Block 2 Immunology

45 Questions
Immunology Quizzes & Trivia
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Questions and Answers
  • 1. 
    Which of the following represents an important anatomic barrier to infection by microorganisims?
    • A. 

      Lymphocytes

    • B. 

      Interferons

    • C. 

      Mucous membranes

    • D. 

      Kinin system

  • 2. 
    Which of the following is NOT an example of an innate immune mechanisms?
    • A. 

      Interferons

    • B. 

      Complement

    • C. 

      Phagocytes

    • D. 

      T cell receptors

  • 3. 
    Which of the following classes of MHC proteins are produced only by antigen presenting cells?
    • A. 

      Class I

    • B. 

      Class II

    • C. 

      Class III

    • D. 

      Class II & Class III

  • 4. 
    All of the following would be classified as cytokines, except:
    • A. 

      Interleukins

    • B. 

      Kinins

    • C. 

      Tumor necrosis factors

    • D. 

      Interferons

  • 5. 
    TcRs are present in the cell membrane of:
    • A. 

      All mature null cells

    • B. 

      All mature lymphocytes

    • C. 

      All mature T lymphocytes

    • D. 

      All mature monocytes

  • 6. 
    The specific portion of an antigen that is recognized by an antibody or TcR is termed:
    • A. 

      The agretope

    • B. 

      The MHC

    • C. 

      The epitope

    • D. 

      The CD

  • 7. 
    A group of serum proteins that participates in an enzymatic cascade which ultimately results in cell lysis:
    • A. 

      Complement system

    • B. 

      Fibrinolytic system

    • C. 

      Kinin system

    • D. 

      Clotting system

  • 8. 
    A hydrolytic enzyme found within mucous secretions which has the ability to degrade the peptidoglycan cell wall of gram + bacteria:
    • A. 

      Interferon

    • B. 

      Histamine

    • C. 

      Complement

    • D. 

      Lysozyme

  • 9. 
    The uptake of particulate material by a cell is termed:
    • A. 

      Phagocytosis

    • B. 

      Pinocytosis

    • C. 

      Apoptosis

    • D. 

      Receptor-mediated endocytosis

  • 10. 
    Which of the following cells do NOT function as APCs?
    • A. 

      B lymphocytes

    • B. 

      Macrophages

    • C. 

      Neutrophils

    • D. 

      Interdigitating dendritic cells

  • 11. 
    In an inflammatory response, which of the following physiological events occurs first:
    • A. 

      Influx of phagocytic cells to the site of injury or infection

    • B. 

      Increased capillary permeability leading to edema

    • C. 

      Constriction of the blood vessels carrying blood away from the site of injury or infection

    • D. 

      Vasodilation of the capillary network leading to the site of injury or infection

  • 12. 
    C reactive protein is classified as:
    • A. 

      A cytokine

    • B. 

      A chemokine

    • C. 

      An acute-phase protein

    • D. 

      A kinin

  • 13. 
    Fibrin is produced during:
    • A. 

      The kinin cascade

    • B. 

      The clotting cascade

    • C. 

      The complement cascade

    • D. 

      The fibrinolytic cascade

  • 14. 
    The kinin cascade, clotting cascade, and fibrinolytic cascade are all activated by a substance known as:
    • A. 

      Plasmin

    • B. 

      Bradykinin

    • C. 

      Prostaglandin

    • D. 

      Hageman Factor

  • 15. 
    Prostaglandins and leukotrienes are classifed as:
    • A. 

      Lipid inflammatory mediators

    • B. 

      Kinins

    • C. 

      Acute phase proteins

    • D. 

      Chemokines

  • 16. 
    The most abundant leucocyte in the blood of normal humans is the:
    • A. 

      Monocyte

    • B. 

      neutrophil

    • C. 

      Eosinophil

    • D. 

      Lymphocyte

  • 17. 
    What is an opsonin?
    • A. 

      A chemotactic factor

    • B. 

      A substance that enhances phagocytosis

    • C. 

      A cytokine

    • D. 

      A hydrolytic enzyme

  • 18. 
    Which of the following cell types are known to have Fc receptors on their surface?
    • A. 

      Eosinophil

    • B. 

      Macrophages

    • C. 

      Basophils

    • D. 

      All of the above

  • 19. 
    The functional equivalent to the Bursa of Fabricius in humans is:
    • A. 

      The spleen

    • B. 

      The thymus

    • C. 

      The bone marrow

    • D. 

      The appendix

  • 20. 
    The thymus is considered to be:
    • A. 

      A primary lymphoid organ

    • B. 

      A secondary lymphoid organ

    • C. 

      A reticuloendothelial organ

    • D. 

      A specialized lymph node

  • 21. 
    In which area of the lymph node are considered to be “T cell rich”?
    • A. 

      Primary follicles

    • B. 

      Medulla

    • C. 

      Paracortex

    • D. 

      Germinal centers

  • 22. 
    CD8 is a glycoprotein found on:
    • A. 

      All lymphocytes

    • B. 

      B cells

    • C. 

      Cytotoxic T cells

    • D. 

      Helper T cells

  • 23. 
    In addition to T cells and B cells, there is a third category of cells in the lymphocyte lineage known as:
    • A. 

      Monocytes

    • B. 

      Null cells

    • C. 

      Granulocytes

    • D. 

      Megakaryocytes

  • 24. 
    Antibody-secreting cells are called:
    • A. 

      Plasma cells

    • B. 

      T cell blasts

    • C. 

      Macrophages

    • D. 

      B lymphoblasts

  • 25. 
    Anti-viral proteins produced by virally infected cells are termed:
    • A. 

      Complement

    • B. 

      Lysozyme

    • C. 

      Interferon

    • D. 

      Major basic proteins

  • 26. 
    Which of the following is correctly  matched?
    • A. 

      Dolor - redness

    • B. 

      Rubor - swelling

    • C. 

      Calor - heat

    • D. 

      Tumor - pain

  • 27. 
    Which of the following are known to stimulate pain receptors in the skin during an inflammatory response?
    • A. 

      Mannose binding protein

    • B. 

      Bradykinin

    • C. 

      Complement

    • D. 

      Histamine

  • 28. 
    Phagocytosis, endocytosis and inflammation are all examples of:
    • A. 

      Innate immunity

    • B. 

      The anamnestic response

    • C. 

      Acquired specific immunity

    • D. 

      None of the above

  • 29. 
    T lymphocytes undergo the process of negative selection in which of the following lymphoid organs?
    • A. 

      Bone marrow

    • B. 

      Thymus

    • C. 

      Lymph nodes

    • D. 

      Spleen

  • 30. 
    When monocytes complete their period of circulation in the blood and enter the tissues they become:
    • A. 

      Natural killer cells

    • B. 

      Macrophages

    • C. 

      Mast cells

    • D. 

      Polymorphonuclear cells

  • 31. 
    Macrophages activated with lipopolysaccharide and IFN-g express are known to produce high levels of:
    • A. 

      IL-2

    • B. 

      Nitric oxide

    • C. 

      Hydrogen peroxide

    • D. 

      Complement proteins

  • 32. 
    The superoxide anion (O2)  leads to the formation of all of the following except:
    • A. 

      Hydrogen peroxide (H2O2)

    • B. 

      Hydroxyl radicals (OH’)

    • C. 

      Nitric oxide (NO)

    • D. 

      Singlet oxygen

  • 33. 
    Cysteine-rich cationic peptides which circularize and form ion-permeable channels in bacterial and mammalian cell membranes are termed:
    • A. 

      Cytokines

    • B. 

      Defensins

    • C. 

      Kinins

    • D. 

      Histamines

  • 34. 
    Which of the following cell types are not in the myeloid pathway of cellular differentiation?
    • A. 

      Megakaryocytes

    • B. 

      Lymphocytes

    • C. 

      Macrophages

    • D. 

      Basophils

  • 35. 
    The hematopoietic growth factor which is believed to act at the level of the pluripotent stem cell is:
    • A. 

      IL-3

    • B. 

      IL-4

    • C. 

      IL-5

    • D. 

      IL-6

  • 36. 
    Which of the following would not be considered a secondary lymphoid organ?
    • A. 

      Lymph nodes

    • B. 

      Spleen

    • C. 

      Thymus

    • D. 

      Tonsils

  • 37. 
    In humans, the thymus is at its largest actual size:
    • A. 

      At birth

    • B. 

      At puberty

    • C. 

      In the mid-20s

    • D. 

      In elderly individuals

  • 38. 
    • A. 

      Those bearing a TcR specific for self MHC + self antigen

    • B. 

      Those bearing a TcR specific for foreign MHC + foreign antigen

    • C. 

      Those bearing a TcR specific for self MHC + foreign antigen

    • D. 

      Those bearing a TcR specific for foreign MHC + self antigen

  • 39. 
    Mature T cells are found in which of the following regions of the thymus?
    • A. 

      Subcapsular region

    • B. 

      Cortex

    • C. 

      Medulla

    • D. 

      Hassal’s corpuscles

  • 40. 
    Which of the following statements is true?
    • A. 

      95% of the progenitor T cells which enter the thymus leave as mature T cells

    • B. 

      50% of the progenitor T cells which enter the thymus leave as mature T cells

    • C. 

      1-5% of the progenitor T cells which enter the thymus leave as mature T cells

    • D. 

      10% of the progenitor T cells which enter the thymus leave as mature T cells

  • 41. 
    In humans, B cells undergo a process of negative selection in:
    • A. 

      The bone marrow

    • B. 

      The spleen

    • C. 

      The thymus

    • D. 

      The lymph nodes

  • 42. 
    • A. 

      Macrophages and lymphocytes

    • B. 

      Erythrocytes and macrophages

    • C. 

      Erythrocytes and lymphocytes

    • D. 

      Plasma cells

  • 43. 
    The T cell region of the spleen is known as:
    • A. 

      The primary follicles

    • B. 

      The marginal zone

    • C. 

      The periarteriolar lymphoid sheath

    • D. 

      The subcapsular region

  • 44. 
    The specific part of an antigen that combines with a specific antibody or T cell receptor is the
    • A. 

      Epitope

    • B. 

      Agretope

    • C. 

      Allotope

    • D. 

      Paratope

  • 45. 
    Differentiation of myeloid cells from committed progenitors to mature cells occurs primarily in:
    • A. 

      Bone marrow

    • B. 

      Thymus

    • C. 

      Spleen

    • D. 

      Lymph nodes