From U of Virg med school
Decreases gastric acid secretion
Blocks cholinergic receptors in the stomach wall
Decreases the tone of the lower esophageal sphincter (LES)
Acts as an antagonist of 5-HT in myenteric plexuses
Stimulates gastric contractions and increases peristalsis in the small intestine
Failure of physiological herniation to return to the abdominal cavity
Incomplete closure of the lateral folds
Failure of the pleuroperitoneal folds to fuse with the septum transversum
Failure of the vitelline duct to degenerate
Non-rotation of the midgut
Ascending colon
Cecum
Descending colon
Ileum
Ranitidine
Omeprazole
Bismuth
Cimetidine
Al(OH)3
The more severe the phenotype the higher the recurrence risk
The more affected family members the higher the recurrence risk
The recurrence risk is highest in first degree relative
The recurrence risk is highest in families who have affected individuals of the less susceptible sex
Secretion of mucus and polypeptide hormones
Production of chylomicrons and delivery to the lymph
Hydrolysis of peptides and absorption of amino acids
Synthesis and secretion of pepsinogen
May slow gastric emptying
May cause mild alkalosis due to excess plasma bicarbonate
Heal duodenal ulcers more rapidly than does esomeprazole
Can cause constipation
May cause diarrhea in high doses
Cancer in rodents and humans
Cancer in rodents but not humans
Prolonged QT syndrome
Cardiac arrhythmias
Gastroparesis
Often have lower GI tract hemorrhage.
Virtually never have a pathogenic organism that causes the colitis.
Typically have symptoms that resolve over a two week period.
Have deposition of collagen in the muscularis propria (muscularis externa)
Usually have involvement of the proximal small intestine.
May slow gastric emptying
May cause mild alkalosis due to excess plasma bicarbonate
Heal duodenal ulcers more rapidly than does esomeprazole
Can cause constipation
May cause diarrhea in high doses
The male sib of a male proband
The female sib of a female proband
The male sib of a female proband
The female sib of a male proband
The prominent IgA isotype in mucosa (IgA2) is not affected in the deficiency
Secretary IgA, as the most plentiful immunoglobuin in the body, is diminished but not absent in the deficiency
In these circumstances, the body is able to repair the poly-Ig receptor on epithelium as well as make new secretory component and J chain, and thus overcome the deficiency
IgM can substitute for IgA in mucosa and can be actively transported across epithelium and released as a complex containing secretory component/J chain /the IgM pentamer, to carry out the same functions as secretory IgA.
Colonoscopy
CT enterography
Gluten-free diet
Symptomatic management
EGD
Organic stool softener; promotes colonic motility
Poorly absorbed; used for rapid effect before bowel surgery
Poorly absorbed opioid; slows transit of intestinal contents
Can promote healing of peptic ulcers
Promotes secretion of H2O into the colon; chronic use can produce "cathartic colon"
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