Blood Components: Preparation, Storage And Characteristics
(228).jpg "Blood Components: Preparation, Storage And Characteristics")
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- 1.The correct temperature for shipping RBCs is
- A.
- B.
1 to 6C
- C.
1 to 10C
- D.
20 to 24C
- E.
37C
- 2.RBC storage times vary with the anticoagulant/preservative used. Which of the following is properly paired?
- A.
Citrate-phosphate-dextrose (CPD): 35 days
- B.
Additive solution (AS): 47 days
- C.
Citrate-phosphate-dextrose-adenine (CPDA)-1: 21 days
- D.
Acid-citrate-dextrose (ACD): 35 days
- E.
Citrate-phosphate-dextrose-dextrose (CP2D): 21 days
- 3.Which of the following represents a change seen in a unit of RBCs stored with CPDA-1 at the end of its shelf life?
- A.
Percentage of viable cells at 24 hours after transfusion decreases to 71%
- B.
Supernatant K+ (potassium ion) concentration decreases
- C.
Supernatant pH increases
- D.
Red cell 2, 3-DPG increases
- E.
Supernatant hemoglobin decreases
- 4.A unit of RBCs is issued to the floor and returned without being transfused. How long can blood be out of the refrigerator and still be used for transfusion?
- A.
10 minutes
- B.
30 minutes
- C.
1 hour
- D.
4 hours
- E.
6 hours
- 5.The maximal shelf life of irradiated RBCs is :
- A.
4 hours
- B.
6 hours
- C.
24 hours
- D.
21 days
- E.
28 days
- 6.The preferred method for generating leukocyte- reduced RBC components is:
- A.
Thawing and deglycerolizing a frozen unit
- B.
Filtering using a leukocyte-reduction filter
- C.
Irradiation
- D.
Centrifugation
- E.
Washing
- 7.The most common concentration of glycerol used in the U.S. for freezing RBCs is:
- A.
5%
- B.
10%
- C.
20%
- D.
40%
- E.
65%
- 8.The rationale for deglycerolizing frozen RBCs with extensive washing is:
- A.
Glycerol is not approved by the FDA
- B.
Glycerol is toxic to kidneys
- C.
Glycerol can cause hemolysis
- D.
Glycerol can cause anaphylaxis
- E.
Glycerol can cause thrombocytopenia
- 9.Which of the following choices explains why a unit of blood may form an insoluble jelly-like mass during deglycerolization?
- A.
Inadequate deglycerolization
- B.
Bacterial contamination
- C.
Insufficient anticoagulant
- D.
Inadvertent use of hypotonic saline for washing
- E.
Red cells from a donor with sickle cell trait
- 10.Two S-s-U- units are deglycerolized in preparation for possible transfusion. The patient, however, is stabilized and transfusion is no longer required. The medical director should:
- A.
Refrigerate the units until the expiration time and discard if not clinically needed
- B.
Advise the medical staff to transfuse the units because they are rare
- C.
Document the value of the antigen-negative units and refreeze for up to another 10 years
- D.
Release the rare units so that they can be made available for another patient
- 11.According to the AABB standards, the maximum allowable shelf-life of platelets without gentle agitation is:
- A.
1 hour
- B.
4 hours
- C.
8 hours
- D.
24 hours
- E.
36 hours
- 12.According to AABB standards, 90% of the units of random-donor platelets prepared from whole blood should contain a minimum of _______ platelets per unit.
- A.
5.5 x 10^ 9
- B.
5.5 x 10 ^ 10
- C.
5.5 x 10 ^11
- D.
3 x 10 ^ 10
- E.
3 x 10 ^ 11
- 13.The minimum acceptable pH of platelet units at the end of the storage period is:
- A.
4.2
- B.
5.2
- C.
6.2
- D.
7.2
- E.
8.2
- 14.Which of the following is a change associated with platelet storage?
- A.
Decreased H+ concentration
- B.
Platelet activation
- C.
Change in shape from round to discoid
- D.
Increased swirling effect
- E.
Increased expression of glycoprotein Ib and glycoprotein IIb/IIIa
- 15.Transfusion of one platelet concentrate (ie the platelets present in one whole blood donation) into a hematologically stable adult of average size with no history of transfusion and/or pregnancy is expected to increase the platelet count by:
- A.
1000 to 5000 /uL
- B.
3000 to 5000 /uL
- C.
3000 to 12000 /uL
- D.
5000 to 10000/ uL
- E.
30000 to 40000 .uL
- 16.Which of the following is a theoretical advantage associated with transfusion of a whole-blood derived pooled-platelet unit compared with an apheresis platelet unit?
- A.
Decreased donor exposure for infectious disease transmission
- B.
Decreased risk of TRALI
- C.
Decreased donor exposure for HLA alloimmunization
- D.
Decreased risk of septic transfusion reaction
- E.
All of the above
- 17.FFP that has been thawed and is being stored at 1 to 6 C should be transfused within
- A.
4 hours
- B.
6 hours
- C.
12 hours
- D.
18 hours
- E.
24 hours
- 18.Which of the following is true?
- A.
To prepare FFP plasma must be separated from red cells within 24 hours
- B.
If an additive solution is used, the expiration date for RBCs stored at 1 to 6 C is 42 days after phlebotomy
- C.
To prepare Cryo FFP is thawed at 20 to 24 C
- D.
Platelets derived from a unit of whole blood must contain 3 x 10 ^ 11 platelets in 75% of units released
- E.
The expiration date of RBCs that are frozen and stored at
- 19.A group B Rh positive patient requires FFP. Group B FFP is not available. The substitute component of choice is:
- A.
Group O FFP
- B.
Group B, Rh positive cryo
- C.
Group A FFP
- D.
Group AB FFP
- E.
Group A, Rh negative cryo
- 20.Which of the following is true?
- A.
Cryo can be made from cryo-reduced plasma (CRP) or FFP
- B.
CRP can not be used in manufacturing albumin and immunoglobulins
- C.
CRP and cryo can not be prepared from FFP collected by apheresis
- D.
CRP is rich in fibrinogen, factor VIII, and vWF
- E.
CRP is deficient in ADAMTS13
- 21.Cryo should be stored at
- A.
- B.
1 to 6 C
- C.
20 to 22C
- D.
30 C
- E.
37C
- 22.After thawing cryo should be stored at:
- A.
42C
- B.
37C
- C.
20 to 24 C
- D.
1 to 6 C
- E.
-18 C
- 23.According to AABB standards each bag of cryo must contain a minimum of how many Internation Units of Factor VIII?
- A.
70
- B.
80
- C.
100
- D.
120
- E.
150
- 24.Cryo contains which of the following?
- A.
Factor XI
- B.
Protein C
- C.
Protein S
- D.
Factor XIII
- E.
Factor XII
- 25.Which is true regarding cryo?
- A.
Is prepared from FFP thawed at 20 to 24C
- B.
Once thawed is stored at 1 to 6 C and given within 6 hours of thawing or 4 hours of pooling
- C.
It is prepared by filtering thawed FFP at 1 to 6 C
- D.
It is prepared by centrifuging thawed FFP at 1 to 6 C
- E.
Thawed cryo is stored at 1 to 6 C during transport
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