Qsar Quiz..
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The Quiz is based on QSAR problems. Answer the following questions.
- 1.What value does the regression coefficient have for a perfect fit?
- A.
0.1
- B.
1
- C.
100
- D.
0
- 2.What does the symbol P represent in a QSAR equation?
- A.
PH
- B.
Plasma Concentration
- C.
Partition coefficient
- D.
None of the above
- 3.What is the symbol π in a QSAR equation?
- A.
The electronic effect of a substituent
- B.
The substituent hydrophobicity constant
- C.
The hydrophobicity of the molecule
- D.
Steric parameter
- 4.
![Calculate the logP value for the structure shown; logP for benzene = 2.13; π(OH) -0.67; π(CH3) 0.52 ?]( "Calculate the logP value for the structure shown; logP for benzene = 2.13; π(OH) -0.67; π(CH3) 0.52 ?")
Calculate the logP value for the structure shown; logP for benzene = 2.13; π(OH) -0.67; π(CH3) 0.52 ?- A.
3.32
- B.
1.98
- C.
1.53
- D.
2.12
- 5.What does MR represent in a QSAR equation?
- A.
Molar refractivity is a steric factor
- B.
Molar refractivity is an electronic factor
- C.
Molar refractivity is a hydrophobic factor
- D.
Molar refractivity is a stereoelectronic factor
- 6.What does a negative value of σ signify for a substituent?
- A.
It is electron donating
- B.
It is electron withdrawing
- C.
It is neutral
- D.
It is hydrophobic
- 7.
- A.
3D QSAR has a predictive quality unlike QSAR.
- B.
Experimental parameters are not required by 3D QSAR, but are for QSAR.
- C.
Only drugs of the same structural class should be studied by 3D QSAR or QSAR.
- D.
3D QSAR has a predictive quality unlike QSAR.
- 8.
![The QSAR equation relating the insecticidal activity of a series of diethyl phenylphosphonates versus σ is shown below.
What does r represent?]( "The QSAR equation relating the insecticidal activity of a series of diethyl phenylphosphonates versus σ is shown below.
What does r represent?")
The QSAR equation relating the insecticidal activity of a series of diethyl phenylphosphonates versus σ is shown below. What does r represent?- A.
The number of compounds tested
- B.
The regression or correlation coefficient
- C.
Mean Square Error
- D.
The F Statistic
- 9.
![A series of phenanthrene derivatives is tested for antimalarial activity and found to fit the following Hansch equation:]( "A series of phenanthrene derivatives is tested for antimalarial activity and found to fit the following Hansch equation:")
- A.
It indicates that activity rises to a maximum value as πsum increases to an optimum value, then falls again as sum increases beyond that value.
- B.
It indicates that activity falls to a minimum value as πsum increases to an optimum value, then rises again as πsum increases beyond that value.
- C.
It indicates that activity falls to a minimum value as πsum increases to an optimum value, then rises again as πsum increases beyond that value.
- D.
It indicates that activity rises to a maximum value as πsum decreases to a certain value, then falls again as πsum decreases beyond that value.
- 10.Using the same equation in question 9 What does the term Σ πX represent in the equation?
- A.
The sum of the hydrophobic factors corresponding to the substituent X present in the molecule.
- B.
The sum of the electronic factors corresponding to the substituent X present in the molecule
- C.
The largest hydrophobic factor of the substituent X present in the molecule.
- D.
The smallest hydrophobic factor of the substituent X present in the molecule.
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