Quizzes, Questions & Answers

Top Trending Quizzes

Understanding Alzheimer's Disease: Pathogenesis, Diagnosis, and Treatment

Understanding Alzheimer's Disease: Pathogenesis, Diagnosis, And Treatment

Explore the complexities of Alzheimer's disease, focusing on its symptoms, diagnosis, and management. This educational content is designed to enhance understanding of neurodegenerative disorders, pertinent for students and...

Questions: 4 | Attempts: 10 | Last updated: Sep 30, 2025

Sample Question 1
What is the pathogenesis of Alzheimer's Disease (AD)?

AD is caused by excess dopamine levels in the brain.

AD is due to a deficiency of acetylcholine neurotransmitter.

Neurofibrillary tangles develop when microtubule tau proteins become hyperphosphorylated and aggregate within the neuronal cells. These tangles break down the neurons' ability to transport molecules along the axon. Neurofibrillary tangles initially form in the medial aspect and pole of the temporal lobe, especially the hippocampus. With increasing disease progression, they spread throughout the cortex, beginning in the high-order association regions and less commonly in the primary motor and sensory regions.

AD results from a buildup of amyloid beta plaques, leading to neuronal death.

Sample Question 2
What does neuroimaging provide in terms of examining the brain?

Neuroimaging is primarily used for studying the effects of medication on the brain.

Neuroimaging cannot provide any information about the brain's structure or volume.

Neuroimaging provides an excellent means of grossly examining the brain. It allows for volumetric measurements of individual structures and can be repeated over time as a coarse means of measuring disease progression. Neuroimaging also allows for exclusion of many reversible causes of dementia. Magnetic resonance imaging (MRI) is the preferred modality of imaging because it allows for excellent 3-dimensional visualization, especially of the hippocampus. The most common findings are cortical atrophy, dilated ventricles, and accentuated cortical sulci. On the T1-weighted MRI shown, extensive hippocampal atrophy has occurred on the right side (see arrow).

Neuroimaging is only useful for diagnosing brain tumors.

Sample Question 3
What is the primary use of CT scan in diagnosing Alzheimer's disease?

Computed tomography (CT) is not as useful as MRI in diagnosing or following the progression of Alzheimer's disease, although it is commonly used as a first-line modality in patients who present with dementia. The principal findings are similar in both modalities and changes over time are useful; however, on a CT scan, the etiology of cerebral atrophy is more difficult to discriminate between Alzheimer's disease and normal aging. The CT scan shown here demonstrates several areas of calcification within the basal ganglia, the result of extreme degeneration in a patient with Down's syndrome and early Alzheimer's disease

CT scan is the preferred imaging modality for diagnosing Alzheimer's disease.

CT scan is more accurate than MRI in diagnosing Alzheimer's disease.

CT scan is primarily used to monitor the progression of Alzheimer's disease.