Genetics - 20 Difficult Questions
Unless you studied the topic, don't attempt !
- 1.Klenow fragment lacks
- A.
5'→3' polymerase
- B.
3'→5' exonuclease
- C.
5'→3' exonuclease activity
- D.
None
- 2.Similarity between DNA polymerase and Glycogen synthase
- A.
Both need a primer
- B.
Both enzymes are processive in adding substrates
- C.
Either of the above
- D.
None
- 3.Basic protein that binds to DNA in spermatid
- A.
Histone
- B.
Protamine
- C.
Polyamine
- D.
None
- 4.Signal recognition particle contains
- A.
28S RNA
- B.
60S RNA
- C.
40S RNA
- D.
7S RNA
- 5.Possibly more than 90% of genome is transcribed.
- A.
True
- B.
False
- 6.Carboxy terminal domain (CTD) of RNA polymerase is phosphorylated by
- A.
TFIID
- B.
TFIIA
- C.
TFIIB
- D.
TFIIH
- 7.Special transcription factors bind to
- A.
TATA box
- B.
Inr element
- C.
DPE
- D.
CAAT box
- 8.Which is NOT a DNA binding domain ?(Don't worry, No marks for this question)
- A.
Zinc finger
- B.
Helix-turn-Helix
- C.
Helix-loop-helix
- D.
Basic domains
- 9.Which is a template independent DNA polymerase ?
- A.
Poly A polymerase
- B.
CCA adding enzyme
- C.
Terminal deoxynucleotidyl transferase
- D.
None
- 10.Sequence of an intron always starts and ends with(Don't worry, No marks for this question)
- A.
GU,AG
- B.
AG,GU
- C.
GA,GU
- D.
UG,AG
- 11.RNA splicing requires ATP hydrolysis.
- A.
True
- B.
False
- 12.Instead of poly A tail histone pre-mRNA has stem-loop structure.
- A.
True
- B.
False
- 13.5S RNA is transcribed by
- A.
RNA polymerase I
- B.
RNA polymerase II
- C.
RNA polymerase III
- D.
All of the above
- 14.Self-splicing is mediated by (No marks for this question!!!)
- A.
Adenosine
- B.
Guanosine
- C.
Cytosine
- D.
None
- 15.Promoters of eukaryotic tRNA lie within the gene itself.
- A.
True
- B.
False
- 16.Which amino acid(s) is/are coded by a single codon
- A.
Tryptophan
- B.
Methionine
- C.
Both
- D.
None
- 17.ApoB48 & apoB100 production is due to
- A.
Alternative splicing
- B.
MRNA editing
- C.
Alternative polyadenylation
- D.
MRNA silencing
- 18.Mirtrons are miRNAs located in introns
- A.
True
- B.
False
- 19.All ribonucleases are ribozymes
- A.
True
- B.
False
- 20.During translation, initiator tRNA binds to
- A.
A site
- B.
P site
- C.
E site
- D.
None
Questions: 14 | Attempts: 20352 | Last updated: Nov 6, 2020
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