QSAR Classification Model: Chemistry Quiz!

10 Questions | Total Attempts: 2520

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QSAR Classification Model: Chemistry Quiz!

Have you ever heard of QSAR? Let's see if you can pass this quiz? QSAR stands for Quantitative Structure acting relationship models are regression or classification models used in the chemical and biological sciences and engineering. It is based on the idea that when we change the composition of a molecule, then the substance's action or property will be altered. Take this quiz and learn more about QSAR.


Questions and Answers
  • 1. 
    What value does the regression coefficient have for a perfect fit?
    • A. 

      0.1

    • B. 

      1

    • C. 

      100

    • D. 

      0

  • 2. 
    What does the symbol P represent in a QSAR equation?
    • A. 

      PH

    • B. 

      Plasma Concentration

    • C. 

      Partition coefficient

    • D. 

      None of the above

  • 3. 
    What is the symbol π in a QSAR equation?
    • A. 

      The electronic effect of a substituent

    • B. 

      The substituent hydrophobicity constant

    • C. 

      The hydrophobicity of the molecule

    • D. 

      Steric parameter

  • 4. 
    Calculate the logP value for the structure shown; logP for benzene = 2.13; π(OH) -0.67; π(CH3) 0.52 ? 
    • A. 

      3.32

    • B. 

      1.98

    • C. 

      1.53

    • D. 

      2.12

  • 5. 
    What does MR represent in a QSAR equation?
    • A. 

      Molar refractivity is a steric factor

    • B. 

      Molar refractivity is an electronic factor

    • C. 

      Molar refractivity is a hydrophobic factor

    • D. 

      Molar refractivity is a stereoelectronic factor

  • 6. 
    What does a negative value of σ signify for a substituent?
    • A. 

      It is electron donating

    • B. 

      It is electron withdrawing

    • C. 

      It is neutral

    • D. 

      It is hydrophobic

  • 7. 
    • A. 

      3D QSAR has a predictive quality unlike QSAR.

    • B. 

      Experimental parameters are not required by 3D QSAR, but are for QSAR.

    • C. 

      Only drugs of the same structural class should be studied by 3D QSAR or QSAR.

    • D. 

      3D QSAR has a predictive quality unlike QSAR.

  • 8. 
    The QSAR equation relating to the insecticidal activity of a series of diethyl phenyl phosphonate versus σ is shown below. What does r represent?
    • A. 

      The number of compounds tested

    • B. 

      The regression or correlation coefficient

    • C. 

      Mean Square Error

    • D. 

      The F Statistic

  • 9. 
    A series of phenanthrene derivatives are tested for antimalarial activity and found to fit the following Hansch equation:
    • A. 

      It indicates that activity rises to a maximum value as πsum increases to an optimum value, then falls again as sum increases beyond that value.

    • B. 

      It indicates that activity falls to a minimum value as πsum increases to an optimum value, then rises again as πsum increases beyond that value.

    • C. 

      It indicates that activity falls to a minimum value as πsum increases to an optimum value, then rises again as πsum increases beyond that value.

    • D. 

      It indicates that activity rises to a maximum value as πsum decreases to a certain value, then falls again as πsum decreases beyond that value.

  • 10. 
    Using the same equation in question 9  What does the term Σ πX represent in the equation?
    • A. 

      The sum of the hydrophobic factors corresponding to the substituent X present in the molecule.

    • B. 

      The sum of the electronic factors corresponding to the substituent X present in the molecule

    • C. 

      The largest hydrophobic factor of the substituent X present in the molecule.

    • D. 

      The smallest hydrophobic factor of the substituent X present in the molecule.