Mpharm-cet Test No.1
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MPHARM-CET TEST NO. 1Designed by Dr. Anwar R. ShaikhCourtesy:1) Dr. Aman B. Upaganlawar (M. Pharm,PhD,MAMS)Associate Professor, Department of Pharmacology. SNJBs SSDJ College of Pharmacy,Neminagar,Chandwad. Dist:Nashik:423 1012) Mr. C V PanchalAsst. ProfessorDept. Of Pharmacognosy,Maharashtra College of Pharmacy,Nilanga, Dist. Latur, PIN-413521
- 1.All of the following hormones have cell surface receptors except
- A.
Adrenaline
- B.
Growth Hormone
- C.
Insulin
- D.
Thyroxin
- 2.A highly ionized drug
- A.
Is excreted mainly by the kidney
- B.
Can cross the placental barrier easily
- C.
Is well absorbed from the intestine
- D.
Accumulates in the cellular lipids
- 3.Which one of the following is true of adrenal suppression due to steroid therapy?
- A.
It is not associated with atrophy of adrenal glands
- B.
It does not occur in patients receiving inhaled steroids
- C.
It should be expected in anyone receiving greater than 5mg of prednisolone daily
- D.
Following cessation, the stress response normalizes after 8 weeks
- 4.With which of the following theophylline has an antagonistic interaction?
- A.
Histamine receptors
- B.
Bradykinin receptors
- C.
Adenosine receptors
- D.
Imidazoline receptors
- 5.Which one of the following drugs increases gastrointestinal motility?
- A.
Glycopyrrolate
- B.
Atropine
- C.
Neostigmine
- D.
Fentanyl
- 6.Which one of the following drugs has been shown to offer protection from gastric aspiration syndrome in a patient with symptoms of flux?
- A.
Ondansetron
- B.
Metaclopramide
- C.
Sodium citrate
- D.
Atropine
- 7.Which one of the following drugs has been shown to offer protection from gastric aspiration syndrome in a patient with symptoms of flux?
- A.
Ondansetron
- B.
Metaclopramide
- C.
Sodium citrate
- D.
Atropine
- 8.Inverse agonist of benzodiazepine receptor is
- A.
Phenobarbitone
- B.
Flumazenil
- C.
Beta-carboline
- D.
Gabapentin
- 9.
- At the end of phase III clinical trial the drug will be submitted to the relevant regulatory authority for:
- A.
Licensing
- B.
Evaluation
- C.
Post Marketing studies
- D.
All of above
- 10.Rectal administration of drugs:
- A.
Gives predictable blood levels
- B.
From lower 1/3rd avoids first pass & upper 2/3rds doesn’t
- C.
None undergoes first pass metabolism
- D.
All of it undergoes first pass metabolism
- 11.Different species of Ephedra can be identified by observing the nature of
- A.
Inner surface
- B.
Outer surface
- C.
Trichomes
- D.
Scaly Leaves
- 12.Indian Rhubarb can be distinguished from Rhapontic Rhubarb by the flurorescence it emits under UV light, Indian Rhubarb gives:
- A.
Deep yellow
- B.
Deep Violate
- C.
Orange
- D.
Pale Green
- 13.Genetically modified species of papaver namely papaver bracetum and papver oriental contain the predominant alkaloid:
- A.
Morphine
- B.
Codeine
- C.
Thebaine
- D.
Narcotine
- 14.A substance used for the modification of silica gel for reversed phase TLC is:
- A.
Benzene
- B.
Glycerine
- C.
Silicone Oil
- D.
Ether
- 15.Klunge's Test is for the identification of:
- A.
Barbaloin
- B.
Isobarbaloin
- C.
Alionosides
- D.
Aleosin
- 16.Microscopic character of Ginger Rhizome are:
- A.
Spindle shaped lignified fibers and sclerides
- B.
Cluster crystals of calcium oxalate and sclerides
- C.
Non lignified vessels and sac shaped starch grains
- D.
Non lignified vessels and sclerides
- 17.A transeverse section of the root of Glycerrhiza glabra when treated with 80% Sulphuric acid gives:
- A.
Deep yellow colour
- B.
No reaction but only charring
- C.
Deep blue colour
- D.
Deep red colour
- 18.A naturally occuring amino acid which does not have a chiral centre is :
- A.
Glycine
- B.
Alanine
- C.
Tryptophane
- D.
Tyrosine
- 19.Match Group I with II:Group I Group II1. Gentisin a. Flavonol2. Genistein b. Flavone3. Apigenin c. Xanthone4. Quercetin d. Isoflavone
- A.
1-d, 2-c, 3-a, 4-b
- B.
1-a, 2-b, 3-d, 4-c
- C.
1-c, 2-d, 3-b, 4-a
- D.
1-b, 2-a, 3-c, 4-d
- 20.Microscopy of the bulbs of Urgenia indica family Liliaceae shows:
- A.
Prism of calcium oxalate
- B.
Calcium carbonate and silica
- C.
Rosetters of calcium oxalate
- D.
Rhaphides of calcium oxalate
- 21.What term is used to indicate the ability of a cancer to invade other parts of the body and to produce secondary tumours?
- A.
Carcinogenesis
- B.
Apoptosis
- C.
Metastasis
- D.
Mutagenesis
- 22.Which molecules are involved in the anchoring of cells to an extracellular matrix?
- A.
Integrins
- B.
Interleukins
- C.
Angiostatin
- D.
Cyclins
- 23.Which of the following statements is false with respect to an enzyme's ability to catalyse a reaction?
- A.
An enzyme provides a reaction surface and a suitable environment for the reaction to take place
- B.
An enzyme binds reactants such that they are positioned correctly and can attain their transition-state configurations
- C.
An enzyme allows the reaction to go through a less stable transition state than would normally be the case
- D.
An enzyme can weaken bonds in reactants through the binding process
- 24.Which of the following statements is not true regarding the active site of an enzyme?
- A.
An active site is normally a hollow or cleft on the surface of an enzyme.
- B.
An active site is normally hydrophilic in nature.
- C.
Substrates fit into active sites and bind to functional groups within the active site.
- D.
An active site contains amino acids which are important to the binding process and the catalytic mechanism.
- 25.Which of the following statements best describes an allosteric binding site?
- A.
It is a binding site containing amino acids with aliphatic side chains.
- B.
It is a binding site that can accept a wide variety of differently shaped molecules.
- C.
It is a binding site, which is separate from the active site, and affects the activity of an enzyme when it is occupied by a ligand.
- D.
It is a description of an active site which has undergone an induced fit.
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