Vancomycin And Aminoglycosides Review

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| By Skysdalimit637
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Skysdalimit637
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Quizzes Created: 1 | Total Attempts: 180
Questions: 31 | Attempts: 181

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Vancomycin And Aminoglycosides Review - Quiz

Questions and Answers
  • 1. 

    Gentamicin: What is desired peak concentration (mg/L) for UTI? **numeric answer only**

    Explanation
    The desired peak concentration for Gentamicin in the treatment of urinary tract infections (UTI) is between 4-5 mg/L. This range ensures that the antibiotic reaches an effective concentration in the body to effectively kill the bacteria causing the infection. Going below this range may result in inadequate treatment, while going above it may lead to potential toxicity and side effects. Therefore, maintaining a peak concentration within the 4-5 mg/L range is crucial for optimal therapeutic outcomes in UTI cases.

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  • 2. 

    Gentamicin: What is desired peak concentration (mg/L) for pyelonephritis? **numeric answer only**

    Explanation
    The desired peak concentration for pyelonephritis when using Gentamicin is 5-6.5 mg/L. This range indicates the optimal level of the drug in the bloodstream to effectively treat the infection. It is important to achieve the right concentration to ensure maximum efficacy while minimizing the risk of potential side effects or toxicity.

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  • 3. 

    Gentamicin: What is desired peak concentration (mg/L) for cellulitis? **numeric answer only**

    Explanation
    depends on the organism and site

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  • 4. 

    Gentamicin: What is desired peak concentration (mg/L) for intra-abdominal infections? **numeric answer only**

    Explanation
    depends on organism

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  • 5. 

    Gentamicin: What is desired peak concentration (mg/L) for pneumonia? **numeric answer only**

    Explanation
    depnds on organism and whether it is HCAP (harder to treat)

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  • 6. 

    Gentamicin: What is desired peak concentration (mg/L) for bacteremia? **numeric answer only**

    Explanation
    The desired peak concentration of Gentamicin for bacteremia is between 7-8.5 mg/L. This range ensures that the drug is present in the bloodstream at a sufficient concentration to effectively kill the bacteria causing the infection. If the peak concentration falls below 7 mg/L, the drug may not be effective, and if it exceeds 8.5 mg/L, it may lead to toxic side effects. Therefore, maintaining the concentration within this range is crucial for optimal treatment outcomes.

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  • 7. 

    Gentamicin: What is desired peak concentration (mg/L) for septic shock, neutropenia? **numeric answer only**

    Explanation
    The desired peak concentration of Gentamicin for septic shock and neutropenia is between 7.5-8.5 mg/L.

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  • 8. 

    Gentamicin: What is desired peak concentration (mg/L) for abscess? **numeric answer only**

    Explanation
    The desired peak concentration of Gentamicin for abscess is between 6-9 mg/L. This range ensures that the antibiotic is present in sufficient concentration in the body to effectively treat the abscess, while also minimizing the risk of toxicity. Maintaining the peak concentration within this range helps to optimize the therapeutic efficacy of Gentamicin in combating the infection.

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  • 9. 

    Gentamicin: What is desired peak concentration (mg/L) for gram positive organism synergy? **numeric answer only**

    Explanation
    i.e., staph epidermidis, staph aureus

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  • 10. 

    At what trough level concentration (mg/L) has gentamicin been associated with nephro and ototoxicity?

    Explanation
    Gentamicin has been associated with nephro and ototoxicity when its trough level concentration exceeds 2 mg/L. This means that if the concentration of gentamicin in the body, specifically in the blood, is greater than 2 mg/L, it can cause damage to the kidneys and ears. Monitoring the trough level concentration of gentamicin is important to prevent these toxic effects and ensure the safe use of the medication.

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  • 11. 

    True or  false: lasix can accelerate drug toxicities.

    • A.

      True

    • B.

      False

    Correct Answer
    A. True
    Explanation
    Lasix, also known as furosemide, is a diuretic medication that helps the body get rid of excess water and salt through urine. It can accelerate drug toxicities because it increases the excretion of certain drugs from the body, leading to higher drug concentrations and potentially increasing the risk of adverse effects or toxicity. This is particularly important to consider when prescribing or administering medications in combination with Lasix.

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  • 12. 

    Gentamicin: 1mg/kg traditional dosing will produce peaks in what range (mg/L)?

    Correct Answer
    3-4.5
    Explanation
    The correct answer is 3-4.5. Gentamicin is a medication that is commonly used to treat bacterial infections. When it is administered in the traditional dosing of 1mg/kg, it produces peaks in the range of 3-4.5 mg/L. This means that the concentration of Gentamicin in the blood reaches its highest level within this range. It is important to monitor these peaks to ensure that the medication is being effectively absorbed and distributed in the body, and to avoid toxicity or suboptimal treatment.

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  • 13. 

    Gentamicin: 2mg/kg traditional dosing will produce peaks in what range (mg/L)?

    Correct Answer
    6-8
    Explanation
    The traditional dosing of Gentamicin at 2mg/kg will result in peak levels in the range of 6-8 mg/L. This means that after administration, the concentration of Gentamicin in the bloodstream will reach its highest level within this range. This information is important for monitoring the drug's efficacy and ensuring that it remains within the therapeutic range to effectively treat infections.

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  • 14. 

    What is the standard infusion rate for traditional gentamicin dosing?

    Correct Answer
    30 minutes
    30 min
    0.5 hours
    0.5 hr
    0.5 hr
    Explanation
    The standard infusion rate for traditional gentamicin dosing is 30 minutes, 30 min, 0.5 hours, or 0.5 hr.

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  • 15. 

    What is the standard infusion rate for high gentamicin dosing?

    Correct Answer
    1 hour
    1 hr
    Explanation
    The standard infusion rate for high gentamicin dosing is 1 hour or 1 hr. This means that the medication should be administered over the course of one hour. This rate allows for the proper distribution and absorption of the medication in the body, ensuring its effectiveness. It is important to follow the recommended infusion rate to avoid any adverse effects or potential harm to the patient.

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  • 16. 

    If there is no change in renal function, how often should you monitor serum creatinine and other levels?

    Correct Answer
    5-7 days
    every 5-7 days
    Explanation
    The correct answer is "5-7 days, every 5-7 days". This means that serum creatinine and other levels should be monitored on a regular basis, specifically every 5-7 days. This frequency allows for close monitoring of renal function and ensures that any changes or abnormalities can be detected and addressed promptly. Regular monitoring is important in order to assess the effectiveness of any treatments or interventions and to prevent any potential complications or worsening of renal function.

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  • 17. 

    Vancomycin: What is the empiric volume of distribution (L/kg)?

    Correct Answer
    0.7
    Explanation
    The empiric volume of distribution refers to the theoretical volume in which a drug is distributed throughout the body. In this case, the empiric volume of distribution of Vancomycin is stated to be 0.7 L/kg. This means that for every kilogram of body weight, Vancomycin is expected to distribute itself in a volume of 0.7 liters. This information is important for determining the appropriate dosage of Vancomycin based on a patient's body weight.

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  • 18. 

    Vancomycin: What loading dose (mg/kg) is used in patients on dialysis?

    Correct Answer
    20-30
    Explanation
    The loading dose of Vancomycin in patients on dialysis is 20-30 mg/kg. This means that for every kilogram of the patient's body weight, a dose of 20-30 milligrams of Vancomycin is administered initially to achieve therapeutic levels in the bloodstream. This loading dose is necessary because dialysis can affect the drug's distribution and elimination, requiring a higher initial dose to ensure adequate drug levels.

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  • 19. 

    Vancomycin: At serum level (mg/L) would you redose a dialysis patient who had been loading dosed?

    Correct Answer
    <20
    Explanation
    in lecture she said

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  • 20. 

    Vancomycin: What is the max dose for one infusion? Max dose in a day?

    Correct Answer
    2g/dose, 4g/day
    2, 4
    Explanation
    The maximum dose for one infusion of Vancomycin is 2g, and the maximum dose in a day is 4g. This means that each individual dose of Vancomycin should not exceed 2g, and the total amount administered in a day should not exceed 4g.

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  • 21. 

    Vancomycin: Empiric dose?

    Correct Answer
    15mg/kg
    15mg/kg/dose
    Explanation
    The correct answer is 15mg/kg, 15mg/kg/dose. This means that the empiric dose of Vancomycin is 15mg per kilogram of body weight, and each dose should also be 15mg per kilogram of body weight. This dosing regimen ensures that an appropriate amount of the medication is given based on the patient's weight, which is important for achieving therapeutic levels in the body.

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  • 22. 

    Vancomycin: In what rare exceptions can it be helpful to take vancomycin peaks?

  • 23. 

    Vancomycin: Which of the following conditions require trough goals of 10-15mg/L?

    • A.

      SSTI (cellulitis)

    • B.

      UTI

    • C.

      Pneumonia

    • D.

      Meningitis

    • E.

      Osteomyelitis

    • F.

      Bacteremia

    • G.

      Endocarditis

    Correct Answer(s)
    A. SSTI (cellulitis)
    B. UTI
    Explanation
    The conditions that require trough goals of 10-15mg/L are SSTI (cellulitis) and UTI.

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  • 24. 

    Vancomycin: Which of the following conditions require trough goals of 15-20mg/L?

    • A.

      SSTI (cellulitis)

    • B.

      UTI

    • C.

      Pneumonia

    • D.

      Meningitis

    • E.

      Osteomyelitis

    • F.

      Bacteremia

    • G.

      Endocarditis

    Correct Answer(s)
    C. Pneumonia
    D. Meningitis
    E. Osteomyelitis
    F. Bacteremia
    G. Endocarditis
    Explanation
    The conditions that require trough goals of 15-20mg/L are pneumonia, meningitis, osteomyelitis, bacteremia, and endocarditis. Vancomycin is a potent antibiotic used to treat serious infections caused by Gram-positive bacteria. In order to achieve effective treatment, the drug concentration in the blood needs to be maintained within a specific range. Trough levels, which are measured just before the next dose, are used to monitor the concentration of vancomycin in the body. For these specific conditions, higher trough goals of 15-20mg/L are necessary to ensure adequate treatment and prevent the development of resistance.

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  • 25. 

    Aminoglycosides: According to the high dose nomogram for Gentamicin/Tobramycin, what is the appropriate dosing interval based on a creatinine clearance of >60ml/min?

    Correct Answer(s)
    q24h
    every 24 hours
    24
    Explanation
    The appropriate dosing interval based on a creatinine clearance of >60ml/min is every 24 hours. This means that the medication should be administered once a day. The high dose nomogram for Gentamicin/Tobramycin recommends this dosing frequency for patients with a creatinine clearance above 60ml/min.

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  • 26. 

    Aminoglycosides: According to the high dose nomogram for Gentamicin/Tobramycin, what is the appropriate dosing interval based on a creatinine clearance of 40-60 ml/min?

    Correct Answer(s)
    q36h
    every 36 hours
    36
    Explanation
    The appropriate dosing interval based on a creatinine clearance of 40-60 ml/min is every 36 hours (q36h). This means that the medication should be administered once every 36 hours to ensure proper dosing and avoid potential toxicity. The dosing interval is determined based on the patient's renal function, as indicated by their creatinine clearance. In this case, with a creatinine clearance of 40-60 ml/min, a dosing interval of every 36 hours is appropriate.

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  • 27. 

    Aminoglycosides: According to the high dose nomogram for Gentamicin/Tobramycin, what is the appropriate dosing interval based on a creatinine clearance of 20-40 ml/min?

    Correct Answer(s)
    q48h
    every 48 hours
    48
    Explanation
    The appropriate dosing interval based on a creatinine clearance of 20-40 ml/min is every 48 hours. This means that the medication should be administered once every 48 hours. The dosing interval is determined based on the patient's creatinine clearance, which indicates their kidney function. In this case, with a creatinine clearance of 20-40 ml/min, a longer dosing interval of 48 hours is appropriate to prevent accumulation of the medication and potential toxicity.

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  • 28. 

    Aminoglycosides: According to the high dose nomogram for Gentamicin/Tobramycin, what is the appropriate dosing interval based on a creatinine clearance of <20ml/min?

    Correct Answer(s)
    PRN
    redose when random <2
    Explanation
    The appropriate dosing interval for Gentamicin/Tobramycin based on a creatinine clearance of

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  • 29. 

    What is equation for dosing weight?

    Correct Answer(s)
    0.4(ABW-IBW)+IBW
    DW=0.4(ABW-IBW)+IBW
    Explanation
    The equation for dosing weight is calculated by taking 0.4 times the difference between the actual body weight (ABW) and the ideal body weight (IBW), and then adding the ideal body weight (IBW) to it. This equation is represented as DW=0.4(ABW-IBW)+IBW.

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  • 30. 

    Aminoglycosides: what is considered a "normal" volume of distribution (L/kg)?

    Correct Answer(s)
    0.22-0.25
    Explanation
    Low: 0.15-0.21
    High: 0.26-0.35 (ICU, edema, ventilator, neutropenia, malnutrition)

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