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Advanced Renal Disorders and Management Quiz

Explore the intricacies of kidney diseases with our Renal Pathology assessment. This evaluation focuses on diagnosing and understanding various renal disorders, essential for medical students and professionals in nephrology and...

Questions: 26 | Attempts: 10 | Last updated: Aug 4, 2025

Sample Question 1
A female develops middle-aged PALPABLE Purpura along with sudden onset of oliguria with proteinuria/RBC casts after a course of penicillin. She soon dies due to renal failure. A photograph shows glomeruli with proliferation of parietal epithelial cells in Bowman's capsule forming a crescent around the glomerulus. What antibodies are likely present in the patient's serum? (SUPER HY: Composition of crescents?)

*Patient has classic case of MICROSCOPIC Polyangitis precipitated by drug(Like penicillin),patient developed type 3 rapidly progressiveCRESCENTRIC glomerulonephritis>nEphritic presentation with RBC casts,proliferation of parietal epithelial cells in Bowman’s capsule forming a crescent around the glomerulus is classic finding for this PAUCI-immune glomeruloneprhitis(No Ig/C3), Patients with MICROSCOPIC POLYANGITIS often are positive for MPO-ANCA/P-ANCA....*Palpable purpura is More suggestive of microscopic polyangitis than Wegener granulomatosis(Which could also cause Pauci-immune glomerulonephritis, these patients would be positive for PR3-ANCA/C-ANCA) i just remember one to not confuse them, i remember later one by:I had to do CPR 3 times to bring Wegener alive)...*Well Crescents are composed of Fibrin,Macrophages,glomerular PARIETAL cells,Monocytes,plasma proteins(C3B), but most important(Testable) content is FIBRIN+MACROPHAGES so know them...

Anti-dsDNA antibodies

Anti-GBM antibodies

Antinuclear antibodies

Sample Question 2
After upper airway infection, a young boy develops palpable purpura on buttocks, abdominal pain, and arthralgias. What are the most likely biopsy findings in this case? What are the C3 levels in serum?

The biopsy findings would reveal fibrinoid necrosis of blood vessel walls. The C3 levels in serum would be low.

*Palpable purpura in young boy, especially after recent URI is a giveaway for HSP-Kidney biopsy in this disease is characterized by MESANGIAL HYPERcellularity(proliferation) with igA and C3 staining of Mesangium(SUPER HY), also note that C3 levels in serum are NORMAL...they've asked about most likely progression of disease and that is Recovery(SELF-LIMITING) with high-rate of recurrence....BERGER disease(igA nephropathy) is basically KIDNEY pathology of HSP, IF shows igA based immune complexes in MESANGIUM...*HSP, Berger disease are common after URI,Enteritis because mucosal surfaces increase igA secretion in this conditions, don't confuse berger disease with bUErger disease(Segmental inflammation of MEDIUM-sized vessels associated with smoking,contrast this with HSP which is SMALL vessel vasculitis)

The biopsy findings would indicate perivascular infiltration of eosinophils. The C3 levels in serum would be elevated.

The biopsy findings would show granulomatous inflammation with giant cells. The C3 levels in serum would be elevated.

Sample Question 3
What is the most common Extraintestinal manifestation of ADPKD?

Hypertension

Pulmonary AVMs

Subarachnoid hemorrhage from rupture of Berry aneurysm

*COLONIC Diverticuli, however on boards they love to test the fact that these patients have hypertension and are at risk of SUBarachnoid hemorrhage due to RUPTURE of Berry aneurysm...

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