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Advanced Endocrine Disorders and Diagnostic Insights Quiz

Advanced Endocrine Disorders And Diagnostic Insights Quiz

Explore the complexities of endocrine system diseases with our focused quiz. Assess and enhance your understanding of endocrine pathology, crucial for medical students and professionals. This quiz aids in preparing for key...

Questions: 24 | Attempts: 12 | Last updated: Aug 4, 2025

Sample Question 1
MOST common symptom of Pituitary adenoma? HY anatomy correlate? MOST common type of pituitary adenoma?

The most common type of pituitary adenoma is Somatotroph adenoma

While Bitemporal hemianopia is often tested(As pituitary adenoma can compress optich chiasm), MOST common symptom is HEADACHE and it can be tested too.*MOST common pituitary adenoma is PROLACTINOMA(Derived from LACTOTROPHS-ACIDOPHILS)*Second most common is NON-functioning tumors that present with signs of PANHYPOpituitarism(can even cause STOMACH pain,fatigue,excessive thirst/urination,basically any sign caused by decreased hormone levels of ANY Hormone from pituitary) along with signs of mass-effect(bitemporal hemianopsia,headache).*Somatotroph ademona secreting GH is third most common.

Pituitary adenoma most commonly presents with signs of hyperpituitarism

Bitemporal hemianopia is the most common symptom of Pitutary adenoma

Sample Question 2
Pituitary adenoma secreting GH increases risk of which cancers?diagnosis?What is Most common cause of death in these patients?Acromegaly vs Gigantism?

*Increased GH>Increased cell growth of proliferation>Increased risk of cancer(especially COLORECTAL Cancer/Polyps).*Most common cause of death in patients with pituitary tumor secreting GH is Heart failure(due to hyperTROPHY), hypertrophy in response to GH is also what contributes to LARYNGEAL/TONGUE swelling(Contributing to DEEPER voice) and development of colorectal polyps/cancer.*Gigantism is when GH secreting hormone affects persons BEFORE epiphysela plates close(>MORE LINEAR GROWTH>GIGANT) vs ACROMEGALY happens when epiphyesal plates have already closed(So you mainly increase width of bones usually HANDS and feet get larger/thicker and facial features become more coarse, especially MANDIBLE is affected>Separation of teeth on lower jow)..*GH has pulsatile secretion and thus isn't really used for diagnosis instead we use IGF1 levels(mediates effects of GH and is stable) but they might also hint you on GH secreting tumor if GH serum levels did NOT decrease in response to oral glucose(Normally hyperglycemia>Decreased GH secretion).MRI showing mass could also help(remember BODYBUILDER can be getting GH/IGF1 from exogenous sources for gains)*Treatment should BEGIN with SURGERY(remove adenoma), but they often test the fact that Long-acting Somatostatin analog(OCTREOTIDE) can be used for treatment and you should also know that growth hormone RECEPTOR antagonist known as PEGVISOMANT.*Dopamine AGONISTS(like carbergoline) can be used too.

Gigantism is when GH secreting hormone mainly affects bone density and structure.

Most common cause of death in patients with pituitary tumor secreting GH is respiratory failure.

Increased GH>Increased cell growth of proliferation>Increased risk of lung cancer.

Sample Question 3
A boy with dwarfism (Laron syndrome) presents with short stature, small head circumference, prominent forehead, saddle nose, and micropenis. Despite these physical characteristics, his growth hormone (GH) levels are increased. Why might his GH levels be increased?

Excessive consumption of GH supplements

Due to a pituitary tumor secreting excess GH

*He likely has dwarfism(laron syndrome) and thus his GH receptors can NOT be activated by GH, hence GH can't promote IGF1 from LIVER(HY)secretion to mediate its effects and so you get less feedback inhibition and so you get INCREASED serum GH with DECREASED IGF1.

Genetic mutation leading to GH hypersecretion