Pharmacology Quinolones

22 Questions | Total Attempts: 1556

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Pharmacology Quinolones

Quinolones not too short anymore eh?


Questions and Answers
  • 1. 
    Quinolones work on which mechanism to kill bacteria?
    • A. 

      Inhibit topoisomerase II

    • B. 

      Inhibit topoisomerase IV

    • C. 

      Inhibit DNA gyrase

    • D. 

      Inhibit cell wall production

    • E. 

      Inhibit cell membrane permeability

  • 2. 
    Where are FQNs concentrated/what systems are they used to treat?
    • A. 

      Liver/hepatosepsis

    • B. 

      GI tract infection

    • C. 

      Urinary tract infections

    • D. 

      Lungs infection

    • E. 

      Kidney infection

  • 3. 
    Which of the following quinolones has a halflife longer than 6 hours? OR are all of the halflives for FQNs the same?
    • A. 

      Ciprofloxacin

    • B. 

      Lomefloxacin

    • C. 

      Sparfloxacin

    • D. 

      Moxifloxacin

    • E. 

      Nalidixic acid

  • 4. 
    Which groups on the FQN molecule add potency or extended spectrum?
    • A. 

      Fluorine

    • B. 

      Pipirizine ring adds gram negative action

    • C. 

      COOH group adds gram negative action

    • D. 

      Other side chains

  • 5. 
    Metal binding and chelation are caused by which structure on a flouroquinolone?
    • A. 

      N group

    • B. 

      Fluorine

    • C. 

      Pipirizine ring

    • D. 

      Keto group

    • E. 

      COOH

  • 6. 
    FQNs interact with what drugs?
    • A. 

      Theophylline

    • B. 

      NSAIDs

    • C. 

      Polyvalent cations

    • D. 

      APAP

    • E. 

      Penicillin

  • 7. 
    What are important adverse effects for FQNs?
    • A. 

      Phototoxicity

    • B. 

      Genetic toxicity (contra'd in pregnancy)

    • C. 

      Ototoxicity

    • D. 

      Renal toxicity

    • E. 

      Liver toxicity

  • 8. 
    Which of the following are particularly sensitive to FQNs?
    • A. 

      Mycoplasma pneumonia

    • B. 

      Legionella

    • C. 

      Chlamydia

    • D. 

      Staphylococcus

    • E. 

      Mycobacterium

  • 9. 
    Which are of the following are sensitive to fluoroquinolones in general?
    • A. 

      Salmonella and E Coli

    • B. 

      Neisseria gonorrhea

    • C. 

      Klebsiella

    • D. 

      MRSA

    • E. 

      Haemophilus

  • 10. 
    Which FQN is used more to treat Pseudomonis aeruginosa?
    • A. 

      Moxifloxacin

    • B. 

      Levofloxacin

    • C. 

      Nalidixic Acid

    • D. 

      Ciprofloxacin

    • E. 

      Sprafloxacin

  • 11. 
    Which FQN is preferred to treat Enterococci?
    • A. 

      Ciprofloxacin

    • B. 

      Moxifloxacin

    • C. 

      Sparfloxacin

    • D. 

      Levofloxacin

    • E. 

      Nalidixic acid

  • 12. 
    Which FQN is preferred to treat bacteroides?
    • A. 

      Moxifloxacin

    • B. 

      Levofloxacin

    • C. 

      Ciprofloxacin

    • D. 

      Nalidixic acid

    • E. 

      Sprafloxacin

  • 13. 
    Which FQN is preferred to treat Streptococci/
    • A. 

      Ciprofloxacin

    • B. 

      Nalidixic acid

    • C. 

      Moxifloxacin

    • D. 

      Levofloxacin

    • E. 

      Sparfloxacin

  • 14. 
    Which of the following are indications for FQNs?
    • A. 

      UTIs

    • B. 

      Bacterial gastroenteritis

    • C. 

      Skin infection

    • D. 

      Pneumonia

    • E. 

      Oral infection

  • 15. 
    Which FQNs are likely to cause long QT syndrome?
    • A. 

      Moxifloxacin

    • B. 

      Moxifloxacin

    • C. 

      Ciprofloxacin

    • D. 

      Sprafloxacin

    • E. 

      Nalidixic acid

  • 16. 
    Which effects are most common for FQs?
    • A. 

      GI disturbances

    • B. 

      Photosensitivity

    • C. 

      CNS toxicity

    • D. 

      Myalgia

  • 17. 
    What do Nalidixic acid, Methenamine, and nitrofurantoin have in common?
    • A. 

      They are all FQNs

    • B. 

      They concentrate in the urine

    • C. 

      They are wide spectrum antibiotics

    • D. 

      They are mainly used to combat UTIs

    • E. 

      They all damage the DNA of invading bacteria

  • 18. 
    Which of the following are more active in lower pH?
    • A. 

      Methenamine

    • B. 

      NAlidixic Acid

    • C. 

      Nitrofurantoin

    • D. 

      Ciprofloxacin

    • E. 

      Moxifloxacin

  • 19. 
    Which drugs are affected by Metronidazole and why?
    • A. 

      Only aerobic are affected because they activate nitroreductase

    • B. 

      Only gram negative are affected because they allow penetration of the cell much easier

    • C. 

      Only anaerobic species are affected because they activate nitroreductase

    • D. 

      Only gram positive are affected because they allow penetration of cell much easier

  • 20. 
    Which of the following are affected by metronidazole?
    • A. 

      Anaerobic bacteria

    • B. 

      Aerobic bacteria

    • C. 

      Bacteroides

    • D. 

      Gram positive bacteria

    • E. 

      Parasites

  • 21. 
    What are common side effects of metronidazole?
    • A. 

      Reddish brown urine

    • B. 

      Cramping and GI effects

    • C. 

      Cartialge damage

    • D. 

      Thrush and Yeast infection

    • E. 

      Hepatitis

  • 22. 
    Which of the following are specialized non-FQNs used for UTIs exclusively?
    • A. 

      Metronidazole

    • B. 

      Moxifloxacin

    • C. 

      Nalidixic acid

    • D. 

      Nitrofurantoin

    • E. 

      Methenzmine

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