Pharm Anti Cholinergic W Exp Part 2

15 Questions | Total Attempts: 171

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Pharm Anti Cholinergic W Exp Part 2

Questions and Answers
  • 1. 
    A 71-year-old man with atrial fibrillation had diarrheal stools after eating at a restaurant during a vacation in Mexico. The man took an over-the-counter preparation, bought at a local pharmacy, in order to relieve the diarrhea. Few hours later he developed palpitations, dyspnea and an urgent need to urinate. Which of the following drugs could have facilitated the appearance of these symptoms in the patient?
    • A. 

      Phenylephrine

    • B. 

      Epinephrine

    • C. 

      Atropine

    • D. 

      Albuterol

    • E. 

      Propranolol

  • 2. 
    A 62-year-old man has been recently diagnosed with benign prostatic hyperplasia and has been scheduled for surgery. Which of the following drugs would be absolutely contraindicated in this patient?
    • A. 

      Prazosin

    • B. 

      Propranolol

    • C. 

      Labetalol

    • D. 

      Clonidine

    • E. 

      Atropine

  • 3. 
    A 58-year-old woman is admitted to the hospital with shallow breathing, wheezing, profuse rhinorrhea, lacrimation, ocular pain and diminished vision. She refers that symptoms started when she was in her garden spraying flowers with an insecticide containing carbaryl (a reversible cholinesterase inhibitor). Which of the following drugs would be the appropriate to treat the patient’s disorder?
    • A. 

      Pralidoxime

    • B. 

      Albuterol

    • C. 

      Epinephrine

    • D. 

      Glycopyrrolate

    • E. 

      Atropine

  • 4. 
    A 56-year-old male with chronic obstructive pulmonary disease started a therapy with ipratropium bromide through a metered dose inhaler. Which of the following statements best explains why ipratropium is the only antimuscarinic drug used to treat bronchospastic disorders?
    • A. 

      It is more potent than other antimuscarinic drugs

    • B. 

      Its oral bioavailability is higher than that of other antimuscarinic drugs

    • C. 

      It has an excellent absorption, when given by inhalatory route

    • D. 

      It does not decrease bronchial secretions and mucociliary clearance

    • E. 

      Central effects are negligible since it does not cross the blood brain barrier

  • 5. 
    A 35-year-old woman has been recently diagnosed with gastroesophageal reflux disease. Which of the following drug classes would be contraindicated in this patient?
    • A. 

      Beta-1 antagonists

    • B. 

      Beta-1 agonists

    • C. 

      M3-antagonists

    • D. 

      M3-agonists

    • E. 

      Alpha-2 agonists

  • 6. 
    A 45-year-old man collapsed at work and was found to be unresponsive. When the paramedics arrived he had ventricular fibrillation and was cardioverted successfully. He was admitted to the coronary unit but shortly thereafter he developed asystole. Cardiopulmonary resuscitation was started and escalating doses of epinephrine were given without success. Another drug was tried. Which of the following drugs was most likely administered?
    • A. 

      Neostigmine

    • B. 

      Norepinephrine

    • C. 

      Dopamine

    • D. 

      Atropine

    • E. 

      Ipratropium

  • 7. 
    Which of the following drugs can most likely prevent the fast EPSP in an autonomic ganglion cell?
    • A. 

      Atropine

    • B. 

      Neostigmine

    • C. 

      Atropine

    • D. 

      Pilocarpine

    • E. 

      Dopamine

    • F. 

      Ipratropium

  • 8. 
    which of the following is the most likely central effect of a moderate dose of nicotine?
    • A. 

      Depression of the reticular formation

    • B. 

      Stimulation of respiratory center

    • C. 

      Depression of vomiting center

    • D. 

      Inhibition of ADH secretion

    • E. 

      Depression of vasomotor centers

  • 9. 
    Which of the following statement best explains the nicotine-induced ganglionic blockade that usually occurs after an initial stimulating action?
    • A. 

      Long-lasting activation of nicotinic receptors

    • B. 

      Long lasting blockade of M2 receptors

    • C. 

      Long lasting blockade of M1 receptors

    • D. 

      Prevention of acetylcholine release from presynaptic terminals

    • E. 

      Prevention of catecholamine release from small intensely fluorescent cells

  • 10. 
    Pretreatment with a ganglionic blocker will most effectively prevent which of the following drug-induced effects?
    • A. 

      Neostigmine-induced increase in intestinal peristalsis

    • B. 

      Nicotine-induced contraction of skeletal muscle

    • C. 

      Norepinephrine-induced bradycardia

    • D. 

      Epinephrine-induced tachycardia

    • E. 

      Propranolol-induced hypotension

  • 11. 
    A 3-year-old boy is rushed to the emergency department by his mother after she discovered he had put on his skin 4 medication patches found in his father drawer. The boy presents with vomiting, diarrhea, profuse salivation, cold sweat, rapid and irregular pulse, tachypnea and mental confusion. Soon after admission the boy experiences a tonic-clonic seizure. Poisoning of this patient is most likely due to which of the following drugs?
    • A. 

      Clonidine

    • B. 

      Scopolamine

    • C. 

      Nicotine

    • D. 

      Bethanechol

    • E. 

      Neostigmine

  • 12. 
    A new synthetic drug is to be studied for its cardiovascular effects. The drug is given IV to three laboratory animals while the blood pressure is recorded. The first animals has received no pretreatment, the second has received an effective dose of mecamylamine before drug X, and the third has received an effective dose of atropine before drug X. The NET CHANGES (+ or -) in heart rate and mean blood pressure induced by drug X (not by the pretreatment) are shown in the following table. Which of the following agents does the new drug most closely resemble?
    • A. 

      Epinephrine

    • B. 

      Acetylcholine

    • C. 

      Propranolol

    • D. 

      Nicotine

    • E. 

      Histamine

  • 13. 
    A new synthetic drug is to be studied for its cardiovascular effects. The drug is given IV to four laboratory animals while the heart rate is recorded. The first animals has received no pretreatment, the second has received an effective dose of mecamylamine before drug X, the third has received an effective dose of atropine before drug X and the fourth has received effective dose of prazosin before drug X . The NET CHANGES (+ or -) in heart rate induced by drug X (not by the pretreatment) are shown in the following table. Which of the following agents does the new drug most closely resemble?
    • A. 

      An anticholinesterase agent

    • B. 

      A M2 receptor agonist

    • C. 

      An alpha-1 antagonist

    • D. 

      An alpha-2 agonist

    • E. 

      A beta-1 agonist

  • 14. 
    A new synthetic drug is to be studied for its cardiovascular effects. The drug is given IV to three laboratory animals while the blood pressure is recorded. The first animals has received no pretreatment, the second has received an effective dose of mecamylamine before drug X, and the third has received an effective dose of atropine before drug X. The NET CHANGES (+ or -) in mean blood pressure induced by drug X (not by the pretreatment) are shown in the following table. Which of the following agents does the new drug most closely resemble?
    • A. 

      Acetylcholine

    • B. 

      Nicotine

    • C. 

      Epinephrine

    • D. 

      Angiotensin II

    • E. 

      Neostigmine

  • 15. 
    A new synthetic drug is to be studied for its cardiovascular effects. The drug is given IV to four laboratory animals while the heart rate and blood pressure is recorded. The first animals has received no pretreatment, the second has received an effective dose of prazosin before drug X, third has received an effective dose of propranolol before drug X and the fourth has received an effective dose of atropine before drug X. The net CHANGES (+ or -) in heart rate and mean blood pressure induced by drug X (not by the pretreatment) are shown in the following table. Which of the following agents does the new drug most closely resemble?
    • A. 

      Norepinephrine

    • B. 

      Epinephrine

    • C. 

      Isoproterenol

    • D. 

      Phenylephrine

    • E. 

      Acetylcholine

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