Genetics - 20 Difficult Questions

Reviewed by Editorial Team
The ProProfs editorial team is comprised of experienced subject matter experts. They've collectively created over 10,000 quizzes and lessons, serving over 100 million users. Our team includes in-house content moderators and subject matter experts, as well as a global network of rigorously trained contributors. All adhere to our comprehensive editorial guidelines, ensuring the delivery of high-quality content.
Learn about Our Editorial Process
| By Kar
Kar, Assistant Professor (Biochemistry)
Karthikeyan Pethusamy is an assistant professor in the Department of Biochemistry at the All India Institute of Medical Sciences in New Delhi
Quizzes Created: 33 | Total Attempts: 50,708
| Attempts: 2,752 | Questions: 20
Quiz Flashcard Lesson
Please wait...
Question 1 / 20
0 %
0/100
Score 0/100
1. Instead of poly A tail histone pre-mRNA has stem-loop structure.

Explanation

Fact !

Submit
Please wait...
About This Quiz
Genetics - 20 Difficult Questions - Quiz

Explore the complexities of genetic mechanisms with 'Genetics - 20 difficult questions'. This quiz assesses knowledge on DNA interactions, enzyme functions, and transcription processes, essential for advanced studies... see morein genetics and molecular biology. see less

2. Promoters of eukaryotic tRNA lie within the gene itself. 

Explanation

Intergenic promoters.

Submit
3. Mirtrons are miRNAs located in introns

Explanation

Fact !

Submit
4. All ribonucleases are ribozymes

Explanation

RNAse P is the only ribozyme among ribonucleases.

Submit
5. Possibly more than 90% of genome is transcribed. 

Explanation

Not all of them are translated. Many of them are long non coding RNA, rRNA, snRNA, miRNA, SnoRNA, SiRNA.

Submit
6. During translation, initiator tRNA binds to 

Explanation

initiator tRNA is the only tRNA that comes and binds to P site. All others will bind to A site.

Submit
7. Klenow fragment lacks 

Explanation

Klenow Fragment is a fragment of DNA polymerase I. It was used in PCR

Submit
8. Which is a template independent DNA polymerase ?

Explanation

Usually DNA & Polymerases need a template.
But certain polymerases are unique and can add nucleotides without a template.

Submit
9. RNA splicing requires ATP hydrolysis.

Explanation

As the number of phosphate-ester bond is unchanged, no energy is consumed.

Submit
10. 5S RNA is transcribed by

Explanation

All rRNAs are transcribed by RNAP I except 5sRNA.

Submit
11. Self-splicing is mediated by (No marks for this question!!!)

Explanation

Splicesome mediated splicing requires OH group of adenosine.

Submit
12. Which amino acid(s) is/are coded by a single codon

Explanation

AUG for methionine and UGG for tryptophan

Submit
13. Basic protein that binds to DNA in spermatid

Explanation

protamines are small arginine-rich proteins helping in sperm head stabilization in the sperm head

Submit
14. Similarity between DNA polymerase and Glycogen synthase

Explanation

processiivity is the ability to continue of continous addition without dissociating from its substrate.

Submit
15. Sequence of an intron always starts and ends with(Don't worry, No marks for this question)

Explanation

The correct answer is GU,AG. This is because the sequence of an intron always starts with GU and ends with AG. This is a consensus sequence that is recognized by the spliceosome, which is responsible for removing introns from pre-mRNA during the process of splicing. The GU at the 5' end of the intron is recognized by the U1 snRNP, while the AG at the 3' end is recognized by the U2AF protein. These sequences are essential for proper splicing and the removal of introns from the mRNA transcript.

Submit
16. Special transcription factors bind to

Explanation

others are cis-elements for binding of trans acting basal transcription factors.

Submit
17. Signal recognition particle contains

Explanation

SRP is a ribonucleoprotein that binds to N-terminal signal sequence of the proteins to be associated with ER.

Submit
18. Which is NOT a DNA binding domain ?(Don't worry, No marks for this question)

Explanation

Helix loop helix won't bind to DNA. It is a dimerization domain like leucine zipper. (Very important)
(ps I'll try to make a video for this topic)

Submit
19. ApoB48 & apoB100 production is due to

Explanation

CAA, 2152 nd nucleotide of 4536 long apoB100 mRNA is acted upon by cytosine deaminase to produce UAA, stop codon resulting in production of apoB48.

Submit
20. Carboxy terminal domain (CTD) of RNA polymerase is phosphorylated by 

Explanation

TFIIH has helicase and kinase activity. CTD phosphorylation is important for the elongation to begin.

Submit
View My Results

Quiz Review Timeline (Updated): Apr 17, 2025 +

Our quizzes are rigorously reviewed, monitored and continuously updated by our expert board to maintain accuracy, relevance, and timeliness.

  • Current Version
  • Apr 17, 2025
    Quiz Edited by
    ProProfs Editorial Team
  • Jan 27, 2015
    Quiz Created by
    Kar
Cancel
  • All
    All (20)
  • Unanswered
    Unanswered ()
  • Answered
    Answered ()
Instead of poly A tail histone pre-mRNA has stem-loop structure.
Promoters of eukaryotic tRNA lie within the gene itself. 
Mirtrons are miRNAs located in introns
All ribonucleases are ribozymes
Possibly more than 90% of genome is transcribed. 
During translation, initiator tRNA binds to 
Klenow fragment lacks 
Which is a template independent DNA polymerase ?
RNA splicing requires ATP hydrolysis.
5S RNA is transcribed by
Self-splicing is mediated by (No marks for this question!!!)
Which amino acid(s) is/are coded by a single codon
Basic protein that binds to DNA in spermatid
Similarity between DNA polymerase and Glycogen synthase
Sequence of an intron always starts and ends with(Don't worry, No...
Special transcription factors bind to
Signal recognition particle contains
Which is NOT a DNA binding domain ?(Don't worry, No marks for this...
ApoB48 & apoB100 production is due to
Carboxy terminal domain (CTD) of RNA polymerase is phosphorylated...
Alert!

Advertisement