Normocytic / Normochromic Anemias
MLT study questions for ASCP exam
- 1.Hypersplenism is characterized by:
- A.
Polycythemia
- B.
Pancytosis
- C.
Leukopenia
- D.
Myelodysplasia
- 2.Which of the following organs is reponsible for the "pitting process" for RBC's?
- A.
Liver
- B.
Spleen
- C.
Kidney
- D.
Lymph nodes
- 3.Spherocytes differ from normal red cells in all of the following except:
- A.
Decreased surface to volume
- B.
No central pallor
- C.
Decreased resistance to hypotonic saline
- D.
Increase deformability
- 4.Which of the following is not associated with hereditary spherocytosis?
- A.
Increased osmotic fragility
- B.
An MCHC greater than 36%
- C.
Intravascular hemolysis
- D.
Extravascular hemolysis
- 5.Which of the following disorders has an increase in osmotic fragility?
- A.
Iron deficiency anemia
- B.
Hereditary elliptocytosis
- C.
Hereditary stomatocytosis
- D.
Hereditary spherocytosis
- 6.The anemia seen in sickle cell disease is usually:
- A.
Microcytic, normochromic
- B.
Microcytic, hypochromic
- C.
Normocytic, normochromic
- D.
Normocytic, hypochromic
- 7.Which is the major Hgb found in the RBC's of patients with sickle cell trait?
- A.
Hgb S
- B.
Hgb F
- C.
Hgb A2
- D.
Hgb A
- 8.Select the amino acid substitution that is responsible for sickle cell anemia.
- A.
Lysine is substituted for glutamic acid at the sixth position of the a-chain
- B.
Valine is substituted for glutamic acid at the sixth position of the B-chain
- C.
Valine is substituted for glutamic acid at the sixth position for the a-chain
- D.
Glutamine is substituted for glutamic acid at the sixth position of the B-chain
- 9.All of the following are usually found in Hgb C disease except:
- A.
Hgb C crystals
- B.
Target cells
- C.
Lysine substituted for glutamic acid at the sixth position of the B-chain
- D.
Fast mobility of Hbg C at pH 8.6
- 10.Which of the following hemoglobins migrates to the same position as Hgb A2 at pH 8.6?
- A.
Hgb H
- B.
Hgb F
- C.
Hgb C
- D.
Hgb S
- 11.Which of the following electrophoretic results is consistent with a diagnosis of sickle cell trait?
- A.
Hgb A: 40% Hgb S: 35% Hgb F: 5%
- B.
Hgb A: 60% Hgb S: 40% Hgb A2: 2%
- C.
Hgb A: 0% Hgb A2: 5% Hgb F: 95%
- D.
Hgb A: 80% Hgb S: 10% Hgb A2: 10%
- 12.In which of the following conditions will autosplenectomy most likely occur?
- A.
Thalassemia major
- B.
Hgb C disease
- C.
Hgb SC disease
- D.
Sickle cell disease
- 13.Whic of the following is most true about praoxysmal nocturnal hemoglobinuria (PNH)?
- A.
It is an acquired hemolytic anemia
- B.
It is inherited as a sex-linked trait
- C.
It is inherited as an autosomal dominant trait
- D.
It is inherited as an autosomal recessive trait
- 14.Hemolytic uremic syndrome (HUS) is characterized by all of the following except:
- A.
Hemorrhage
- B.
Thrombocytopenia
- C.
Hemoglobinuria
- D.
Reticulocytopenia
- 15.An autohemolysis test is positive in all the following areas except:
- A.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency
- B.
Hereditary spherocytosis
- C.
Pyruvate kinase deficiency
- D.
Paroxysmal nocturnal hemoglobinuria
- 16.Which antibody is associated with paroxysmal cold hemoglobinuria (PCH)?
- A.
Anti-I
- B.
Anti-i
- C.
Anti-M
- D.
Anti-P
- 17.All of the following are associated with hemolytic anemia except:
- A.
Methemoglobinemia
- B.
Hemoglobinuria
- C.
Hemoglobinemia
- D.
Increased haptoglobin
- 18.Autoimmune hemolytic anemia is best characterized by which of the following?
- A.
Increased levels of plasma C3
- B.
Spherocytic red cells
- C.
Decreased osmotic fragility
- D.
Decreased unconjugated bilirubin
- 19."Bite cells" are usually seen in patients with:
- A.
Rh null trait
- B.
Chronic granulomatous disease
- C.
G6PD deficiency
- D.
PK deficiency
- 20.The morphological classification on anemias is based on which of the following:
- A.
M:E ratio
- B.
Prussian blue stain
- C.
RBC indicies
- D.
Reticulocyte count
- 21.Which of the following is a common finding in aplastic anemia?
- A.
A monoclonal disorder
- B.
Tumor infiltration
- C.
Peripheral blood pancytopenia
- D.
Defective DNA synthesis
- 22.Congenital dyserythropoietic anemias (CDAs) are characterized by:
- A.
Bizarre multinucleated erythroblasts
- B.
Cytogenetic disorders
- C.
Megaloblastic erythropoiesis
- D.
An elevated M:E ratio
- 23.Microangiopathic hemolytic anemia is characterized by:
- A.
Target cells and cabot rings
- B.
Toxic granulation and Dohle bodies
- C.
Pappenheimer bodies and basophilic stippling
- D.
Schistocytes and nucleated RBCs
- 24.Which antibiotics are most often implicated in the development of aplastic anemia?
- A.
Sulfonamides
- B.
Penicillin
- C.
Tertrcycline
- D.
Chloramphenicol
- 25.Sickle cell disorders are:
- A.
Hereditary, intracorpuscular RBC defect
- B.
Hereditary, extracorpuscular RBC defect
- C.
Acquired, intracorpuscular RBC defects
- D.
Acquired, extracorpuscular RBC defects
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