Stimulant Pharmacology (Hoyt)

1. The area of the brain, in which elevated levels of DA and NE release is associated with ADHD treatment is:

Locus ceruleus

Limbic system

Nucleus accumbens

Prefrontal cortex

Striatum

2. The CV associated risks of stimulants such as, elevated systolic and diastolic blood pressures, weak bronchodilator and respiratory stimulant action is associated with peripheral or chronic actions?

Central

Peripheral

3. Cocaine and amphetamines produce their psychoactive effects by potentiating monoaminergic neurotransmission. Which of the following neurotransmitters are monoamines? (Check all that apply)

Acetylcholine

Dopamine

Norepinephrine

Serotonin

All of the above

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4. While stimulants affect both NE and DA levels, the nonstimulant ADHD agent, atomoxetine (strattera) act to selectively inhibit the reuptake of what neurotransmitter?

Acetylcholine

Dopamine

Norepinephrine

Serotonin

Tyramine

5. Approved uses of CNS stimulants include all of the following except:

Attention Deficit Hyperactivity Disorder

Appetite suppression

Migraines

Narcolepsy

All of the above are approved uses for CNS stimulants

6. Stimulants, which increase the levels of DA and NE are contraindicated in which of the following patient population groups? (Check all that apply)

Advanced arteriosclerosis

Agitated states

History of abuse

Symptomatic cardiovascular disease

MAOi user in the past 14 days

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7. There are two agents that are used for narcolepsy, modafinil (provigil) and sodium oxybate (xyrem). Match the mechanism of action with the correct agent pair. (Check 2 that apply)

Modafinil - amphetamine, wakefulness-promoting

Modafinil - non-amphetamine, wakefulness-promoting

Sodium oxybate - CNS depressant, decreases neuronal activation

Sodium oxybate - CNS activator, increases neuronal activation

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