Central nervous system disorders are a group of neurological disorders that affect the structure or function of the brain or spinal cord. Degenerative brain diseases have an enormous impact on our aging society. Take this pharmacology test on the CNS degenerative diseases and test your knowledge on the prescribed drugs for a patient.
Dopamine metabolism in the striatum
Active transport of levodopa outside the brain
Conversion of dopamine into norepinephrine in the striatum
Peripheral biotransformation of levodopa
Dopamine reuptake in the striatum
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Increased sensitivity of dopaminergic receptors in the striatum
Increased sensitivity of dopamine receptors in the substantia nigra
Increased availability of dopamine in the striatum
Inhibition of DOPA decarboxylase in the striatum
Inhibition of dopamine reuptake in the substantia nigra
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The drug inhibits levodopa metabolism in the striatum
The drug inhibits the abnormally high cholinergic tone in the striatum
The drug activates dopaminergic receptors in the striatum
The drug blocks beta-2 receptors which mediate the tremor in the skeletal muscle
The drug activate a specific transport system that allows levodopa to enter the brain
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Propranolol
Selegiline
Benztropine
Haloperidol
Imipramine
Diazepam
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Amantadine
Entacapone
Methyldopa
Benztropine
Bromocriptine
Haloperidol
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Fluoxetine
Chlorpromazine
Donepezil
Amitriptyline
Trazodone
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Benztropine
Selegiline
Bromocriptine
Amantadine
Pergolide
Entacapone
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Cholinergic agonists exacerbate hyperkinetic disorders and alleviate hypokinetic disorders
Cholinergic agonists alleviate both hyperkinetic and hypokinetic disorders
Dopaminergic agonists alleviate both hyperkinetic and hypokinetic disorders
Dopaminergic agonists exacerbate hyperkinetic disorders and alleviate hypokinetic disorders
Dopaminergic agonists alleviate hyperkinetic disorders and exacerbate hypokinetic disorders
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Drug 1
Drug 2
Drug 3
Drug 4
Drug 5
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Levodopa
Carbidopa
Selegiline
Amantadine
Bromocriptine
Benztropine
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Chlorpropamide
Amantadine
Carbidopa
Metformin
Metoclopramide
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Blurred vision
Diarrhea
Postural hypotension
Bradycardia
Bradykinesia
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Hypertension, palpitations
Nausea, vomiting and diarrhea
Dry mouth, anhydrosis
Drowsiness, lethargy
Mydriasis, cycloplegia
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To decrease the dose of carbidopa
To substitute levodopa/carbidopa with bromocriptine
To withdraw benztropine
To add propranolol to the present drug regimen
To start brief periods of ‘drug holidays‘ during therapy
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Amantadine
Benztropine
Bromocriptine
Entacapone
Entacapone
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Levodopa - inhibits dopamine metabolism in the brain
Benztropine - blocks central Nn cholinergic receptors
Selegiline - selectively inhibits MAO B
Amantadine - selectively inhibits catechol-O-methyl-transferase
Bromocriptine - activates central dopaminergic receptors
Entacapone - blocks central muscarinic receptors
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Carbidopa
Entacapone
Benztropine
Pramipexole
Clonazepam
Propranolol
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To substitute levodopa with selegiline
To substitute levodopa with bromocriptine
To add benztropine to the present regimen
To add amantadine to the present regimen
To add clozapine to the present regimen
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Amantadine
Benztropine
Haloperidol
Bromocriptine
Fluoxetine
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