Pharm 1- Hematology Drugs

69 Questions | By Chinedua | Updated: Mar 21, 2022 | Attempts: 1373

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Review quiz based on pharmacology lecture on Hematology

Questions and Answers

1.

Which of the following does not contribute to thrombosis?
- A.
  
  Blood flow abnormalities
- B.
  
  Contact surface abnormalities
- C.
  
  Complement abnormalities
- D.
  
  None of the above
2.

Vrichow's Triad features 3 broad catergories of Factors that prevent thrombosis
- A.
  
  True
- B.
  
  False
3.

The non-living fluid matrix of blood is called
- A.
  
  Formed elements
- B.
  
  Connective tissue
- C.
  
  Plasma
- D.
  
  None of the above
4.

Thrombocytes are a part of plasma
- A.
  
  True
- B.
  
  False
5.

Which of the following is not found dissolved in plasma
- A.
  
  Proteins
- B.
  
  Nutrients
- C.
  
  Platelets
- D.
  
  Waste products
- E.
  
  None of the above
6.

Which plasma protein is converted to form the basic framework for a blood clot
- A.
  
  Globulin
- B.
  
  Fibrinogen
- C.
  
  Albumin
- D.
  
  Bilirubin
7.

Pt. presents with liver disorder, which of the following is least likely to result from this
- A.
  
  Increased synthesis of vitamin K
- B.
  
  Decreased synthesis of Fibrinogen
- C.
  
  Clotting factor problems
- D.
  
  Decreased plasma protein levels
- E.
  
  None of the above
8.

When megakaryocytes shed their cytoplasm into small membrane enclosed packets these packets leave the bone marrow and enter the blood to become
- A.
  
  Red blood cells
- B.
  
  Platelets
- C.
  
  Lymphocytes
- D.
  
  Mast cells
9.

Platelets aid in which one of the major functions of blood?
- A.
  
  Regulation of pH & ion concentration of interstitial fluids
- B.
  
  Defense against toxins and pathogens
- C.
  
  Stabilization of body temperature
- D.
  
  Transportation of nutrients hormones, wastes and dissolved gasses
- E.
  
  Restriction of fluid losses at injury sites
10.

The intrinsic pathway/ contact activation pathway and extrinsic pathway converge at the point of thrombin formation
- A.
  
  True
- B.
  
  False
11.

Which of the following would affect hemostatis
- A.
  
  Vit. k synthesis
- B.
  
  Clotting factors
- C.
  
  Liver disorder
- D.
  
  All of the above
12.

Normal clotting occurs in __________ minutes
- A.
  
  2
- B.
  
  6
- C.
  
  12
- D.
  
  15
13.

Extrinisc pathway is activated by
- A.
  
  Abnormal vessel wall in the absence of injury
- B.
  
  tissue injury
- C.
  
  All of the above
14.

An abnormal vessel wall in the absense of injury may activate clotting through the _________ pathway
- A.
  
  Intrinsic
- B.
  
  Extrinsic
- C.
  
  Contact activation
- D.
  
  A & C
- E.
  
  None of the above
15.

Hemostasis is the process that halts bleeding, which of its following phases are the last to occur
- A.
  
  Coagulation
- B.
  
  Vascular spasms
- C.
  
  platelet plug formation
16.

During the Vascular phase of Hemostasis serotonin causes
- A.
  
  Platelets to pile up to form a platelet plug
- B.
  
  Blood vessel to spasm
- C.
  
  Complement activation
- D.
  
  Drowsiness
17.

The exposure of collagen fibers in a broken blood vessel initiate which stage of hemostasis
- A.
  
  Vascular spasm
- B.
  
  Platelet plug formation
- C.
  
  Coagulation
- D.
  
  None of the above
18.

During the coagulation phase of hemostasis platelets release thromboplastin which combines with clotting factors and triggers the clotting cascade
- A.
  
  True
- B.
  
  False
19.

Which is the correct chronological order of the clotting cascade
- A.
  
  Prothrombin activator -> thrombin -> prothrombin-> fibrinogen-> fibrin-> meshwork
- B.
  
  Meshwork-> thrombin->prothrombin activator-> prothrombin->fibrin-> fibrinogen
- C.
  
  Prothrombin activator-> Prothrombin-> Thrombin-> Fibrinogen-> Fibrin-> Meshwork
- D.
  
  Fibrin-> fibrinogen-> Prothrombin->thrombin-> Meshwork
20.

Coagulation lab studies include all of the following except
- A.
  
  Platelet count
- B.
  
  INR
- C.
  
  PT
- D.
  
  PTT
- E.
  
  PPD
21.

Lab tests reveal patient does not have enough platelets and tiny blood clots are "eating" platelets. This patient is suffering from
- A.
  
  Sickle Cell Anemia
- B.
  
  Thrombotic Thrombocytopenic Purpura
- C.
  
  Idiopathic thrombocytopenia
- D.
  
  None of the above
22.

Lab studies reveal the patient's platelets are being coated with IgG and are not being recognized as self. As a result, macrohpages are destroying the platelets. This is dx as ________
- A.
  
  Thrombotic thrombocytopenic purpura
- B.
  
  Idiopathic thrombocytopenia
- C.
  
  Disseminated intravascular coagulation
- D.
  
  None of the above
23.

Lab tests reveal that your patient is experiencing pathological activation of the clotting cascade and there are multiple little blood clots all through out the vasculature this consumption of clotting factors and platelets will lead to
- A.
  
  Disseminated intravascular coagulation
- B.
  
  TTP
- C.
  
  Bleeding
- D.
  
  A & C
- E.
  
  All of the above
24.

Which of the following is correct
- A.
  
  Von Willebrand's Disease - Factor IX deficient
- B.
  
  Hemophilia B (Christmas Disease) - Factor VII deficient
- C.
  
  Hemophilia A - Factor IX deficient
- D.
  
  None of the above
25.

Hemophilia and Von Willebrand's disease are hereditary
- A.
  
  True
- B.
  
  False