Pharmacology Final Part 1
.
- 1.
![Graphs B and C show Physiological effect vs concentration and Binding vs concentration for the same drug respectively. Comparing the two graphs, is it apparent that there are spare receptors?
In the image above, - ProProfs]( "Graphs B and C show Physiological effect vs concentration and Binding vs concentration for the same drug respectively. Comparing the two graphs, is it apparent that there are spare receptors?
In the image above,")
Graphs B and C show Physiological effect vs concentration and Binding vs concentration for the same drug respectively. Comparing the two graphs, is it apparent that there are spare receptors? In the image above,- A.
Yes
- B.
No
- 2._______ is a measure of efficacy
- A.
Emax
- B.
Bmax
- C.
EC50
- D.
Kd
- 3.Which of the following is true?
- A.
An inverse agonist is a partial agonist
- B.
A partial agonist can produce the full effect as long as all receptors are bound
- C.
A physiological antagonist binds to the same receptor as the agonist
- D.
A partial agonist is inhibitory in the presence of a full agonist
- 4.When an agonist is in the presence of an irreversible competitive antagonist:
- A.
Emax will decrease
- B.
EC50 will decrease
- C.
The dose response curve will shift to the right
- D.
A and B
- E.
B and C
- F.
All of the above
- 5.Which receptor type achieves its physiological response the most rapidly?
- A.
G protein
- B.
Kinase linked receptors
- C.
Ligand gated ion channel
- D.
Nuclear receptors
- 6.
![Which drug is the most potent? - ProProfs]( "Which drug is the most potent?")
Which drug is the most potent?- A.
Drug A
- B.
Drug B
- C.
Drug C
- D.
Drug D
- 7.Which of the following receptors has only a single transmembrane region (subunit) capable of binding with the ligand?
- A.
Tyrosine Kinase
- B.
Tyrosine Phosphatase
- C.
JAK-STAT
- D.
Tyrosine kinase associaated
- 8.Insulin is an example of a ligand for what receptor type?
- A.
Intracellular receptor
- B.
Receptor tyrosine kinase
- C.
Cytokine receptor
- D.
Receptor tyrosine phosphatase
- 9.Following G protein receptor activation, _________ dissociates from the alpha subunit and ______ binds to it causing dissociation of the alpha subunit from the beta-gamma subunit.
- A.
GTP;GDP
- B.
GDP;GTP
- C.
ADP;ATP
- D.
ATP;ADP
- 10.Which of the following would decrease the amount of norepinephrine in the synapse?
- A.
Calcium moving into the synaptic terminal
- B.
Reserpine
- C.
Cocaine
- D.
Amphetamine
- 11.Which of the following drug's effect would not be blocked or blunted by reserpine?
- A.
Amphetamine
- B.
Phenylephrine
- C.
Ephedrine
- D.
All of the above are blocked or blunted by reserpine
- 12.Which of the following is false?
- A.
Substitution at the alpha carbon of a sympathomimetic amine results in MAO protection
- B.
An increase in the size of the substituent on the N substituent of an sympathomimetic amine results in greater alpha activity
- C.
An -OH group at the 3 and 4 position of the benzene ring of a sympathomimetic amine gives it greater alpha and beta activity
- D.
An -OH group at the 3 and 4 position of the benzene ring of a sympathomimetic amine subjects it to COMT metabolism
- 13.Which of the following is the only available depolarizing nicotinic antagonist?
- A.
D-tubocurarine
- B.
Succinylcholine
- C.
Pilocarpine
- D.
Varenicline
- 14.Which of the following is an irreversible acetycholinesterase inhibitor that is used therapeutically?
- A.
Echothiophate
- B.
Sarin
- C.
Parathion
- D.
Physostigmine
- 15.Which of the following receptors has intrinsic kinase ability?
- A.
JAK-STAT
- B.
Tyrosine-Kinase associated receptor
- C.
Receptor Tyrosine Phosphatase
- D.
Receptor Serine Threonine Kinase
- 16.An agonist of which of the following receptors would likely treat nasal congestion?
- A.
A1
- B.
A2
- C.
B1
- D.
B2
- 17.An agonist of which of the following receptors would likely treat hypertension?
- A.
A1
- B.
A2
- C.
B1
- D.
B2
- 18.An antagonist of which of the following receptors would have anti-arrhythmic activity?
- A.
A1
- B.
A2
- C.
B1
- D.
B2
- 19.Which of these is not a result of muscarinic antagonists binding to their receptor?
- A.
Bronchodilation
- B.
Decreased salivation
- C.
Decreased GI motility
- D.
Decreased Heart Rate
- 20.Which of the following mechanisms of horizontal gene transfer would involve the uptake of naked DNA from the environment by a competent bacteria?
- A.
Transduction
- B.
Transformation
- C.
Conjugation
- D.
Not horizontal but vertical gene transfer
- 21.Which generation penicillin has best activity against enteric organisms?
- A.
1
- B.
2
- C.
3
- D.
4
- 22.The mechanism by which vancomycin treats bacterial infection is:
- A.
Inhibition of transpeptidase
- B.
Inhibition of transglucuronidase
- C.
Inhibition of transglycosylase
- D.
Inhibition of beta lactamase
- 23.Which of the following is a monobactam?
- A.
Meropenem
- B.
Ertapenem
- C.
Imipenem
- D.
Aztreonam
- 24.Which of the following is a 30S inhibitor?
- A.
Erythromycin
- B.
Gentamycin
- C.
Vancomycin
- D.
Telithromycin
- 25.Which of the following is a bacteriocidal agent that is known to cause photosensitivity?
- A.
Doxycycline
- B.
Levofloxacin
- C.
Penicillin
- D.
Paromomycin
Questions: 20 | Attempts: 24847 | Last updated: Jan 8, 2021
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