Mdcm - Cephalosporins & Others

48 Questions | Total Attempts: 51

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Mdcm - Cephalosporins & Others

Questions and Answers
  • 1. 
    Which is true regarding cephalosporins (in comparison to PCNs).  Select all that apply.
    • A. 

      Less strained ring system

    • B. 

      Less allergenic

    • C. 

      Less potent

    • D. 

      Less expensive

  • 2. 
     This cephalosporin was synthesized from...
    • A. 

      A cephalosporin

    • B. 

      A natural penicillin

  • 3. 
    Cephalosporins are excreted primarily by the...
    • A. 

      Liver

    • B. 

      Kidney

  • 4. 
    Which generation is the least stable to beta lactamases?
    • A. 

      1st

    • B. 

      2nd

    • C. 

      3rd

    • D. 

      4th

  • 5. 
    Cefazolin This is the drug of choice for surgical prophylaxis.  Which of the following is also true?
    • A. 

      It can be used for MRSA

    • B. 

      It is the least stable of all the cephalosporins to beta lactamases

    • C. 

      It is dose once daily

  • 6. 
    Which feature conveys oral activity?
    • A. 

      C3 substituent

    • B. 

      C7 side chain

    • C. 

      Beta lactam

    • D. 

      COOH

    • E. 

      Dihydrothiazine ring

  • 7. 
    CefamandoleWhich of the following is true regarding this drug?
    • A. 

      It is the drug of choice for infant meningitis

    • B. 

      It is useful against MRSA and VRSA

    • C. 

      It can cause prolonged bleeding

    • D. 

      It can cause carnitine deficiency

    • E. 

      It is the most active drug against p. aeruginosa

  • 8. 
    CefotaximeWhich of the following is true regarding this drug?  Select all that apply.
    • A. 

      It is the drug of choice for infant meningitis

    • B. 

      It is useful against MRSA and VRSA

    • C. 

      It can cause prolonged bleeding

    • D. 

      It has a metabolically vulnerable acetoxy group at C-3

    • E. 

      It is the most active cephalosporin against p. aeruginosa

    • F. 

      The polar aminothiazole ring increases Gram - activity

  • 9. 
    CeftazadmineWhich of the following is true regarding this drug?  Select all that apply.
    • A. 

      It can complex with iron and cause reddish stools

    • B. 

      It can cause prolonged bleeding

    • C. 

      It is the most active cephalosporin against p. aeruginosa

    • D. 

      It is used in combination with an aminoglycoside in PCN allergic patients

    • E. 

      It is available PO

    • F. 

      It is highly water soluble (zwitter ionic)

  • 10. 
    Cefotaxime is used in combination with ___________ for the empiric therapy of neonatal and inflant meningitis.
  • 11. 
    CefotetanWhich of the following is true regarding this drug?  Select all that apply.
    • A. 

      It has special binding affinity towards PBPs (specifically PBP3 of gram - bacteria)

    • B. 

      It is the only 4th generation cephalosporin currently on the market

    • C. 

      It is chemically incompatible with tetracyclines, aminoglycosides, and heparin

    • D. 

      It can cause carnitine deficiency

    • E. 

      It can cause prothrombin deficiency and alcohol intolerance

  • 12. 
    CefaclorWhich of the following is true regarding this drug?
    • A. 

      Prodrug, enhanced absorption when given with food, can be dispersed in apple juice

    • B. 

      PO, good for otitis media in kids (but serum-sickness SEs can be a problem)

    • C. 

      PO, fatty foods decrease absorption, can complex with iron to cause reddish stools

  • 13. 
    A woman asks you if her child can eat a normal dinner while he is taking "cef-dinir."  You tell her...
    • A. 

      Fatty foods and antacids diminish blood levels of this drug

    • B. 

      Fatty foods enhance the absorption of this drug

    • C. 

      Food can be taken without regard to this drug

  • 14. 
    Which drug has the longest half life of all of the cephalosporins due to protein binding and slow urinary excretion?
    • A. 

      Cefdinir

    • B. 

      Cefixime

    • C. 

      Cefditoren

    • D. 

      Ceftibuten

    • E. 

      Cefpodoxime proxetil

    • F. 

      Ceftriaxone

  • 15. 
    Cefpodoxime Proxetil This drug has better activity against s. aureus than cefixime.  What else is true regarding this drug?
    • A. 

      It is not indicated for children under 12

    • B. 

      Absorption is enhanced by food but reduced by antacids

    • C. 

      A main side effect is diarrhea due to enhanced biliary excretion

    • D. 

      It is used in combination with aminoglycosides

  • 16. 
    Ceftibuten Oral bioavailability with this drug is decreased by food. What else is true regarding this drug?
    • A. 

      The beta lactam carbonyl is not very potent

    • B. 

      The beta lactam carbonyl is potent

  • 17. 
    CeftriaxoneWhich of the following is true regarding this drug?  Select all that apply.
    • A. 

      Longest half life of all of the cephalosporins

    • B. 

      Disulfiram life effects may occur

    • C. 

      Bleeding may occur

    • D. 

      Diarrhea is common due to greater biliary excretion

  • 18. 
    Which drug should you avoid if you have a carnitine deficiency and/or a milk protein hypersensitivity?
    • A. 

      Ceftobiprole

    • B. 

      Cefuroxime

    • C. 

      Cefixime

    • D. 

      Cefditoren

    • E. 

      Loracarbef

  • 19. 
    LoracarbefThis drug is a carbacepham due to the replacement of the sulfur with a carbon.  What does this mean for ring strain?
    • A. 

      Decreases ring strain, making the drug less potent

    • B. 

      Increases ring strain, making the drug more potent

  • 20. 
    Which drug(s) are active against MRSA?
    • A. 

      Cefditoren

    • B. 

      Cefixime

    • C. 

      Ceftobiprole

    • D. 

      Ceftibuten

    • E. 

      Ceftaroline

  • 21. 
    Which is true regarding imipenem?  Select all that apply.
    • A. 

      Synergistic with aminoglycosides for the treatment of p. aeruginosa

    • B. 

      Often used alone to treat p. aeruginosa

    • C. 

      Orally active

    • D. 

      Renal dehydropeptidase I causes hydrolysis and deactivation of the drug

    • E. 

      Good for community acquired infections and prophlaxis in surgery

    • F. 

      No cross allergy with PCNs

    • G. 

      Can cause seizures (esp in the eldery, with high doses, and in renal impairment)

    • H. 

      Less likely to cause seizure than other carbapenems

    • I. 

      Broader antibacterial spectrum than the third generation cephalosporins

    • J. 

      Active against MRSA

  • 22. 
    This drug is inhibited by renal dehydropeptidase I?
    • A. 

      True

    • B. 

      False

  • 23. 
    Which drug is resistant to most beta lactamases including some metallo-beta-lactamases.
    • A. 

      Imipenem

    • B. 

      Meropenem

    • C. 

      Ertapenem

    • D. 

      Doripenem

    • E. 

      Faropenem

  • 24. 
    Monobactam reactivity is due to the electron withdrawing group on the nitrogen.
    • A. 

      True

    • B. 

      False

  • 25. 
    This drug is active only against gram negative organisms and is synergistic with aminoglycosides.
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