Genetics - 20 Difficult Questions

20 Questions | Total Attempts: 1228

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Genetics - 20 Difficult Questions

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Questions and Answers
  • 1. 
    Klenow fragment lacks 
    • A. 

      5'→3' polymerase

    • B. 

      3'→5' exonuclease

    • C. 

      5'→3' exonuclease activity

    • D. 

      None

  • 2. 
    Similarity between DNA polymerase and Glycogen synthase
    • A. 

      Both need a primer

    • B. 

      Both enzymes are processive in adding substrates

    • C. 

      Either of the above

    • D. 

      None

  • 3. 
    Basic protein that binds to DNA in spermatid
    • A. 

      Histone

    • B. 

      Protamine

    • C. 

      Polyamine

    • D. 

      None

  • 4. 
    Signal recognition particle contains
    • A. 

      28S RNA

    • B. 

      60S RNA

    • C. 

      40S RNA

    • D. 

      7S RNA

  • 5. 
    Possibly more than 90% of genome is transcribed. 
    • A. 

      True

    • B. 

      False

  • 6. 
    Carboxy terminal domain (CTD) of RNA polymerase is phosphorylated by 
    • A. 

      TFIID

    • B. 

      TFIIA

    • C. 

      TFIIB

    • D. 

      TFIIH

  • 7. 
    Special transcription factors bind to
    • A. 

      TATA box

    • B. 

      Inr element

    • C. 

      DPE

    • D. 

      CAAT box

  • 8. 
    Which is NOT a DNA binding domain ?(Don't worry, No marks for this question)
    • A. 

      Zinc finger

    • B. 

      Helix-turn-Helix

    • C. 

      Helix-loop-helix

    • D. 

      Basic domains

  • 9. 
    Which is a template independent DNA polymerase ?
    • A. 

      Poly A polymerase

    • B. 

      CCA adding enzyme

    • C. 

      Terminal deoxynucleotidyl transferase

    • D. 

      None

  • 10. 
    Sequence of an intron always starts and ends with(Don't worry, No marks for this question)
    • A. 

      GU,AG

    • B. 

      AG,GU

    • C. 

      GA,GU

    • D. 

      UG,AG

  • 11. 
    RNA splicing requires ATP hydrolysis.
    • A. 

      True

    • B. 

      False

  • 12. 
    Instead of poly A tail histone pre-mRNA has stem-loop structure.
    • A. 

      True

    • B. 

      False

  • 13. 
    5S RNA is transcribed by
    • A. 

      RNA polymerase I

    • B. 

      RNA polymerase II

    • C. 

      RNA polymerase III

    • D. 

      All of the above

  • 14. 
    Self-splicing is mediated by (No marks for this question!!!)
    • A. 

      Adenosine

    • B. 

      Guanosine

    • C. 

      Cytosine

    • D. 

      None

  • 15. 
    Promoters of eukaryotic tRNA lie within the gene itself. 
    • A. 

      True

    • B. 

      False

  • 16. 
    Which amino acid(s) is/are coded by a single codon
    • A. 

      Tryptophan

    • B. 

      Methionine

    • C. 

      Both

    • D. 

      None

  • 17. 
    ApoB48 & apoB100 production is due to
    • A. 

      Alternative splicing

    • B. 

      MRNA editing

    • C. 

      Alternative polyadenylation

    • D. 

      MRNA silencing

  • 18. 
    Mirtrons are miRNAs located in introns
    • A. 

      True

    • B. 

      False

  • 19. 
    All ribonucleases are ribozymes
    • A. 

      True

    • B. 

      False

  • 20. 
    During translation, initiator tRNA binds to 
    • A. 

      A site

    • B. 

      P site

    • C. 

      E site

    • D. 

      None

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