Immunology Quiz- Antigen Processing And Presentation

11 Questions

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Immunology Quizzes & Trivia

Questions and Answers
  • 1. 
    The____ T cell-APC interaction is MHC____-restricted, and the____ T cell-target cell interaction is MHC____-restricted.
    • A. 

      CD4+; Class I; CD8+; Class II

    • B. 

      CD4+; Class II; CD8+; Class I

    • C. 

      CD8+; Class I; CD4+; Class II

    • D. 

      CD8+; Class II; CD4+; Class I

  • 2. 
    Which of the following describes where class I MHC is found and not where class II MHC is found?
    • A. 

      B cells

    • B. 

      Dendritic cells

    • C. 

      Macrophages

    • D. 

      Antigen presenting cells (A, B, & C)

    • E. 

      All nucleated cells

  • 3. 
    Peptides antigens generated in the cytosolic compartment (intracellular infection, e.g. virus) bind to____ MHC molecules for presentation to____ T cells. Peptide antigens generated in vesicles (extracellular infection, e.g. bacteria) bind to____ MHC molecules for presentation to____ T cells.
    • A. 

      Class I; CD4+; Class II; CD8+

    • B. 

      Class II; CD4+; Class I; CD8+

    • C. 

      Class I; CD8+; Class II; CD4+

    • D. 

      Class II; CD8+; Class I; CD4+

  • 4. 
    In the processing pathway for extracellular antigens, synthesis of MHC class II and invariant chain (li) occurs in the____.
    • A. 

      Cytosol

    • B. 

      Golgi apparatus

    • C. 

      Endoplasmic reticulum

    • D. 

      Ribosomes

    • E. 

      Lysosomes

  • 5. 
    The invariant chain____ the empty peptide-binding groove. After vesicle fusion, the invariant chain is____ and peptides can enter the MHC class II grove.
    • A. 

      Activates; Added

    • B. 

      Activates; Degraded

    • C. 

      Blocks; Added

    • D. 

      Blocks; Degraded

  • 6. 
    In the processing pathway for intracellular antigens, the proteasome will____ viral protein molecules until peptides of____ residues are formed; these can bind to class I MHC molecules.
    • A. 

      Build; 8-11

    • B. 

      Build; 9-30

    • C. 

      Break down; 8-11

    • D. 

      Break down; 9-30

  • 7. 
    • A. 

      Permits; Class I

    • B. 

      Permits; Class II

    • C. 

      Does not allow; Class I

    • D. 

      Does not allow; Class II

  • 8. 
    Mutations in TAP-1 or TAP-2 may alter the function of the heterodimer TAP. Which of the following is common for patients with TAP mutations?
    • A. 

      Human immuno-deficiency virus (HIV) infection

    • B. 

      Acquired immune deficiency syndrome (AIDS)

    • C. 

      Upper respiratory tract infections

    • D. 

      Coagulation disorders (hemophilia)

    • E. 

      Systemic inflammatory response syndrome (SIRS, sepsis)

  • 9. 
    • A. 

      Reduced likelihood that peptides will be expressed at the cell surface

    • B. 

      Fewer peptides are available to bind to class I MHC

    • C. 

      Reduced number of class I MHC molecules available to display peptides to CD8+ lymphocytes

  • 10. 
    • A. 

      Reduced likelihood that peptides will be expressed at the cell surface

    • B. 

      Fewer peptides are available to bind to class I MHC

    • C. 

      Reduced number of class I MHC molecules available to display peptides to CD8+ lymphocytes

  • 11. 
    Bacteria such as Mycobacterium tuberculosis have acquired the capacity to inhibit phagosome-lysosome fusion. What is a consequence of this?
    • A. 

      Reduced likelihood that peptides will be expressed at the cell surface

    • B. 

      Fewer peptides are available to bind to class I MHC

    • C. 

      Reduced number of class I MHC molecules available to display peptides to CD8+ lymphocytes Reduced number of class I MHC molecules available to display peptides to CD8+ lymphocytes