Pharm Antineoplastic Drugs Part 2

20 Questions | By Chachelly | Updated: Mar 21, 2022 | Attempts: 636

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Welcome back to another chapter in our ongoing series of pharmacological quizzes on the topic of neoplasms, or tumours, and the pharmaceuticals used to prevent their development. What do you know about these antineoplastic drugs? Take the quiz right now and we’ll find out right now!

Questions and Answers

1.

A 42-year-old woman presented with fever, night sweats, cough and a 8 kg weight loss. Chest x-rays displayed a mediastinal mass and a CT scan of the abdomen showed multiple enlarged lymph nodes. A biopsy of an inguinal node revealed Reed-Sternberg cells. The patient was scheduled for a combination ABVD anticancer chemotherapy (doxorubicin, bleomycin vinblastine and dacarbazine). Which of the following malignancies was the patient most likely to suffer from?
- A.
  
  Bladder cancer
- B.
  
  Chronic myelogenous leukemia
- C.
  
  Hodgkin’s disease
- D.
  
  Acute lymphoblastic leukemia
- E.
  
  Lung cancer
2.

A 6-year-old girl with acute lymphoblastic leukemia completed her induction therapy with a multidrug regimen. Now she is scheduled for maintenance therapy with a regimen that includes a CCS anticancer drug administered daily, for 7 days every 4 weeks. Which of the following is the drug she is about to receive?
- A.
  
  Cyclophosphamide
- B.
  
  Doxorubicin
- C.
  
  Mercaptopurine
- D.
  
  Cisplatin
- E.
  
  Carmustine
3.

A 39-year-old man with acute lymphoblastic leukemia was admitted to the hospital for remission chemotherapy. After three week of therapy the patient started complaining of numbness of his fingers and the soles of his feet. Physical examination showed loss of ankle jerk and depression of deep tendon reflexes. Which of the following drugs most likely caused these patient’s signs and symptoms?
- A.
  
  Vincristine
- B.
  
  Prednisone
- C.
  
  Methotrexate
- D.
  
  Mercaptopurine
- E.
  
  Doxorubicin
4.

A 56-year-old woman with a long history of heavy smoking, presented with cough ,fever, chest pain and bloody sputum. A chest x-ray revealed a 3.5 cm hilar mass and a transbronchial biopsy specimen showed infiltrating groups of anaplastic small cells with hyperchromatic nuclei and no nucleoli. Which of the following drugs was most likely included in the therapeutic regimen of this patient?
- A.
  
  Isoniazid
- B.
  
  Ceftazidime
- C.
  
  Streptomycin
- D.
  
  Asparaginase
- E.
  
  Etoposide
5.

A 45-year-old man presented to the hospital with increasing weakness and decreased exercise tolerance. A CBC showed a WBC count of 50000/mm 3 with 90% neutrophils and a platelet count of 1200000/mm3. Chromosomal studies on a bone marrow aspirate found the present of a Philadelphia chromosome. Which of the following drugs was most likely included in the patient chemotherapeutic regimen?
- A.
  
  Hydroxyurea
- B.
  
  Rifampin
- C.
  
  Metronidazole
- D.
  
  Ciprofloxacin
- E.
  
  Isoniazid
6.

A 66-year-old man came to his physician complaining of a persistent backache. He was found on rectal examination to have a single, hard, irregular nodule within his prostate. Subsequent exams found his prostatic specific antigen to be 100 ng/mL ( normal: < 3.0 ) and a CT scan showed several enlarged pelvic lymph nodes and multiple sclerotic lesions in his spine. Which of the following pairs of drugs would be most appropriate for that patient?
- A.
  
  Paclitaxel and cisplatin
- B.
  
  Vincristine and prednisone
- C.
  
  Leuprolide and flutamide
- D.
  
  Tamoxifen anastrozole
- E.
  
  Vincristine and dactinomycin
7.

A 62-year-old woman with advanced Hodgkin’s disease is to begin chemotherapy with the ABVD regimen (doxorubicin, bleomycin vinblastine and dacarbazine). Which of the following statements best explains the mechanism of anticancer action of doxorubicin?
- A.
  
  It intercalates between DNA strands and inhibit topoisomerase II
- B.
  
  It prevent microtubule disassembly into tubulin monomers
- C.
  
  It prevents assembly of tubulin dimers into microtubules
- D.
  
  It alkylates nucleophilic groups on DNA bases
- E.
  
  It blocks the synthesis of both ribonucleotides and deoxynucleotides
8.

A 3 year-old boy diagnosed with a favorable histology Wilms’ tumor underwent surgery followed by 18 week of vincristine and dactinomycin therapy. Which of the following statement best explains the mechanism of action of dactinomycin?
- A.
  
  It alkylates nucleophilic groups on RNA bases
- B.
  
  It inhibit dihydrofolate reductase
- C.
  
  It inhibits pyrimidine biosynthesis
- D.
  
  It binds to double-stranded DNA so inhibiting DNA transcription
- E.
  
  It inhibits free radical formation
9.

A 42-year-old man with stage III Hodgkin’s disease received six courses of chemotherapy with the ABVD regimen. Which of the following drugs of this regimen acts mainly in the G2 phase of the tumor cell cycle?
- A.
  
  Doxorubicin
- B.
  
  Bleomycin
- C.
  
  Vinblastine
- D.
  
  Dacarbazine
10.

A 4-year-old girl presented with increasing weakness and bleeding gums. Physical examination revealed hepatospenomelaly. A CBC with differential showed a WBC count of 65000 with 43% lymphoblasts and a bone marrow biopsy revealed 92% lymphoblasts. The girl received systemic remission chemotherapy and also intrathecal chemotherapy in order to prevent relapse within the CNS. Which of the following drugs was most likely injected intrathecally?
- A.
  
  Cisplatin
- B.
  
  Paclitaxel
- C.
  
  Etoposide
- D.
  
  Bleomycin
- E.
  
  Methotrexate
11.

A 45-year-old woman, who had undergone a radical mastectomy for infiltrating ductal carcinoma, started adjuvant combination therapy with CMF (cyclophosphamide, methotrexate and fluorouracil). Which of the following statements best explains the mechanism of action of methotrexate?
- A.
  
  Inhibition of purine and pyrimidine biosynthesis
- B.
  
  Inhibition of DNA chain elongation
- C.
  
  Inhibition of ribonucleotide reductase
- D.
  
  Inhibition of topoisomerase II
- E.
  
  Inhibition of microtubule assembly
12.

A 32-year-old man presented to the hospital with increasing fatigue, anorexia, weight loss. and widespread ecchymoses. A blood examination revealed a white blood cell count of 70000/mm3 with 90% myeloblasts and a bone marrow biopsy showed blast cells that made up about 40% of the nucleated cells in the marrow (normal < 5%). Which of the following drugs was most likely included in the initial chemotherapy of this patient?
- A.
  
  Cisplatin
- B.
  
  Paclitaxel
- C.
  
  Bleomycin
- D.
  
  Cytarabine
- E.
  
  Fluorouracil
13.

A 67-year-old man underwent surgery to remove an adenocarcinoma of the colon. Since the regional lymph nodes showed evidence of tumor involvement, adjuvant therapy was initiated after surgery. Which of the following drugs was most likely included in the therapeutic regimen of this patient?
- A.
  
  Cytarabine
- B.
  
  Fludarabine
- C.
  
  Asparaginase
- D.
  
  Hydroxyurea
- E.
  
  Fluorouracil
14.

A 45-year-old man recently diagnosed with small cell lung cancer starts his first course of combination chemotherapy with cisplatin, topotecan and etoposide. Which of the following peripheral blood cells will decrease first in this patient?
- A.
  
  Lymphocytes
- B.
  
  Platelets
- C.
  
  Monocytes
- D.
  
  Granulocytes
- E.
  
  Erythrocytes
15.

A 32-year-old man, recently diagnosed with acute myelogenous leukemia, received a standard remission chemotherapy with daunorubicin and cytarabine. Drug dosage was maximized to a toxicity limit of a 2-log decrease in blood platelets. Which of the following represents the percentage of platelets killed by the drug regimen?
- A.
  
  99.9%
- B.
  
  99%
- C.
  
  90%
- D.
  
  80%
- E.
  
  70%
16.

A 50-year-old woman, recently diagnosed with ovarian cancer, started her first cycle of . combination chemotherapy with paclitaxel, cisplatin and cyclophosphamide. Which of the following drugs should also be administered in order to counteract a specific adverse effect of cyclophosphamide?
- A.
  
  Erythropoietin
- B.
  
  Leucovorin
- C.
  
  MESNA (2-mercaptoethane sulfonate)
- D.
  
  Acetylcysteine
- E.
  
  Vitamin K
17.

A 75-year-old man recently diagnosed with chronic lymphocytic leukemia started a treatment with chlorambucil. Which of the following statements best explains the mechanism of action of this anticancer drug?
- A.
  
  Formation of covalent bonds with nucleophile groups on DNA bases
- B.
  
  Inhibition of DNA chain elongation
- C.
  
  Inhibition of thymidylate synthetase
- D.
  
  Prevention of resealing of nicked strands of DNA
- E.
  
  Inhibition of microtubule assembly
18.

A 52-year-old woman recently diagnosed with malignant glioblastoma received radiation therapy followed by a cycle of combination therapy which included carmustine. Which of the following statements best explains why this anticancer drug is most often used to treat CNS neoplasms?
- A.
  
  It inhibits only tumor cells which originate from neurons
- B.
  
  It is highly lipid soluble and therefore can easily enter the brain
- C.
  
  Has negligible neurological adverse effects
- D.
  
  It is uptaken into the nerve terminals by the amine pump
- E.
  
  It is biotransformed into active metabolites in the brain only
19.

A 10-year-old boy recently diagnosed with neuroblastoma, received his first course of combination chemotherapy. Now he complains of tinnitus and earing loss. Which of the following drugs most likely caused these symptoms?
- A.
  
  Cisplatin
- B.
  
  Vincristine
- C.
  
  Doxorubicin
- D.
  
  Dactinomycin
- E.
  
  Cyclophosphamide
20.

A 50-year-old woman underwent surgical operation to resect an ovarian carcinoma. Following surgery she started her first course of combination chemotherapy in order to eradicate the remaining tumor cells. Which of the following pairs of drugs were most likely included in her combination regimen?
- A.
  
  Mercaptopurine and asparaginase
- B.
  
  Methotrexate and hydroxyurea
- C.
  
  Cytarabine and prednisone
- D.
  
  Cisplatin and paclitaxel
- E.
  
  Methotrexate and tamoxifen