1.
Posterior communicating artery a branch of
Correct Answer
A. Internal carotid
Explanation
Posterior communicating arises from the internal carotid artery before it bifurcates into anterior and middle cerebral artery. It communicates with the posterior cerebral artery and is a part of the circle of Willis.
2.
Which of the following is not a branch of Cavernous segment of Internal Carotid Artery?
Correct Answer
D. OpHthalmic branch
Explanation
Branches of cavernous segment of internal carotid artery:
-Cavernous branches
-Meningeal branches
-Inferior hypophyseal branch
3.
Difference between typical cervical & thoracic vertebrae?
Correct Answer
B. Has a foramen transversarium
Explanation
Foramen transversarium is found only is the cervical vertebrae. In the upper six cervical vertebrae, the foramen transmits the vertebral artery, vertebral vein, and a plexus of sympathetic nerves from inferior cervical ganglion. Foramen transversarium of C7 does not contain the artery, but contains the vein and sympathetic nerves.
4.
Males and females show difference in the age of onset of puberty. The difference in the age of onset of puberty amongst males may be explained by:
Correct Answer
C. Increased Inhibin levels
Explanation
Inhibin can suppress FSH secretion which in turn delays results in delay in the onset of puberty in boys.
5.
True regarding endothelin-1 are all except
Correct Answer
A. Bronchodilatation
Explanation
Endothelin I is a bronchoconstrictor.
6.
Cerebral blood flow is regulated by all except
Correct Answer
C. Potassium ions
Explanation
Blood brain barrier is not permeable to ions. Hence they cannot influence cerebral blood flow.
7.
All of the following occur in mitochondria except:
Correct Answer
B. Glycogenolysis
Explanation
Glycogenolysis occurs in the cytoplasm.
8.
Regarding HMP shunt all of the following are true except:
Correct Answer
D. The oxidative pHase generates NADpH and the Non oxidative pHase generates pyruvate
Explanation
HMP - The oxidative phase generates NADPH and the Non oxidative phase generates ribose precursors for nucleic acid synthesis.
9.
Within the RBC, hypoxia stimulates glycolysis by which of the following regulating pathways?
Correct Answer
C. Hypoxia stimulates release of all Glycolytic enzymes from Band 3 on RBC membrane
Explanation
Hypoxia stimulates RBC glycolysis by promoting release of all glycolytic enzymes from Band 3 on RBC membrane.
10.
The following is an antiapoptotic gene
Correct Answer
C. Bcl-X
Explanation
Bcl-2 is another antiapoptotic gene.
11.
A patient in an ICU is on central venous line for the past one week. He is on ceftazidime and and amikacin. After 7 days of antibiotics he develops a spike of fever and his blood culture is positive for gram positive cocci in chains, which are catalase negative. Following this vancomycin was started but the culture remained positive for the same organism even after 10 days of therapy. The most likely organism causing this infection is
Correct Answer
C. Enterococcus faecalis
Explanation
Catalase negative gram positive cocci in chains - indicates that they are staphylococci. Enterococci are commonly seen in hospital acquired infections and they are resistant to cephalosporins and even to vancomycin.
12.
Anagen phase of the hair indicates:
Correct Answer
A. The pHase of activity and growth
Explanation
During the anagen phase of the hair growth cycle, the hair follicles are actively producing new cells and the hair is growing. This is the phase of activity and growth, as opposed to the other phases such as the transitional phase (catagen), resting phase (telogen), and degeneration phase. In the anagen phase, the hair shaft is firmly rooted in the follicle and continues to grow longer. This phase can last for several years before transitioning into the catagen phase.
13.
(Imaging based question - As per new MCI norms) What is the abnormality seen in the CT scan?
Correct Answer
A. Extradural haemorrhage
Explanation
The image shows the classical lentiform (biconvex) shape of extradural haemorrhage. The blood accumulates between the skull bone and the dura. This pushes the dura away from the bone and the hematoma assumes a biconvex shape.
Subdural haemorrhage - crescent shape (convexo concave)
Subarachnoid haemorrhage - bleed in the subarachnoid space - can be visualised in the sulci.
Intracerebral hemorrhage - collection of blood seen within the brain parenchyma
14.
Which of the following is not an antiepileptic agent:
Correct Answer
C. Flunarizine
Explanation
Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity.
15.
All of the following antiepileptic agents act via Na+ channel except
Correct Answer
A. Vigabatrin
Explanation
Vigabatrin is an antiepileptic drug that inhibits the catabolism of gamma-aminobutyric acid (GABA) by irreversibly inhibiting GABA transaminase.
16.
Prothrombin Time of a patient is 26. Control PT is 13 seconds and Sensitivity index is 1.41. What will be the INR of this patient?
Correct Answer
C. (26/13) ^ 1.41
Explanation
INR = (Prothrombin time / control ) ^ Sensitivity index.
(^ indicated raised to the power of)
17.
All of the following statements about Heparin are true except?
Correct Answer
D. Causes Hypokalemia
Explanation
Heparin causes hyperkalemia.
18.
The following drug is not useful for MRSA?
Correct Answer
A. Cefaclor
Explanation
MRSA is resistant to cefaclor. (and other cephalosporins)
19.
Spalding sign is seen in?
Correct Answer
B. Maceration
Explanation
Spalding's sign is the observation of overriding of fetal skull bones in xray. It indicates intrauterine fetal death.
20.
The highest percentage of poly unsaturated fatty acids are present in?
Correct Answer
D. Soya bean oil
Explanation
Among the options given, soya bean oil has the highest percentage of poly unsaturated fatty acids.
21.
Chlorine demand is measured by
Correct Answer
A. Horrock’s apparatus
Explanation
Horrock’s apparatus is used to measure cholrine demand.
Double pot is a method of well water chlorination.
Berkefeld filter is a water filter made of diatomaceous earth or Kieselguhr.
22.
All can be incinerated except
Correct Answer
B. Sharps
Explanation
Sharps should not be incinerated.
23.
Direct standardization is used to compare the mortality rates between two countries. This is done because of the difference in
Correct Answer
C. Age distributions
Explanation
If there is not standardisation, the mortality rate calculated will be higher in countries with greater proportion of elderly people.
24.
A patient presents with acute anterior wall infarction and hypotension. Which will be the immediate treatment modality for this patient?
Correct Answer
D. AngiograpHy and Primary angioplasty
Explanation
Angiography and primary angioplasty is the best modality of treatment in case of ST eleveation MI presenting within 12 hours.
25.
A 70 year old man develops pneumonia and septicemia. Patient goes into renal failure and has a BP of 70/50 mm of Hg. Drug that should be used to maintain BP is:
Correct Answer
D. Nor epinepHrine
Explanation
The patient is in septic shock. Dopamine is the recommended drug for maintenance of BP in a case of septic shock. If there is no response, nor epinephrine should be tried. Since nor epinephrine is the only one given among the options, it is the best answer.
26.
A patient presents with decreased vital capacity and total lung volume. What is the most probable diagnosis?
Correct Answer
B. Sarcoidosis
Explanation
A restrictive lung disease causes decrease in vital capacity and total lung volume. Among the options provided, sarcoidosis is the only one causing a restrictive lung disease.
27.
All of the following drugs are commonly used in regimens against H. pylori except:
Correct Answer
A. Oxytetracycline
Explanation
Oxytetracycline is not a recommended drug for treatment of H.pylori.
28.
A patient with H. Pylori infection is treated with drugs. The best method to detect presence of residual H.Pylori infection in this person is :
Correct Answer
B. Urea breath test
Explanation
Recommended test for confirmation of H.pylori eradication - urea breath test.
29.
A patient presents with chronic small bowel diarrhea, duodenal biopsy shows villous atrophy. Anti endomysial antibodies and IgA TTG antibodies are positive. What is the treatment of choice?
Correct Answer
A. Gluten free diet
Explanation
The clinical picture and investigation findings are suggestive of coeliac sprue. The treatment is gluten free diet.
30.
The test used to diagnose Dubin Johnson syndrome is:
Correct Answer
B. BromsulpHalein test (BSP)
Explanation
The correct answer is the Bromsulphalein test (BSP). Dubin Johnson syndrome is a rare genetic disorder that affects the liver's ability to process bilirubin, resulting in a buildup of bilirubin in the body. The BSP test is a diagnostic test that measures the liver's ability to excrete bilirubin into the bile. In individuals with Dubin Johnson syndrome, the BSP test will show impaired bilirubin excretion, confirming the diagnosis. Serum transaminases and gamma glutamyl transferase levels may be elevated in individuals with liver disease, but they are not specific to Dubin Johnson syndrome. The hippurate test is used to assess liver function but is not specific to Dubin Johnson syndrome.
31.
A patient comes with hematemesis and malena. On the upper GI endoscopy there was no significant lesion. 2 days later the patient rebleeds. Next line of investigation is
Correct Answer
D. Laprotomy
Explanation
In case of rebleed, laparotomy should be done.
32.
Colonic diverticulosis is best diagnosed by
Correct Answer
C. Barium enema
Explanation
Diverticula are easily visualised with barium enema.
33.
30 year old female presented with unilateral breast cancer associated with axilary lymph node enlargement. Modified radical mastectomy was done, further treatment plan will be
Correct Answer
B. Adriamycin based chemotherapy followed by tamoxifen depending on estrogen/progesterone receptor status
Explanation
Based on the information provided, the 30-year-old female presented with unilateral breast cancer associated with axillary lymph node enlargement. Modified radical mastectomy was performed. The treatment plan will involve Adriamycin-based chemotherapy followed by tamoxifen, depending on the estrogen/progesterone receptor status. This approach is commonly used in the management of breast cancer. Adriamycin-based chemotherapy is a standard treatment for breast cancer, while tamoxifen is a hormonal therapy that is often given to patients with estrogen/progesterone receptor-positive breast cancer. The combination of chemotherapy and hormonal therapy is recommended to improve outcomes and reduce the risk of recurrence.
34.
Lactational amenorrhoea is due to
Correct Answer
A. Prolactin induced inhibition of GnRH
Explanation
During lactation, the hormone prolactin is produced in high levels. Prolactin inhibits the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus. GnRH is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. FSH is necessary for the development of ovarian follicles and the production of estrogen. Therefore, the inhibition of GnRH by prolactin leads to a decrease in FSH levels, which ultimately prevents ovulation and the resumption of menstrual cycles, resulting in lactational amenorrhea.
35.
Which of the following anti tuberculosis drug is not given in pregnancy
Correct Answer
A. Streptomycin
Explanation
Streptomycin can cause congenital deafness. It is contraindicated in pregnancy.
36.
Late hyperglycemia in pregnancy is associated with
Correct Answer
A. Macrosomia
Explanation
Late hyperglycemia is associated with macrosomia.
Hyperglycemia during conception and organogenesis period has increased risk of congenital anomalies.
37.
Red degeneration most commonly occurs in
Correct Answer
B. 2nd trimester
Explanation
Red degeneration of fibroid occurs mostly in 2nd trimester.
38.
A baby presenting with multiple deformities, cleft lip, cleft palate, microcephaly, small eyes, scalp defect and polydactyly. Probable diagnosis is?
Correct Answer
A. Trisomy 13
Explanation
The clinical features are suggestive of Patau syndrome - trisomy 13.
39.
ln SCHWARTZ formula for calculation of creatinine clearance in a child, the constant depends on the following except :
Correct Answer
D. Severity of renal failure
Explanation
Schwartz formula:
Creatinine clearance = K x height / creatinine
(K = a constant which depends on age, muscle mass and method of creatinine estimation)
40.
Which organ is the primary site of hematopoiesis in the fetus before midpregnancy?
Correct Answer
B. Liver
Explanation
During the early stages of fetal development, hematopoiesis, the process of forming blood cells, primarily occurs in the liver. The liver is responsible for producing red blood cells, white blood cells, and platelets until around midpregnancy when the bone marrow takes over as the primary site of hematopoiesis. The liver's role in hematopoiesis gradually decreases as the fetus develops, and the bone marrow becomes fully functional after birth.
41.
The important fatty acid present in breast milk which is important for growth is
Correct Answer
A. Docosahexaenoic acid
Explanation
It is required for development of nervous system and vision in the first 6 months of life.
42.
Which of the following tumors arise from epiphysis
Correct Answer
B. Osteoclastoma (GCT)
Explanation
Site of origin of common bone tumours:
Ewing's sarcoma - diaphysis
Osteoclastoma (GCT) - epiphysis
Osteosarcoma - Metaphysis
43.
Transient synovitis (toxic synovitis) of the hip is characterized by all of the following, except:
Correct Answer
D. The hip is typically held in adduction and internal rotation
Explanation
In toxic synovitis, the hip is held in abduction and external rotation.
44.
The malunion of supracondylar fracture of the humerus most commonly leads to:
Correct Answer
B. Cubitus varus
Explanation
Malunion of supracondylar fracture of humerus results in cubitus varus deformity (gun stock deformity).
45.
The crystalline lens derives its nourishment from:
Correct Answer
C. Aqueous and vitreous
Explanation
Lens is an avascular structure. Nutrition and oxygen for the lens is derived from the aqueous humor (major part) and vitreous humor.
46.
Rhinophyma is associated with:
Correct Answer
A. HypertropHy of the sebaceous glands
Explanation
Rhinophyma is a condition of the external nose caused by hypertrophy of the sebaceous tissue and inflammation of the tissues around the gland over the skin of nose.
47.
A 3 year old child has eczematous dermatitis on extensor surfaces, His mother has a history of Bronchial asthma. Diagnosis should be
Correct Answer
A. Atopic dermatitis
Explanation
Site of involvement, family history of asthma - indicates diagnosis of atopic dermatitis.
48.
Tuberculids are seen in
Correct Answer
C. Lichen scrofulosorum
Explanation
Tuberculides are a group of cutaneous disorders in which the tuberculous etiology is not definite. But they have a tuberculous granuloma in histology. Treatment is by antituberculous treatment.
-Lichen scrofulosorum
-Papulonecrotic tuberculid
49.
True regarding Pityriasis Rosea is:
Correct Answer
A. Self limiting
Explanation
Pityriasis Rosea is a self limiting disease. Herald patch is the characteristic lesion.
50.
‘Chancre redux’ is a clinical feature of:
Correct Answer
A. Early relapsing sypHlis
Explanation
'Chancre redux' refers to the reappearance of a chancre, which is a painless ulcer that is characteristic of syphilis. Early relapsing syphilis is a stage of syphilis where symptoms reappear after initial treatment. Therefore, it is likely that 'Chancre redux' is a clinical feature of early relapsing syphilis. Late syphilis refers to the later stages of the disease and is not associated with the reappearance of a chancre. Chancroid is a sexually transmitted infection caused by the bacteria Haemophilus ducreyi, and recurrent herpes simplex infection is caused by the herpes simplex virus. Neither of these conditions is specifically associated with the reappearance of a chancre.