Cell Wall Inhibitors

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Cell Wall Inhibitors - Quiz

Cell wall inhibitors


Questions and Answers
  • 1. 
    All of the above , kill the enzyme secrete from the bacteria , except : 
    • A. 

      Clavulanic acid

    • B. 

      B-Lactamase inhibitors

    • C. 

      Teicoplanin

    • D. 

      Sulbactam

    • E. 

      Tazobactam

  • 2. 
    All of the above refer to the B-lactams except :
    • A. 

      Monobactams

    • B. 

      Cephalosporins

    • C. 

      Penicillins

    • D. 

      Cycloserine

    • E. 

      Cabapenems

  • 3. 
    All of the above isn't true regarding the D-cycloserine , except :
    • A. 

      It occurs in the cytoplasm & involves a racemase enzyme which converts the D-alanine to L-alanine, and ligase which couples two D-alanines together.

    • B. 

      They have found major applications in the treatment of infections

    • C. 

      They can blocked forming the stem peptide .

    • D. 

      Interferes with the early stage of synthesis of peptidoglycan involving the assembly of the dipeptide D-alanine-D-alanine

    • E. 

      All answer is correct

  • 4. 
    All of the above is correct regarding activity of vancomycin, except:
    • A. 

      Vancomycin is active against G+ve bacteria

    • B. 

      Vancomycin is inactive against G-ve bacteria

    • C. 

      Vancomycin isn't inactive against MRSA

    • D. 

      Vancomycin is active against Streptococci

    • E. 

      Vancomycin isn't active against Enterococcus faecalis

  • 5. 
    The inactivity  of Vancomycin towered Gram-negative bacteria because
    • A. 

      Can penetrate through the outer membrane of Gram-negative bacteria

    • B. 

      The large molecule size of Gram-negative bacteria

    • C. 

      Can't penetrate through the outer membrane of Gram-negative bacteria

    • D. 

      The large molecule size of vancomycin

    • E. 

      2 answer is correct

  • 6. 
    Teicoplanin :
    • A. 

      Can treat infection of gram +ve and -ve

    • B. 

      Its similar to vancomycin in does and all things

    • C. 

      Its similar to vancomycin in chemical structure but vancomycin posses more fatty acid side chains

    • D. 

      Can treat infection of gram +ve and cant of -ve

    • E. 

      All answer correct except 1 opition

  • 7. 
    About the difference between Vancomycin and Teicoplanin :
    • A. 

       Vancomycin posses less fatty acid side chains than Teicoplani

    • B. 

       Vancomycin more acidic than Teicoplani

    • C. 

      Vancomycin given IV and IM while Teicoplani given at one of site when Vancomycin is given

    • D. 

      Vancomycin more lipophilic than Teicoplani

    • E. 

      Vancomycin more effect than Teicoplani

    • F. 

      Vancomycin administered per 12 hours while Teicoplani administered per 6 hours

    • G. 

      Vancomycin are a slightly higher potency against most target organisms and a better toxicity profile rather thanTeicoplanin

    • H. 

      3 Answer is correct

    • I. 

      All answer is not correct

  • 8. 
    Select true answer  regarding Peptidoglycan biosynthesis in bacteria  :  
    • A. 

      The process of formation of Peptidoglycan take place in cytoplasm

    • B. 

      Peptidoglycan is a macromolecule composed of sugar (glycan)^NAM and NAG ^ ( bound with b-1,4-glycosidic bond ) cross-linked by short peptide chains.

    • C. 

      Each (NAM) contains a short peptide substituent made up of four amino acids (the stem peptides).

    • D. 

      In the stem peptides there are the D-isomers of some amino acids (particularly D-alanine and D-glutamic acid) and unusual amino acids such as meso-diaminopimelic acid which are not found in proteins

    • E. 

      All answer is correct

  • 9. 
    Select true answer  regarding Peptidoglycan biosynthesis in bacteria  :  
    • A. 

      The crosslinking of the stem peptides : a direct peptide bond between the fourth amino acid on one chain and the third amino acid on an adjacent chain (NOT same amino acids )

    • B. 

      The crosslinking of the stem peptides :may involve a short peptide bridge between the same amino acids on the stem peptides.

    • C. 

      The functions of peptidoglycan: Responsible for maintaining the shape AND Act as a mechanical strength of the bacterial cell.

    • D. 

      If it is damaged in any way, or its synthesis is inhibited, then the shape of the cells becomes distorted and they will eventually burst (lyse) due to the high internal osmotic pressure.

    • E. 

      ALL answer is correct

  • 10. 
    Antibiotics which interfere with the synthesis and assembly of peptidoglycan show excellent selective toxicity compared with other antibiotics (e.g. protein synthesis inhibitors).This is because:
    • A. 

      Mammalian cells do not possess a cell wall

    • B. 

      Mammalian contain no other macromolecules resembling peptidoglycan.

    • C. 

      Mammalian cells possess a cell wall

    • D. 

      Mammalian contain other macromolecules resembling peptidoglycan.

    • E. 

      2 answer is correct

  • 11. 
    All of the above is NOT true regarding Peptidoglycan biosynthesis in bacteria  , except :
    • A. 

      L-alanine converts to D-alanine in present of ligase

    • B. 

      Couples two D-alanines together occur in present of racemase

    • C. 

      Transglycosylase enzyme Form glycosidic bond between the new monomer and the existing Peptidoglycan

    • D. 

      The final stage of peptidoglycan assembly is the cross-linking of the linear glycan strands assembled by transglycosylation to the existing peptidoglycan in the cell wall occur without penicillin binding protein

    • E. 

      The transfer new monomer (NAM and NAG) to the existing Peptidoglycan does not need carrier

  • 12. 
    All of the above is true regarding MOA of Vancomycin & teicoplanin , Except: 
    • A. 

      Work in the stage when the transglycosylase enzyme work.

    • B. 

      Does not penetrate the cell membrane of bacteria but must cross the cell wall to reach the outer face of the cell membrane

    • C. 

      It has been suggested that two vancomycin molecules from a back-to-back dimer which bridges between pentapeptides on separate glycan chains, thus preventing further peptidoglycan assembly

    • D. 

      Glycopeptides prevent Form peptidoglycan

    • E. 

      Bind to the enzyme itself, but do not to the disaccharide peptidoglycan precursor (disaccharide-pentapeptide )

    • F. 

      They are not active against G-ve organisms due to the presence of the outer membrane.

  • 13. 
    One of the above is not correct regarding sources of penicillins:
    • A. 

      Naturally occurring: produced by fermentation of moulds such as Penicillium notatum and P. chrysogenum.

    • B. 

      The most important examples of Semisynthetic penicillins : benzylpenicillin and phenoxymethylpenicillin

    • C. 

      Benzylpenicillin is (penicillin G) while phenoxymethylpenicillin is (penicillin V).

    • D. 

      In Semisynthetic Penicillins 6-aminopenicillanic acid (6-APA) is needed

    • E. 

      No answer is correct

  • 14. 
    ALL of the above effect or  (inactivation) by b-lactamases EXCPET:
    • A. 

      Anti-staphylococcal penicillins

    • B. 

      Broad Spectrum Penicillins

    • C. 

      Extended penicillins

    • D. 

      Anti-pseudomonal penicillins

    • E. 

      Natural penicillins

    • F. 

      No answer is correct

  • 15. 
    Penicillin G, Procaine, Penicillin V treat all of the above except:
    • A. 

      G+ve strains of streptococci

    • B. 

      Staphylococci

    • C. 

      Meningococcus

    • D. 

      All G-ve bacteria

    • E. 

      No answer is correct

  • 16. 
    All of the above isnt true regarding  Anti-staphylococcal penicillins , Except:
    • A. 

      The group contain Methicillin, Carbenicillin, ticarcillin, piperacillin, and dicloxacillin

    • B. 

      The group effect in Methicillin - resistant strains of Staphylococcus aureus

    • C. 

      This group isn’t targets a specific group of bacteria which produces the β-lactamase enzyme/penicillinase-producing Staphylococci

    • D. 

      The group contain Ampicillin and amoxicillin

    • E. 

      The group isn't effect in (MRSA)

  • 17. 
    Anti-pseudomonal penicillins :
    • A. 

      It isn't extended penicillins

    • B. 

      They are susceptible to activation by b-lactamases

    • C. 

      They are susceptible to inactivation by penicillinase-producing pseudomonal

    • D. 

      It isn't has an activity against Pseudomonas aeruginosa

    • E. 

      All answer is correct

  • 18. 
    About Broad Spectrum Penicillins:
    • A. 

      Have an antibacterial spectrum similar to Penicillin G but more effective against G+ve bacteria

    • B. 

      Resistance to these antibiotics is a major clinical problem because of activation by penicillinase

    • C. 

      Formulations are made by combining these compounds with β-lactamase inhibitors such as Cephalexin acid because it inactivation β-lactamase enzyme

    • D. 

      Have an antibacterial spectrum similar to Penicillin V but more effective against G-ve bacteria

    • E. 

      All answer is correct

    • F. 

      All answer isn't correct

  • 19. 
    All of the above is'nt correct regarding ,1st Generation ,EXCEPT: 
    • A. 

      They are drug of choice for such infections caused by Streptococcus

    • B. 

      They are good drug active against MRSA

    • C. 

      They are active against EKP G-ve Bacteria

    • D. 

      This group can cross BBB so it can treat meningitis

    • E. 

      They are susceptible to inactivation by b-lactamases

    • F. 

      Active against P. aeruginosa

    • G. 

      2 answer is correct

  • 20. 
    All of the above is correct regarding , 2nd Generation of cephalosporins  ,EXCEPT: 
    • A. 

      More activity against G-ve compared with 1st generation.

    • B. 

      Same activity against G+ve compared with 1st generation.

    • C. 

      More resistant to b-lactamase compared with 1st generation.

    • D. 

      More resistant to Escherichia coli , Klebsiella and Proteus compared with 1st generation.

    • E. 

      Same activity against P. aeruginosa. compared with 1st generation.

    • F. 

      Less resistant to meningitis than 4th generation

    • G. 

      Same activity against P. aeruginosa. compared with 3rd generation.

    • H. 

      3 Answer is correct

  • 21. 
    All of the above isn't correct regarding , 3rd generation cephalosporins ,EXCEPT:
    • A. 

      Extended spectrum of activity against G+ve organisms.

    • B. 

      They have a greater resistance to beta-lactamases than the Fourth generation cephalosporins.

    • C. 

      Can't reach the central nervous system (CNS).

    • D. 

      They aren't susceptible to inactivation by b-lactamases

    • E. 

      2 answer is correct

  • 22. 
    All of the above is correct regarding Cephalosporins drugs to treat P. aeruginosa , ,EXCEPT:
    • A. 

      Ceftazidime has more activity against P. aeruginosa compared with Cefpirome and Cefquinome

    • B. 

      Cefadroxil and Cefazolin has same activity against P. aeruginosa compared with cafaclor and cefprozil

    • C. 

      Cephradine and cephapirin has less activity against P. aeruginosa than Ceftazidime

    • D. 

      Cephradine and cephapirin has less activity against P. aeruginosa than cafaclor and cefprozil

    • E. 

      Cephradine and cephapirin has less activity against P. aeruginosa than cafaclor and cefprozil

    • F. 

      Cephalexin and Cephalothin has less activity against P. aeruginosa than Ceftazidime

  • 23. 
    All of the above is correct regarding Cephalosporins drugs can cross BBB , ,EXCEPT:
    • A. 

      Cefazolin can't cross BBB while cefepime it can

    • B. 

      Cefuroxime can't cross BBB while ceftazidime it can

    • C. 

      Cefozopran can cross BBB while cefaclor it can't

    • D. 

      Cefoxitin can't cross BBB while Ceftriaxone it can

    • E. 

      Cefuroxime can't cross BBB while ceftazidime it can

    • F. 

      Cefuroxime can't cross BBB while ceftazidime it can

  • 24. 
    All of the above isn't correct regarding Cephalosporins drugs can treat MRSA  , ,EXCEPT:
    • A. 

      Ceftriiaxone can't treat MRSA while cefaclor it can

    • B. 

      Cefepime can't treat MRSA while ceftiraxone it can

    • C. 

      Cefozopran can't treat MRSA while cefiquinome it can

    • D. 

      Cefprozil can't treat MRSA while cefoxitin it can

    • E. 

      Cefuroxime can't treat MRSA while ceftobiprole it can

  • 25. 
    All of the above is correct regarding Cephalosporins drugs can treat VRE , ,EXCEPT:
    • A. 

      Cephalexin can't treat it

    • B. 

      Ceftaroline can't treat it

    • C. 

      Ceftobiprole can't treat it

    • D. 

      Ceftriaxone can't treat it

    • E. 

      Cephalothin can't treat it

    • F. 

      Cephalothin can't treat it