Principles Of Pharmacology Quiz: Test!

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  • 1/15 Questions

    If a drug is 80% bound to blood elements or plasma proteins, what part is considered the free form?

    • 20%
    • 40%
    • 50%
    • 80%
    • 100%
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About This Quiz

This Principles of Pharmacology Quiz tests your understanding of drug mechanisms, receptor interactions, and the biological origin of toxins. It evaluates key concepts such as agonist activity, xenobiotics, and enantiomer potency, essential for students and professionals in pharmacology.

Principles Of Pharmacology Quiz: Test! - Quiz

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  • 2. 

    What type of drug is propranolol (Inderal)?

    • Anticonvulsive

    • Antihypertensive

    • Antihistamine

    • Antinauseant

    • Antipyretic

    Correct Answer
    A. Antihypertensive
    Explanation
    Propranolol (Inderal) is classified as an antihypertensive drug. It is commonly used to treat high blood pressure and prevent angina (chest pain) and heart attacks. Propranolol works by blocking the effects of adrenaline, which helps to lower blood pressure and reduce the workload on the heart. It is not an anticonvulsive, antihistamine, antinauseant, or antipyretic drug.

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  • 3. 

    Which of the following describes an agonist?

    • Any substance that brings about a change in biologic function through its chemical action

    • A specific regulatory molecule in the biologic system where a drug interacts

    • A drug that binds to a receptor and stimulates cellular activity

    • A drug that binds to a receptor and inhibits or opposes cellular activity

    • A drug directed at parasites infecting the patient

    Correct Answer
    A. A drug that binds to a receptor and stimulates cellular activity
    Explanation
    An agonist is a drug that binds to a receptor and stimulates cellular activity. Unlike an antagonist, which inhibits or opposes cellular activity, an agonist activates the receptor and triggers a response in the cell. This can lead to various physiological effects, such as increased neurotransmitter release or muscle contraction. Agonists are commonly used in medical treatments to mimic the effects of natural substances in the body or to enhance cellular activity for therapeutic purposes.

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  • 4. 

    Which of the following is NOT part of the etymology of the word pharmacology?

    • MEDICINES

    • DRUG

    • HERB

    • POISON

    • STUDY

    Correct Answer
    A. HERB
    Explanation
    The word pharmacology is derived from the Greek words "pharmakon" meaning drug or medicine, and "logos" meaning study. Therefore, the etymology of the word does not include the term "HERB".

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  • 5. 

    If a patient misses three doses of their daily drug, which of the following (in general) is the best solution?

    • Take a 4x dose at the next dose time

    • Wait 3 more days (week total) then return to normal regimen

    • Do nothing and continue normal regimen

    • Setup an appointment to have the patient evaluated

    • Prescribe a higher dosage pill so missed doses will have less effect

    Correct Answer
    A. Do nothing and continue normal regimen
    Explanation
    If a patient misses three doses of their daily drug, the best solution, in general, is to do nothing and continue with the normal regimen. This is because abruptly changing the dosage or waiting for a longer period before resuming the normal regimen can have adverse effects on the patient's health. It is important to maintain consistency in medication schedules, and missing a few doses does not necessarily warrant any immediate changes or evaluations.

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  • 6. 

    Which of the following would be a toxin (poison of biological origin)?

    • Pb

    • As

    • Hg

    • ATROPINE

    Correct Answer
    A. ATROPINE
    Explanation
    Atropine would be considered a toxin because it is a naturally occurring compound found in plants such as deadly nightshade. It acts as a competitive antagonist of acetylcholine at muscarinic receptors, blocking the effects of the neurotransmitter. Atropine can cause various toxic effects such as dry mouth, blurred vision, increased heart rate, and even hallucinations in high doses. Therefore, it qualifies as a poison of biological origin.

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  • 7. 

    Which of the following is an example of a drug acting directly through receptors?

    • Protamine binds stoichiometrically to heparin anticoagulants

    • Adrenergic beta blockers for thyroid hormone-induced tachycardia

    • Epinephrine for increasing heart rate and blood pressure

    • Cancer chemotherapeutic agents

    • Mannitol for subarachnoid hemmorhage

    Correct Answer
    A. Epinephrine for increasing heart rate and blood pressure
    Explanation
    Epinephrine acts directly through receptors to increase heart rate and blood pressure. Epinephrine binds to adrenergic receptors in the heart and blood vessels, activating them and causing an increase in heart rate and constriction of blood vessels, leading to an increase in blood pressure. This direct interaction with receptors is what allows epinephrine to have its desired physiological effects on the cardiovascular system.

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  • 8. 

    The drug chloramphenicol (Chloromycetin) is risky for which of the following?

    • Congestive heart failure patients

    • Obese patients

    • Adult males

    • Geriatric patients

    • Neonates

    Correct Answer
    A. Neonates
    Explanation
    Chloramphenicol is risky for neonates because it can cause a serious condition called gray baby syndrome, where the baby's skin turns gray and they experience difficulty in breathing, low body temperature, low blood pressure, and even death. Neonates have immature liver function, which leads to the accumulation of chloramphenicol in their body, causing toxicity. Therefore, it is important to avoid using chloramphenicol in neonates and choose alternative antibiotics instead.

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  • 9. 

    Xenobiotics are considered:

    • Endogenous

    • Exogenous

    • Inorganic poisons

    • Toxins

    • Ligands

    Correct Answer
    A. Exogenous
    Explanation
    Xenobiotics are considered exogenous because they are substances that are foreign to the body and are not naturally produced or found within it. They can include drugs, chemicals, pollutants, and other substances that are introduced into the body from external sources. These exogenous substances can have various effects on the body, including toxicity and the potential to cause harm. Therefore, xenobiotics are categorized as exogenous rather than endogenous, which refers to substances that are naturally produced within the body.

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  • 10. 

    Which of the following is NOT a protein target for drug binding?

    • Side of action (transport)

    • Enzymes

    • Carrier molecules

    • Receptors

    • Ion channels

    Correct Answer
    A. Side of action (transport)
    Explanation
    The side of action (transport) is not a protein target for drug binding. Drug targets are typically proteins that are involved in specific biological processes or pathways, such as enzymes, carrier molecules, receptors, and ion channels. These proteins play crucial roles in mediating the effects of drugs on cells and tissues. However, the side of action (transport) refers to the location or site where a drug exerts its effects, such as the site of action for drug absorption, distribution, metabolism, or excretion. It is not a specific protein target for drug binding.

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  • 11. 

    Drugs fit receptors using the lock and key model. Covalent bonds are the ____ and the ____ specific.

    • Strongest; Most

    • Strongest; Least

    • Weakest; Most

    • Weakest; Least

    Correct Answer
    A. Strongest; Least
    Explanation
    In the lock and key model, drugs fit receptors through covalent bonds. Covalent bonds are the strongest type of chemical bond, meaning they require a significant amount of energy to break. Therefore, when drugs form covalent bonds with receptors, it creates a strong and stable interaction. On the other hand, the term "least specific" refers to the fact that covalent bonds are not highly selective in terms of the specific receptors they interact with. They are more likely to form bonds with a variety of different receptors, making them less specific compared to other types of bonds.

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  • 12. 

    How does the glomerular filtration rate (GFR) change after the age of 40?

    • Increase 1% each year

    • Increases 2% each year

    • Decreases 1% each year

    • Decreases 2% each year

    • Does not depend on age

    Correct Answer
    A. Decreases 1% each year
    Explanation
    The glomerular filtration rate (GFR) is the rate at which blood is filtered by the kidneys. As a person ages, the GFR tends to decrease gradually. This is because the kidneys become less efficient in filtering waste products from the blood. The decrease in GFR is estimated to be around 1% per year after the age of 40. This decline in kidney function is a normal part of the aging process and can lead to a decreased ability to remove waste products from the body.

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  • 13. 

    Which of the following describes minimal effective concentration (MEC)?

    • The minimal drug plasma concentration that can be detected

    • The minimal drug plasma concentration to enter tissues

    • The minimal drug plasma concentration to interact with receptors

    • The minimal drug plasma concentration to produce effect

    • The minimal drug plasma concentration to reach therapeutic levels

    Correct Answer
    A. The minimal drug plasma concentration to produce effect
    Explanation
    The minimal effective concentration (MEC) refers to the minimum drug plasma concentration required to produce a therapeutic effect. This means that the drug needs to reach a certain concentration in the bloodstream in order to have the desired effect on the body. It is important to reach this minimal concentration to ensure that the drug is effective and produces the desired outcome.

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  • 14. 

    A decrease in renal and liver function, as seen in the elderly, would prolong drug half-life, ____ plasma protein binding, and ____ volume of distribution.

    • Increase; Increase

    • Decrease; Decrease

    • Increase; Decrease

    • Decrease; Increase

    Correct Answer
    A. Decrease; Decrease
    Explanation
    As renal and liver function decreases in the elderly, the ability to eliminate drugs from the body is impaired. This leads to a longer drug half-life, meaning it takes longer for the drug to be cleared from the body. Additionally, a decrease in renal and liver function can also result in a decrease in plasma protein binding, which is the process by which drugs bind to proteins in the blood. When the binding decreases, more of the drug remains free and active in the bloodstream, further prolonging its effects. Finally, a decrease in renal and liver function can also lead to a decrease in the volume of distribution, which refers to the distribution of the drug throughout the body. With a smaller volume of distribution, the drug is more concentrated in the bloodstream, increasing its potency and prolonging its effects.

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  • 15. 

    Warfarin (Coumadin) is given as a racemic mixture with the S enantiomer being four times more active than the R enantiomer. If the mixture of Warfarin given is 50% S and 50% R, what is the potency compared with a 100% R enantiomer solution?

    • 4 * R + 1 * S = 1

    • 4 * R + 1 * S = 1.5

    • 4 * R + 1 * S = 2

    • 4 * R + 1 * S = 2.5

    • 4 * R + 1 * S = 4

    Correct Answer
    A. 4 * R + 1 * S = 2.5
    Explanation
    The correct answer is 4 * R + 1 * S = 2.5. This equation represents the potency of the mixture of Warfarin given, which is 50% S and 50% R. Since the S enantiomer is four times more active than the R enantiomer, it is given a potency of 4, while the R enantiomer is given a potency of 1. By multiplying the potency of each enantiomer by their respective percentages and summing them up, we get the total potency of the mixture. In this case, it is 4 * R + 1 * S = 2.5.

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  • Mar 21, 2023
    Quiz Edited by
    ProProfs Editorial Team
  • Jul 14, 2012
    Quiz Created by
    Knoweducation
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