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Define The Following Terms Of Hematology-pathology Quiz

Explore the intricate world of blood disorders and cellular pathology with this focused assessment. Enhance your understanding and diagnostic skills in hematology-pathology, crucial for medical professionals and students aiming...

Questions: 27 | Attempts: 10 | Last updated: Aug 4, 2025

Sample Question
What is the next best step in the workup for a 21-year-old asymptomatic African-American woman with recurrent microscopic hematuria, normal renal ultrasonography, negative urine culture, and no casts present in the urine sediment?

Perform a kidney biopsy for further evaluation

Start empiric treatment with antibiotics for a possible urinary tract infection

Repeat urinalysis in one week

*Sickle cell screen (Induce sickling)The patient most likely has sickle cell trait(Aa), which causes recurrent microscopic hematuria.In sickle cell trait, the percentage of sickle hemoglobin is 40% to 45%, and the remainder of hemoglobin is hemoglobin A.*There are no sickle cells in the peripheral smear in sickle cell trait,therefore, a sickle cell screen is required to induce sickling of RBCs containing sickle hemoglobin. However, the O2 tension in the renal medulla is low enough to induce sickling of RBCs in the peritubular capillaries. This causes microinfarctions in the renal medulla leading to hematuria.*There is also the potential for renal papillary necrosis and subsequent loss of both concentration and dilution.