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Understanding Alzheimer's Disease: Pathogenesis, Diagnosis, and Treatment

Understanding Alzheimer's Disease: Pathogenesis, Diagnosis, And Treatment

Explore the complexities of Alzheimer's disease, focusing on its symptoms, diagnosis, and management. This educational content is designed to enhance understanding of neurodegenerative disorders, pertinent for students and...

Questions: 4 | Attempts: 10 | Last updated: Aug 4, 2025

Sample Question
What is the pathogenesis of Alzheimer's Disease (AD)?

AD is caused by excess dopamine levels in the brain.

AD is due to a deficiency of acetylcholine neurotransmitter.

Neurofibrillary tangles develop when microtubule tau proteins become hyperphosphorylated and aggregate within the neuronal cells. These tangles break down the neurons' ability to transport molecules along the axon. Neurofibrillary tangles initially form in the medial aspect and pole of the temporal lobe, especially the hippocampus. With increasing disease progression, they spread throughout the cortex, beginning in the high-order association regions and less commonly in the primary motor and sensory regions.

AD results from a buildup of amyloid beta plaques, leading to neuronal death.