Blood Pathophysiology

1. The patients with polycythaemia and elevated the viscosity of the blood , we can find in this patients :

The movement of blood decrease

Hypotension

The venous return to the heart decreases

Blue color of the skin

All answer is correct

2. The Spherocytosis happen due to deficiency of :

Protein Erythropoietin

Protein Haemoglobin

Protein spectrin

Vitamin B12

Iron

3. The cytoplasm of platelets contains , except :

Dense granules

Phospholipids

α Granules

Actin and myosin proteins

Lysosomes

4. All of the above is correct regarding the Thalassemias ,except:

It is inherited impairment of Hb polypeptide chains production

It is either a partial or complete failure of synthesis of a specific type of polypeptide chain.

The genes responsible for synthesis of alpha chain are on chromosomes 11

The genes responsible for synthesis of beta chain are on chromosomes 11

No answer is correct

5. Thromboasthenia is ......................... Thrombocytopenia is ........................... Hemophilia is ......................... Warfarin therapy is .......................

Bleeding disorders due to Congenital causes///Bleeding disorders due to Acquired causes// Abnormal functioning platelets ///A decreased in platelets no

Abnormal functioning platelets ///A decreased in platelets no//Bleeding disorders due to Congenital causes///Bleeding disorders due to Acquired causes

Bleeding disorders due to Congenital causes///Bleeding disorders due to Acquired causes//A decreased in platelets no// Abnormal functioning platelets

Bleeding disorders due to Acquired causes///Bleeding disorders due to Congenital causes//A decreased in platelets no// Abnormal functioning platelets

A decreased in platelets no ///Abnormal functioning platelets//Bleeding disorders due to Congenital causes///Bleeding disorders due to Acquired causes

6. Disseminated intravascular coagulation :

It is due to activation of clotting process inside circulation (due to recurrent trauma)

It means widespread intravascular clotting

May occur due to Damaged tissue

May occur due to Activation of endothelial cells by bacterial infection to produce tissue factor

All answer is correct

7. Von Willebrand's disease:

It is an autosomal genetic bleeding disorder

It is due to low level of Von willebrand factor (VWF)

Leads to bleeding after trauma

Causes epistaxis, bruising, menorrhagia and gastro intestinal bleeding

All answer is correct

8. Intrinsic pathway start by :........................... and Extrinsic pathway start by :...........................

Activation of clotting factor XII /// Activation of clotting factor VI

Activation of clotting factor X /// Activation of clotting factor V

Activation of clotting factor XII /// Activation of clotting factor VII

Activation of clotting factor VII /// Activation of clotting factor XII

9. I can see all of the above in microcytic anemia except :

Hb level in the blood is reduced

The number of RBC is normal

Plasma iron level is reduced

Mean corpuscular volume = 100Fl

No answer is correct

10. I can see all of the above in Megaloblastic anemia except :

Hb level in the blood is reduced

The number of RBC is normal

Plasma iron level is elveted

Mean corpuscular volume = 120Fl or more

No answer is correct

11. Fibrin - stabilizing factor convert :

Fibrinogen TO Prothrombin

Prothrombin TO Fibrinogen

Fibrin TO fiber

Fibrinogen TO Fibrin

Fibrin TO Fibrinogen

12. Platelets production by megakaryocytes are regulated by:

Thrombin

Prothrombin

Colony stimulating factors

Thromboxane A2

All answer is correct

13. All of the above is true regarding the Factor Antihemophilic A , except:

The deficiency of it lead to Hemophilia A

Is mainly produced by liver

It's half - life is ~ 10 days

Its gene is on X chromosome

It is carried in the plasma attaching to another factor called (vWF)

14. All of the above isn't correct regarding the Hemoglobin except :

Presence of iron in the ferrous state Fe2+ isn’t good for carrying oxygen

Presence of iron in the Fe3+ is good for carrying oxygen

Met-hemoglobin can't carry oxygen

There are 4 pairs of polypeptides in each Hb molecule E

All answer is correct

15. The Vessel wall abnormalities MAKE :

Senile purpura

Embolic purpura

Henoch - schonlein purpura

Non-Thromboastheniaic purpura

Non-Thrombocytopenic purpura

16. The characteristic features of the Anemia of chronic diseases :

A- It occurs in the setting of chronic inflammation or neoplasm

B-It is related to bleeding or hemolysis

C-It is differ of Aplastic Anemia

D-It is not a common type of anemia

E- (A+B)

17. All of the above is true regarding the Characteristics of PLATELETS , except:

Are small granulated discs

Produced by megakaryocytes

Platelets lifespan is ~10 days

Destruction and stored of platelets occurs in the spleen

No answer is correct

18. If the Father is with Hemophilia and the mother carrier for Hemophilia genes what you predict about the son and daughter :

One son carrier and other Not BUT the all daughters carrier

One son with Hemophilia and other Not BUT the all daughters with Hemophilia

One son and One daughter with Hemophilia and other son and daughter carrier

One son with Hemophilia and other Not BUT One daughter carrier and other with Hemophilia

One son and One daughter with Hemophilia and other son and daughter NOT

19. All of the above is true regarding the Causes of thrombocytopenia, except:

Increased platelets consumption

Rapid or premature removal of platelets

Problem in Thrombopoietin or Colony stimulating factors

Problem in megakaryocytes

No answer is correct

20. All of the above is true regarding the Thromboasthenia, except:

Aspirin isn't lead to it .

It is Abnormalities in platelets function

Arise from defects in: Platelets membrane

Non-steroidal anti-inflammatory drugs lead to it

2 answer is correct

21. Both pathways (Intrinsic and Extrinsic ), through series and complex activation of certain proteins (clotting factor) DO :

FORM Xa FROM X

FORM Thrombin FROM Factor 2

FORM Factor 2 FROM Thrombin

FORM Tissue thromboplastin FROM Factor 2

2 answer is correct

22. All of the above is true regarding the Hemostasis , except:

Is a mechanism by which the fluid state of blood is arrested (stopped)

Keeping the bleeding for damaged blood vessels

Local vasodilatation of injured B.V occurs immediately

When Thromboxane A2 released it Disables Hemostasis

All answer is correct

23. All of the above isn't true regarding the polycythaemia, except:

Polycythaemia lead to Hypoxia

All types of cells increase; RBC, WBC and platelets, in Polycythaemia Vera

Relative polycythaemia divided to Primary and Secondary

Polycythaemia: An decrease in RBC’s number

24. ALL of the above is Clinical features of hemophilia except :

Hemophiliac babies show signs of bleeding when they born .

Sever hemophilia (depends on level of factor VII deficiency)

Sometimes the bleeding begins spontaneously with apparent trauma

Bleeding into confined spaces like intracranial area aren't dangerous

The Treatment:Infusion of factor VII concentrate

All answer is correct

25. All of the above isn't true regarding the Clotting factors, except:

Most of them isn't proteolytic proteins

Most of them are synthesized by the spleen

Activation of most clotting factors needs Ca

They are found in active forms in plasma

The synthesis of Christmas factor NEED vitamin K

26. Match the following

Polycythaemia

Relative Polycythaemia

True polycythaemia

Secondary polycythaemia

Polycythaemia Vera

Submit

27. If the Father is without Hemophilia and the mother carrier for Hemophilia genes what you predict about the son and daughter :

50% of daughter are carriers and 50% of son without Hemophilia

50% of daughter are carriers and 50% of son Hemophilic

50% of daughter are't carriers or Hemophilic and 50% of son Hemophilic

50% of all the Children are't carriers or Hemophilic

All answer is correct

28. Activation of this clotting factor need vitamin K Except :

X

II

IX

VII

All answer above is correct

NO answer is correct

29. Which of the above convert prothrombin into thrombin:

Calcium citrate

Factor X

Factor IV

Vitamin K

Lysosomes

30. About Liver disease in the Acquired bleeding disorders and warfarin , chose the correct answer :

Liver is the site where some of clotting factors are synthesized

Warfarin compete with vitamin K for the reactive sites in the liver and is used as coagulant drug

Warfarin: It's action immediate

No answer is correct

Blood Pathophysiology

1. The patients with polycythaemia and elevated the viscosity of the blood , we can find in this patients :

2.

What first name or nickname would you like us to use?

2. The Spherocytosis happen due to deficiency of :

3. The cytoplasm of platelets contains , except :

4. All of the above is correct regarding the Thalassemias ,except:

5. Thromboasthenia is ......................... Thrombocytopenia is ........................... Hemophilia is ......................... Warfarin therapy is .......................

6. Disseminated intravascular coagulation :

7. Von Willebrand's disease:

8. Intrinsic pathway start by :........................... and Extrinsic pathway start by :...........................

9. I can see all of the above in microcytic anemia except :

10. I can see all of the above in Megaloblastic anemia except :

11. Fibrin - stabilizing factor convert :

12. Platelets production by megakaryocytes are regulated by:

13. All of the above is true regarding the Factor Antihemophilic A , except:

14. All of the above isn't correct regarding the Hemoglobin except :

15. The Vessel wall abnormalities MAKE :

16. The characteristic features of the Anemia of chronic diseases :

17. All of the above is true regarding the Characteristics of PLATELETS , except:

18. If the Father is with Hemophilia and the mother carrier for Hemophilia genes what you predict about the son and daughter :

19. All of the above is true regarding the Causes of thrombocytopenia, except:

20. All of the above is true regarding the Thromboasthenia, except:

21. Both pathways (Intrinsic and Extrinsic ), through series and complex activation of certain proteins (clotting factor) DO :

22. All of the above is true regarding the Hemostasis , except:

23. All of the above isn't true regarding the polycythaemia, except:

24. ALL of the above is Clinical features of hemophilia except :

25. All of the above isn't true regarding the Clotting factors, except:

26. Match the following

27. If the Father is without Hemophilia and the mother carrier for Hemophilia genes what you predict about the son and daughter :

28. Activation of this clotting factor need vitamin K Except :

29. Which of the above convert prothrombin into thrombin:

30. About Liver disease in the Acquired bleeding disorders and warfarin , chose the correct answer :