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Advanced Immunology and Immunopathology Quiz

Advanced Immunology And Immunopathology Quiz

Explore the complex world of immune system responses and disorders in our Immunology\/immunopathology quiz. Assess your understanding of key immunological concepts and their pathological implications, crucial for students and...

Questions: 28 | Attempts: 10 | Last updated: Aug 4, 2025

Sample Question 1
What is responsible for the immediate reaction to a bee sting and what is responsible for the delayed response?

*PREFORMED ANTIBODY(IGE) is the cause of Rapid reaction after exposure.*IgE cross linking on mast cells after re-exposure to presensitized antigen >Degranulation of mast cells>Histamine release(PRE-formed, just like ArylsuflatASE(Neutralizes leukotrienes) and HistaminASE(neutralizes histamine) from eosinophils along with serotonin).*But Delayed response is due to Leukotrienes(Arachidonic acid metabolite) released from mast cells(DE NOVO synthesized not preformed- other late phase recatants are also de novo synthesized like PAF and PG) and BOY THEY WILL ASK about delayed response(6-24 hours after repeat exposure).**Note Trypatase is a marker of Mast cell degranulation.

*Leukotrienes are responsible for the immediate reaction and histamine is responsible for the delayed response.

*IgG antibodies are responsible for the immediate reaction and cytokines are responsible for the delayed response.

*Histamine release is responsible for the immediate reaction and prostaglandins are responsible for the delayed response.

Sample Question 2
What lab test should you order first when suspecting a patient has an autoimmune disease?

Thyroid function tests (TFTs)

*ANA+ is highly sensitive marker that can help you to know that patient really does have autoimmune problem, afterwards you go to more specific tests to diagnose particular condition(anti Ds DNA, SnRP antibodies in SLE for example)

Complete blood count (CBC)

Liver function tests (LFTs)

Sample Question 3
A baby with recurrent bacterial pneumonia at the age of 9 months has a defect in?

*Maturation of Pre B cells into Mature B cells can not take place, Due to defective BTK(Tyrosine Kinase), if they want to fck you up:Maturation stops After HEAVY chain recombination so you do HHave HHeavy chains but you LLack LLight chains.*This B cell maturation defect predisposes to Bacterial infections after 6 month of age(IgG of mother goes away- Remember igG is an Opsonin that tags bacteria and facilitates phagocytosis and begins to be synthesized in baby after 3 months<doesn't happen here)*Patient will most likely be boy as this disorder is X-linked recessive and he will have decrease in ALL TYPES OF IMMUNOGLOBULINS(Due to B cell maturation defect), So lack of IgA would also predispose to Salmonella,influenza,Giardia Lamblia and Enteroviral infections.*Avoid LIVE vaccines like Salmonella-Oral(can still give polysaccharide vaccine-IM), BCG, POLIO(Sabin)

Production of antibodies by plasma cells

Maturation of neutrophils in the bone marrow

Maturation of T cells in the thymus