Block 9 Pharm Anti Cholinergic W Exp Prt 1
- 1.This drug is currently used in bronchospastic disorders
- A.
Atropine
- B.
Benztropine
- C.
Darifenacin
- D.
Glycopyrrolate
- E.
Homatropine
- F.
Ipratropium
- G.
Mecamylamine
- H.
Nicotine
- I.
Scopolamine
- 2.This drug can block M3 receptors only
- A.
Atropine
- B.
Benztropine
- C.
Darifenacin
- D.
Glycopyrrolate
- E.
Homatropine
- F.
Ipratropium
- G.
Mecamylamine
- H.
Nicotine
- I.
Scopolamine
- 3.This drug can block Nn receptors only
- A.
Atropine
- B.
Benztropine
- C.
Darifenacin
- D.
Glycopyrrolate
- E.
Homatropine
- F.
Ipratropium
- G.
Mecamylamine
- H.
Nicotine
- I.
Scopolamine
- 4.This drug can increase epinephrine release from adrenal medulla
- A.
Atropine
- B.
Benztropine
- C.
Darifenacin
- D.
Glycopyrrolate
- E.
Homatropine
- F.
Ipratropium
- G.
Mecamylamine
- H.
Nicotine
- I.
Scopolamine
- 5.Which of the following molecular actions can result from the blockade of M3 receptors by antimuscarinic drugs in non-vascular smooth muscle?
- A.
Less negative resting membrane potential
- B.
Binding of Ca++ to troponin C
- C.
Increased concentration of cytosolic calcium
- D.
Decreased synthesis of intracellular IP3
- E.
Direct opening of K+ channels
- 6.Which of the following is an effects of atropine upon the respiratory system?
- A.
Increased contraction of airway smooth muscle
- B.
Increased secretion of bronchial glands
- C.
Decreased mucociliary clearance
- D.
Decreased pulmonary vital capacity
- E.
Decreased diaphragmatic performance
- 7.Which of the following is a common side effect of quaternary ammonium antimuscarinic drugs?
- A.
Urge incontinence
- B.
Drowsiness
- C.
Difficulty in near vision
- D.
AV block
- E.
Hallucinations
- 8.Antimuscarinic drugs usually increase the heart rate because they can counteract which of the following acetylcholine-induced actions?
- A.
Release of nitric oxide
- B.
Opening of K+ channels in SA node
- C.
Decrease in cardiac contractility
- D.
Opening of Na+ channels in ganglionic neurons
- E.
Activation of cardiac presynaptic autoreceptors
- 9.Which of the following statements correctly pairs the antimuscarinic drug with one of its common adverse effects?
- A.
Atropine - cough
- B.
Darifenacin - constipation
- C.
Glycopyrrolate -insomnia
- D.
Ipratropium -restlessness
- E.
Scopolamine - impairment of far vision
- 10.Antimuscarinic drugs are contraindicated, or should be used with caution, in which of the following disease states?
- A.
Irritable bowel syndrome
- B.
Sialorrhea
- C.
Travelers’ diarrhea
- D.
Urinary urge incontinence
- E.
Sinus bradycardia
- F.
Ulcerative colitis
- 11.Atropine can most effectively counteract which of the following drug-induced effects?
- A.
Physostigmine-induced sweating
- B.
Epinephrine-induced increased in blood pressure
- C.
Nicotine-induced increase in peripheral vascular resistance
- D.
Prazosin-induced reflex tachycardia
- E.
Scopolamine-induced sleepiness
- 12.A 32-year-old woman suffering from irritable bowel syndrome was prescribed glycopyrrolate. The blockade of which of the following pairs of receptors best explains the mechanism of the therapeutic effect of the drug in this patient?
- A.
Beta-2 and Nm
- B.
M2 and Nn
- C.
M3 Nn
- D.
Alpha-1 and M2
- E.
M1 M3
- 13.A 85-year-old man resident of a nursing facility recently developed urinary incontinence. He was treated with darifenacin, which was able to decrease the urge to urinate and the pain associated with it. Which of the following molecular mechanism of action most likely mediated the therapeutic effect of the drug in this patient?
- A.
Decreased potassium efflux from cells of detrusor muscle
- B.
Decreased availability of cytosolic calcium in cells of detrusor muscle
- C.
Activation of alpha-1 receptors in bladder internal sphincter
- D.
Activation of M3 receptors in bladder internal sphincter
- E.
Increased sodium influx into cells of detrusor muscle
- 14.A 5-year-old boy was prescribed ophthalmic drops in order to prepare the eye for measurement of refractive errors. One hour after the first administration the boy showed mental confusion, restlessness, incoherence and hallucinatory behavior. His pulse rate was 120 bpm. Which of the following drugs was most likely administered?
- A.
Phenylephrine
- B.
Epinephrine
- C.
Atropine
- D.
Timolol
- E.
Apraclonidine
- 15.A 48-year-old man was admitted to the coronary unit with an acute myocardial infarction. He had been suffering from a left bundle branch block which now changed into a Mobiz 1 AV block. His heart rate decreased from 70 bpm to 48 bpm. Which of the following drugs would be appropriate to manage the patient’s bradycardia?
- A.
Epinephrine
- B.
Propranolol
- C.
Clonidine
- D.
Phenylephrine
- E.
Atropine
Related Topics
Recent Quizzes
Back to top