Ch.5 Antigen Recognition By T Lymphocytes

92 Questions | Total Attempts: 67

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Healthcare Quizzes & Trivia

T-cells are is a type of white blood cell that is of key importance to the immune system and is at the core of adaptive immunity. A molecule that is capable of binding to an antibody or to an antigen receptor on a T-cell is defined as an antigen. What do you know about how an antigen gets recognized by a T-lymphocyte? Take up the quiz to find out.


Questions and Answers
  • 1. 
    The antigen receptor on T cells
    • A. 

      T-cell receptor

    • B. 

      B-cell receptor

    • C. 

      MHC receptor

    • D. 

      MHC II receptor

    • E. 

      Both a and b

  • 2. 
    The ligand for a TCR is
    • A. 

      Made of only DNA

    • B. 

      Created when a B-chain is nonproductive

    • C. 

      The combination of peptide and MHC molecule on a cell surface

    • D. 

      Carried throughout the blood by a protein carrier

    • E. 

      Needed to bind to a B-cell

  • 3. 
    The genes that encode the MHC molecules are clustered in the chromosomal region called
    • A. 

      The nuceloid region

    • B. 

      The major histocompatibility complex

    • C. 

      The germinal center

    • D. 

      The terminal center

    • E. 

      The RNA region

  • 4. 
    The differences between MHC molecules of the donor and recipient are the major cause of 
    • A. 

      The involution of the thymus

    • B. 

      B-cell variation

    • C. 

      T-cell overload

    • D. 

      Tissue incompatibility and transplant rejection

    • E. 

      Organ acceptance

  • 5. 
    T-cell receptors are always
    • A. 

      Nonproductive

    • B. 

      Self-reactive

    • C. 

      Membrane bound

    • D. 

      Released into the cytoplasm

    • E. 

      Immature

  • 6. 
    When a T-cell is stimulated with antigen, somatic hypermutation occurs.
    • A. 

      True

    • B. 

      False

  • 7. 
    How many chains are in a T-cell?
    • A. 

      1

    • B. 

      2

    • C. 

      4

    • D. 

      8

    • E. 

      22

  • 8. 
    T-cell receptor a-chain is located on 
    • A. 

      Chromosome 14

    • B. 

      Chromosome 21

    • C. 

      Chromosome 13

    • D. 

      Chromosome 87

    • E. 

      None of the above

  • 9. 
    T-cell receptor B chain is located on 
    • A. 

      Chromosome 1

    • B. 

      Chromosome 14

    • C. 

      Chromosome 7

    • D. 

      Chromosome 8

    • E. 

      Chromosome 9

  • 10. 
    The antigen-recogntion site of T-cell receptors is formed from the 
    • A. 

      Valpha domain

    • B. 

      Vbeta domain

    • C. 

      Vlamda domain

    • D. 

      Both a and b

    • E. 

      Vdelta domain

  • 11. 
    The TCR alpha and beta chain V domains each have
    • A. 

      4 CDR loops

    • B. 

      6 CDR loops

    • C. 

      199 CDR loops

    • D. 

      3 CDR loops

    • E. 

      No CDR loops

  • 12. 
    TCR receptors posses a
    • A. 

      Nonproductive alpha chain

    • B. 

      CDR loop that is mutated

    • C. 

      Single binding site for antigen

    • D. 

      Noncoding region

    • E. 

      Immature chain

  • 13. 
    Mechanisms for generating T-cell diversity.
    • A. 

      Gene rearrangements that generate V-region sequence

    • B. 

      Changes in mRNA splicing

    • C. 

      Both a and b

    • D. 

      Changes in tRNA splicing

    • E. 

      None of the above

  • 14. 
    How many alpha and beta chain genes are in the C region of a T-cell?
    • A. 

      1 alpha, 2 beta

    • B. 

      0 alpha, 3 beta

    • C. 

      4 alpha, 2 beta

    • D. 

      2 alpha, 1 beta

    • E. 

      11 alpha, 33 beta

  • 15. 
    The TCR a-chain contains V and J segments only.
    • A. 

      True

    • B. 

      False

  • 16. 
    The TCR B-chain contains only V and D segments.
    • A. 

      True

    • B. 

      False

  • 17. 
    Where does TCR rearrangement occur?
    • A. 

      Heart

    • B. 

      Bone marrow

    • C. 

      Thyroid

    • D. 

      Lymph node

    • E. 

      Thymus

  • 18. 
    In TCR, P and N nucleotides are inserted in the junctions between
    • A. 

      V, D, and J segments

    • B. 

      V and J segments

    • C. 

      D and J segments

    • D. 

      V and D segments

    • E. 

      None of the above

  • 19. 
    P and N nucleotides add to junctional diversity in CDR3 in TCRs.
    • A. 

      True

    • B. 

      False

  • 20. 
    Exons in TCRs are separated by introns
    • A. 

      True

    • B. 

      False

  • 21. 
    The RAG genes have introns that characterize eukaryotic genes.
    • A. 

      True

    • B. 

      False

  • 22. 
    The human RAG genes are located on chromosome
    • A. 

      65

    • B. 

      21

    • C. 

      34

    • D. 

      11

    • E. 

      14

  • 23. 
    The CD3 complex contains how many complements?
    • A. 

      5

    • B. 

      4

    • C. 

      3

    • D. 

      1

    • E. 

      2

  • 24. 
    RSS genes lie between the V and J genes of a TCR.
    • A. 

      True

    • B. 

      False

  • 25. 
    What is T cell binding called?
    • A. 

      Promiscuous

    • B. 

      Specific

    • C. 

      Unknown

    • D. 

      Retractable

    • E. 

      Nonproductive