Aminoglycosides Practice Test

10 Questions | By Medicinemcq | Updated: Sep 18, 2022 | Attempts: 2011

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Do you understand Aminoglycosides well? With this Aminoglycosides MCQ questions with answers, you can test your knowledge. Here, in this quiz, we have some basic questions for your practice and check your understanding of Aminoglycosides. You just need to pick the correct answers for a perfect score on this quiz. Even if you miss out on something, we will help you with a correct answer. Go for it and test your memory. All the best! If you find the quiz informative, share it with others also.

Questions and Answers

1.

Regarding the mechanism of action of aminoglycosides, the drugs
- A.
  
  Are bacteriostatic
- B.
  
  Bind to the 50S ribosomal subunit
- C.
  
  Cause misreading of the code on the mRNA template
- D.
  
  Inhibit peptidyl transferase
- E.
  
  Stabilize polysomes
2.

A 72-kg patient with creatinine clearance of 80 mL/min has a gram-negative infection. Amikacin is administered intramuscularly at a dose of 5 mg/kg every 8 h, and the patient begins to respond. After 2 d, creatinine clearance declines to 40 mL/min. If no information is available about amikacin plasma levels, what would be the most reasonable approach to the management of the patient at this point?
- A.
  
  Administer 5 mg/kg every 12 h
- B.
  
  Decrease the dosage to a daily total of 200 mg
- C.
  
  Decrease the dosage to 180 mg every 8 h
- D.
  
  Discontinue amikacin and switch to gentamicin
- E.
  
  Maintain the patient on the present dosage and test auditory function
3.

All the following statements about the clinical uses of the aminoglycosides are accurate, except
- A.
  
  Effective in the treatment of infections caused by anaerobes such as Bacteroides fragilis
- B.
  
  Gentamycin is used with ampicillin for synergistic effects in the treatment of enterococcal endocarditis.
- C.
  
  In the treatment of a hospital-acquired infection caused by Serratia marcescens, netilmicin is more effective than streptomycin.
- D.
  
  Often used with cephalosporins in the empiric treatment of life-threatening bacterial infections.
- E.
  
  Owing to their polar nature, aminoglycosides are not absorbed after oral administration.
4.

Which statement is accurate regarding the antibacterial action of the aminoglycoside amikacin?
- A.
  
  Antibacterial activity is often reduced by the presence of an inhibitor of cell wall synthesis.
- B.
  
  Antibacterial action is not concentration-dependent.
- C.
  
  Antibacterial action is time-dependent.
- D.
  
  Efficacy is directly proportional to the duration of time that the plasma level is greater than the minimal inhibitory concentration.
- E.
  
  The drug continues to exert antibacterial effects even after plasma levels decrease below detectable levels.
5.

An adult patient (weight 80 kg) has bacteremia suspected to be due to a gram-negative rod. Tobramycin is to be administered using a once-daily dosing regimen, and the loading dose must be calculated to achieve a peak plasma level of 20 mg/L. Assume that the patient has normal renal function. Pharmacokinetic parameters of tobramycin in this patient are as follows: Vd = 30 L; t1/2 = 3 h; CL = 80 mL/min. What should the loading dose be given?
- A.
  
  100 mg
- B.
  
  200 mg
- C.
  
  400 mg
- D.
  
  600 mg
- E.
  
  800 mg
6.

Renal damage is a potential adverse effect of aminoglycosides. In which part of the kidney are aminoglycosides retained due to which this effect is caused?
- A.
  
  Glomerulus
- B.
  
  Distal tubule
- C.
  
  Proximal tubule
- D.
  
  Loop of Henle
7.

Aminoglycosides are not well absorbed from the gut, so they should be delivered via parenteral routes.
- A.
  
  True
- B.
  
  False
8.

Aminoglycosides have no activity against streptococci.
- A.
  
  True
- B.
  
  False
9.

Aminoglycosides are effective against what kind of microorganisms?
- A.
  
  Anaerobic gram-negative bacteria
- B.
  
  Aerobic gram-positive bacteria
- C.
  
  Anaerobic gram-positive bacteria
- D.
  
  Aerobic gram-negative bacteria
10.

Which of the following drugs is NOT an aminoglycoside?
- A.
  
  Neomycin
- B.
  
  Azithromycin
- C.
  
  Amikacin
- D.
  
  Streptomycin