How Much Do You Know About Natural Killer Cells?

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| By Tanya Mishra
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Tanya Mishra
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How Much Do You Know About Natural Killer Cells? - Quiz

We welcome you to this awesome natural killer cells quiz. The human immune system is made up of an array of cells that perform many different functions. Natural killers are a type of immune cells that are made for killing cancer cells and foreign invasions of the body. Do you believe you know everything about these specialized immune cells? If you think so, then why don't you test your knowledge? We hope you can also learn something new with this fun quiz! If you liked the quiz, don't forget to share! Good Luck!


Questions and Answers
  • 1. 

    Which of the following substances stimulate the activity of NK cells? 

    • A.

      IFN-alpha

    • B.

      IFN-beta

    • C.

      IL-12

    • D.

      All of the above

    Correct Answer
    D. All of the above
    Explanation
    IFN-alpha, IFN-beta, and IL-12 are all substances that stimulate the activity of NK cells. IFN-alpha and IFN-beta are types of interferons that are released in response to viral infections and have immunomodulatory effects, including enhancing NK cell activity. IL-12 is a cytokine that plays a critical role in activating NK cells and promoting their cytotoxic functions. Therefore, all of these substances can enhance the activity of NK cells.

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  • 2. 

    Which of the following is an NK cell membrane marker? 

    • A.

      Insulin

    • B.

      Titin

    • C.

      Integrin

    • D.

      Angiotensin

    Correct Answer
    C. Integrin
    Explanation
    Integrin is an NK cell membrane marker. Integrins are a family of cell adhesion molecules that play a crucial role in the immune response. They are involved in the attachment of NK cells to target cells and facilitate the killing of these cells. Insulin, Titin, and Angiotensin are not NK cell membrane markers and do not have a direct role in NK cell function.

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  • 3. 

    Who discovered natural killer cells?

    • A.

      Rudolf Virchow

    • B.

      Rolf Keissling

    • C.

      Stephen Jay Gould

    • D.

      Linus Pauling

    Correct Answer
    B. Rolf Keissling
    Explanation
    Rolf Keissling is credited with the discovery of natural killer cells. He is a Swedish immunologist who first identified these cells in the 1970s. Natural killer cells are a type of white blood cell that play a critical role in the immune system's defense against viruses and cancer cells. Keissling's discovery has greatly contributed to our understanding of the immune response and has paved the way for further research in immunology.

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  • 4. 

    Where do NK cells differentiate in the body?

    • A.

      Brain

    • B.

      Heart

    • C.

      Liver

    • D.

      Bone marrow

    Correct Answer
    D. Bone marrow
    Explanation
    NK cells, also known as natural killer cells, are a type of lymphocyte that plays a crucial role in the innate immune response. They are responsible for detecting and eliminating infected or cancerous cells. NK cells differentiate in the bone marrow, where they undergo maturation and acquire their functional properties. This process involves the expression of specific cell surface markers and the development of their cytotoxic abilities. Once differentiated, NK cells migrate to various tissues and organs throughout the body, where they can carry out their immune surveillance and defense functions.

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  • 5. 

    What is the basic structure of an NK cell?

    • A.

      Large, granular

    • B.

      Small, convex

    • C.

      Big, circular with semi permeable membrane

    • D.

      None of the above

    Correct Answer
    A. Large, granular
    Explanation
    NK cells, also known as natural killer cells, are a type of lymphocyte that play a crucial role in the immune system's defense against viral infections and tumor cells. The basic structure of an NK cell is characterized by its large size and granular appearance. These cells have abundant cytoplasm filled with granules containing various proteins and enzymes that aid in their cytotoxic activities. The large, granular structure of NK cells allows them to efficiently recognize and destroy infected or abnormal cells in the body.

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  • 6. 

    Which of the following activating receptors of the NK plays a role in antibody-dependent cell-mediated cytotoxicity?

    • A.

      Ly49 

    • B.

      LIR 

    • C.

      CD16 

    • D.

      Killer-cell immunoglobulin-like receptors

    Correct Answer
    C. CD16 
    Explanation
    CD16 is the correct answer because it is an activating receptor of the NK (Natural Killer) cells that plays a role in antibody-dependent cell-mediated cytotoxicity. CD16, also known as FcγRIII, is a receptor for the Fc portion of immunoglobulin G (IgG) antibodies. When IgG antibodies bind to target cells, CD16 on NK cells recognizes and binds to the Fc portion of the bound antibodies, leading to the activation of NK cells and subsequent killing of the target cells.

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  • 7. 

    When were NK cells discovered? 

    • A.

      1975

    • B.

      1983

    • C.

      1998

    • D.

      2000

    Correct Answer
    A. 1975
    Explanation
    NK cells, also known as natural killer cells, were discovered in 1975. These cells are a type of lymphocyte that play a crucial role in the immune system's defense against cancer and viral infections. They are able to recognize and kill infected or abnormal cells without the need for prior activation, making them an important component of the body's innate immune response. The discovery of NK cells in 1975 marked a significant advancement in our understanding of the immune system and its mechanisms of defense.

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  • 8. 

    Which of the following molecules plays a crucial role in NK cell activation?

    • A.

      Dopamine

    • B.

      Cytokines

    • C.

      Glutamine

    • D.

      None of the above

    Correct Answer
    B. Cytokines
    Explanation
    Cytokines play a crucial role in NK cell activation. Cytokines are small proteins that are secreted by various immune cells and act as chemical messengers to regulate immune responses. They can stimulate NK cell proliferation, enhance their cytotoxicity, and promote their activation and differentiation. By binding to specific receptors on NK cells, cytokines can trigger signaling pathways that lead to the activation of NK cells and their subsequent killing of infected or cancerous cells. Therefore, cytokines are essential for the proper functioning of NK cells in immune responses.

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  • 9. 

    How much percentage of lymphocytes do NK cells make up in the body?

    • A.

      50 % 

    • B.

      23 - 26 %

    • C.

      5-10%

    • D.

      Less than 3%

    Correct Answer
    C. 5-10%
    Explanation
    NK cells, or natural killer cells, are a type of lymphocyte that play a crucial role in the immune system's defense against viruses and cancer cells. They are known for their ability to kill infected or abnormal cells without prior sensitization. While the exact percentage may vary among individuals, on average, NK cells make up approximately 5-10% of the total lymphocyte population in the body.

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  • 10. 

    Which of the following is true about NK cells?

    • A.

      The have strong cytotoxic abilities

    • B.

      They do not have T or B cell receptors 

    • C.

      The are the first line of defense against the foreign substances

    • D.

      Cytokines are essential molecules for their activation

    Correct Answer
    B. They do not have T or B cell receptors 
    Explanation
    NK cells do not have T or B cell receptors. T and B cells are part of the adaptive immune response and have receptors that allow them to recognize specific antigens. In contrast, NK cells are part of the innate immune response and do not have these specific receptors. Instead, NK cells have receptors that recognize general patterns on infected or abnormal cells, allowing them to target and kill these cells.

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Our quizzes are rigorously reviewed, monitored and continuously updated by our expert board to maintain accuracy, relevance, and timeliness.

  • Current Version
  • Nov 16, 2023
    Quiz Edited by
    ProProfs Editorial Team
  • Nov 04, 2022
    Quiz Created by
    Tanya Mishra
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