Pharm Adrenocortigoids And Antag Part 1

15 Questions | Total Attempts: 60

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Pharm Adrenocortigoids And Antag Part 1

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Questions and Answers
  • 1. 
    DIRECTIONS 1-6 Match each corticosteroid or antagonist with the appropriate description (each lettered option can be selected only once): A glucocorticoid devoid of salt retaining activity
    • A. 

      Aminoglutethimide

    • B. 

      Aldosterone

    • C. 

      Desoxycorticosterone

    • D. 

      Dexamethasone

    • E. 

      Fludrocortisone

    • F. 

      Hydrocortisone

    • G. 

      Ketoconazole

    • H. 

      Mifepristone

    • I. 

      Prednisone

    • J. 

      Spironolactone

  • 2. 
    DIRECTIONS 1-6 Match each corticosteroid or antagonist with the appropriate description (each lettered option can be selected only once): A mineralocorticoid antagonist
    • A. 

      Aminoglutethimide

    • B. 

      Aldosterone

    • C. 

      Desoxycorticosterone

    • D. 

      Dexamethasone

    • E. 

      Fludrocortisone

    • F. 

      Hydrocortisone

    • G. 

      Ketoconazole

    • H. 

      Mifepristone

    • I. 

      Prednisone

    • J. 

      Spironolactone

  • 3. 
    DIRECTIONS 1-6 Match each corticosteroid or antagonist with the appropriate description (each lettered option can be selected only once): A drug that inhibits several steps of steroidogenesis requiring cytochrome P450 enzymes
    • A. 

      Aminoglutethimide

    • B. 

      Aldosterone

    • C. 

      Desoxycorticosterone

    • D. 

      Dexamethasone

    • E. 

      Fludrocortisone

    • F. 

      Hydrocortisone

    • G. 

      Ketoconazole

    • H. 

      Mifepristone

    • I. 

      Prednisone

    • J. 

      Spironolactone

  • 4. 
    DIRECTIONS 1-6 Match each corticosteroid or antagonist with the appropriate description (each lettered option can be selected only once): A mineralocorticoid used to treat adrenal insufficiency
    • A. 

      Aminoglutethimide

    • B. 

      Aldosterone

    • C. 

      Desoxycorticosterone

    • D. 

      Dexamethasone

    • E. 

      Fludrocortisone

    • F. 

      Hydrocortisone

    • G. 

      Ketoconazole

    • H. 

      Mifepristone

    • I. 

      Prednisone

    • J. 

      Spironolactone

  • 5. 
    DIRECTIONS 1-6 Match each corticosteroid or antagonist with the appropriate description (each lettered option can be selected only once): A drug that blocks of the conversion of cholesterol to pregnenolone
    • A. 

      Aminoglutethimide

    • B. 

      Aldosterone

    • C. 

      Desoxycorticosterone

    • D. 

      Dexamethasone

    • E. 

      Fludrocortisone

    • F. 

      Hydrocortisone

    • G. 

      Ketoconazole

    • H. 

      Mifepristone

    • I. 

      Prednisone

    • J. 

      Spironolactone

  • 6. 
    DIRECTIONS 1-6 Match each corticosteroid or antagonist with the appropriate description (each lettered option can be selected only once): A drug that blocks the cytoplasmic glucocorticoid receptors
    • A. 

      Aminoglutethimide

    • B. 

      Aldosterone

    • C. 

      Desoxycorticosterone

    • D. 

      Dexamethasone

    • E. 

      Fludrocortisone

    • F. 

      Hydrocortisone

    • G. 

      Ketoconazole

    • H. 

      Mifepristone

    • I. 

      Prednisone

    • J. 

      Spironolactone

  • 7. 
    Most of the known effects of corticosteroids are mediated by actions on which of the following molecular targets?
    • A. 

      G-protein coupled receptors

    • B. 

      Tyrosine kinase receptors

    • C. 

      Specific nucleotide sequences of the DNA

    • D. 

      Ion channel coupled receptors

    • E. 

      Specific nucleotide sequences of RNA

    • F. 

      Specific nucleotide sequences of ribosomes

  • 8. 
    Which of the following actions most likely contributes to the antiinflammatory effects of glucocorticoids?
    • A. 

      Inhibition of ACTH release

    • B. 

      Increased catabolism of prostaglandins

    • C. 

      Increased capillary permeability

    • D. 

      Increased release of interleukin-1

    • E. 

      Induction of lipocortin synthesis

  • 9. 
    Which of the following actions most likely contributes to the immunosuppressive effect of glucocorticoids ?
    • A. 

      Increased plasma levels of free fatty acids

    • B. 

      Increased gluconeogenesis

    • C. 

      Reduced production of TNF in macrophages

    • D. 

      Increased protein synthesis in the liver

    • E. 

      Decreased calcium absorption from the intestine

  • 10. 
    Which of the following statements regarding the pharmacokinetics of corticosteroids are correct? (Check all that apply)
    • A. 

      Oral bioavailability is generally very good

    • B. 

      Substantial absorption does occur through the skin

    • C. 

      They distribute into peripheral tissues but cross the blood-brain barrier with difficulty

    • D. 

      Their biological half-lives can be long (up to 72 hours)

    • E. 

      They are mainly excreted unchanged by the kidney

  • 11. 
    Which of the following are effects of glucocorticoids upon carbohydrate metabolism? (Check all that apply)
    • A. 

      Decreased gluconeogenesis in liver

    • B. 

      Increased glucose uptake by skeletal muscle

    • C. 

      Increased glycogen synthesis in liver

    • D. 

      Decreased glucose uptake by adipose tissue

    • E. 

      Increased glucose utilization in peripheral tissues

  • 12. 
    Glucocorticoids are used clinically in many disease states. However they are used only rarely to treat which of the following diseases?
    • A. 

      Autoimmune diseases

    • B. 

      Malignancies

    • C. 

      Infectious diseases

    • D. 

      Inflammatory bowel diseases

    • E. 

      Skin diseases

  • 13. 
    A 54-year-old man, recently diagnosed with immunologic thrombocytopenic purpura started a treatment with a large dose of a drug. The molecular mechanism of action of that drug involved binding to a receptor-heat-shock protein complex in the cytoplasm. Which of the following drugs was most likely prescribed?
    • A. 

      Fludrocortisone

    • B. 

      Azathioprine

    • C. 

      Norethindrone

    • D. 

      Prednisone

    • E. 

      Calcitriol

    • F. 

      Ethinyl estradiol

  • 14. 
    A 44-year-old woman suffering from Crohn’ disease had been receiving high doses of oral prednisone to treat an acute stage of the disease. Which of the following actions most likely contributed to the therapeutic effect of the drug in this patient?
    • A. 

      Increased catabolism of prostaglandins

    • B. 

      Decreased number of circulating neutrophils

    • C. 

      Increased proliferation of T cells

    • D. 

      Increased activation of complement system

    • E. 

      Inhibition of lymphocyte-mediated production of interleukin-2

  • 15. 
    A 55-year-old man with Addison’s disease presented to the hospital complaining of episodic weakness, paresthesias, and constipation. He had been taking cortisol and fludrocortisone for several months. On admission his blood pressure was 160/98 mm Hg and an ECG showed prolongation of Q-T interval. Lab results revealed a plasma K+ level of 2.5 mEq/L. Which of the following events best explains the patient syndrome?
    • A. 

      Cortisol induced hyperglycemia

    • B. 

      Fludrocortisone excess

    • C. 

      Inadequate therapy of adrenal insufficiency

    • D. 

      Cortisol induced myopathy

    • E. 

      Essential hypertension

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