Mpharm-cet Test No.1
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MPHARM-CET TEST NO. 1Designed by Dr. Anwar R. ShaikhCourtesy:1) Dr. Aman B. Upaganlawar (M. Pharm,PhD,MAMS)Associate Professor, Department of Pharmacology. SNJBs SSDJ College of Pharmacy,Neminagar,Chandwad. Dist:Nashik:423 1012) Mr. C V PanchalAsst. ProfessorDept. Of Pharmacognosy,Maharashtra College of Pharmacy,Nilanga, Dist. Latur, PIN-413521
- 1.All of the following hormones have cell surface receptors except
- A.
Adrenaline
- B.
Growth Hormone
- C.
Insulin
- D.
Thyroxin
- 2.A highly ionized drug
- A.
Is excreted mainly by the kidney
- B.
Can cross the placental barrier easily
- C.
Is well absorbed from the intestine
- D.
Accumulates in the cellular lipids
- 3.Which one of the following is true of adrenal suppression due to steroid therapy?
- A.
It is not associated with atrophy of adrenal glands
- B.
It does not occur in patients receiving inhaled steroids
- C.
It should be expected in anyone receiving greater than 5mg of prednisolone daily
- D.
Following cessation, the stress response normalizes after 8 weeks
- 4.With which of the following theophylline has an antagonistic interaction?
- A.
Histamine receptors
- B.
Bradykinin receptors
- C.
Adenosine receptors
- D.
Imidazoline receptors
- 5.Which one of the following drugs increases gastrointestinal motility?
- A.
Glycopyrrolate
- B.
Atropine
- C.
Neostigmine
- D.
Fentanyl
- 6.Which one of the following drugs has been shown to offer protection from gastric aspiration syndrome in a patient with symptoms of flux?
- A.
Ondansetron
- B.
Metaclopramide
- C.
Sodium citrate
- D.
Atropine
- 7.Which one of the following drugs has been shown to offer protection from gastric aspiration syndrome in a patient with symptoms of flux?
- A.
Ondansetron
- B.
Metaclopramide
- C.
Sodium citrate
- D.
Atropine
- 8.Inverse agonist of benzodiazepine receptor is
- A.
Phenobarbitone
- B.
Flumazenil
- C.
Beta-carboline
- D.
Gabapentin
- 9.
- At the end of phase III clinical trial the drug will be submitted to the relevant regulatory authority for:
- A.
Licensing
- B.
Evaluation
- C.
Post Marketing studies
- D.
All of above
- 10.Rectal administration of drugs:
- A.
Gives predictable blood levels
- B.
From lower 1/3rd avoids first pass & upper 2/3rds doesn’t
- C.
None undergoes first pass metabolism
- D.
All of it undergoes first pass metabolism
- 11.Different species of Ephedra can be identified by observing the nature of
- A.
Inner surface
- B.
Outer surface
- C.
Trichomes
- D.
Scaly Leaves
- 12.Indian Rhubarb can be distinguished from Rhapontic Rhubarb by the flurorescence it emits under UV light, Indian Rhubarb gives:
- A.
Deep yellow
- B.
Deep Violate
- C.
Orange
- D.
Pale Green
- 13.Genetically modified species of papaver namely papaver bracetum and papver oriental contain the predominant alkaloid:
- A.
Morphine
- B.
Codeine
- C.
Thebaine
- D.
Narcotine
- 14.A substance used for the modification of silica gel for reversed phase TLC is:
- A.
Benzene
- B.
Glycerine
- C.
Silicone Oil
- D.
Ether
- 15.Klunge's Test is for the identification of:
- A.
Barbaloin
- B.
Isobarbaloin
- C.
Alionosides
- D.
Aleosin
- 16.Microscopic character of Ginger Rhizome are:
- A.
Spindle shaped lignified fibers and sclerides
- B.
Cluster crystals of calcium oxalate and sclerides
- C.
Non lignified vessels and sac shaped starch grains
- D.
Non lignified vessels and sclerides
- 17.A transeverse section of the root of Glycerrhiza glabra when treated with 80% Sulphuric acid gives:
- A.
Deep yellow colour
- B.
No reaction but only charring
- C.
Deep blue colour
- D.
Deep red colour
- 18.A naturally occuring amino acid which does not have a chiral centre is :
- A.
Glycine
- B.
Alanine
- C.
Tryptophane
- D.
Tyrosine
- 19.Match Group I with II:Group I Group II1. Gentisin a. Flavonol2. Genistein b. Flavone3. Apigenin c. Xanthone4. Quercetin d. Isoflavone
- A.
1-d, 2-c, 3-a, 4-b
- B.
1-a, 2-b, 3-d, 4-c
- C.
1-c, 2-d, 3-b, 4-a
- D.
1-b, 2-a, 3-c, 4-d
- 20.Microscopy of the bulbs of Urgenia indica family Liliaceae shows:
- A.
Prism of calcium oxalate
- B.
Calcium carbonate and silica
- C.
Rosetters of calcium oxalate
- D.
Rhaphides of calcium oxalate
- 21.What term is used to indicate the ability of a cancer to invade other parts of the body and to produce secondary tumours?
- A.
Carcinogenesis
- B.
Apoptosis
- C.
Metastasis
- D.
Mutagenesis
- 22.Which molecules are involved in the anchoring of cells to an extracellular matrix?
- A.
Integrins
- B.
Interleukins
- C.
Angiostatin
- D.
Cyclins
- 23.Which of the following statements is false with respect to an enzyme's ability to catalyse a reaction?
- A.
An enzyme provides a reaction surface and a suitable environment for the reaction to take place
- B.
An enzyme binds reactants such that they are positioned correctly and can attain their transition-state configurations
- C.
An enzyme allows the reaction to go through a less stable transition state than would normally be the case
- D.
An enzyme can weaken bonds in reactants through the binding process
- 24.Which of the following statements is not true regarding the active site of an enzyme?
- A.
An active site is normally a hollow or cleft on the surface of an enzyme.
- B.
An active site is normally hydrophilic in nature.
- C.
Substrates fit into active sites and bind to functional groups within the active site.
- D.
An active site contains amino acids which are important to the binding process and the catalytic mechanism.
- 25.Which of the following statements best describes an allosteric binding site?
- A.
It is a binding site containing amino acids with aliphatic side chains.
- B.
It is a binding site that can accept a wide variety of differently shaped molecules.
- C.
It is a binding site, which is separate from the active site, and affects the activity of an enzyme when it is occupied by a ligand.
- D.
It is a description of an active site which has undergone an induced fit.
- 26.
- A.
Treatment of myasthenia gravis
- B.
'Switching off' the gastrointestinal tract prior to surgery
- C.
'Switching on' the urinary tract after surgery
- D.
Increasing heart muscle activity in certain heart defects
- 27.
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Atropine has been used to decrease gastrointestinal motility and to counteract anticholinesterase poisoning.What function does this molecule have?- A.
Muscarinic agonist
- B.
Muscarinic antagonist
- C.
Nicotinic agonist
- D.
Nicotinic antagonist
- 28.
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Which feature of acetylcholine interacts with the binding site of cholinergic receptors by hydrogen bonding?What function does this molecule have?- A.
The acyl methyl group
- B.
The ester
- C.
The quaternary nitrogen
- D.
All three N-methyl groups
- 29.One of the following belongs to imidazolidine-2,4-dione class:
- A.
Phenytoin
- B.
Trimethadione
- C.
Phensuximide
- D.
Paramethadione
- 30.Indication of clonazepam is:
- A.
Myoclonic epilepsy
- B.
Partial motor seizers
- C.
Status epilepticus
- D.
Partial complex seizures
- 31.Of the following oral liquid formulations which would be considered as an oropharyngeal formulation?
- A.
Syrup
- B.
Elixir
- C.
Mouthwash
- D.
Linctus
- 32.Which of the following formulations would not be applicable to ocular administration?
- A.
Solution
- B.
Liniment
- C.
Suspension
- D.
Ointment
- 33.A tablet to treat a headache must first be dissolved in water before swallowing. Which one of the following best describes this type of tablet?
- A.
Modified release
- B.
Oral disintegrating
- C.
Effervescent
- D.
Buccal
- 34.Name two different types of inhaler?
- A.
MDI & API
- B.
IV & SC
- C.
DPI & MDI
- D.
GIT & ATP
- 35.If 25 g of a liquid occupies 20 cm3 in a measuring cylinder, what is the density of the liquid?
- A.
0.25 g cm-3
- B.
0.8 g cm-3
- C.
1.25 g cm-3
- D.
5 g cm-3
- 36.Which property measures the resistance of a liquid to flow?
- A.
Density
- B.
Viscosity
- C.
Volume
- D.
Solubility
- 37.What is the correct definition of a pseudoplastic liquid?
- A.
A liquid which becomes less viscous as the rate of shear increases
- B.
A liquid which becomes more viscous as the rate of shear increases
- C.
A liquid which becomes less viscous over time when a constant shear stress is applied
- D.
A liquid which becomes more viscous over time when a constant shear stress is applied
- 38.What is the kinematic viscosity of a liquid that has a density of 1.2 g cm-3 and a dynamic viscosity of 2 cP?
- A.
0.6 m2 s-1
- B.
1.67 m2 s-1
- C.
0.6 x10-6 m2 s-1
- D.
1.67 x10-6 m2 s-1
- 39.What is the concentration of a 0.5 % (w/v) solution when expressed as mg mL-1?
- A.
0.005 mg mL-1
- B.
0.05 mg mL-1
- C.
0.5 mg mL-1
- D.
5 mg mL-1
- 40.In a solution the substance that is being dissolved is called the___
- A.
Solvent
- B.
Emulsifier
- C.
Solute
- D.
Filtrate
- 41.Which of the following wavelength ranges is associated with UV spectroscopy?
- A.
0.8 - 500µm
- B.
400 - 100nm
- C.
380 - 750nm
- D.
0.01 - 10nm
- 42.Which of the following compounds does not absorb light in the UV/visible spectrum?
- A.
Aspirin
- B.
Paracetamol
- C.
Chloral hydrate
- D.
Phenobarbitone
- 43.
- A.
50mg
- B.
60mg
- C.
100mg
- D.
120mg
- 44.A series of 3 coloured glass plates of equal thickness are placed in a light beam. Each sheet absorbs one quarter of the light incident upon it. What is the intensity of the light transmitted by the third glass plate?
- A.
1.56%
- B.
42.19%
- C.
56.25%
- D.
75.00%
- 45.In infrared spectroscopy which frequency range is known as the fingerprint region?
- A.
400 - 1400cm-1
- B.
1400 - 900cm-1
- C.
900 - 600cm-1
- D.
600 - 250cm-1
- 46.In which region of the infrared spectrum would you expect to find a peak characteristic of a triple bond stretch?
- A.
4000 - 3000cm-1
- B.
2500 - 2000cm-1
- C.
2000 - 1500cm-1
- D.
1500 - 750cm-1
- 47.In a chromatographic separation, which of the following indices is most appropriate for the qualitative identification of a substance?
- A.
Relative retention factor Rrel
- B.
Retention factor Rf
- C.
Retention time
- D.
Resolution
- 48.Which of the following techniques would be most useful to identify and quantify the presence of a known impurity in a drug substance?
- A.
NMR
- B.
MS
- C.
IR
- D.
HPLC
- 49.Which of the following assays could not be performed by gas chromatography?
- A.
Characterisation of volatile oils
- B.
Measurement of drugs and metabolites in biological fluids
- C.
Characterisation of raw materials for drug synthesis
- D.
Analysis of intravenous sodium chloride infusion
- 50.Following are tablet coating defects except:
- A.
Friability
- B.
Orange Peel Effect
- C.
Blistering
- D.
Picking and sticking
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