Types Of Anemia

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Types Of Anemia - Quiz

In today’s quiz, we’ll be tackling the topic of anaemia; a common disorder that involves the levels of oxygen supply throughout your body being impeded by a deficiency in the red blood cells, typically as a result of a lack of iron. What types of anaemia are there? You tell us!


Questions and Answers
  • 1. 
    A 30-year-old woman has H/O mild fatigue for many years. O/E Palpable spleen tip. Labs- Hb 11.1 g/dL, Hct 28.8%, MCV 83fL, platelets 229,000/µL, WBC count 7340/µL. Corrected retic. Count-12%. PBS- Small RBCs that lack central pallor. Osmotic fragility of RBCs is increased. Coombs test is negative. Defects in which of the following are involved in the pathogenesis of this disorder
    • A. 

      DNA synthesis

    • B. 

      Erythrocyte cytoskeleton

    • C. 

      Clonal stem cell defect

    • D. 

      Hemoglobin synthesis

    • E. 

      Iron utilization from iron stores

  • 2. 
    The patients described in the previous question is at an increased risk of developing which of the following conditions?
    • A. 

      Cirrhosis

    • B. 

      Cholelithiasis

    • C. 

      Portal hypertension

    • D. 

      Congestive heart failure

    • E. 

      Nephrolithiasis

  • 3. 
    A 10-yr-old black girl is brought to the ER with severe pain in her chest, abdomen and bones. O/E- Jaundice and anemia. CBC shows abnormal shaped RBCs and Howell-Jolly bodies. Labs - Increased amount of an abnormal Hb in her peripheral blood. The child’s chest and bone pain symptoms are caused by which of the following mechanisms?
    • A. 

      Infection

    • B. 

      Ischemia

    • C. 

      Vasculitis

    • D. 

      Amyloidosis

  • 4. 
    In the patient described in the previous question, which of the following is the most likely mechanism for initiation of her pulmonary problems?
    • A. 

      Intra-vascular hemolysis

    • B. 

      Increased RBC adhesion to endothelium

    • C. 

      Abnormality in spectrin

    • D. 

      Increased osmotic fragility of RBCs

    • E. 

      Reduced expression of adhesion molecules on endothelial cells

  • 5. 
    A 10-month-old boy presents with failure to thrive. O/E- Jaundice. CBC- Microcytic hypochromic anemia. Most of the Hb is HbF type. PBS is shown. BM aspirate shows marked erythroid hyperplasia and increased iron stores. What is your diagnosis?
    • A. 

      Beta-thalassemia major

    • B. 

      Beta-thalassemia minor

    • C. 

      Alpha-thalassemia major

    • D. 

      Alpha-thalassemia minor

  • 6. 
    What is the pathogenesis of anemia seen in the patient just described?
    • A. 

      Decreased heme synthesis

    • B. 

      Abnormal spectrin assembly

    • C. 

      Clonal stem cell defect

    • D. 

      Decreased beta-globin chain synthesis

    • E. 

      Impaired utilization of iron from storage sites

  • 7. 
    A 16-year-old boy has had a low energy level for as long as he can remember. O/E- Palpable spleen tip. CBC shows Hb- 8.8 g/dL, Hct 24.1%, MCV 65 fL, platelet count 187,000/µL, WBC count 7400/µL. His serum ferritin is 3740 ng/mL (Normal-10-200µg/L). BM biopsy reveals a myeloid : erythroid ratio of 1:4 with 4+ stainable iron. Which of the following is the most likely diagnosis?
    • A. 

      G6PD deficiency

    • B. 

      Beta-thalassemia

    • C. 

      Sickle cell anemia

    • D. 

      Hereditary spherocytosis

    • E. 

      Malaria

  • 8. 
    A 19 year old primigravida of Southeast Asian ancestry gives birth at 35 wks gestation a male infant. O/E infant is markedly hydropic. Lab. studies show his hematocrit is 17% and PBS reveals numerous nucleated red blood cells. RBCs show marked anisocytosis and poikilocytosis. Which of the following diseases is most likely to be present in this infant?
    • A. 

      Sickle cell anemia

    • B. 

      Alpha-thalassemia

    • C. 

      G6PD deficiency

    • D. 

      Hereditary elliptocytosis

  • 9. 
    A 49-year-old female presents with signs of anemia and states that every morning her urine is dark. Work-up reveals that her RBCs lyse in vitro with acid (positive Ham’s test). What is the best diagnosis for this patient?
    • A. 

      Warm, autoimmune hemolytic anemia

    • B. 

      Paroxysmal nocturnal hemoglobinuria

    • C. 

      Cold-agglutinin autoimmune hemolytic anemia

    • D. 

      G6PD deficiency

  • 10. 
    A 25-year-old African-American man is given anti-malarial prophylaxis for a trip to West Africa. Over the next week he develops increasing fatigue. O/E - No abnormal findings. Labs- Hematocrit -30%. PBS shows RBCs with numerous Heinz bodies. There is a family history of this disorder, with males, but not females, affected. Which of the following is the most likely diagnosis?
    • A. 

      Beta-thalassemia

    • B. 

      Sickle cell anemia

    • C. 

      Alpha-thalassemia

    • D. 

      Hereditary spherocytosis

    • E. 

      G6PD deficiency

  • 11. 
    Which of the following underlying conditions would you most likely expect to be present in a 27-year old female with the peripheral blood smear shown here:
    • A. 

      Aplastic anemia

    • B. 

      Anemia of chronic disease

    • C. 

      Iron deficiency anemia

    • D. 

      Megaloblastic anemia

    • E. 

      DIC

  • 12. 
    A 38-year-old woman has become increasingly fatigued for the past 3 months.O/E- Purpuric areas of skin on her trunk and extremities. No hepato-splenomegaly/LN. Labs- Hb 6.8 g/dL, Hct 20.7%, MCV 91 fL, platelet count 28,760/µL, and WBC count 1940/µL. Which of the following is the most likely diagnosis?
    • A. 

      Aplastic anemia

    • B. 

      Chronic myelogenous leukemia

    • C. 

      Infectious mononucleosis

    • D. 

      Large B cell lymphoma

    • E. 

      Hereditary spherocytosis

  • 13. 
    A 32-yr-old man presents with fever, recurrent URIs and chronic fatigue. He is an immigrant from Russia and has worked in a benzene factory. O/E- Petechiae seen, no LN/splenomegaly. CBC shows pancytopenia. Retic. count is low. BM biopsy shows a hypocellular marrow with increased fat. Which of the following is the most likely underlying mechanism of the patient’s condition?
    • A. 

      Folate deficiency

    • B. 

      Impaired globin chain synthesis

    • C. 

      Damage to stem cells

    • D. 

      Mutation in PIGA gene

  • 14. 
    A 38-year-old woman has a history of rheumatoid arthritis. She is currently receiving immunosuppressive therapy including corticosteroids. O/E - Minimal erythema, warmth, and swelling of the small joints of her hands. Lab. studies show Hb 10.1 g/dL, Hct 30.4%, MCV 74 fL, WBC count 6500/µL, and platelet count 137,000/µL. Retic. Count-1.5%. She has a serum iron of 28 µg/dl and  TIBC of 200 µg/dl . Her serum ferritin is 420 ng/mL. Which of the following is the most likely diagnosis?
    • A. 

      Chronic blood loss

    • B. 

      Beta-thalassemia

    • C. 

      Anemia of chronic disease

    • D. 

      Auto-immune hemolytic anemia

  • 15. 
    A 38-yr-old man presents with fatigue. He has a 3-yr history of TB. CBC shows a microcytic hypochromic anemia. Blood profile shows low serum iron, low iron binding capacity and increased serum ferritin. Which of the following explains the pathogenesis of anemia in this patient?
    • A. 

      Impaired heme synthesis

    • B. 

      Impaired utilization of iron from storage sites

    • C. 

      Synthesis of structurally abnormal globin chains

    • D. 

      Vit. B12 deficiency

    • E. 

      Sickle cell anemia

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