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Advanced Endocrine System and Hormonal Regulation Quiz

Advanced Endocrine System And Hormonal Regulation Quiz

Explore the intricate functions of the endocrine system through this focused assessment. Understand hormonal regulation, interactions, and their physiological impacts. Ideal for students and professionals in medical and health...

Questions: 26 | Attempts: 10 | Last updated: Aug 4, 2025

Sample Question 1
How do Insulin and C-Peptide levels vary with Exogenous insulin use (such as a bodybuilder trying to bulk up) versus Insulinoma and Sulfonylurea use?

Exogenous insulin use will have no effect on C-peptide levels.

*KEY POINT: C-peptide is marker of Endogenous Insulin synthesis.(insulin and C-peptide are released together from secretory granules)*So with EXOgenous insulin it will be decreased as ENDOgenous synthesis will be suppressed .vs*With insulinoma and Sulfonylurea use ENDOgenous insulin synthesis and secretion is INCREASED.*if you suspect insulinoma, for screening you can need abdominal CT.

Insulin and C-Peptide levels will decrease with Insulinoma and Sulfonylurea use.

Insulin and C-Peptide levels will increase with Exogenous insulin use.

Sample Question 2
In which organelles does cleavage of proinsulin into insulin happen and how does insulin leave the cell?

Golgi Apparatus

*Proinsulin is cleaved into INSULIN and Inactive C-peptide inside the SECRETORY GRANULES.*Well then insulin leaves the cell by EXOcytosis(Those secretory granules travel towards the plasma membrane and help insulin leave the cell)

Peroxisomes

Lysosomes

Sample Question 3
What are the structures of PREPROinsulin, PROinsulin, and insulin, and in which organelle is PREPROinsulin synthesized?

IMage is illlegal draw it.*Well, you should know structure of PROinsulin(alpha,Beta chains,DISULFIDE Bonds and C-peptide) then if you know that insulin doesn't have C-peptide attached to it you can deduce that anything that is different from Proinsulin but has C-peptide is PREPROinsulin and then anything that looks like proinsulin but has no C-peptide should be insulin.*SUPER HY: PREPRO INSULIN is Synthesized in ROUGH endoplasmic Reticulum.

PROinsulin contains C-peptide while insulin does not.

PREPROinsulin contains only alpha and beta chains, no C-peptide.

PREPROinsulin is synthesized in the smooth endoplasmic reticulum.