Qsar Quiz..

10 Questions

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Qsar Quiz..

The Quiz is based on QSAR problems. Answer the following questions.


Questions and Answers
  • 1. 
    What value does the regression coefficient have for a perfect fit?  
    • A. 

      0.1

    • B. 

      1

    • C. 

      100

    • D. 

      0

  • 2. 
    What does the symbol P represent in a QSAR equation?
    • A. 

      PH

    • B. 

      Plasma Concentration

    • C. 

      Partition coefficient

    • D. 

      None of the above

  • 3. 
    What is the symbol π in a QSAR equation?
    • A. 

      The electronic effect of a substituent

    • B. 

      The substituent hydrophobicity constant

    • C. 

      The hydrophobicity of the molecule

    • D. 

      Steric parameter

  • 4. 
    Calculate the logP value for the structure shown; logP for benzene = 2.13; π(OH) -0.67; π(CH3) 0.52 ? 
    • A. 

      3.32

    • B. 

      1.98

    • C. 

      1.53

    • D. 

      2.12

  • 5. 
    What does MR represent in a QSAR equation?
    • A. 

      Molar refractivity is a steric factor

    • B. 

      Molar refractivity is an electronic factor

    • C. 

      Molar refractivity is a hydrophobic factor

    • D. 

      Molar refractivity is a stereoelectronic factor

  • 6. 
    What does a negative value of σ signify for a substituent?  
    • A. 

      It is electron donating

    • B. 

      It is electron withdrawing

    • C. 

      It is neutral

    • D. 

      It is hydrophobic

  • 7. 
    • A. 

      3D QSAR has a predictive quality unlike QSAR.

    • B. 

      Experimental parameters are not required by 3D QSAR, but are for QSAR.

    • C. 

      Only drugs of the same structural class should be studied by 3D QSAR or QSAR.

    • D. 

      3D QSAR has a predictive quality unlike QSAR.

  • 8. 
    The QSAR equation relating the insecticidal activity of a series of diethyl phenylphosphonates versus σ is shown below. What does r represent?
    • A. 

      The number of compounds tested

    • B. 

      The regression or correlation coefficient

    • C. 

      Mean Square Error

    • D. 

      The F Statistic

  • 9. 
    • A. 

      It indicates that activity rises to a maximum value as πsum increases to an optimum value, then falls again as sum increases beyond that value.

    • B. 

      It indicates that activity falls to a minimum value as πsum increases to an optimum value, then rises again as πsum increases beyond that value.

    • C. 

      It indicates that activity falls to a minimum value as πsum increases to an optimum value, then rises again as πsum increases beyond that value.

    • D. 

      It indicates that activity rises to a maximum value as πsum decreases to a certain value, then falls again as πsum decreases beyond that value.

  • 10. 
    Using the same equation in question 9  What does the term Σ πX represent in the equation?
    • A. 

      The sum of the hydrophobic factors corresponding to the substituent X present in the molecule.

    • B. 

      The sum of the electronic factors corresponding to the substituent X present in the molecule

    • C. 

      The largest hydrophobic factor of the substituent X present in the molecule.

    • D. 

      The smallest hydrophobic factor of the substituent X present in the molecule.