Normocytic / Normochromic Anemias

30 Questions | Total Attempts: 610

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MLT study questions for ASCP exam


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  • 1. 
    Hypersplenism is characterized by:
    • A. 

      Polycythemia

    • B. 

      Pancytosis

    • C. 

      Leukopenia

    • D. 

      Myelodysplasia

  • 2. 
    Which of the following organs is reponsible for the "pitting process" for RBC's?
    • A. 

      Liver

    • B. 

      Spleen

    • C. 

      Kidney

    • D. 

      Lymph nodes

  • 3. 
    Spherocytes differ from normal red cells in all of the following except:
    • A. 

      Decreased surface to volume

    • B. 

      No central pallor

    • C. 

      Decreased resistance to hypotonic saline

    • D. 

      Increase deformability

  • 4. 
    Which of the following is not associated with hereditary spherocytosis?
    • A. 

      Increased osmotic fragility

    • B. 

      An MCHC greater than 36%

    • C. 

      Intravascular hemolysis

    • D. 

      Extravascular hemolysis

  • 5. 
    Which of the following disorders has an increase in osmotic fragility?
    • A. 

      Iron deficiency anemia

    • B. 

      Hereditary elliptocytosis

    • C. 

      Hereditary stomatocytosis

    • D. 

      Hereditary spherocytosis

  • 6. 
    The anemia seen in sickle cell disease is usually:
    • A. 

      Microcytic, normochromic

    • B. 

      Microcytic, hypochromic

    • C. 

      Normocytic, normochromic

    • D. 

      Normocytic, hypochromic

  • 7. 
    Which is the major Hgb found in the RBC's of patients with sickle cell trait?
    • A. 

      Hgb S

    • B. 

      Hgb F

    • C. 

      Hgb A2

    • D. 

      Hgb A

  • 8. 
    Select the amino acid substitution that is responsible for sickle cell anemia.
    • A. 

      Lysine is substituted for glutamic acid at the sixth position of the a-chain

    • B. 

      Valine is substituted for glutamic acid at the sixth position of the B-chain

    • C. 

      Valine is substituted for glutamic acid at the sixth position for the a-chain

    • D. 

      Glutamine is substituted for glutamic acid at the sixth position of the B-chain

  • 9. 
    All of the following are usually found in Hgb C disease except:
    • A. 

      Hgb C crystals

    • B. 

      Target cells

    • C. 

      Lysine substituted for glutamic acid at the sixth position of the B-chain

    • D. 

      Fast mobility of Hbg C at pH 8.6

  • 10. 
    Which of the following hemoglobins migrates to the same position as Hgb A2 at pH 8.6?
    • A. 

      Hgb H

    • B. 

      Hgb F

    • C. 

      Hgb C

    • D. 

      Hgb S

  • 11. 
    Which of the following electrophoretic results is consistent with a diagnosis of sickle cell trait?
    • A. 

      Hgb A: 40% Hgb S: 35% Hgb F: 5%

    • B. 

      Hgb A: 60% Hgb S: 40% Hgb A2: 2%

    • C. 

      Hgb A: 0% Hgb A2: 5% Hgb F: 95%

    • D. 

      Hgb A: 80% Hgb S: 10% Hgb A2: 10%

  • 12. 
    In which of the following conditions will autosplenectomy most likely occur?
    • A. 

      Thalassemia major

    • B. 

      Hgb C disease

    • C. 

      Hgb SC disease

    • D. 

      Sickle cell disease

  • 13. 
    Whic of the following is most true about praoxysmal nocturnal hemoglobinuria (PNH)?
    • A. 

      It is an acquired hemolytic anemia

    • B. 

      It is inherited as a sex-linked trait

    • C. 

      It is inherited as an autosomal dominant trait

    • D. 

      It is inherited as an autosomal recessive trait

  • 14. 
    Hemolytic uremic syndrome (HUS) is characterized by all of the following except:
    • A. 

      Hemorrhage

    • B. 

      Thrombocytopenia

    • C. 

      Hemoglobinuria

    • D. 

      Reticulocytopenia

  • 15. 
    An autohemolysis test is positive in all the following areas except:
    • A. 

      Glucose-6-phosphate dehydrogenase (G6PD) deficiency

    • B. 

      Hereditary spherocytosis

    • C. 

      Pyruvate kinase deficiency

    • D. 

      Paroxysmal nocturnal hemoglobinuria

  • 16. 
    Which antibody is associated with paroxysmal cold hemoglobinuria (PCH)?
    • A. 

      Anti-I

    • B. 

      Anti-i

    • C. 

      Anti-M

    • D. 

      Anti-P

  • 17. 
    All of the following are associated with hemolytic anemia except:
    • A. 

      Methemoglobinemia

    • B. 

      Hemoglobinuria

    • C. 

      Hemoglobinemia

    • D. 

      Increased haptoglobin

  • 18. 
    Autoimmune hemolytic anemia is best characterized by which of the following?
    • A. 

      Increased levels of plasma C3

    • B. 

      Spherocytic red cells

    • C. 

      Decreased osmotic fragility

    • D. 

      Decreased unconjugated bilirubin

  • 19. 
    "Bite cells" are usually seen in patients with:
    • A. 

      Rh null trait

    • B. 

      Chronic granulomatous disease

    • C. 

      G6PD deficiency

    • D. 

      PK deficiency

  • 20. 
    The morphological classification on anemias is based on which of the following:
    • A. 

      M:E ratio

    • B. 

      Prussian blue stain

    • C. 

      RBC indicies

    • D. 

      Reticulocyte count

  • 21. 
    Which of the following is a common finding in aplastic anemia?
    • A. 

      A monoclonal disorder

    • B. 

      Tumor infiltration

    • C. 

      Peripheral blood pancytopenia

    • D. 

      Defective DNA synthesis

  • 22. 
    Congenital dyserythropoietic anemias (CDAs) are characterized by:
    • A. 

      Bizarre multinucleated erythroblasts

    • B. 

      Cytogenetic disorders

    • C. 

      Megaloblastic erythropoiesis

    • D. 

      An elevated M:E ratio

  • 23. 
    Microangiopathic hemolytic anemia is characterized by:
    • A. 

      Target cells and cabot rings

    • B. 

      Toxic granulation and Dohle bodies

    • C. 

      Pappenheimer bodies and basophilic stippling

    • D. 

      Schistocytes and nucleated RBCs

  • 24. 
    Which antibiotics are most often implicated in the development of aplastic anemia?
    • A. 

      Sulfonamides

    • B. 

      Penicillin

    • C. 

      Tertrcycline

    • D. 

      Chloramphenicol

  • 25. 
    Sickle cell disorders are:
    • A. 

      Hereditary, intracorpuscular RBC defect

    • B. 

      Hereditary, extracorpuscular RBC defect

    • C. 

      Acquired, intracorpuscular RBC defects

    • D. 

      Acquired, extracorpuscular RBC defects

  • 26. 
    Which of the following conditions may produce spherocytes in a peripheral smear?
    • A. 

      Pelger-Huet anomaly

    • B. 

      Pernicious anemia

    • C. 

      Autoimmune hemolytic anemia

    • D. 

      Sideroblastic anemia

  • 27. 
    A patient's peripheral smear reveals numerous NRBC's marked variation of red cell morphology, and pronounced polychromasia. In addition to a decreased Hgb and decreased Hct values, what other CBC parameters may be anticipated?
    • A. 

      Reduced platelets

    • B. 

      Increased MCHC

    • C. 

      Increased MCV

    • D. 

      Decreased red cell distribution width (RDW)

  • 28. 
    What red cell inclusions may be seen in the peripheral blood smear of a patient postsplenectomy?
    • A. 

      Toxic granulation

    • B. 

      Howell-Jolly bodies

    • C. 

      Malarial parasite

    • D. 

      Siderotic granules

  • 29. 
    Reticulocytosis usually indicates:
    • A. 

      Response to inflammation

    • B. 

      Neoplastic process

    • C. 

      Aplastic anemia

    • D. 

      Red cell regeneration

  • 30. 
    Hereditary pyropoikilocytosis (HP) is a red cell membrance defect characterized by:
    • A. 

      Increased pencil-shaped cells

    • B. 

      Increased oval macrocytes

    • C. 

      Misshappen budding fragmented cells

    • D. 

      Bite cells