Protein Synthesis Inhibitors

15 Questions | By Saskia1 | Last updated: Nov 13, 2017 | Total Attempts: 1644

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Protein synthesis is the term given to the biological process whereby cells generate new proteins, and it is balanced by the loss of cellular proteins via degradation or export. What inhibits this process? You tell us!

Questions and Answers

1.

Which of the following protein synthesis inhibitors have a wide spectrum (H. influenzae, N. mening, Bacteroides, Rickettsia, Salmonella), whose mechanism of resistance is plasmid-mediated acetyltransferases that inactivate the drug. Site of inhibition is 50 S.
- A.
  
  Chloramphenicol
- B.
  
  Tetracyclines (doxycyline, minocycline)
- C.
  
  Macrolides ( erythromycin, azithromycin)
- D.
  
  Ketolides (telithromycin)
- E.
  
  Clindamycin
- F.
  
  Aminoglycosides (gentamycin, neomycin, tobramycin, streptomycin)
- G.
  
  Oxazolidinones (Linezolid)
2.

Which of the following is 50 S, vs Gram Positive and some Gram Negative (chlamydia, mycoplasma, ureaplasma, legionella, campylobacter). It´s mech of resistance is methylation of binding site on 50S and increased efflux from multidrug exporters.
- A.
  
  Chloramphenicol
- B.
  
  Tetracyclines (doxycycline /minocycline)
- C.
  
  Macrolides (erythromycin, azithromycin)
- D.
  
  Ketolides (telithromycin)
- E.
  
  Clindamycin
- F.
  
  Aminoglycosides (gentamycin/neomycin/tobramycin/streptomycin)
- G.
  
  Oxazolidinones (Linezolid)
3.

Which of the following can cause Fanconi Syndrome when expired:
- A.
  
  Chloramphenicol
- B.
  
  Tetracyclines (doxycyline/minocycline)
- C.
  
  Macrolides (erythromycin/azithromycin)
- D.
  
  Ketolides (telitrhomycin)
- E.
  
  Clindamycin
- F.
  
  Aminoglycosydes (gentamycin/neomycin/tobramycin/streptomycin)
- G.
  
  Oxazolidinones (Linezolid)
4.

Which protein synthesis inhibitors are best know for causing otoxicity and nephrotoxicity?
- A.
  
  Chloramphenicol
- B.
  
  Tetracyclines (doxycyline/minocycline)
- C.
  
  Macrolides (erythromycin/azithromycin)
- D.
  
  Ketolides (telithromycin)
- E.
  
  Clindamycin
- F.
  
  Aminoglycosides (gentamycin/neomycin/tobramycin/streptomycin)
- G.
  
  Oxazolidinones (Linezolid)
5.

Which one resistance is rare? (50S)
- A.
  
  Chloramphenicol
- B.
  
  Tetracyclines (doxycycline/minocycline)
- C.
  
  Macrolides (erythromlycin/azithromycin)
- D.
  
  Ketolides (telithromycin)
- E.
  
  Clindamycin
- F.
  
  Aminoglycosides (gentamycin/neomycin/tobramycin/streptomycin)
- G.
  
  Oxazolidinones (Linezolid)
6.

Name the site of inhibition for the following protein synthesis inhibitors:ChloramphenicolTetracyclinesMacrolidesKetolidesClindamycinAminoglycosidesOxazolidinones
7.

What protein synthesis inhibitor has a very similar spetrum to macrolides but many macrolide resistant strains are susceptible to it. It´s use is limited because of toxicity (severe hepatoxicity, visual disturbances, fainting).
- A.
  
  Chloramphenicol
- B.
  
  Tetracyclines (doxycycline/ minocycline)
- C.
  
  Macrolides /erythromycin/ azithromycin)
- D.
  
  Ketolides (telithromycin)
- E.
  
  Clindamycin
- F.
  
  Aminoglycosides (gentamycin/neomycin/tobramycin/streptomycin)
- G.
  
  Oxazolidinones (Linezolid)
8.

Which macrolide does not inhibit CYP3A4?
- A.
  
  Erhtyromycin
- B.
  
  Azythromycin
- C.
  
  Clarithromycin
9.

Which protein synthesis inhibitor is useful in atypical pneumonia?
- A.
  
  Chloramphenicol
- B.
  
  Tetracyclines (doxycycline/minocycline)
- C.
  
  Macrolides (erythromycin/azithromycin)
- D.
  
  Ketolide (telithromycin)
- E.
  
  Clindamycin
- F.
  
  Aminglycosides (gentamycin/neomycin/tobramycin(streptomycin)
- G.
  
  Oxazolidinones (Linezolid)
10.

Which protein synthesis inhibitors (30S) have spectrum of equal Gram Positive and Gram Negative (ricketssia, chlamydia, mycoplasma, H. pylori, Brucella, vibrio).
- A.
  
  Chloramphenicol
- B.
  
  Tetracyclines (doxycycline/minocycline)
- C.
  
  Macrolides (erythromycin/azithromycin)
- D.
  
  Ketolides (telithromycin)
- E.
  
  Clindamycin
- F.
  
  Aminoglycosides (gentamycin, neomycin, tobramycin, streptomycin)
- G.
  
  Oxazolidinenons (Linezolid)
11.

Which of the following protein synthesis inhibitors can cause the following toxicities: - tooth enamel dysplasia- bone growth irregularities-hepatotoxicity-photosensitivity-vestibular toxicity-GI irritation
- A.
  
  Chloramphenicol (50S)
- B.
  
  Tetracycline (30S)
- C.
  
  Macrolide (50S)
- D.
  
  Ketolide (50S)
- E.
  
  Clindamycin (50S)
- F.
  
  Aminoglycoside (30S)
- G.
  
  Oxazolidinones (50S)
12.

Which of the following is CI with MAO Inhibitors (dietary and drug restrictions)?
- A.
  
  Chloramphenicol (50S)
- B.
  
  Tetracycline (30S)
- C.
  
  Macrolide (50S)
- D.
  
  Ketolide (50S)
- E.
  
  Clindamycin (50S)
- F.
  
  Aminoglycosides (30S)
- G.
  
  Oxazolidinones (50S)
13.

Gray Baby Syndrome, caused by chloramphenicol use, is due to a decrease in glucoronyl transferase in neonates.
- A.
  
  True
- B.
  
  False
14.

Which of the following MC causes aplastic anemia or BMS?
- A.
  
  Chloramphenicol (50S)
- B.
  
  Tetracyclines (30S)
- C.
  
  Macrolides (50S)
- D.
  
  Ketolides (50S)
- E.
  
  Clindamycin (50S)
- F.
  
  Aminoglycosides (30S)
- G.
  
  Oxazolidinones (50S)
15.

Which of the following MC causes thrombocytopenia or neutropenia, especially in immunocompromised patients?
- A.
  
  Chloramphenicol
- B.
  
  Tetracyclines
- C.
  
  Macrolides
- D.
  
  Ketolides
- E.
  
  Clindamycin
- F.
  
  Aminoglycoside
- G.
  
  Oxazolidinones

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