Mpharm-cet Test No.1
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MPHARM-CET TEST NO. 1Designed by Dr. Anwar R. ShaikhCourtesy:1) Dr. Aman B. Upaganlawar (M. Pharm,PhD,MAMS)Associate Professor, Department of Pharmacology. SNJBs SSDJ College of Pharmacy,Neminagar,Chandwad. Dist:Nashik:423 1012) Mr. C V PanchalAsst. ProfessorDept. Of Pharmacognosy,Maharashtra College of Pharmacy,Nilanga, Dist. Latur, PIN-413521
- 1.All of the following hormones have cell surface receptors except
- A.
Adrenaline
- B.
Growth Hormone
- C.
Insulin
- D.
Thyroxin
- 2.A highly ionized drug
- A.
Is excreted mainly by the kidney
- B.
Can cross the placental barrier easily
- C.
Is well absorbed from the intestine
- D.
Accumulates in the cellular lipids
- 3.Which one of the following is true of adrenal suppression due to steroid therapy?
- A.
It is not associated with atrophy of adrenal glands
- B.
It does not occur in patients receiving inhaled steroids
- C.
It should be expected in anyone receiving greater than 5mg of prednisolone daily
- D.
Following cessation, the stress response normalizes after 8 weeks
- 4.With which of the following theophylline has an antagonistic interaction?
- A.
Histamine receptors
- B.
Bradykinin receptors
- C.
Adenosine receptors
- D.
Imidazoline receptors
- 5.Which one of the following drugs increases gastrointestinal motility?
- A.
Glycopyrrolate
- B.
Atropine
- C.
Neostigmine
- D.
Fentanyl
- 6.Which one of the following drugs has been shown to offer protection from gastric aspiration syndrome in a patient with symptoms of flux?
- A.
Ondansetron
- B.
Metaclopramide
- C.
Sodium citrate
- D.
Atropine
- 7.Which one of the following drugs has been shown to offer protection from gastric aspiration syndrome in a patient with symptoms of flux?
- A.
Ondansetron
- B.
Metaclopramide
- C.
Sodium citrate
- D.
Atropine
- 8.Inverse agonist of benzodiazepine receptor is
- A.
Phenobarbitone
- B.
Flumazenil
- C.
Beta-carboline
- D.
Gabapentin
- 9.
- At the end of phase III clinical trial the drug will be submitted to the relevant regulatory authority for:
- A.
Licensing
- B.
Evaluation
- C.
Post Marketing studies
- D.
All of above
- 10.Rectal administration of drugs:
- A.
Gives predictable blood levels
- B.
From lower 1/3rd avoids first pass & upper 2/3rds doesn’t
- C.
None undergoes first pass metabolism
- D.
All of it undergoes first pass metabolism
- 11.Different species of Ephedra can be identified by observing the nature of
- A.
Inner surface
- B.
Outer surface
- C.
Trichomes
- D.
Scaly Leaves
- 12.Indian Rhubarb can be distinguished from Rhapontic Rhubarb by the flurorescence it emits under UV light, Indian Rhubarb gives:
- A.
Deep yellow
- B.
Deep Violate
- C.
Orange
- D.
Pale Green
- 13.Genetically modified species of papaver namely papaver bracetum and papver oriental contain the predominant alkaloid:
- A.
Morphine
- B.
Codeine
- C.
Thebaine
- D.
Narcotine
- 14.A substance used for the modification of silica gel for reversed phase TLC is:
- A.
Benzene
- B.
Glycerine
- C.
Silicone Oil
- D.
Ether
- 15.Klunge's Test is for the identification of:
- A.
Barbaloin
- B.
Isobarbaloin
- C.
Alionosides
- D.
Aleosin
- 16.Microscopic character of Ginger Rhizome are:
- A.
Spindle shaped lignified fibers and sclerides
- B.
Cluster crystals of calcium oxalate and sclerides
- C.
Non lignified vessels and sac shaped starch grains
- D.
Non lignified vessels and sclerides
- 17.A transeverse section of the root of Glycerrhiza glabra when treated with 80% Sulphuric acid gives:
- A.
Deep yellow colour
- B.
No reaction but only charring
- C.
Deep blue colour
- D.
Deep red colour
- 18.A naturally occuring amino acid which does not have a chiral centre is :
- A.
Glycine
- B.
Alanine
- C.
Tryptophane
- D.
Tyrosine
- 19.Match Group I with II:Group I Group II1. Gentisin a. Flavonol2. Genistein b. Flavone3. Apigenin c. Xanthone4. Quercetin d. Isoflavone
- A.
1-d, 2-c, 3-a, 4-b
- B.
1-a, 2-b, 3-d, 4-c
- C.
1-c, 2-d, 3-b, 4-a
- D.
1-b, 2-a, 3-c, 4-d
- 20.Microscopy of the bulbs of Urgenia indica family Liliaceae shows:
- A.
Prism of calcium oxalate
- B.
Calcium carbonate and silica
- C.
Rosetters of calcium oxalate
- D.
Rhaphides of calcium oxalate
- 21.What term is used to indicate the ability of a cancer to invade other parts of the body and to produce secondary tumours?
- A.
Carcinogenesis
- B.
Apoptosis
- C.
Metastasis
- D.
Mutagenesis
- 22.Which molecules are involved in the anchoring of cells to an extracellular matrix?
- A.
Integrins
- B.
Interleukins
- C.
Angiostatin
- D.
Cyclins
- 23.Which of the following statements is false with respect to an enzyme's ability to catalyse a reaction?
- A.
An enzyme provides a reaction surface and a suitable environment for the reaction to take place
- B.
An enzyme binds reactants such that they are positioned correctly and can attain their transition-state configurations
- C.
An enzyme allows the reaction to go through a less stable transition state than would normally be the case
- D.
An enzyme can weaken bonds in reactants through the binding process
- 24.Which of the following statements is not true regarding the active site of an enzyme?
- A.
An active site is normally a hollow or cleft on the surface of an enzyme.
- B.
An active site is normally hydrophilic in nature.
- C.
Substrates fit into active sites and bind to functional groups within the active site.
- D.
An active site contains amino acids which are important to the binding process and the catalytic mechanism.
- 25.Which of the following statements best describes an allosteric binding site?
- A.
It is a binding site containing amino acids with aliphatic side chains.
- B.
It is a binding site that can accept a wide variety of differently shaped molecules.
- C.
It is a binding site, which is separate from the active site, and affects the activity of an enzyme when it is occupied by a ligand.
- D.
It is a description of an active site which has undergone an induced fit.
- 26.
- A.
Treatment of myasthenia gravis
- B.
'Switching off' the gastrointestinal tract prior to surgery
- C.
'Switching on' the urinary tract after surgery
- D.
Increasing heart muscle activity in certain heart defects
- 27.
![Atropine has been used to decrease gastrointestinal motility and to counteract anticholinesterase poisoning.What function does this molecule have?]( "Atropine has been used to decrease gastrointestinal motility and to counteract anticholinesterase poisoning.What function does this molecule have?")
Atropine has been used to decrease gastrointestinal motility and to counteract anticholinesterase poisoning.What function does this molecule have?- A.
Muscarinic agonist
- B.
Muscarinic antagonist
- C.
Nicotinic agonist
- D.
Nicotinic antagonist
- 28.
![Which feature of acetylcholine interacts with the binding site of cholinergic receptors by hydrogen bonding?What function does this molecule have?]( "Which feature of acetylcholine interacts with the binding site of cholinergic receptors by hydrogen bonding?What function does this molecule have?")
Which feature of acetylcholine interacts with the binding site of cholinergic receptors by hydrogen bonding?What function does this molecule have?- A.
The acyl methyl group
- B.
The ester
- C.
The quaternary nitrogen
- D.
All three N-methyl groups
- 29.One of the following belongs to imidazolidine-2,4-dione class:
- A.
Phenytoin
- B.
Trimethadione
- C.
Phensuximide
- D.
Paramethadione
- 30.Indication of clonazepam is:
- A.
Myoclonic epilepsy
- B.
Partial motor seizers
- C.
Status epilepticus
- D.
Partial complex seizures
- 31.Of the following oral liquid formulations which would be considered as an oropharyngeal formulation?
- A.
Syrup
- B.
Elixir
- C.
Mouthwash
- D.
Linctus
- 32.Which of the following formulations would not be applicable to ocular administration?
- A.
Solution
- B.
Liniment
- C.
Suspension
- D.
Ointment
- 33.A tablet to treat a headache must first be dissolved in water before swallowing. Which one of the following best describes this type of tablet?
- A.
Modified release
- B.
Oral disintegrating
- C.
Effervescent
- D.
Buccal
- 34.Name two different types of inhaler?
- A.
MDI & API
- B.
IV & SC
- C.
DPI & MDI
- D.
GIT & ATP
- 35.If 25 g of a liquid occupies 20 cm3 in a measuring cylinder, what is the density of the liquid?
- A.
0.25 g cm-3
- B.
0.8 g cm-3
- C.
1.25 g cm-3
- D.
5 g cm-3
- 36.Which property measures the resistance of a liquid to flow?
- A.
Density
- B.
Viscosity
- C.
Volume
- D.
Solubility
- 37.What is the correct definition of a pseudoplastic liquid?
- A.
A liquid which becomes less viscous as the rate of shear increases
- B.
A liquid which becomes more viscous as the rate of shear increases
- C.
A liquid which becomes less viscous over time when a constant shear stress is applied
- D.
A liquid which becomes more viscous over time when a constant shear stress is applied
- 38.What is the kinematic viscosity of a liquid that has a density of 1.2 g cm-3 and a dynamic viscosity of 2 cP?
- A.
0.6 m2 s-1
- B.
1.67 m2 s-1
- C.
0.6 x10-6 m2 s-1
- D.
1.67 x10-6 m2 s-1
- 39.What is the concentration of a 0.5 % (w/v) solution when expressed as mg mL-1?
- A.
0.005 mg mL-1
- B.
0.05 mg mL-1
- C.
0.5 mg mL-1
- D.
5 mg mL-1
- 40.In a solution the substance that is being dissolved is called the___
- A.
Solvent
- B.
Emulsifier
- C.
Solute
- D.
Filtrate
- 41.Which of the following wavelength ranges is associated with UV spectroscopy?
- A.
0.8 - 500µm
- B.
400 - 100nm
- C.
380 - 750nm
- D.
0.01 - 10nm
- 42.Which of the following compounds does not absorb light in the UV/visible spectrum?
- A.
Aspirin
- B.
Paracetamol
- C.
Chloral hydrate
- D.
Phenobarbitone
- 43.
- A.
50mg
- B.
60mg
- C.
100mg
- D.
120mg
- 44.A series of 3 coloured glass plates of equal thickness are placed in a light beam. Each sheet absorbs one quarter of the light incident upon it. What is the intensity of the light transmitted by the third glass plate?
- A.
1.56%
- B.
42.19%
- C.
56.25%
- D.
75.00%
- 45.In infrared spectroscopy which frequency range is known as the fingerprint region?
- A.
400 - 1400cm-1
- B.
1400 - 900cm-1
- C.
900 - 600cm-1
- D.
600 - 250cm-1
- 46.In which region of the infrared spectrum would you expect to find a peak characteristic of a triple bond stretch?
- A.
4000 - 3000cm-1
- B.
2500 - 2000cm-1
- C.
2000 - 1500cm-1
- D.
1500 - 750cm-1
- 47.In a chromatographic separation, which of the following indices is most appropriate for the qualitative identification of a substance?
- A.
Relative retention factor Rrel
- B.
Retention factor Rf
- C.
Retention time
- D.
Resolution
- 48.Which of the following techniques would be most useful to identify and quantify the presence of a known impurity in a drug substance?
- A.
NMR
- B.
MS
- C.
IR
- D.
HPLC
- 49.Which of the following assays could not be performed by gas chromatography?
- A.
Characterisation of volatile oils
- B.
Measurement of drugs and metabolites in biological fluids
- C.
Characterisation of raw materials for drug synthesis
- D.
Analysis of intravenous sodium chloride infusion
- 50.Following are tablet coating defects except:
- A.
Friability
- B.
Orange Peel Effect
- C.
Blistering
- D.
Picking and sticking
.jpg "Which feature of acetylcholine interacts with the binding site of cholinergic receptors by hydrogen bonding?What function does this molecule have?")
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