.
CD4+; Class I; CD8+; Class II
CD4+; Class II; CD8+; Class I
CD8+; Class I; CD4+; Class II
CD8+; Class II; CD4+; Class I
B cells
Dendritic cells
Macrophages
Antigen presenting cells (A, B, & C)
All nucleated cells
Class I; CD4+; Class II; CD8+
Class II; CD4+; Class I; CD8+
Class I; CD8+; Class II; CD4+
Class II; CD8+; Class I; CD4+
Cytosol
Golgi apparatus
Endoplasmic reticulum
Ribosomes
Lysosomes
Activates; Added
Activates; Degraded
Blocks; Added
Blocks; Degraded
Build; 8-11
Build; 9-30
Break down; 8-11
Break down; 9-30
Permits; Class I
Permits; Class II
Does not allow; Class I
Does not allow; Class II
Human immuno-deficiency virus (HIV) infection
Acquired immune deficiency syndrome (AIDS)
Upper respiratory tract infections
Coagulation disorders (hemophilia)
Systemic inflammatory response syndrome (SIRS, sepsis)
Reduced likelihood that peptides will be expressed at the cell surface
Fewer peptides are available to bind to class I MHC
Reduced number of class I MHC molecules available to display peptides to CD8+ lymphocytes
Reduced likelihood that peptides will be expressed at the cell surface
Fewer peptides are available to bind to class I MHC
Reduced number of class I MHC molecules available to display peptides to CD8+ lymphocytes
Reduced likelihood that peptides will be expressed at the cell surface
Fewer peptides are available to bind to class I MHC
Reduced number of class I MHC molecules available to display peptides to CD8+ lymphocytes Reduced number of class I MHC molecules available to display peptides to CD8+ lymphocytes