Immunology Quiz- Antigen Processing And Presentation

10 Questions | By Smb6 | Updated: Jun 26, 2022 | Attempts: 5275

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Immunology Quiz- Antigen Processing And Presentation - Quiz

Get ready for an immunology quiz that we have brought here for you. Antigen processing, or the cytosolic pathway, is meant by an immunological process that prepares antigens for presentation to special cells of the immune system that is called T lymphocytes. The quiz is about antigen processing and presentation. Here will be asking you a few questions that will be useful not only for your test but also to give you more in-depth knowledge of the subject. We hope you do your best!

Questions and Answers

1.

The____ T cell-APC interaction is MHC____-restricted, and the____ T cell-target cell interaction is MHC____-restricted.
- A.
  
  CD4+; Class I; CD8+; Class II
- B.
  
  CD4+; Class II; CD8+; Class I
- C.
  
  CD8+; Class I; CD4+; Class II
- D.
  
  CD8+; Class II; CD4+; Class I
2.

Which of the following describes where class I MHC is found and not where class II MHC is found?
- A.
  
  B cells
- B.
  
  Dendritic cells
- C.
  
  Macrophages
- D.
  
  Antigen-presenting cells (A, B, & C)
- E.
  
  All nucleated cells
3.

Peptides antigens generated in the cytosolic compartment (intracellular infection, e.g. virus) bind to____ MHC molecules for presentation to____ T cells. Peptide antigens generated in vesicles (extracellular infection, e.g. bacteria) bind to____ MHC molecules for presentation to____ T cells.
- A.
  
  Class I; CD4+; Class II; CD8+
- B.
  
  Class II; CD4+; Class I; CD8+
- C.
  
  Class I; CD8+; Class II; CD4+
- D.
  
  Class II; CD8+; Class I; CD4+
4.

In the processing pathway for extracellular antigens, synthesis of MHC class II and invariant chain (li) occurs in the____.
- A.
  
  Cytosol
- B.
  
  Golgi apparatus
- C.
  
  Endoplasmic reticulum
- D.
  
  Ribosomes
- E.
  
  Lysosomes
5.

The invariant chain____ the empty peptide-binding groove. After vesicle fusion, the invariant chain is____, and peptides can enter the MHC class II grove.
- A.
  
  Activates; Added
- B.
  
  Activates; Degraded
- C.
  
  Blocks; Added
- D.
  
  Blocks; Degraded
6.

In the processing pathway for intracellular antigens, the proteasome will____ viral protein molecules until peptides of____ residues are formed; these can bind to class I MHC molecules.
- A.
  
  Build; 8-11
- B.
  
  Build; 9-30
- C.
  
  Break down; 8-11
- D.
  
  Break down; 9-30
7.

The transporter associated with antigen presentation (TAP)____ the peptides to traverse the membrane bilayer of the endoplasmic reticulum and bind in the empty the peptide-binding groove of nascent MHC____ molecules being synthesized in the endoplasmic reticulum.
- A.
  
  Permits; Class I
- B.
  
  Permits; Class II
- C.
  
  Does not allow; Class I
- D.
  
  Does not allow; Class II
8.

Mutations in TAP-1 or TAP-2 may alter the function of the heterodimer TAP. Which of the following is common for patients with TAP mutations?
- A.
  
  Human immunodeficiency virus (HIV) infection
- B.
  
  Acquired immune deficiency syndrome (AIDS)
- C.
  
  Upper respiratory tract infections
- D.
  
  Coagulation disorders (hemophilia)
- E.
  
  Systemic inflammatory response syndrome (SIRS, sepsis)
9.

Certain strains of adenovirus express a protein that inhibits the transcription of class. I MHC molecules. What is the consequence of this?
- A.
  
  Reduced likelihood that peptides will be expressed at the cell surface
- B.
  
  Fewer peptides are available to bind to class I MHC.
- C.
  
  Reduced number of class I MHC molecules available to display peptides to CD8+ lymphocytes
- D.
  
  None of these
10.

A protein of herpes simplex virus (HSV) binds to TAP and inhibits peptide transport into the endoplasmic reticulum. What is the consequence of this?
- A.
  
  Reduced likelihood that peptides will be expressed at the cell surface
- B.
  
  Fewer peptides are available to bind to class I MHC.
- C.
  
  Reduced number of class I MHC molecules available to display peptides to CD8+ lymphocytes
- D.
  
  None of these