Mdcm - Cephalosporins & Others

48 Questions | By Caitlinb | Updated: Mar 18, 2022 | Attempts: 123

Questions

Settings

Create your own Quiz

Questions and Answers

1.

Which is true regarding cephalosporins (in comparison to PCNs). Select all that apply.
- A.
  
  Less strained ring system
- B.
  
  Less allergenic
- C.
  
  Less potent
- D.
  
  Less expensive
2.

This cephalosporin was synthesized from...
- A.
  
  A cephalosporin
- B.
  
  A natural penicillin
3.

Cephalosporins are excreted primarily by the...
- A.
  
  Liver
- B.
  
  Kidney
4.

Which generation is the least stable to beta lactamases?
- A.
  
  1st
- B.
  
  2nd
- C.
  
  3rd
- D.
  
  4th
5.

Cefazolin This is the drug of choice for surgical prophylaxis. Which of the following is also true?
- A.
  
  It can be used for MRSA
- B.
  
  It is the least stable of all the cephalosporins to beta lactamases
- C.
  
  It is dose once daily
6.

Which feature conveys oral activity?
- A.
  
  C3 substituent
- B.
  
  C7 side chain
- C.
  
  Beta lactam
- D.
  
  COOH
- E.
  
  Dihydrothiazine ring
7.

CefamandoleWhich of the following is true regarding this drug?
- A.
  
  It is the drug of choice for infant meningitis
- B.
  
  It is useful against MRSA and VRSA
- C.
  
  It can cause prolonged bleeding
- D.
  
  It can cause carnitine deficiency
- E.
  
  It is the most active drug against p. aeruginosa
8.

CefotaximeWhich of the following is true regarding this drug? Select all that apply.
- A.
  
  It is the drug of choice for infant meningitis
- B.
  
  It is useful against MRSA and VRSA
- C.
  
  It can cause prolonged bleeding
- D.
  
  It has a metabolically vulnerable acetoxy group at C-3
- E.
  
  It is the most active cephalosporin against p. aeruginosa
- F.
  
  The polar aminothiazole ring increases Gram - activity
9.

CeftazadmineWhich of the following is true regarding this drug? Select all that apply.
- A.
  
  It can complex with iron and cause reddish stools
- B.
  
  It can cause prolonged bleeding
- C.
  
  It is the most active cephalosporin against p. aeruginosa
- D.
  
  It is used in combination with an aminoglycoside in PCN allergic patients
- E.
  
  It is available PO
- F.
  
  It is highly water soluble (zwitter ionic)
10.

Cefotaxime is used in combination with ___________ for the empiric therapy of neonatal and inflant meningitis.
11.

CefotetanWhich of the following is true regarding this drug? Select all that apply.
- A.
  
  It has special binding affinity towards PBPs (specifically PBP3 of gram - bacteria)
- B.
  
  It is the only 4th generation cephalosporin currently on the market
- C.
  
  It is chemically incompatible with tetracyclines, aminoglycosides, and heparin
- D.
  
  It can cause carnitine deficiency
- E.
  
  It can cause prothrombin deficiency and alcohol intolerance
12.

CefaclorWhich of the following is true regarding this drug?
- A.
  
  Prodrug, enhanced absorption when given with food, can be dispersed in apple juice
- B.
  
  PO, good for otitis media in kids (but serum-sickness SEs can be a problem)
- C.
  
  PO, fatty foods decrease absorption, can complex with iron to cause reddish stools
13.

A woman asks you if her child can eat a normal dinner while he is taking "cef-dinir." You tell her...
- A.
  
  Fatty foods and antacids diminish blood levels of this drug
- B.
  
  Fatty foods enhance the absorption of this drug
- C.
  
  Food can be taken without regard to this drug
14.

Which drug has the longest half life of all of the cephalosporins due to protein binding and slow urinary excretion?
- A.
  
  Cefdinir
- B.
  
  Cefixime
- C.
  
  Cefditoren
- D.
  
  Ceftibuten
- E.
  
  Cefpodoxime proxetil
- F.
  
  Ceftriaxone
15.

Cefpodoxime Proxetil This drug has better activity against s. aureus than cefixime. What else is true regarding this drug?
- A.
  
  It is not indicated for children under 12
- B.
  
  Absorption is enhanced by food but reduced by antacids
- C.
  
  A main side effect is diarrhea due to enhanced biliary excretion
- D.
  
  It is used in combination with aminoglycosides
16.

Ceftibuten Oral bioavailability with this drug is decreased by food. What else is true regarding this drug?
- A.
  
  The beta lactam carbonyl is not very potent
- B.
  
  The beta lactam carbonyl is potent
17.

CeftriaxoneWhich of the following is true regarding this drug? Select all that apply.
- A.
  
  Longest half life of all of the cephalosporins
- B.
  
  Disulfiram life effects may occur
- C.
  
  Bleeding may occur
- D.
  
  Diarrhea is common due to greater biliary excretion
18.

Which drug should you avoid if you have a carnitine deficiency and/or a milk protein hypersensitivity?
- A.
  
  Ceftobiprole
- B.
  
  Cefuroxime
- C.
  
  Cefixime
- D.
  
  Cefditoren
- E.
  
  Loracarbef
19.

LoracarbefThis drug is a carbacepham due to the replacement of the sulfur with a carbon. What does this mean for ring strain?
- A.
  
  Decreases ring strain, making the drug less potent
- B.
  
  Increases ring strain, making the drug more potent
20.

Which drug(s) are active against MRSA?
- A.
  
  Cefditoren
- B.
  
  Cefixime
- C.
  
  Ceftobiprole
- D.
  
  Ceftibuten
- E.
  
  Ceftaroline
21.

Which is true regarding imipenem? Select all that apply.
- A.
  
  Synergistic with aminoglycosides for the treatment of p. aeruginosa
- B.
  
  Often used alone to treat p. aeruginosa
- C.
  
  Orally active
- D.
  
  Renal dehydropeptidase I causes hydrolysis and deactivation of the drug
- E.
  
  Good for community acquired infections and prophlaxis in surgery
- F.
  
  No cross allergy with PCNs
- G.
  
  Can cause seizures (esp in the eldery, with high doses, and in renal impairment)
- H.
  
  Less likely to cause seizure than other carbapenems
- I.
  
  Broader antibacterial spectrum than the third generation cephalosporins
- J.
  
  Active against MRSA
22.

This drug is inhibited by renal dehydropeptidase I?
- A.
  
  True
- B.
  
  False
23.

Which drug is resistant to most beta lactamases including some metallo-beta-lactamases.
- A.
  
  Imipenem
- B.
  
  Meropenem
- C.
  
  Ertapenem
- D.
  
  Doripenem
- E.
  
  Faropenem
24.

Monobactam reactivity is due to the electron withdrawing group on the nitrogen.
- A.
  
  True
- B.
  
  False
25.

This drug is active only against gram negative organisms and is synergistic with aminoglycosides.