Quinidine and doxycycline
Primaquine and clindamycin
Pyrimethamine and metronidazole
Chloroquine and paromomycin
Mefloquine and ciprofloxacin
Primaquine
Metronidazole
Pyrimethamine
Mefloquine
Chloroquine
Quinine
Primaquine-quinine
Mefloquine-metronidazole
Pyrimethamine-sulfadoxine
Doxycycline-iodoquinol
Chloroquine-paromomycin
Primaquine
Mefloquine
Quinidine
Pyrimethamine
Doxycycline
Sulfadoxine
Thymidylate synthase
Uroporphyrinogen decarboxylase
Pyruvate kinase
Dihydrofolate reductase
Glucose-6-phosphate-dehydrogenase
P. Vivax hypnozoites
P. Falciparum gametocytes
P. Vivax tissue schizonts
P. Falciparum hypnozoites
P. Malarie blood schizonts
P. Malarie tissue schizonts
Purine phosphoribosyl transferase
Ornithine decarboxylase
Ferredoxin oxidoreductase
Dihydropteroate synthetase
Dihydrofolate reductase
Increased inactivation of the drug
Increased activity of DNA repair mechanism
Increased drug transport outside plasmodia cells
Decreased chloroquine binding sites on plasmodia cells
Decreased of conversion of free heme into hemozoin
Inhibition of dihydropteroate synthase
Blockade of translocation of peptidyl-tRNA
Incorrect amino acid incorporation into the polypeptide chain
Inhibition of DNA-dependent RNA polymerase
Prevention of polymerization of free heme into hemozoin
Metronidazole
Chloroquine
Clindamycin
Paromomycin
Pyrimethamine
Sulfadoxine