This Pharmacology Final Part 1 assesses understanding of drug efficacy, receptor types, and agonist-antagonist interactions. It challenges students to analyze graphs, understand drug potency, and differentiate between types of agonists, preparing them for advanced medical and pharmaceutical applications.
Emax
Bmax
EC50
Kd
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An inverse agonist is a partial agonist
A partial agonist can produce the full effect as long as all receptors are bound
A physiological antagonist binds to the same receptor as the agonist
A partial agonist is inhibitory in the presence of a full agonist
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Emax will decrease
EC50 will decrease
The dose response curve will shift to the right
A and B
B and C
All of the above
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G protein
Kinase linked receptors
Ligand gated ion channel
Nuclear receptors
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Drug A
Drug B
Drug C
Drug D
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Tyrosine Kinase
Tyrosine Phosphatase
JAK-STAT
Tyrosine kinase associaated
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Intracellular receptor
Receptor tyrosine kinase
Cytokine receptor
Receptor tyrosine phosphatase
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GTP;GDP
GDP;GTP
ADP;ATP
ATP;ADP
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Calcium moving into the synaptic terminal
Reserpine
Cocaine
Amphetamine
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Amphetamine
Phenylephrine
Ephedrine
All of the above are blocked or blunted by reserpine
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Substitution at the alpha carbon of a sympathomimetic amine results in MAO protection
An increase in the size of the substituent on the N substituent of an sympathomimetic amine results in greater alpha activity
An -OH group at the 3 and 4 position of the benzene ring of a sympathomimetic amine gives it greater alpha and beta activity
An -OH group at the 3 and 4 position of the benzene ring of a sympathomimetic amine subjects it to COMT metabolism
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D-tubocurarine
Succinylcholine
Pilocarpine
Varenicline
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Echothiophate
Sarin
Parathion
Physostigmine
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JAK-STAT
Tyrosine-Kinase associated receptor
Receptor Tyrosine Phosphatase
Receptor Serine Threonine Kinase
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A1
A2
B1
B2
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A1
A2
B1
B2
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A1
A2
B1
B2
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Bronchodilation
Decreased salivation
Decreased GI motility
Decreased Heart Rate
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Transduction
Transformation
Conjugation
Not horizontal but vertical gene transfer
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1
2
3
4
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Inhibition of transpeptidase
Inhibition of transglucuronidase
Inhibition of transglycosylase
Inhibition of beta lactamase
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Meropenem
Ertapenem
Imipenem
Aztreonam
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Erythromycin
Gentamycin
Vancomycin
Telithromycin
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Doxycycline
Levofloxacin
Penicillin
Paromomycin
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Minocycline
Amikacin
Ciprofloxacin
Streptogramins
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Streptogramins
Linezolid
Chloramphenicol
Paromomycin
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Doxycline
Ciprofloxacin
Tigecycline
Neomycin
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Gram positive
Gram negative
Anaerobic
Aerobic
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Telithromycin
Erythromycin
Ciprofloxacin
Gentamicin
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Macrolides
Tetracyclines
Fluoroquinolones
Aminoglycosides
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Moxifloxacin
Streptomycin
Doxycycline
Chloramphenicol
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Streptogramins
Chloramphenicol
Linezolid
Clindamycin
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Rifampin
Streptomycin
Cycloserine
Isoniazid
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Ethambutol
Isoniazid
Rifampin
Cycloserine
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Isoniazid
P-aminosalicylic acid
Cycloserine
Rifampin
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Azithromycin
Rifampin
Erythromycin
None of the above are inhibitors
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Monobactam
Penicillin
Carbapenem
Cephalosporin
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Clindamycin
Doxycycline
Linezolid
Gemifloxacin
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