Block 7 Pace Quiz 2 Part 1

16 Questions | By Chachelly | Last updated: Feb 14, 2013 | Total Attempts: 135

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Pace quiz 6 sem 2 december 2011 final week of semester

Questions and Answers

1.

In the accompanying drawing, pick the cell (A, B, C, D, or E) that is part of your immune system:
- A.
  
  A
- B.
  
  B
- C.
  
  C
- D.
  
  D
- E.
  
  E
2.

Dr. Moore Which of the cell types in the accompanying drawing is directly responsible for the formation of a keloid?
- A.
  
  A
- B.
  
  B
- C.
  
  C
- D.
  
  D
- E.
  
  NONE OF THE ABOVE
3.

Dr. Kalliecharan Milk protein is produced by which of the following mechanisms?
- A.
  
  Paracrine secretion
- B.
  
  Autocrine secretion
- C.
  
  Holocrine secretion
- D.
  
  Apocrine secretion
- E.
  
  Merocrine secretion
4.

Which of the following statements is characteristic of hair follicles?
- A.
  
  They contain epidermal keratinocytes
- B.
  
  They are always associated with an eccrine sweat gland
- C.
  
  Their associated arrector pili muscles are composed of skeletal muscle fibers
- D.
  
  They are inserted into the papillary layer of the epidermis
- E.
  
  They do not extend into the dermis
5.

Dr. Martin A 45 year old woman is diagnosed with a malignant tumor in the superolateral quadrant of the left breast, including the axillary tail of Spence. If metastasis occurs, the cancer will MOST LIKELY spread first to which of the following locations?
- A.
  
  Deep cervical lymph nodes
- B.
  
  Parasternal lymph nodes
- C.
  
  Contra lateral breast lymph nodes
- D.
  
  Lateral axillary lymph nodes
- E.
  
  Anterior lymph nodes
6.

Dr. Wright MM, a 38 year old female, is in her 19^th week of pregnancy. For this time period, what protein produced by her placenta is the most important in replacing the function of LH in her nonpregnant state to maintain her progesterone secretion at appropriate levels?
- A.
  
  Estradiol
- B.
  
  Human chorionic gonadotropin
- C.
  
  Prolactin
- D.
  
  Human chorionic somatomammotropin
- E.
  
  Dopamine
7.

MM a 38 year old female, is in her 19^th week of pregnancy. She has a family history of type 2 diabetes, so prior to pregnancy she had maintained a very healthy lifestyle with regular exercise and a low-fat, high fiber diet. To date during the pregnancy she has maintained an exercise regimen similar to that of her pre-pregnant state, and only adjusted her diet in accordance with her physician’s instructions. When her blood pressure (BP) is taken, what would be the expected result for this female, relative to that of her (normal) pre-pregnant BP?
- A.
  
  Her BP is slightly elevated (high normal range, pre-hypertensive)
- B.
  
  Her BP is greatly elevated (hypertensive)
- C.
  
  Her BP is greatly decreased (hypotensive)
- D.
  
  Her BP remains unchanged
- E.
  
  Her BP is slightly decreased (low normal range)
8.

Every morning, a woman runs 12 kilometers. Today, conditions are mild (no wind, 3% humidity, overcast skies but no rain forecast). When she reaches the 6 kilometer turnaround point and stops for one minute, her body is producing much more heat than it does at rest. By which of the following heat loss mechanisms will this person dissipate the most heat during this one minute interval?
- A.
  
  Radiation
- B.
  
  Conduction
- C.
  
  Convection
- D.
  
  Evaporation
- E.
  
  Countercurrent
9.

Dr. Adebiyi Which of the following immune cell types in the skin is most likely to be the dominant antigen processing and presenting cell?
- A.
  
  Langerhans cells
- B.
  
  Plasmacytoid dendritic cells
- C.
  
  Dermal dendritic cells
- D.
  
  Macrophages
- E.
  
  Epidermal cells
10.

Dr. Buxbaum An 18-month old with a history of recurrent bacterial and viral infections, failure to thrive, developmental delay, and tremors is submitted to your care. On exam you notice a lack of peripheral lymphoid tissue. Blood analysis reveals lymphopenia with normal B-cell count and normal immunoglobulin levels. Patient is most likely suffering from
- A.
  
  Hypoxanthine guanine phosphoribosyl transferase (HGPRT)
- B.
  
  Purine nucleoside phosphorylase
- C.
  
  Adenine phosphoribosyl transferase (APRT)
- D.
  
  Adenosine desaminase (ADA)
- E.
  
  Adenosine kinase
11.

A child with penicillin allergy is given a sulphonamide against otitis media. Human cells are not affected by sulphonamides because sulphonamides are speciﬁc for bacterial
- A.
  
  Folate synthesis
- B.
  
  DNA polymerases
- C.
  
  RNA polymerases
- D.
  
  Ribonucleotide reductase
- E.
  
  Mismatch repair
12.

You are a neonatologist working in a tertiary care hospital in a state capital. A 4-week old male is transferred to you with severe jaundice that appeared at birth and has been worsening ever since. The boy is the ﬁrst child of a healthy Jewish couple, pregnancy and vaginal delivery were unremarkable. The boy is of average height and weight for his age, in no acute distress, but shows marked jaundice and slight hepatomegaly. Lab: CBC normal, indirect bilirubin high, low fecal urobilinogen. What is the most likely diagnosis?
- A.
  
  Neonatal jaundice
- B.
  
  Dubin-Johnson syndrome
- C.
  
  Rotor (-Manahan-Florentin) syndrome
- D.
  
  Uridyl glucuronyl transferase deﬁciency
- E.
  
  Glucose-6-phosphate dehydrogenase deﬁciency
13.

Dr. Sands What mutational event is often associated with Burkitt’s lymphoma?
- A.
  
  The ras protooncogene is mutated at one nucleotide so that it is less able to hydrolyze bound GTP
- B.
  
  The 3’ end of the c-src gene is deleted so that the SRC protein is always activated.
- C.
  
  There is a translocation of the c-myc gene to one of the immunoglobulin loci.
- D.
  
  There is a deletion of the p16 gene which allows unregulated passage through the G1 restriction point.
- E.
  
  EBV causes the Her-2 protein to dimerize without a ligand binding to the receptor
14.

When DNA damage occurs in a cell that has a functional p53 protein, the activation of p53 enhances oxidative pentose phosphate flux. This causes an increase in the amount of NADPH and R5P, both of which are needed for nucleotide synthesis and DNA repair. How does the cell get enough NADPH for these processes when the cell does not have a functional p53 protein?
- A.
  
  Transketolase-like 1 (TKTL1) is up-regulated and it catalyzes the nonoxidative pentose phosphate flux.
- B.
  
  Fructose 1,6 bisphosphate (F1,6biP) increases concentration in cancer cells and inhibits glucose-6 phosphate dehydrogenase (G6PD).
- C.
  
  Pyruvate kinase-M2 (PK-M2) is up-regulated and allows glycolytic intermediates to accumulate.
- D.
  
  Malic enzyme (ME) is up-regulated and works with lactate dehydrogenase (LDH-A) to convert malate to lactate.
- E.
  
  Hexose kinase II (HKII) is up-regulated and binds to the voltage dependent anion channel (VDAC).
15.

Dr. Blanchetot The pedigree below segregate for Duchenne muscular dystrophy (DMD) and X-linked recessive condition lethal in males. What is the risk for III3 of being a carrier for DMD? (use Bayesian calculation)
- A.
  
  1/20
- B.
  
  1/10
- C.
  
  1/5
- D.
  
  1/3
- E.
  
  1/2
16.

How could the following pedigrees be explained by genetic imprinting?
- A.
  
  Maternal uniparental disomy (UPD)
- B.
  
  Paternal uniparental disomy (UPD)
- C.
  
  Maternal expressed gene
- D.
  
  New mutation
- E.
  
  Paternal expressed gene