Ch.5 Antigen Recognition By T Lymphocytes
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T-cells are is a type of white blood cell that is of key importance to the immune system and is at the core of adaptive immunity. A molecule that is capable of binding to an antibody or to an antigen receptor on a T-cell is defined as an antigen. What do you know about how an antigen gets recognized by a T-lymphocyte? Take up the quiz to find out.
- 1.The antigen receptor on T cells
- A.
T-cell receptor
- B.
B-cell receptor
- C.
MHC receptor
- D.
MHC II receptor
- E.
Both a and b
- 2.The ligand for a TCR is
- A.
Made of only DNA
- B.
Created when a B-chain is nonproductive
- C.
The combination of peptide and MHC molecule on a cell surface
- D.
Carried throughout the blood by a protein carrier
- E.
Needed to bind to a B-cell
- 3.The genes that encode the MHC molecules are clustered in the chromosomal region called
- A.
The nuceloid region
- B.
The major histocompatibility complex
- C.
The germinal center
- D.
The terminal center
- E.
The RNA region
- 4.The differences between MHC molecules of the donor and recipient are the major cause of
- A.
The involution of the thymus
- B.
B-cell variation
- C.
T-cell overload
- D.
Tissue incompatibility and transplant rejection
- E.
Organ acceptance
- 5.T-cell receptors are always
- A.
Nonproductive
- B.
Self-reactive
- C.
Membrane bound
- D.
Released into the cytoplasm
- E.
Immature
- 6.When a T-cell is stimulated with antigen, somatic hypermutation occurs.
- A.
True
- B.
False
- 7.How many chains are in a T-cell?
- A.
1
- B.
2
- C.
4
- D.
8
- E.
22
- 8.T-cell receptor a-chain is located on
- A.
Chromosome 14
- B.
Chromosome 21
- C.
Chromosome 13
- D.
Chromosome 87
- E.
None of the above
- 9.T-cell receptor B chain is located on
- A.
Chromosome 1
- B.
Chromosome 14
- C.
Chromosome 7
- D.
Chromosome 8
- E.
Chromosome 9
- 10.The antigen-recogntion site of T-cell receptors is formed from the
- A.
Valpha domain
- B.
Vbeta domain
- C.
Vlamda domain
- D.
Both a and b
- E.
Vdelta domain
- 11.The TCR alpha and beta chain V domains each have
- A.
4 CDR loops
- B.
6 CDR loops
- C.
199 CDR loops
- D.
3 CDR loops
- E.
No CDR loops
- 12.TCR receptors posses a
- A.
Nonproductive alpha chain
- B.
CDR loop that is mutated
- C.
Single binding site for antigen
- D.
Noncoding region
- E.
Immature chain
- 13.Mechanisms for generating T-cell diversity.
- A.
Gene rearrangements that generate V-region sequence
- B.
Changes in mRNA splicing
- C.
Both a and b
- D.
Changes in tRNA splicing
- E.
None of the above
- 14.How many alpha and beta chain genes are in the C region of a T-cell?
- A.
1 alpha, 2 beta
- B.
0 alpha, 3 beta
- C.
4 alpha, 2 beta
- D.
2 alpha, 1 beta
- E.
11 alpha, 33 beta
- 15.The TCR a-chain contains V and J segments only.
- A.
True
- B.
False
- 16.The TCR B-chain contains only V and D segments.
- A.
True
- B.
False
- 17.Where does TCR rearrangement occur?
- A.
Heart
- B.
Bone marrow
- C.
Thyroid
- D.
Lymph node
- E.
Thymus
- 18.In TCR, P and N nucleotides are inserted in the junctions between
- A.
V, D, and J segments
- B.
V and J segments
- C.
D and J segments
- D.
V and D segments
- E.
None of the above
- 19.P and N nucleotides add to junctional diversity in CDR3 in TCRs.
- A.
True
- B.
False
- 20.Exons in TCRs are separated by introns
- A.
True
- B.
False
- 21.The RAG genes have introns that characterize eukaryotic genes.
- A.
True
- B.
False
- 22.The human RAG genes are located on chromosome
- A.
65
- B.
21
- C.
34
- D.
11
- E.
14
- 23.The CD3 complex contains how many complements?
- A.
5
- B.
4
- C.
3
- D.
1
- E.
2
- 24.RSS genes lie between the V and J genes of a TCR.
- A.
True
- B.
False
- 25.What is T cell binding called?
- A.
Promiscuous
- B.
Specific
- C.
Unknown
- D.
Retractable
- E.
Nonproductive
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