embryopathy
- F.
Cystic Fibrosis
- 9.Cytomegalovirus infection in which trimester poses the greatest risk to the fetus?
- A.
First
- B.
Second
- C.
Third
- 10.The _ _ _ _ _ _ _ _ is a highly conserved,180 nucleotide motif with DNA binding properties on HOX genes. In vertebrates, these genes have been implicated in the patterning of limbs, vertebrae and craniofacial structures.
- 11.Which of the following is caused by a mutation in the PAX2 gene, which causes developmental defects of the eyes, kidneys ears and brain?
- A.
Oligohydramnios sequence
- B.
Holoprosencephaly
- C.
Patau Syndrome
- D.
Klinefelter Syndrome
- E.
Renal-Coloboma Syndrome
- F.
Cystic Fibrosis
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