Blood Pathophysiology
- 1.
The Spherocytosis happen due to deficiency of :
- A.
Protein Erythropoietin
- B.
Protein Haemoglobin
- C.
Protein spectrin
- D.
Vitamin B12
- E.
Iron
Correct Answer
C. Protein spectrin -
- 2.
I can see all of the above in microcytic anemia except :
- A.
Hb level in the blood is reduced
- B.
The number of RBC is normal
- C.
Plasma iron level is reduced
- D.
Mean corpuscular volume = 100Fl
- E.
No answer is correct
Correct Answer
D. Mean corpuscular volume = 100Fl -
- 3.
I can see all of the above in Megaloblastic anemia except :
- A.
Hb level in the blood is reduced
- B.
The number of RBC is normal
- C.
Plasma iron level is elveted
- D.
Mean corpuscular volume = 120Fl or more
- E.
No answer is correct
Correct Answer
B. The number of RBC is normal -
- 4.
The characteristic features of the Anemia of chronic diseases :
- A.
A- It occurs in the setting of chronic inflammation or neoplasm
- B.
B-It is related to bleeding or hemolysis
- C.
C-It is differ of Aplastic Anemia
- D.
D-It is not a common type of anemia
- E.
E- (A+B)
Correct Answer
A. A- It occurs in the setting of chronic inflammation or neoplasm -
- 5.
All of the above is correct regarding the Thalassemias ,except:
- A.
It is inherited impairment of Hb polypeptide chains production
- B.
It is either a partial or complete failure of synthesis of a specific type of polypeptide chain.
- C.
The genes responsible for synthesis of alpha chain are on chromosomes 11
- D.
The genes responsible for synthesis of beta chain are on chromosomes 11
- E.
No answer is correct
Correct Answer
C. The genes responsible for synthesis of alpha chain are on chromosomes 11 -
- 6.
All of the above isn't true regarding the polycythaemia, except:
- A.
Polycythaemia lead to Hypoxia
- B.
All types of cells increase; RBC, WBC and platelets, in Polycythaemia Vera
- C.
Relative polycythaemia divided to Primary and Secondary
- D.
Polycythaemia: An decrease in RBC’s number
- E.
More than one answer
Correct Answer
B. All types of cells increase; RBC, WBC and platelets, in Polycythaemia Vera -
- 7.
The patients with polycythaemia and elevated the viscosity of the blood , we can find in this patients :
- A.
The movement of blood decrease
- B.
Hypotension
- C.
The venous return to the heart decreases
- D.
Blue color of the skin
- E.
All answer is correct
Correct Answer
E. All answer is correct -
- 8.
All of the above is true regarding the Hemostasis , except:
- A.
Is a mechanism by which the fluid state of blood is arrested (stopped)
- B.
keeping the bleeding for damaged blood vessels
- C.
Local vasodilatation of injured B.V occurs immediately
- D.
When Thromboxane A2 released it Disables Hemostasis
- E.
All answer is correct
Correct Answer
E. All answer is correct -
- 9.
All of the above is true regarding the Characteristics of PLATELETS , except:
- A.
Are small granulated discs
- B.
Produced by megakaryocytes
- C.
Platelets lifespan is ~10 days
- D.
Destruction and stored of platelets occurs in the spleen
- E.
No answer is correct
Correct Answer
E. No answer is correct -
- 10.
Platelets production by megakaryocytes are regulated by:
- A.
Thrombin
- B.
Prothrombin
- C.
Colony stimulating factors
- D.
Thromboxane A2
- E.
All answer is correct
Correct Answer
C. Colony stimulating factors -
- 11.
The cytoplasm of platelets contains , except :
- A.
Dense granules
- B.
Phospholipids
- C.
α Granules
- D.
Actin and myosin proteins
- E.
Lysosomes
Correct Answer
B. Phospholipids -
- 12.
Which of the above convert prothrombin into thrombin:
- A.
Calcium citrate
- B.
Factor X
- C.
Factor IV
- D.
Vitamin K
- E.
Lysosomes
Correct Answer
C. Factor IV -
- 13.
Both pathways (Intrinsic and Extrinsic ), through series and complex activation of certain proteins (clotting factor) DO :
- A.
FORM Xa FROM X
- B.
FORM Thrombin FROM Factor 2
- C.
FORM Factor 2 FROM Thrombin
- D.
FORM Tissue thromboplastin FROM Factor 2
- E.
2 answer is correct
Correct Answer
E. 2 answer is correct -
- 14.
Intrinsic pathway start by :........................... and Extrinsic pathway start by :...........................
- A.
Activation of clotting factor XII /// Activation of clotting factor VI
- B.
Activation of clotting factor XII /// Activation of clotting factor VI
- C.
Activation of clotting factor X /// Activation of clotting factor V
- D.
Activation of clotting factor XII /// Activation of clotting factor VII
- E.
Activation of clotting factor VII /// Activation of clotting factor XII
Correct Answer
D. Activation of clotting factor XII /// Activation of clotting factor VII -
- 15.
Fibrin - stabilizing factor convert :
- A.
Fibrinogen TO Prothrombin
- B.
Prothrombin TO Fibrinogen
- C.
Fibrin TO fiber
- D.
Fibrinogen TO Fibrin
- E.
Fibrin TO Fibrinogen
Correct Answer
C. Fibrin TO fiber -
- 16.
All of the above isn't true regarding the Clotting factors, except:
- A.
Most of them isn't proteolytic proteins
- B.
Most of them are synthesized by the spleen
- C.
Activation of most clotting factors needs Ca
- D.
They are found in active forms in plasma
- E.
The synthesis of Christmas factor NEED vitamin K
Correct Answer
E. The synthesis of Christmas factor NEED vitamin K -
- 17.
Activation of this clotting factor need vitamin K Except :
- A.
X
- B.
II
- C.
IX
- D.
VII
- E.
All answer above is correct
- F.
NO answer is correct
Correct Answer
F. NO answer is correct -
- 18.
Von Willebrand's disease:
- A.
It is an autosomal genetic bleeding disorder
- B.
It is due to low level of Von willebrand factor (VWF)
- C.
Leads to bleeding after trauma
- D.
Causes epistaxis, bruising, menorrhagia and gastro intestinal bleeding
- E.
All answer is correct
Correct Answer
E. All answer is correct -
- 19.
The Vessel wall abnormalities MAKE :
- A.
Senile purpura
- B.
Embolic purpura
- C.
Henoch - schonlein purpura
- D.
Non-Thromboastheniaic purpura
- E.
Non-Thrombocytopenic purpura
Correct Answer
E. Non-Thrombocytopenic purpura -
- 20.
Thromboasthenia is ......................... Thrombocytopenia is ........................... Hemophilia is ......................... Warfarin therapy is .......................
- A.
Bleeding disorders due to Congenital causes///Bleeding disorders due to Acquired causes// Abnormal functioning platelets ///A decreased in platelets no
- B.
Abnormal functioning platelets ///A decreased in platelets no//Bleeding disorders due to Congenital causes///Bleeding disorders due to Acquired causes
- C.
Bleeding disorders due to Congenital causes///Bleeding disorders due to Acquired causes//A decreased in platelets no// Abnormal functioning platelets
- D.
Bleeding disorders due to Acquired causes///Bleeding disorders due to Congenital causes//A decreased in platelets no// Abnormal functioning platelets
- E.
A decreased in platelets no ///Abnormal functioning platelets//Bleeding disorders due to Congenital causes///Bleeding disorders due to Acquired causes
Correct Answer
B. Abnormal functioning platelets ///A decreased in platelets no//Bleeding disorders due to Congenital causes///Bleeding disorders due to Acquired causes -
- 21.
All of the above is true regarding the Thromboasthenia, except:
- A.
Aspirin isn't lead to it .
- B.
It is Abnormalities in platelets function
- C.
Arise from defects in: Platelets membrane
- D.
Non-steroidal anti-inflammatory drugs lead to it
- E.
2 answer is correct
Correct Answer
A. Aspirin isn't lead to it . -
- 22.
All of the above is true regarding the Causes of thrombocytopenia, except:
- A.
Increased platelets consumption
- B.
Rapid or premature removal of platelets
- C.
Problem in Thrombopoietin or Colony stimulating factors
- D.
Problem in megakaryocytes
- E.
No answer is correct
Correct Answer
E. No answer is correct -
- 23.
All of the above is true regarding the Factor Antihemophilic A , except:
- A.
The deficiency of it lead to Hemophilia A
- B.
Is mainly produced by liver
- C.
It's half - life is ~ 10 days
- D.
Its gene is on X chromosome
- E.
It is carried in the plasma attaching to another factor called (vWF)
Correct Answer
C. It's half - life is ~ 10 days -
- 24.
If the Father is with Hemophilia and the mother carrier for Hemophilia genes what you predict about the son and daughter :
- A.
One son carrier and other Not BUT the all daughters carrier
- B.
One son with Hemophilia and other Not BUT the all daughters with Hemophilia
- C.
One son and One daughter with Hemophilia and other son and daughter carrier
- D.
One son with Hemophilia and other Not BUT One daughter carrier and other with Hemophilia
- E.
One son and One daughter with Hemophilia and other son and daughter NOT
Correct Answer
D. One son with Hemophilia and other Not BUT One daughter carrier and other with Hemophilia -
- 25.
If the Father is without Hemophilia and the mother carrier for Hemophilia genes what you predict about the son and daughter :
- A.
50% of daughter are carriers and 50% of son without Hemophilia
- B.
50% of daughter are carriers and 50% of son Hemophilic
- C.
50% of daughter are't carriers or Hemophilic and 50% of son Hemophilic
- D.
50% of all the Children are't carriers or Hemophilic
- E.
All answer is correct
Correct Answer
E. All answer is correct -
- 26.
ALL of the above is Clinical features of hemophilia except :
- A.
Hemophiliac babies show signs of bleeding when they born .
- B.
Sever hemophilia (depends on level of factor VII deficiency)
- C.
Sometimes the bleeding begins spontaneously with apparent trauma
- D.
Bleeding into confined spaces like intracranial area aren't dangerous
- E.
The Treatment:Infusion of factor VII concentrate
- F.
All answer is correct
Correct Answer
F. All answer is correct -
- 27.
Disseminated intravascular coagulation :
- A.
It is due to activation of clotting process inside circulation (due to recurrent trauma)
- B.
It means widespread intravascular clotting
- C.
May occur due to Damaged tissue
- D.
May occur due to Activation of endothelial cells by bacterial infection to produce tissue factor
- E.
All answer is correct
Correct Answer
E. All answer is correct -
- 28.
About Liver disease in the Acquired bleeding disorders and warfarin , chose the correct answer :
- A.
Liver is the site where some of clotting factors are synthesized
- B.
Synthesis of clotting factors II, VII, IX and XII by the liver needs vitamin K, so when vitamin K is deficient the concentration of these clotting factor decreases leading to bleeding
- C.
warfarin compete with vitamin K for the reactive sites in the liver and is used as coagulant drug
- D.
Warfarin: It's action immediate
- E.
Excess warfarin( anticoagulant ) causes bleeding tendency, because it increase the level of clotting factors, that need vitamin K, in the blood
- F.
No answer is correct
Correct Answer
F. No answer is correct -
- 29.
All of the above isn’t correct regarding the Hemoglobin except :
- A.
Presence of iron in the ferrous state Fe2+ isn’t good for carrying oxygen
- B.
Presence of iron in the Fe3+ is good for carrying oxygen
- C.
Met-hemoglobin can't carry oxygen
- D.
There are 4 pairs of polypeptides in each Hb molecule E
- E.
All answer is correct
Correct Answer
C. Met-hemoglobin can't carry oxygen -
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Mar 21, 2022Quiz Edited by
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May 01, 2018Quiz Created by
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