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Bind to the 50S ribosomal subunit
Cause misreading of the code on the mRNA template
Inhibit peptidyl transferase
Administer 5 mg/kg every 12 h
Decrease the dosage to a daily total of 200 mg
Decrease the dosage to 180 mg every 8 h
Discontinue amikacin and switch to gentamicin
Maintain the patient on the present dosage and test auditory function
Effective in the treatment of infections caused by anaerobes such as Bacteroides fragilis
Gentamycin is used with ampicillin for synergistic effects in the treatment of enterococcal endocarditis.
In the treatment of a hospital-acquired infection caused by Serratia marcescens, netilmicin is more effective than streptomycin.
Often used with cephalosporins in the empiric treatment of life-threatening bacterial infections.
Owing to their polar nature, aminoglycosides are not absorbed after oral administration.
Antibacterial activity is often reduced by the presence of an inhibitor of cell wall synthesis.
Antibacterial action is not concentration-dependent.
Antibacterial action is time-dependent.
Efficacy is directly proportional to the duration of time that the plasma level is greater than the minimal inhibitory concentration.
The drug continues to exert antibacterial effects even after plasma levels decrease below detectable levels.
Loop of Henle
Anaerobic gram-negative bacteria
Aerobic gram-positive bacteria
Anaerobic gram-positive bacteria
Aerobic gram-negative bacteria
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