Pharmacology Final Part 1

39 Questions | By Uncadf | Updated: Mar 22, 2022 | Attempts: 451

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1.

Graphs B and C show Physiological effect vs concentration and Binding vs concentration for the same drug respectively. Comparing the two graphs, is it apparent that there are spare receptors? In the image above,
- A.
  
  Yes
- B.
  
  No
2.

_______ is a measure of efficacy
- A.
  
  Emax
- B.
  
  Bmax
- C.
  
  EC50
- D.
  
  Kd
3.

Which of the following is true?
- A.
  
  An inverse agonist is a partial agonist
- B.
  
  A partial agonist can produce the full effect as long as all receptors are bound
- C.
  
  A physiological antagonist binds to the same receptor as the agonist
- D.
  
  A partial agonist is inhibitory in the presence of a full agonist
4.

When an agonist is in the presence of an irreversible competitive antagonist:
- A.
  
  Emax will decrease
- B.
  
  EC50 will decrease
- C.
  
  The dose response curve will shift to the right
- D.
  
  A and B
- E.
  
  B and C
- F.
  
  All of the above
5.

Which receptor type achieves its physiological response the most rapidly?
- A.
  
  G protein
- B.
  
  Kinase linked receptors
- C.
  
  Ligand gated ion channel
- D.
  
  Nuclear receptors
6.

Which drug is the most potent?
- A.
  
  Drug A
- B.
  
  Drug B
- C.
  
  Drug C
- D.
  
  Drug D
7.

Which of the following receptors has only a single transmembrane region (subunit) capable of binding with the ligand?
- A.
  
  Tyrosine Kinase
- B.
  
  Tyrosine Phosphatase
- C.
  
  JAK-STAT
- D.
  
  Tyrosine kinase associaated
8.

Insulin is an example of a ligand for what receptor type?
- A.
  
  Intracellular receptor
- B.
  
  Receptor tyrosine kinase
- C.
  
  Cytokine receptor
- D.
  
  Receptor tyrosine phosphatase
9.

Following G protein receptor activation, _________ dissociates from the alpha subunit and ______ binds to it causing dissociation of the alpha subunit from the beta-gamma subunit.
- A.
  
  GTP;GDP
- B.
  
  GDP;GTP
- C.
  
  ADP;ATP
- D.
  
  ATP;ADP
10.

Which of the following would decrease the amount of norepinephrine in the synapse?
- A.
  
  Calcium moving into the synaptic terminal
- B.
  
  Reserpine
- C.
  
  Cocaine
- D.
  
  Amphetamine
11.

Which of the following drug's effect would not be blocked or blunted by reserpine?
- A.
  
  Amphetamine
- B.
  
  Phenylephrine
- C.
  
  Ephedrine
- D.
  
  All of the above are blocked or blunted by reserpine
12.

Which of the following is false?
- A.
  
  Substitution at the alpha carbon of a sympathomimetic amine results in MAO protection
- B.
  
  An increase in the size of the substituent on the N substituent of an sympathomimetic amine results in greater alpha activity
- C.
  
  An -OH group at the 3 and 4 position of the benzene ring of a sympathomimetic amine gives it greater alpha and beta activity
- D.
  
  An -OH group at the 3 and 4 position of the benzene ring of a sympathomimetic amine subjects it to COMT metabolism
13.

Which of the following is the only available depolarizing nicotinic antagonist?
- A.
  
  D-tubocurarine
- B.
  
  Succinylcholine
- C.
  
  Pilocarpine
- D.
  
  Varenicline
14.

Which of the following is an irreversible acetycholinesterase inhibitor that is used therapeutically?
- A.
  
  Echothiophate
- B.
  
  Sarin
- C.
  
  Parathion
- D.
  
  Physostigmine
15.

Which of the following receptors has intrinsic kinase ability?
- A.
  
  JAK-STAT
- B.
  
  Tyrosine-Kinase associated receptor
- C.
  
  Receptor Tyrosine Phosphatase
- D.
  
  Receptor Serine Threonine Kinase
16.

An agonist of which of the following receptors would likely treat nasal congestion?
- A.
  
  A1
- B.
  
  A2
- C.
  
  B1
- D.
  
  B2
17.

An agonist of which of the following receptors would likely treat hypertension?
- A.
  
  A1
- B.
  
  A2
- C.
  
  B1
- D.
  
  B2
18.

An antagonist of which of the following receptors would have anti-arrhythmic activity?
- A.
  
  A1
- B.
  
  A2
- C.
  
  B1
- D.
  
  B2
19.

Which of these is not a result of muscarinic antagonists binding to their receptor?
- A.
  
  Bronchodilation
- B.
  
  Decreased salivation
- C.
  
  Decreased GI motility
- D.
  
  Decreased Heart Rate
20.

Which of the following mechanisms of horizontal gene transfer would involve the uptake of naked DNA from the environment by a competent bacteria?
- A.
  
  Transduction
- B.
  
  Transformation
- C.
  
  Conjugation
- D.
  
  Not horizontal but vertical gene transfer
21.

Which generation penicillin has best activity against enteric organisms?
- A.
  
  1
- B.
  
  2
- C.
  
  3
- D.
  
  4
22.

The mechanism by which vancomycin treats bacterial infection is:
- A.
  
  Inhibition of transpeptidase
- B.
  
  Inhibition of transglucuronidase
- C.
  
  Inhibition of transglycosylase
- D.
  
  Inhibition of beta lactamase
23.

Which of the following is a monobactam?
- A.
  
  Meropenem
- B.
  
  Ertapenem
- C.
  
  Imipenem
- D.
  
  Aztreonam
24.

Which of the following is a 30S inhibitor?
- A.
  
  Erythromycin
- B.
  
  Gentamycin
- C.
  
  Vancomycin
- D.
  
  Telithromycin
25.

Which of the following is a bacteriocidal agent that is known to cause photosensitivity?
- A.
  
  Doxycycline
- B.
  
  Levofloxacin
- C.
  
  Penicillin
- D.
  
  Paromomycin