Cytoskeleton And Muscle Biochemistry

18 Questions | By Karthi_dr | Updated: Mar 21, 2022 | Attempts: 180

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Questions and Answers

1.

Which is a microfilament?
- A.
  
  Actin
- B.
  
  Vimentin
- C.
  
  Keratin
- D.
  
  Desmin
2.

Which is NOT a molecular motor ?
- A.
  
  Dynein
- B.
  
  Actin
- C.
  
  Myosin
- D.
  
  Dynamin
3.

Hutchinson-Gilford progeria syndrome is due to mutation of
- A.
  
  Keratin A
- B.
  
  Keratin B
- C.
  
  Lamin A
- D.
  
  Lamin B
4.

Which component of cytoskeleton is defective in kartageners syndrome ?
- A.
  
  Dynein
- B.
  
  Actin
- C.
  
  Myosin
- D.
  
  Dynamin
5.

Griseofulvin is a tubulin inhibitor
- A.
  
  True
- B.
  
  False
6.

Which component of cytoskeleton is defective in epidermolysis bullosa ?
- A.
  
  Desmin
- B.
  
  Vimentin
- C.
  
  Keratin
- D.
  
  Dynamin
7.

Microfilaments are dynamic structures which undergo rapid assembly and disassembly.
- A.
  
  True
- B.
  
  False
8.

TRUE about positive end of actin filament
- A.
  
  Addition and dissociation of actin monomers are slow at +Ve end
- B.
  
  ATP binding promotes the addition of actin monomers
- C.
  
  ADP binding promotes the addition of actin monomers
- D.
  
  None
9.

Sarcomere is a segment between
- A.
  
  H and I bands
- B.
  
  Two I bands
- C.
  
  Two Z disk
- D.
  
  None
10.

TRUE about A band
- A.
  
  Consists only of thin filaments
- B.
  
  Contains the entire length of a single thick filament
- C.
  
  I band is a component of A band
- D.
  
  None
11.

Myosin binding sites on actin are blocked by Troponin
- A.
  
  True
- B.
  
  False
12.

Calcium binding motif present in calmodulin is known as
- A.
  
  Rossman fold
- B.
  
  EF hand
- C.
  
  Zinc finger
- D.
  
  Actin fold
13.

Calcium binding results in a conformational change in troponin complex that pulls tropomyosin from the actin binding sites of myosin.
- A.
  
  True
- B.
  
  False
14.

Kinesin is involved in retrograde trasport. Dynein is involved in anterograde transport.
- A.
  
  True
- B.
  
  False
15.

Flagella is not found in humans.
- A.
  
  True
- B.
  
  False
16.

Length of actin and myosin doesn't change during muscle contraction
- A.
  
  True
- B.
  
  False
17.

Troponin C binds to
- A.
  
  2 calcium
- B.
  
  3 calcium
- C.
  
  4 calcium
- D.
  
  5 calcium
18.

Malignant hyperthermia is due to mutation of
- A.
  
  RYR1
- B.
  
  ATPase 7A
- C.
  
  ATPase 7B
- D.
  
  None