USMLE Immunology - Part 2
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.JPG "USMLE Immunology - Part 2")
- 1.
- A.
JRA is simply the presence of RA that begins before the age of 21 years
- B.
Patients with JRA are less likely to have systemic symptoms, but the likelihood of high levels of serum rheumatoid factor is the same
- C.
Patients with JRA are more likely to have large joint involvement, but the likelihood of concurrent systemic symptoms is the same
- D.
Patients with JRA are more likely to have systemic symptoms and high levels of serum rheumatoid factor
- E.
Patients with JRA are more likely to have systemic symptoms and large joint involvement
- 2.
- A.
Interleukin-2
- B.
Interleukin-3
- C.
Interleukin-4
- D.
Interleukin-5
- E.
Interleukin-8
- 3.
- A.
B7
- B.
CD2
- C.
CD3
- D.
CD4
- E.
CD19
- F.
T-cell receptor
- 4.
![A 2-year-old girl with a lifelong history of malabsorptive
and foul-smelling diarrhea, weakness,
and general failure to thrive has just undergone
a small intestine biopsy (see image).
Her parents believe her problems began at 6
months of age, when she started eating solid
foods, but have signifi cantly worsened over the
past few months. The only recent change in
her diet is that she eats a bowl of cereal every
morning with her parents before they go to
work. She tried a dairy-free diet a month ago,
but it did not improve her symptoms. Which of
the following is the most likely diagnosis?
- ProProfs]( "A 2-year-old girl with a lifelong history of malabsorptive
and foul-smelling diarrhea, weakness,
and general failure to thrive has just undergone
a small intestine biopsy (see image).
Her parents believe her problems began at 6
months of age, when she started eating solid
foods, but have signifi cantly worsened over the
past few months. The only recent change in
her diet is that she eats a bowl of cereal every
morning with her parents before they go to
work. She tried a dairy-free diet a month ago,
but it did not improve her symptoms. Which of
the following is the most likely diagnosis?")
- A.
Abetalipoproteinemia
- B.
Celiac sprue
- C.
Lactase defi ciency
- D.
Viral enteritis
- E.
Whipple’s disease
- 5.
- A.
Absence of T lymphocytes
- B.
- C.
IgA, IgG, and IgM levels normal
- D.
IgG and IgM levels markedly decreased, no IgA
- E.
IgG and IgM levels normal, IgA markedly decreased
- 6.
- A.
Acute poststreptococcal glomerulonephritis
- B.
Alport’s syndrome
- C.
Goodpasture’s syndrome
- D.
IgA nephropathy
- E.
Membranous glomerulonephritis
- 7.
- A.
Graft-versus-host disease
- B.
Type I hypersensitivity
- C.
Type II hypersensitivity
- D.
Type III hypersensitivity
- E.
Type IV hypersensitivity
- 8.
- A.
Bruton’s agammaglobulinemia
- B.
Chédiak-Higashi disease
- C.
Job’s syndrome
- D.
Thymic aplasia
- E.
Wiskott-Aldrich syndrome
- 9.
- A.
Astrocytes
- B.
Ependymal cells
- C.
Oligodendrocytes
- D.
Schwann cells
- E.
T cells
- 10.
- A.
Androgens such as testosterone have an inhibitory role in the process of clearing immune complexes
- B.
Both estrogens and androgens have the same potency in inhibiting the clearing of immune complexes
- C.
Estrogen has an inhibitory role in the process of antibody production of B cells
- D.
Estrogen has an inhibitory role in the process of clearing immune complexes
- E.
Estrogen has a stimulatory role in the process of clearing immune complexes
- 11.
- A.
A defi cit in IgA level
- B.
A low IgM level, with increased IgA
- C.
A negative nitroblue tetrazolium dye test
- D.
An increase in IgE level
- E.
A normal Ig level for all isotypes
- 12.
- A.
Goodpasture’s syndrome is a disease with a similar reaction pathogenesis
- B.
Histamine is the primary mediator leading to this type of reaction
- C.
The pathogenesis implicates previously sensitized B lymphocytes
- D.
The patient has never been exposed to poison ivy
- E.
The patient is suffering from a type I hypersensitivity reaction
- F.
The patient must have been exposed to a poison ivy plant prior to this instance
- 13.
- A.
Disulfide bonds
- B.
Hydrogen bonds
- C.
Ionic bonds
- D.
Triple covalent bonds
- E.
Van der Waals forces
- 14.
![A 23-year-old woman comes to the physician
for a routine checkup. She has generally been
well over the past year, although she notes that
she has “had a few falls lately.” On physical examination,
the lesion shown in the image is
found on her skin. Blood is drawn for laboratory
evaluation. The results show that the
woman has very low levels of IgA. Based on her
presentation, this patient will most likely also
present with which of the following symptoms?
- ProProfs]( "A 23-year-old woman comes to the physician
for a routine checkup. She has generally been
well over the past year, although she notes that
she has “had a few falls lately.” On physical examination,
the lesion shown in the image is
found on her skin. Blood is drawn for laboratory
evaluation. The results show that the
woman has very low levels of IgA. Based on her
presentation, this patient will most likely also
present with which of the following symptoms?")
- A.
Cerebellar problems
- B.
Granulomas
- C.
Low levels of all other immunoglobulin isotypes
- D.
Tetany
- E.
Visual hallucinations
- 15.
- A.
Anticentromere antibodies
- B.
Antineutrophil cytoplasmic autoantibodies
- C.
Anti-Smith antibodies
- D.
Anti-SS-A (Ro) antibody
- E.
Anti-SS-B (La) antibody
.JPG "A 23-year-old woman comes to the physician
for a routine checkup. She has generally been
well over the past year, although she notes that
she has “had a few falls lately.” On physical examination,
the lesion shown in the image is
found on her skin. Blood is drawn for laboratory
evaluation. The results show that the
woman has very low levels of IgA. Based on her
presentation, this patient will most likely also
present with which of the following symptoms?")
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