This quiz, titled 'Block 9 immunogenetics Dr Sands', assesses key concepts in immunogenetics, focusing on the diversity and class switching of B-cell receptors. It evaluates understanding of mechanisms like non-template nucleotide additions, alternative polyA site usage, and the role of terminal deoxyribonucleotidyl transferase in hypervariability.
The constant regions of H and L chains
The hypervariable regions of H and L chains
The hypervariable regions of H chains
The variable region of H chains
The variable region of L chains
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The variable region of the light chain changes, but its constant region remains the same.
The variable region of the light chain remains the same, but its constant region changes.
The variable region of the heavy chain remains the same but its constant region changes
The variable region of the heavy chain changes but its constant region remains the same
Both the variable and constant regions change
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Mu chain
Gamma chain
Epsilon chain
Alpha chain
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The variable region of the light chain changes, but its constant region remains the same
The variable region of the light chain remains the same, but its constant region changes.
The variable region of the heavy chain remains the same but its constant region changes
The variable region of the heavy chain changes but its constant region remains the same
Both the variable and constant regions change
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Occur in the embryonic thymus
Require the presence of antigen
Involve rearrangement of -chain gene segments
Involve rearrangement of surrogate light-chain gene segments
Involve rearrangement of heavy-chain gene segments
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A rearrangement of a heavy-chain gene on only one chromosome in a lymphocyte
Rearrangements of heavy-chain genes on both chromosomes in a lymphocyte
A rearrangement of a light-chain gene on only one chromosome in a lymphocyte
Rearrangements of light-chain genes on both chromosomes in a lymphocyte
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Immunoglobulin light-chain isotype
Immunoglobulin heavy-chain class
Variable region of the immunoglobulin heavy chain
Constant region of the immunoglobulin light chain
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Somatic hypermutation occurs before a B cell is exposed to antigen.
Isotype switching occurs before a B cell is exposed to antigen.
P- and N-nucleotides are added to D-J gene junctions before a B cell is exposed to antigen.
V-D-J recombinaton events occur after the B cell is exposed to antigen
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Multiple V genes in the germ line
Random assortment of L and H chains
Imprecise recombination of V and J or V, D, and J segments
Inheritance of multiple C-region genes
Somatic mutation
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Alternative splicing of the corresponding pre-RNA during maturation.
Clipping the amino terminal end of the polypeptide during secretion
Presence of multiple J segments within the corresponding gene.
Presence of multiple LV segments within the corresponding gene
Addition of nucleotides between LV and J segments in maturing lymphocytes
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Simultaneous insertion of VH genes adjacent to each CH gene
Successive insertion of a single VH gene adjacent to different CH genes
Activation of homologous genes on chromosome 6
Switching of light-chain types (kappa and lambda)
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Precise nucleotide splicing during gene rearrangement
Somatic hypermutation
Switch recombination.
Combinatorial diversity
Non template nucleotide additions
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Switch recombination
Productive V(D)J recombination on both alleles
Selective pressure
Alternative polyA site usage
Post-translational modifications of the primary protein product
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One alpha, one gamma2, and two kappa chains
One gamma1 chain and two kappa chains
Two gamma1 chains and one kappa and one lambda chain
Two gamma1 chains and two kappa chains
Two gamma2 chains and two kappa chains
Switch recombination
Productive V(D)J recombination on both alleles
Selective pressure
Alternative splicing of a primary RNA transcript.
Post-translational modifications of the primary protein product
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Composition of sugar groups attached to the antibody
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