Bms 300 Final Review Quiz
- 1.Signaling of GnRH to gonadotropes is an example of which of the following:
- A.
Autocrine signaling
- B.
Paracrine signaling
- C.
Neutral signaling
- D.
Endocrine signaling
- E.
Neuroendocrine signaling
- 2.Which of the following is not released by cells in the anterior pituitary?
- A.
Luteinizing hormone (LH)
- B.
Thyroid stimulating hormone (TSH)
- C.
Oxytocin (OT)
- D.
Growth hormone (GH)
- E.
All of the above are released by cells in the anterior pituitary
- 3.Intracellular receptors require which of the following domains?
- A.
Transactivation domain, DNA binding domain, hormone binding domain
- B.
Translation domain, DNA binding domain, hormone binding domain
- C.
Transactivation domain, mitochondrial binding domain, hormone binding domain
- D.
Transactivation domain, DNA binding domain, mitochondrial binding domain
- E.
Membrane binding domain, translation domain, nuclear binding domain
- 4.The insulin receptor is a type of cell surface receptor that is activated by phosphorylation after ligand binding. Specifically, the amino acid that is activated by a ______ is _______.
- A.
Kinase; tyrosine
- B.
Phosphatase; tyrosine
- C.
Kinase; insulin
- D.
Phosphatase; insulin
- E.
None of the above
- 5.Which of the following combinations or statements is INCORRECT?
- A.
GnRH binds cell surface receptors on gonadotropes for release of gonadotropins, which bind cell surface receptors on the gonads
- B.
Estradiol binds primarily to cell surface receptors
- C.
Transcription of protein hormones occurs in the nucleus
- D.
The Pre-prohormone sequence for GnRH is necessary for "signaling" or "localization" information to direct transport
- E.
Intracellular receptors bind small, lipid soluble hormones and can be found in the cytoplasm or nucleus of a cell
- 6.Which of the following hormones is incorrectly paired with its site of action?
- A.
LH: ovaries, testes
- B.
Parathyroid hormone: bone
- C.
Aldosterone: kidney
- D.
Anti-diurectic hormone (ADH/vasopressin):kidney
- E.
Adrenocorticotropic hormone (ACTH): adrenal medulla
- 7.Which of the following is NOT a second messenger used as a method of signal amplification for the cell surface receptors with 7 transmembrane domains, termed G-protein coupled receptors (GPCRs)?
- A.
Cyclic AMP (cAMP)
- B.
Diaclgylcerol (DAG)
- C.
Calcium (Ca2+)
- D.
Inositol trisphosphate (IP3)
- E.
All of the above are 2nd messengers
- 8.Which of the following hormones signal through cell surface receptors? Pick the most appropriate combination of hormones.
- A.
All GI hormones, pancreatic hormones, hypothalamic releasing hormones, and testosterone
- B.
Calcitonin, Parathyroid hormone (PTH), and ALL GI hormones, pancreatic hormones, and hypothalamic releasing hormones
- C.
Estrogen, Calcitonin, Parathyroid hormone (PTH), and ALL GI hormones
- D.
ALL GI hormones, pancreatic hormones, hypothalamic releasing hormones, and phospholipase
- E.
NONE of the above
- 9.Which of the following statements regarding steroid hormones is TRUE?
- A.
All steroid hormones are derived from cholesterol, a 25 carbon structure
- B.
ALL steroid hormones undergo side chain cleavage in the Golgi apparatus
- C.
Enzymatic modification of pregnenalone in each tissue is the rate limiting step of steroid production
- D.
Pregnenalone is the 27 carbon intermediary produced by lateral chain cleavage
- E.
ALL of the above statements are FALSE
- 10.Which of the following statements regarding amino acid derived hormones is TRUE?
- A.
Epinephrine is closely related to Thryoxin (T4) as they are both derived from a Tryptophane amino acid.
- B.
Epinephrine, a catecholamine, is made in the adrenal cortex.
- C.
Iodination of and modification of tyrosine occurs in the thyroid gland for production of T3 and T4
- D.
T3 is produced in the Parathyroid gland and the oaddition of the last iodine occurs in the thyroid gland to produce T4
- E.
ALL of the above statements are FALSE
- 11.RNA polymerase functions as part of _____ to produce ______.
- A.
Translation, protein
- B.
Replication, DNA
- C.
Transcription, RNA
- D.
Translation, RNA
- E.
Transcription, protein
- 12.In the anterior pituitary, hormones are translated (in) on:
- A.
The nucleus
- B.
The Golgi apparatus
- C.
Smooth endoplasmic reticulum
- D.
Rough endoplasmic reticulum
- E.
Free ribosomes
- 13.Transcription factors bind to _______ to promote _______:
- A.
DNA, DNA synthesis
- B.
RNA, RNA synthesis
- C.
RNA, protein synthesis
- D.
DNA, transcription
- E.
Protein, DNA replication
- 14.Following a bad cut in the skin, a scar will often form. A scar is formed by connective tissue cells, which in this case are likely ______ from the _______.
- A.
Epithelial cells, stratum corneum
- B.
Chondrocytes, dermis
- C.
Fibrocytes, dermis
- D.
Epithelial cells, stratum basale
- E.
Fibrocytes, stratum basale
- 15.Two solutions are separated by a membrane that contains only channels permeable to water (aquaporins). The solution in the left-hand compartment contains 50 millimolar NaCl, which dissociates completely, and the right hand compartment contains 100 millimolar urea which is a small, charged molecule that does not dissociate. Which of the following statements is correct?
- A.
Water will not flow because osmotic forces are balanced
- B.
Water will flow from right to left because the osmotic concentration of the NaCl is higher
- C.
Water will flow from left to right because the osmotic concentration of the urea is higher
- D.
Urea will diffuse from right to left
- E.
A and d are correct
- 16.During the synthesis of kinesin, _____ catalyzes the formation of _____.
- A.
Messenger RNA, peptide bonds
- B.
Transfer RNA, ionic bonds
- C.
Ribosomal RNA, peptide bonds
- D.
Transfer RNA, peptide bonds
- E.
Ribosomal RNA, hydrogen bonds
- 17.Kinesin is a(n) ________ that moves _______ along ______.
- A.
Kinase, vesicles, microtubles
- B.
ATPase, microtubules, actin
- C.
Kinase, vesicles, actin
- D.
ATPase, vesicles, actin
- E.
ATPase, vesicles, microtubules
- 18.Keratin, which is found in keratinocytes is a(n):
- A.
Actin complex
- B.
Motor protein
- C.
ATPase
- D.
Intermediate filament protein
- E.
Microtubule binding protein
- 19.Which of the following proteins would be expected to contain a signal peptide?
- A.
A.) actin
- B.
B.) tubulin
- C.
C.) lysosomal proteins
- D.
D.) a calcium channel
- E.
C and d are correct
- 20.In comparison to eukaryotes, prokaryotes lack:
- A.
Endoplasmic reticulum
- B.
Ribosomes
- C.
DNA
- D.
RNA
- E.
Protein
- 21.The signal peptide that emerges from the large ribosomal subunit:
- A.
Is composed of hydrophobic amino acids
- B.
Determines that the protein will be synthesized on rough endoplasmic reticulum
- C.
Binds to a signal recognition particle
- D.
Binds to the protein translocator in the endoplasmic reticulum
- E.
All of the above are correct
- 22.The ______ comprise the hydrophilic region of biological membranes.
- A.
Phosphate head groups
- B.
Fatty acid side chains
- C.
Carbon to carbon bonds
- D.
Glycerol backbone
- E.
Ester bonds
- 23.If a tumor is classified as a carcinoma, you can conclude that the tumor originated as a _______ cell.
- A.
Osteocyte
- B.
Epithelial cell
- C.
Chrondrocyte
- D.
Fibrocyte
- E.
A cell in the dermis
- 24.The role of histones is to:
- A.
Bind to DNA and assist in folding DNA into a chromosome.
- B.
Permit mRNA molecules to fold properly after they are transcribed
- C.
Permit proteins to fold properly in endoplasmic reticulum
- D.
Bind to specific amino acids in the signal sequence
- E.
Escort mRNA molecules through nuclear pores
- 25.Integrins are examples of ________ proteins that connect epithelial cells to ______ in ______.
- A.
Cytoplasmic, keratin filaments, desmosomes
- B.
Transmembrane, one another, desmonsomes
- C.
Extracellular proteins, the basal lamina, hemidesmosomes
- D.
Transmembrane proteins, basal lamina
- E.
Cytoplasmic proteins, basal lamina, hemidesmosomes
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