Immunology Quiz- Antigen Processing And Presentation
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- 1.The____ T cell-APC interaction is MHC____-restricted, and the____ T cell-target cell interaction is MHC____-restricted.
- A.
CD4+; Class I; CD8+; Class II
- B.
CD4+; Class II; CD8+; Class I
- C.
CD8+; Class I; CD4+; Class II
- D.
CD8+; Class II; CD4+; Class I
- 2.Which of the following describes where class I MHC is found and not where class II MHC is found?
- A.
B cells
- B.
Dendritic cells
- C.
Macrophages
- D.
Antigen presenting cells (A, B, & C)
- E.
All nucleated cells
- 3.Peptides antigens generated in the cytosolic compartment (intracellular infection, e.g. virus) bind to____ MHC molecules for presentation to____ T cells. Peptide antigens generated in vesicles (extracellular infection, e.g. bacteria) bind to____ MHC molecules for presentation to____ T cells.
- A.
Class I; CD4+; Class II; CD8+
- B.
Class II; CD4+; Class I; CD8+
- C.
Class I; CD8+; Class II; CD4+
- D.
Class II; CD8+; Class I; CD4+
- 4.In the processing pathway for extracellular antigens, synthesis of MHC class II and invariant chain (li) occurs in the____.
- A.
Cytosol
- B.
Golgi apparatus
- C.
Endoplasmic reticulum
- D.
Ribosomes
- E.
Lysosomes
- 5.The invariant chain____ the empty peptide-binding groove. After vesicle fusion, the invariant chain is____ and peptides can enter the MHC class II grove.
- A.
Activates; Added
- B.
Activates; Degraded
- C.
Blocks; Added
- D.
Blocks; Degraded
- 6.In the processing pathway for intracellular antigens, the proteasome will____ viral protein molecules until peptides of____ residues are formed; these can bind to class I MHC molecules.
- A.
Build; 8-11
- B.
Build; 9-30
- C.
Break down; 8-11
- D.
Break down; 9-30
- 7.The transporter associated with antigen presentation (TAP)____ the peptides to traverse the membrane bilayer of the endoplasmic reticulum and bind in the empty peptide-binding groove of nascent MHC____ molecules being synthesized in the endoplasmic reticulum.
- A.
Permits; Class I
- B.
Permits; Class II
- C.
Does not allow; Class I
- D.
Does not allow; Class II
- 8.Mutations in TAP-1 or TAP-2 may alter the function of the heterodimer TAP. Which of the following is common for patients with TAP mutations?
- A.
Human immuno-deficiency virus (HIV) infection
- B.
Acquired immune deficiency syndrome (AIDS)
- C.
Upper respiratory tract infections
- D.
Coagulation disorders (hemophilia)
- E.
Systemic inflammatory response syndrome (SIRS, sepsis)
- 9.Certain strains of adenovirus express a protein that inhibits the transcription of class I MHC molecules. What is a consequence of this?
- A.
Reduced likelihood that peptides will be expressed at the cell surface
- B.
Fewer peptides are available to bind to class I MHC
- C.
Reduced number of class I MHC molecules available to display peptides to CD8+ lymphocytes
- 10.A protein of herpes simplex virus (HSV) binds to TAP and inhibits peptide transport into the endoplasmic reticulum. What is a consequence of this?
- A.
Reduced likelihood that peptides will be expressed at the cell surface
- B.
Fewer peptides are available to bind to class I MHC
- C.
Reduced number of class I MHC molecules available to display peptides to CD8+ lymphocytes
- 11.Bacteria such as Mycobacterium tuberculosis have acquired the capacity to inhibit phagosome-lysosome fusion. What is a consequence of this?
- A.
Reduced likelihood that peptides will be expressed at the cell surface
- B.
Fewer peptides are available to bind to class I MHC
- C.
Reduced number of class I MHC molecules available to display peptides to CD8+ lymphocytes Reduced number of class I MHC molecules available to display peptides to CD8+ lymphocytes
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