Block 1 Cell Biology Dr Moore
- 1.Which of the following types of proteins are translated on ribosomes bound to the rough endoplasmic reticulum (RER) instead of being completely translated on ribosomes free in the cytosol?
- A.
Cytoskeletal proteins
- B.
Mitochondrial proteins
- C.
Lysosomal proteins
- D.
Peroxisomal proteins
- E.
Nuclear proteins
- 2.Many targeting and sorting processes in the cell require a pH difference between one compartment and another to occur efficiently. Of the choices below, pick the process that DOES NOT require a difference in pH between two compartments to occur.
- A.
Correct trafficking of the mannose-6-phosphate (M6P) receptor
- B.
Correct trafficking of the LDL receptor and its ligand during receptor-mediated endocytosis
- C.
Movement of protons into the mitochondrial matrix through ATP synthase
- D.
Correct trafficking of newly synthesized integral plasma membrane proteins from the rough endoplasmic reticulum to the plasma membrane
- E.
Activation of lysosomal enzymes in the lumen of lysosomes compared to their relative inactivity in the trans Golgi
- 3.You have engineered a protein construct mRNA that will encode for a protein not normally found in nature. To a soluble protein that is normally a cytoplasmic protein you have added an ER signal sequence to its amino terminus, and an NLS to its carboxy terminus. There are no other targeting signals present in this protein. The final protein will be 100 kD in size. After transfection into the cell, what is the final destination of the translated construct protein?
- A.
Cytoplasm
- B.
Lumen of the ER
- C.
Lumen of the Golgi
- D.
Secreted into the extracellular space
- E.
The nuclear interior
- 4.Which of the following is a site of mRNA transcription?
- A.
Ribosome
- B.
Nucleolus
- C.
Heterochromatin
- D.
Rough ER
- E.
Euchromatin
- 5.Of the following cellular compartments, which one maintains the most acidic pH?
- A.
Lumen of early endosome
- B.
Mitochondrial matrix
- C.
Lumen of lysosome
- D.
Lumen of trans-Golgi
- E.
Peroxisomal matrix
- 6.Which of the following WOULD NOT be found on the half of the plasma membrane bilayer facing the cytoplasm?
- A.
Phosphatidylserine
- B.
Phosphatidylethanolamine
- C.
Phosphatidylinositol
- D.
Peripheral membrane protein
- E.
Carbohydrate moiety of glycolipid
- 7.Which of the following post-translational protein modifications DOES NOT occur in the rough ER?
- A.
Formation of disulphide bonds
- B.
Formation of GPI anchors
- C.
Addition of N-linked carbohydrate
- D.
Protein folding
- E.
Addition of O-linked carbohydrate
- 8.Which of the following would probably never pass through nuclear pores in an interphase nucleus?
- A.
MRNA
- B.
Ribosomal protein
- C.
Histones
- D.
TRNA
- E.
SRP (signal recognition particle)
- 9.Which of the following statements is INCORRECT regarding peripheral membrane proteins of the plasma membrane?
- A.
They can be removed from the membrane with high salt
- B.
They can be found on both the cytoplasmic face and the extracellular face of the plasma membrane
- C.
They can be bound at the membrane to either membrane lipids or other membrane proteins
- D.
They are immobile in the membrane
- E.
They are held at the membrane via ionic interactions with membrane components Properties of peripheral membrane proteins.
- 10.Mitochondria DO NOT carry out which of the following processes?
- A.
Lipid synthesis
- B.
Protein synthesis
- C.
Carbohydrate synthesis
- D.
RRNA synthesis
- E.
MRNA synthesis
- 11.Which of the following statements describing the morphology of apoptotic cells is INCORRECT?
- A.
The apoptotic cell shrinks in size
- B.
The nucleus of an apoptotic cell is smaller and appears darker by light or electron microscopy than the nucleus of a healthy cell
- C.
The plasma membrane of an apoptotic cell becomes disrupted
- D.
The apoptotic cell fragments into smaller pieces
- E.
The phospholipid phosphatidylserine (PS) is exposed o the extracellular face of the plasma membrane of an apoptotic cell
- 12.At the end of prophase, how many chromosomes does a mitotic human cell have?
- A.
23
- B.
46
- C.
69
- D.
92
- E.
115
- 13.Which of the following statements about clathrin is INCORRECT?
- A.
Clathrin cycles between an assembled and unassembled state
- B.
Clathrin assembly on a membrane deforms that membrane
- C.
LDL receptors only cluster in clathrin-coasted pits after binding LDL
- D.
Clathrin clusters LDL receptors via adaptins
- E.
Clathrin is not found on caveolae
- 14.Which of the following statements about mitochondria is CORRECT?
- A.
Mitochondria import proteins co-translationally through contact sites in the membrane
- B.
Mitochondria maintain an acidic pH inside the lumen of the intermembrane space.
- C.
Mitochondria localize mot of the protein components of the respiratory chains in the inner mitochondrial membrane or the matrix.
- D.
Mitochondria pump protons across themitochondrial inner membrane into the matrix
- E.
Mitochondria localize their DNA inside the intermembrane space
- 15.Which of the following IS NOT a function of the actin cytoskeleton?
- A.
Forms the mitotic spindle
- B.
Forms the contractile ring that separates daughter cells at mitosis
- C.
Forms microvilli
- D.
Forms lamellopodia
- E.
Forms the terminal web
Questions: 16 | Attempts: 67562 | Last updated: Mar 22, 2022
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Sample QuestionA Cell builds it's proteins from the Instructions encoded inits _________?
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Sample QuestionAll cells contain which of the following:
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