Aminoglycosides (1 - 5 Of 10)

5 Questions | Total Attempts: 1384

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Drug Quizzes & Trivia

Questions and Answers
  • 1. 
    Regarding the mechanism of action of aminoglycosides, the drugs
    • A. 

      Are bacteriostatic

    • B. 

      Bind to the 50S ribosomal subunit

    • C. 

      Cause misreading of the code on the mRNA template

    • D. 

      Inhibit peptidyl transferase

    • E. 

      Stabilize polysomes

  • 2. 
    A 72-kg patient with creatinine clearance of 80 mL/min has a gram-negative infection. Amikacin is administered intramuscularly at a dose of 5 mg/kg every 8 h, and the patient begins to respond. After 2 d, creatinine clearance declines to 40 mL/min. If no information is available about amikacin plasma levels, what would be the most reasonable approach to management of the patient at this point?
    • A. 

      Administer 5 mg/kg every 12 h

    • B. 

      Decrease the dosage to daily total of 200 mg

    • C. 

      Decrease the dosage to 180 mg every 8 h

    • D. 

      Discontinue amikacin and switch to gentamicin

    • E. 

      Maintain the patient on the present dosage and test auditory function

  • 3. 
    All the following statements about the clinical uses of the aminoglycosides are accurate except
    • A. 

      Effective in the treatment of infections caused by anaerobes such as Bacteroides fragilis

    • B. 

      Gentamycin is used with ampicillin for synergistic effects in the treatment of enterococcal endocarditis

    • C. 

      In the treatment of a hospital-acquired infection caused by Serratia marcescens, netilmicin is more effective than streptomycin

    • D. 

      Often used with cephalosporins in the empiric treatment of life-threatening bacterial infections

    • E. 

      Owing to their polar nature, aminoglycosides are not absorbed after oral administration

  • 4. 
    Which statement is accurate regarding the antibacterial action of the aminoglycoside amikacin?
    • A. 

      Antibacterial activity is often reduced by the presence of an inhibitor of cell wall synthesis

    • B. 

      Antibacterial action is not concentration-dependent

    • C. 

      Antibacterial action is time-dependent

    • D. 

      Efficacy is directly proportional to the duration of time that the plasma level is greater than the minimal inhibitory concentration

    • E. 

      The drug continues to exert antibacterial effects even after plasma levels decrease below detectable levels

  • 5. 
    An adult patient (weight 80 kg) has bacteremia suspected to be due to a gram-negative rod. Tobramycin is to be administered using a once-daily dosing regimen, and the loading dose must be calculated to achieve a peak plasma level of 20 mg/L. Assume that the patient has normal renal function. Pharmacokinetic parameters of tobramycin in this patient are as follows: Vd = 30 L; t1/2 = 3 h; CL = 80 mL/min. What loading dose should be given?
    • A. 

      100 mg

    • B. 

      200 mg

    • C. 

      400 mg

    • D. 

      600 mg

    • E. 

      800 mg

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