Ch.5 Antigen Recognition By T Lymphocytes

92 Questions | By Lrswimmer17 | Updated: Mar 19, 2022 | Attempts: 143

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T-cells are is a type of white blood cell that is of key importance to the immune system and is at the core of adaptive immunity. A molecule that is capable of binding to an antibody or to an antigen receptor on a T-cell is defined as an antigen. What do you know about how an antigen gets recognized by a T-lymphocyte? Take up the quiz to find out.

Questions and Answers

1.

The antigen receptor on T cells
- A.
  
  T-cell receptor
- B.
  
  B-cell receptor
- C.
  
  MHC receptor
- D.
  
  MHC II receptor
- E.
  
  Both a and b
2.

The ligand for a TCR is
- A.
  
  Made of only DNA
- B.
  
  Created when a B-chain is nonproductive
- C.
  
  The combination of peptide and MHC molecule on a cell surface
- D.
  
  Carried throughout the blood by a protein carrier
- E.
  
  Needed to bind to a B-cell
3.

The genes that encode the MHC molecules are clustered in the chromosomal region called
- A.
  
  The nuceloid region
- B.
  
  The major histocompatibility complex
- C.
  
  The germinal center
- D.
  
  The terminal center
- E.
  
  The RNA region
4.

The differences between MHC molecules of the donor and recipient are the major cause of
- A.
  
  The involution of the thymus
- B.
  
  B-cell variation
- C.
  
  T-cell overload
- D.
  
  Tissue incompatibility and transplant rejection
- E.
  
  Organ acceptance
5.

T-cell receptors are always
- A.
  
  Nonproductive
- B.
  
  Self-reactive
- C.
  
  Membrane bound
- D.
  
  Released into the cytoplasm
- E.
  
  Immature
6.

When a T-cell is stimulated with antigen, somatic hypermutation occurs.
- A.
  
  True
- B.
  
  False
7.

How many chains are in a T-cell?
- A.
  
  1
- B.
  
  2
- C.
  
  4
- D.
  
  8
- E.
  
  22
8.

T-cell receptor a-chain is located on
- A.
  
  Chromosome 14
- B.
  
  Chromosome 21
- C.
  
  Chromosome 13
- D.
  
  Chromosome 87
- E.
  
  None of the above
9.

T-cell receptor B chain is located on
- A.
  
  Chromosome 1
- B.
  
  Chromosome 14
- C.
  
  Chromosome 7
- D.
  
  Chromosome 8
- E.
  
  Chromosome 9
10.

The antigen-recogntion site of T-cell receptors is formed from the
- A.
  
  Valpha domain
- B.
  
  Vbeta domain
- C.
  
  Vlamda domain
- D.
  
  Both a and b
- E.
  
  Vdelta domain
11.

The TCR alpha and beta chain V domains each have
- A.
  
  4 CDR loops
- B.
  
  6 CDR loops
- C.
  
  199 CDR loops
- D.
  
  3 CDR loops
- E.
  
  No CDR loops
12.

TCR receptors posses a
- A.
  
  Nonproductive alpha chain
- B.
  
  CDR loop that is mutated
- C.
  
  Single binding site for antigen
- D.
  
  Noncoding region
- E.
  
  Immature chain
13.

Mechanisms for generating T-cell diversity.
- A.
  
  Gene rearrangements that generate V-region sequence
- B.
  
  Changes in mRNA splicing
- C.
  
  Both a and b
- D.
  
  Changes in tRNA splicing
- E.
  
  None of the above
14.

How many alpha and beta chain genes are in the C region of a T-cell?
- A.
  
  1 alpha, 2 beta
- B.
  
  0 alpha, 3 beta
- C.
  
  4 alpha, 2 beta
- D.
  
  2 alpha, 1 beta
- E.
  
  11 alpha, 33 beta
15.

The TCR a-chain contains V and J segments only.
- A.
  
  True
- B.
  
  False
16.

The TCR B-chain contains only V and D segments.
- A.
  
  True
- B.
  
  False
17.

Where does TCR rearrangement occur?
- A.
  
  Heart
- B.
  
  Bone marrow
- C.
  
  Thyroid
- D.
  
  Lymph node
- E.
  
  Thymus
18.

In TCR, P and N nucleotides are inserted in the junctions between
- A.
  
  V, D, and J segments
- B.
  
  V and J segments
- C.
  
  D and J segments
- D.
  
  V and D segments
- E.
  
  None of the above
19.

P and N nucleotides add to junctional diversity in CDR3 in TCRs.
- A.
  
  True
- B.
  
  False
20.

Exons in TCRs are separated by introns
- A.
  
  True
- B.
  
  False
21.

The RAG genes have introns that characterize eukaryotic genes.
- A.
  
  True
- B.
  
  False
22.

The human RAG genes are located on chromosome
- A.
  
  65
- B.
  
  21
- C.
  
  34
- D.
  
  11
- E.
  
  14
23.

The CD3 complex contains how many complements?
- A.
  
  5
- B.
  
  4
- C.
  
  3
- D.
  
  1
- E.
  
  2
24.

RSS genes lie between the V and J genes of a TCR.
- A.
  
  True
- B.
  
  False
25.

What is T cell binding called?
- A.
  
  Promiscuous
- B.
  
  Specific
- C.
  
  Unknown
- D.
  
  Retractable
- E.
  
  Nonproductive