Cell Wall Inhibitors

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| By Salem.lababneh
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1. All of the above refer to the B-lactams except :

Explanation

The given options include Monobactams, Cephalosporins, Penicillins, and Cabapenems, which are all types of B-lactams. However, cycloserine is not a B-lactam.

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About This Quiz
Cell Wall Inhibitors - Quiz

This quiz focuses on cell wall inhibitors, assessing knowledge of their mechanisms and specific activities against bacterial structures. It is designed to enhance understanding of antibiotic classes and their clinical applications, crucial for healthcare professionals.

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2. About the Resistance to b-lactam antibiotics

Explanation

هذا السؤال الدكتور حكاه بالشرح وركز كثيييييييييييييييير عليه

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3. All of the above , kill the enzyme secrete from the bacteria , except : 

Explanation

not-available-via-ai

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4. About MOA of penicillins, cephalosporins, carbapenems, monobactams :

Explanation

The given answer states that all of the statements provided are correct. The statements mentioned in the question explain the mechanism of action (MOA) of penicillins, cephalosporins, carbapenems, and monobactams. These antibiotics work in the final stage of peptidoglycan synthesis by inhibiting the cross-linking of the linear glycan strands. They also inhibit transglycosylation through transpeptidase enzymes, and they act as alternative substrates to inhibit transpeptidases. Additionally, β-lactam antibiotics inhibit carboxy/transpeptidase or penicillin-binding proteins (PBPs) involved in the late stages of peptidoglycan biosynthesis. Therefore, all of the statements mentioned are correct.

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5. Piperacillin + tazobactam given: 

Explanation

The correct answer is "parenterally" because piperacillin + tazobactam is a combination antibiotic that is typically administered through injection or infusion directly into the bloodstream. This route of administration allows for the medication to quickly reach the systemic circulation and exert its therapeutic effects throughout the body. Ophthalmic, nasal, and oral routes would not be appropriate for the administration of piperacillin + tazobactam.

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6. Select true answer  regarding Peptidoglycan biosynthesis in bacteria  :  

Explanation

The given answer states that all the statements provided regarding peptidoglycan biosynthesis in bacteria are correct. The statements mentioned in the question describe the process of peptidoglycan formation, its composition, and the presence of specific amino acids in the stem peptides. Since all the statements are accurate and provide correct information, the answer "All answer is correct" is the correct choice.

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7. Select true answer  regarding Peptidoglycan biosynthesis in bacteria  :  

Explanation

The correct answer is ALL answer is correct because all of the statements mentioned in the options are true regarding Peptidoglycan biosynthesis in bacteria. The crosslinking of the stem peptides can occur through a direct peptide bond between specific amino acids on adjacent chains or through a short peptide bridge between the same amino acids. Peptidoglycan is responsible for maintaining the shape and providing mechanical strength to bacterial cells. If it is damaged or its synthesis is inhibited, the cells will become distorted and eventually burst due to high internal osmotic pressure.

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8. Penicillin G, Procaine, Penicillin V treat all of the above except:

Explanation

Penicillin G, Procaine, and Penicillin V are effective in treating G+ve strains of streptococci, staphylococci, and meningococcus. However, they are not effective against G-ve bacteria. Therefore, the correct answer is "All G-ve bacteria."

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9. Active against EKP :

Explanation

الدكتور ما حكى بشكل صريح او بالسلايد انو
الجيل الثالث باثر على
EKP
بس موجود بالسلايد انو الجيل الثالث احسن جيل لل
-VE
وال EKP
تعبر G-ve

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10. All of the above is correct regarding Monobactams (AZTREANAM) , ,EXCEPT:

Explanation

Aztreanam is a monobactam antibiotic that is administered by intravenous injection and can be used for patients with allergies to penicillins and cephalosporins. It is active against G-ve aerobic bacteria, such as Ps. aeruginosa. However, it does not have any activity against G+ve or aerobic bacteria. Therefore, the statement "Aztreanam has no activity against G+ve or aerobic bacteria" is incorrect.

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11. Has been combined with both ampicillin and cefoperazone , but in both products the two ingredients were separate entities :

Explanation

The given question states that sulbactam has been combined with both ampicillin and cefoperazone, but in both products, the two ingredients were separate entities. Therefore, the answer to the question is sulbactam.

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12. Match the following
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13. All of the above is correct regarding activity of vancomycin, except:

Explanation

Vancomycin is a glycopeptide antibiotic that is primarily active against Gram-positive bacteria. It is effective against a wide range of Gram-positive bacteria, including Streptococci and Methicillin-resistant Staphylococcus aureus (MRSA). However, Enterococcus faecalis is known to have intrinsic resistance to vancomycin, making it less effective against this particular Gram-positive bacterium. Therefore, the statement that "Vancomycin isn't active against Enterococcus faecalis" is correct.

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14. Sulbactam & ampicillin, this problem was partly overcome by covalently linking the two molecules to create sultamicillin which is well absorbed following 

Explanation

Sultamicillin, created by covalently linking sulbactam and ampicillin, is well absorbed following oral administration. This means that when sultamicillin is taken orally, it is efficiently absorbed into the bloodstream, allowing it to be effective in treating infections. However, the explanation does not provide any information about the absorption of sultamicillin following ophthalmic, nasal, or parental administration.

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15. The inactivity  of Vancomycin towered Gram-negative bacteria because

Explanation

Vancomycin is an antibiotic that is effective against Gram-positive bacteria but not Gram-negative bacteria. This is because Gram-negative bacteria have an outer membrane that acts as a barrier, preventing the entry of large molecules like vancomycin. Therefore, the statement "The large molecule size of vancomycin can't penetrate through the outer membrane of Gram-negative bacteria" is correct.

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16. Antibiotics which interfere with the synthesis and assembly of peptidoglycan show excellent selective toxicity compared with other antibiotics (e.g. protein synthesis inhibitors).This is because:

Explanation

Antibiotics that interfere with the synthesis and assembly of peptidoglycan are effective in selectively targeting bacteria because mammalian cells do not possess a cell wall. This means that the antibiotics can specifically target the bacterial cell wall without affecting the mammalian cells, resulting in excellent selective toxicity. Additionally, mammalian cells do not contain any other macromolecules resembling peptidoglycan, further enhancing the selectivity of these antibiotics. Therefore, the second answer stating that mammalian cells do not possess a cell wall and do not contain other macromolecules resembling peptidoglycan is correct.

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17. One of the above is not correct regarding sources of penicillins:

Explanation

The correct answer is the most important examples of semisynthetic penicillins are benzylpenicillin and phenoxymethylpenicillin. This is because benzylpenicillin (penicillin G) and phenoxymethylpenicillin (penicillin V) are both widely used and effective semisynthetic penicillins. They are derived from the naturally occurring penicillin and have been modified to enhance their properties and improve their stability. These two penicillins are commonly used in the treatment of various bacterial infections.

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18. All of the above isn't correct regarding Cephalosporins drugs can treat MRSA  , ,EXCEPT:

Explanation

طبعا هذا السؤال الدكتووووووور حكى مهم ومو موجود بالسلايد عن
5th generation

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19. Production of 6-APA through:

Explanation

The correct answer is fermentation from Penicillium mould because Penicillium mould is known to produce the enzyme penicillin acylase, which is necessary for the production of 6-APA (6-aminopenicillanic acid). This enzyme is used to convert penicillin G into 6-APA, which is a key intermediate in the synthesis of various penicillin antibiotics. Penicillium yeast may not possess the necessary enzyme for this conversion, and the combination of both mould and yeast may not be required for the production of 6-APA.

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20. All of the above is correct regarding cilastatin , ,EXCEPT:

Explanation

Cilastatin is a renal peptidase inhibitor and is considered an inhibitor to the Dehydropeptidase Enzyme. It enhances the stability of imipenem, but it does not enhance the stability of meropenem. Therefore, the statement "Enhances stability of Meropenem" is incorrect.

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21. Anti-pseudomonal penicillins :

Explanation

The correct answer is "They are susceptible to inactivation by penicillinase-producing pseudomonal." This means that anti-pseudomonal penicillins can be rendered ineffective by the presence of penicillinase-producing pseudomonal bacteria. Penicillinase is an enzyme that breaks down penicillin, so if the bacteria produce this enzyme, it can neutralize the effects of the penicillin. This is an important consideration when choosing the appropriate antibiotic for treating infections caused by these bacteria.

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22. ALL of the above effect or  (inactivation) by b-lactamases EXCPET:

Explanation

The correct answer is "No answer is correct". This means that all of the mentioned types of penicillins can be affected or inactivated by β-lactamases, except for none of them. In other words, β-lactamases can potentially impact the effectiveness of all the listed types of penicillins.

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23. All of the above is NOT true regarding Peptidoglycan biosynthesis in bacteria  , except :

Explanation

The correct answer is "transglycosylase enzyme Form glycosidic bond between the new monomer and the existing Peptidoglycan". This statement is true regarding Peptidoglycan biosynthesis in bacteria. Transglycosylase enzyme is responsible for forming the glycosidic bond between the new monomer (NAM and NAG) and the existing Peptidoglycan. The other statements mentioned in the question are not true. L-alanine does not convert to D-alanine in the presence of ligase, two D-alanines do not couple together in the presence of racemase, cross-linking of glycan strands occurs with the involvement of penicillin binding protein, and the transfer of new monomers to existing Peptidoglycan does not require a carrier.

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24. All of the above isnt true regarding  Anti-staphylococcal penicillins , Except:

Explanation

The correct answer is "The group isn't effect in (MRSA)". This means that Anti-staphylococcal penicillins do not have an effect on Methicillin-resistant strains of Staphylococcus aureus (MRSA). MRSA is resistant to many antibiotics, including penicillins, due to the production of the β-lactamase enzyme/penicillinase. Therefore, the group of Anti-staphylococcal penicillins mentioned in the question is not effective against MRSA.

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25. All of the above is correct regarding Clavulanic acid ,EXCEPT:

Explanation

The correct answer is "No answer is correct." This means that all of the statements provided in the question are correct and there is no exception. Clavulanic acid is indeed isolated from streptomyces species, it cannot be used alone and is commonly combined with amoxicillin orally or with ticarcillin parenterally. Additionally, the statement about not being able to make a combination of meropenem with clavulanic acid because meropenem does not need it is also correct.

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26. All of the above is correct regarding Cephalosporins and Carbapenems , ,EXCEPT:

Explanation

Carbapenems are generally considered to have a broader antibacterial spectrum compared to cephalosporins. However, the statement mentions that the 3rd generation of cephalosporins is actually superior to carbapenems in terms of antibacterial spectrum. This means that there are certain cephalosporins that have a wider range of activity against bacteria compared to carbapenems. Therefore, the statement is incorrect.

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27. All of the above isn't correct regarding , 3rd generation cephalosporins ,EXCEPT:

Explanation

Third generation cephalosporins are susceptible to inactivation by beta-lactamases, which are enzymes produced by bacteria to break down the beta-lactam ring in antibiotics. This is one of the reasons why fourth generation cephalosporins were developed, as they have a greater resistance to beta-lactamases. Therefore, the statement "They aren't susceptible to inactivation by beta-lactamases" is incorrect.

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28. All of the above is correct regarding Cephalosporins drugs can treat VRE , ,EXCEPT:

Explanation

برضو هذا السؤال من حكي الدكتور ومهم

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29. About Broad Spectrum Penicillins:

Explanation

The given correct answer is "All answer isn't correct." This means that none of the statements provided about Broad Spectrum Penicillins are accurate. The statements mentioned in the question, such as having an antibacterial spectrum similar to Penicillin G, being more effective against G+ve bacteria, and being resistant to activation by penicillinase, are all incorrect. Additionally, the statement about combining these compounds with β-lactamase inhibitors is also incorrect. Therefore, the correct answer is that none of the answers provided are correct.

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30. All of the above isn't correct regarding Carbapenems drugs , ,EXCEPT:

Explanation

Ertapenem has more activity than Meropenem, which is why it is administered once daily while Meropenem is administered twice daily. This means that Ertapenem is more potent and effective in treating bacterial infections compared to Meropenem, so it can be given in a lower frequency.

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31. All of the above is correct regarding About Beta-Lactamases, ,EXCEPT:

Explanation

Sulbactam and clavulanic acid are both beta-lactamase inhibitors that have been developed. They work by inhibiting the action of beta-lactamases, which are enzymes that can break down beta-lactam antibiotics and make them ineffective against bacteria. Both sulbactam and clavulanic acid have a similar spectrum of activity against beta-lactamases, meaning they can inhibit a wide range of these enzymes. However, sulbactam is more potent than clavulanic acid, meaning it is more effective at inhibiting the enzymes and restoring the activity of beta-lactam antibiotics.

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32. All of the above isn't true regarding the D-cycloserine , except :

Explanation

D-cycloserine does not block the formation of the stem peptide. The correct answer is that D-cycloserine occurs in the cytoplasm and involves a racemase enzyme which converts D-alanine to L-alanine, and ligase which couples two D-alanines together. It also interferes with the early stage of synthesis of peptidoglycan involving the assembly of the dipeptide D-alanine-D-alanine. D-cycloserine has major applications in the treatment of infections.

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33. All of the above is'nt correct regarding ,1st Generation ,EXCEPT: 

Explanation

The correct answer is "They are susceptible to inactivation by b-lactamases." The other statements mention the positive attributes and effectiveness of 1st generation antibiotics, such as being the drug of choice for infections caused by Streptococcus, being active against MRSA, EKP G-ve Bacteria, and P. aeruginosa, and their ability to cross the blood-brain barrier to treat meningitis. However, 1st generation antibiotics are indeed susceptible to inactivation by b-lactamases, which are enzymes produced by bacteria that can break down the antibiotics and render them ineffective.

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34. All cephalosporins possesing acetoxymethyl derivatives of :

Explanation

Cephalosporins are a type of antibiotic that are classified based on their structure. The acetoxymethyl derivatives of 7-ACA (7-aminocephalosporanic acid) refers to a specific modification of the cephalosporin molecule. According to the given answer, cephalosporins with this modification are orally inactive, meaning they cannot be taken by mouth and must be administered through other routes such as injection. This is an important consideration when prescribing these antibiotics, as the route of administration can affect patient compliance and convenience.

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35. All of the above is true regarding MOA of Vancomycin & teicoplanin , Except: 

Explanation

Vancomycin and teicoplanin bind to the transglycosylase enzyme, which is involved in the formation of the peptidoglycan cell wall. They do not bind to the disaccharide peptidoglycan precursor directly. This prevents further peptidoglycan assembly and inhibits cell wall synthesis. The other statements provided are true: they work in the stage when the transglycosylase enzyme works, they do not penetrate the cell membrane but must cross the cell wall, and they are not active against Gram-negative organisms due to the presence of the outer membrane.

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36. Teicoplanin :

Explanation

Teicoplanin can treat infections caused by gram-positive bacteria but is ineffective against gram-negative bacteria. This means that it can effectively target and eliminate bacteria such as Staphylococcus and Streptococcus, which are examples of gram-positive bacteria. However, it is not effective against gram-negative bacteria like Escherichia coli or Pseudomonas aeruginosa. Therefore, the correct answer states that teicoplanin can treat gram-positive infections but not gram-negative infections.

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37. About the difference between Vancomycin and Teicoplanin :

Explanation

Vancomycin possesses fewer fatty acid side chains than Teicoplanin. This means that Vancomycin has a simpler chemical structure compared to Teicoplanin. The presence of fatty acid side chains can affect the pharmacokinetics and pharmacodynamics of a drug. Therefore, the difference in the number of fatty acid side chains between Vancomycin and Teicoplanin may contribute to variations in their effectiveness, toxicity, and administration frequency.

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38. All of the above is correct regarding Cephalosporins drugs can cross BBB , ,EXCEPT:

Explanation

Cephalosporins are a group of antibiotics that can be classified into different generations based on their spectrum of activity and pharmacokinetic properties. One important property of cephalosporins is their ability to cross the blood-brain barrier (BBB), which is a protective barrier that prevents the entry of many substances into the brain.

The given answer states that cefuroxime cannot cross the BBB, while ceftazidime can. This means that cefuroxime is unable to penetrate the BBB and reach the brain tissue, while ceftazidime has the ability to do so. This difference in BBB penetration can be attributed to their structural and chemical properties, which affect their ability to pass through the BBB.

It is important to note that the other statements in the question are repetitive and do not provide any additional information.

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39. All of the above is correct regarding , 2nd Generation of cephalosporins  ,EXCEPT: 

Explanation

The given answer is correct because it states that the 2nd generation of cephalosporins has the same activity against P. aeruginosa compared to the 3rd generation. This means that there is no improvement in activity against P. aeruginosa when moving from the 2nd to the 3rd generation of cephalosporins.

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40. All of the above is correct regarding Cephalosporins drugs to treat P. aeruginosa , ,EXCEPT:

Explanation

The given answer states that Cephradine and cephapirin have less activity against P. aeruginosa compared to cafaclor and cefprozil. This means that Cephradine and cephapirin are less effective in treating P. aeruginosa infections than cafaclor and cefprozil. The other options in the question discuss the activity of different cephalosporin drugs against P. aeruginosa, but this option specifically highlights the lower activity of Cephradine and cephapirin compared to cafaclor and cefprozil.

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All of the above refer to the B-lactams except :
About the Resistance to b-lactam antibiotics
All of the above , kill the enzyme secrete from the bacteria , except...
About MOA of penicillins, cephalosporins, carbapenems, monobactams :
Piperacillin + tazobactam given: 
Select true answer  regarding Peptidoglycan biosynthesis in...
Select true answer  regarding Peptidoglycan biosynthesis in...
Penicillin G, Procaine, Penicillin V treat all of the above except:
Active against EKP :
All of the above is correct regarding Monobactams (AZTREANAM) ,...
Has been combined with both ampicillin and cefoperazone , but in both...
Match the following
All of the above is correct regarding activity of vancomycin, except:
Sulbactam & ampicillin, this problem was partly overcome by...
The inactivity  of Vancomycin towered Gram-negative bacteria...
Antibiotics which interfere with the synthesis and assembly of...
One of the above is not correct regarding sources...
All of the above isn't correct regarding Cephalosporins drugs can...
Production of 6-APA through:
All of the above is correct regarding cilastatin , ,EXCEPT:
Anti-pseudomonal penicillins :
ALL of the above effect or  (inactivation) by b-lactamases...
All of the above is NOT true regarding Peptidoglycan biosynthesis in...
All of the above isnt true regarding  Anti-staphylococcal...
All of the above is correct regarding Clavulanic...
All of the above is correct regarding Cephalosporins...
All of the above isn't correct regarding , 3rd generation...
All of the above is correct regarding Cephalosporins drugs can treat...
About Broad Spectrum Penicillins:
All of the above isn't correct regarding Carbapenems drugs ,...
All of the above is correct regarding About Beta-Lactamases,...
All of the above isn't true regarding the D-cycloserine , except :
All of the above is'nt correct regarding ,1st...
All cephalosporins possesing acetoxymethyl derivatives of :
All of the above is true regarding MOA of Vancomycin &...
Teicoplanin :
About the difference between Vancomycin and Teicoplanin :
All of the above is correct regarding Cephalosporins drugs can cross...
All of the above is correct regarding , 2nd Generation of...
All of the above is correct regarding Cephalosporins drugs to...
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