During filtration, as the wall of vessel is increased the centrifugal force is:

No relation between diameter of vessel and centrifugal force

Which of the following factor or factors is/are influenced by Biopharmaceutics?

Protection as well as stability of the drug within the product.

The rate of dissolution of the drug

The availability of the drug at its site of action.

Which of the following statement shows “Bioavailability”?

The rate and extent of drug absorption and its utilization by the body.

The study of the effects of drugs

The movement of the material through a cell membrane

PH-II: Filtration & Biopharmaceutics

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| By RAJAT RASHID

RAJAT RASHID

Community Contributor

Quizzes Created: 2 | Total Attempts: 291

Questions: 10 | Attempts: 173 | Updated: Mar 19, 2023

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PH-II: Filtration & Biopharmaceutics

Questions and Answers

1.

During filtration, as the wall of vessel is increased the centrifugal force is:
- A.
  
  Increased
- B.
  
  Decreased
- C.
  
  Depend upon the filter media
- D.
  
  No relation between diameter of vessel and centrifugal force
Correct Answer
B. Decreased

Explanation
As the wall of the vessel is increased during filtration, the available space for the liquid to flow through decreases. This results in a decrease in the velocity of the liquid, and consequently, a decrease in the centrifugal force acting on the particles in the liquid. Therefore, the centrifugal force is decreased when the wall of the vessel is increased during filtration.

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2.

Glass filtration funnel are made up of
- A.
  
  Soda ash
- B.
  
  Pyrex
- C.
  
  Quartz
- D.
  
  Limestone
Correct Answer
B. Pyrex

Explanation
Pyrex is the correct answer because it is a type of glass that is known for its durability and resistance to thermal shock. It is commonly used in laboratory equipment, including filtration funnels, because it can withstand high temperatures without breaking or shattering. Soda ash, quartz, and limestone are not typically used to make glass filtration funnels.

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3.

Process used to separate insoluble particles from liquids is:
- A.
  
  Drying
- B.
  
  Filtration
- C.
  
  Sieving
- D.
  
  Extraction
Correct Answer
B. Filtration

Explanation
Filtration is the process used to separate insoluble particles from liquids. It involves passing the mixture through a filter medium, such as a porous material or a membrane, which allows the liquid to pass through while trapping the solid particles. This method is commonly used in various industries and laboratories to separate solids from liquids, purify substances, and remove impurities. Filtration is effective in separating particles of different sizes, making it a suitable choice for separating insoluble particles from liquids.

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4.

Which of the following factor or factors is/are influenced by Biopharmaceutics?
- A.
  
  Protection as well as stability of the drug within the product.
- B.
  
  The rate of dissolution of the drug
- C.
  
  The availability of the drug at its site of action.
- D.
  
  All of the above.
Correct Answer
D. All of the above.

Explanation
Biopharmaceutics is the study of how the physical and chemical properties of a drug, as well as the formulation and dosage form, affect its absorption, distribution, metabolism, and excretion in the body. The factors influenced by biopharmaceutics include the protection and stability of the drug within the product, the rate of dissolution of the drug, and the availability of the drug at its site of action. Therefore, the correct answer is "All of the above."

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5.

“Absorption” is not found in which of the following route or routes of administration?
- A.
  
  Oral
- B.
  
  Subcutaneous
- C.
  
  Intramuscular
- D.
  
  Intravenous
Correct Answer
D. Intravenous

Explanation
Intravenous administration is the route of administration where the medication is directly injected into the bloodstream. Absorption refers to the process by which a medication is taken up by the body and enters the bloodstream. Since intravenous administration bypasses the need for absorption, it is not found in this route of administration.

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6.

Drug metabolism is the process that converts chemicals into less polar metabolites so that they are more difficult to excrete.
- A.
  
  True
- B.
  
  False
- C.
  
  N.A.
- D.
  
  N.A.
Correct Answer
B. False

Explanation
The statement is false because drug metabolism actually converts chemicals into more polar metabolites, making them easier to excrete. This process typically involves adding functional groups to the drug molecule, which increases its water solubility and facilitates elimination from the body.

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7.

The plasma drug concentration versus time curve for a drug eliminated by zero order kinetics is linear.
- A.
  
  True
- B.
  
  False
- C.
  
  N.A.
- D.
  
  N.A.
Correct Answer
A. True

Explanation
The statement is true because in zero-order kinetics, the drug is eliminated at a constant rate regardless of its concentration. This means that the plasma drug concentration decreases by a fixed amount over time, resulting in a linear curve when plotted against time.

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8.

The rate of drug transport across a cell membrane by lipid diffusion depends on all of the following EXCEPT:
- A.
  
  Concentration gradient
- B.
  
  Surface area of absorption
- C.
  
  Lipid partition coefficient
- D.
  
  Density of transporters
Correct Answer
D. Density of transporters

Explanation
The rate of drug transport across a cell membrane by lipid diffusion depends on the concentration gradient, surface area of absorption, and lipid partition coefficient. These factors determine the driving force, availability of the membrane surface for absorption, and the solubility of the drug in the lipid bilayer. However, the density of transporters does not directly affect lipid diffusion as it is a passive process that does not involve specific transport proteins.

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9.

Which of the following statement shows “Bioavailability”?
- A.
  
  The body’s reaction to drugs
- B.
  
  The study of the effects of drugs
- C.
  
  The movement of the material through a cell membrane
- D.
  
  The rate and extent of drug absorption and its utilization by the body.
Correct Answer
D. The rate and extent of drug absorption and its utilization by the body.

Explanation
The term "bioavailability" refers to the rate and extent at which a drug is absorbed by the body and its subsequent utilization. This statement directly mentions the key components of bioavailability, which are the rate and extent of drug absorption and its utilization by the body. Therefore, this statement accurately represents the concept of bioavailability.

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10.
A fundamental characteristic of all first order pharmacokinetic processes is that the rate of the process is proportional to drug concentration:
- A.
  
  True
- B.
  
  False
- C.
  
  None of these
- D.
  
  None of these
Correct Answer
A. True

Explanation
The explanation for the given correct answer is that in first order pharmacokinetic processes, the rate of the process is directly proportional to the drug concentration. This means that as the drug concentration increases, the rate of the process also increases, and vice versa. This fundamental characteristic is important in understanding how drugs are absorbed, distributed, metabolized, and eliminated in the body. It helps in predicting the time it takes for a drug to reach its maximum effect and the rate at which it is cleared from the body.

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Current Version
Mar 19, 2023

Quiz Edited by
ProProfs Editorial Team
Mar 14, 2018

Quiz Created by
RAJAT RASHID

pH-II: Filtration & BiopHarmaceutics

During filtration, as the wall of vessel is increased the centrifugal force is:

Glass filtration funnel are made up of

Process used to separate insoluble particles from liquids is:

Which of the following factor or factors is/are influenced by Biopharmaceutics?

“Absorption” is not found in which of the following route or routes of administration?

Drug metabolism is the process that converts chemicals into less polar metabolites so that they are more difficult to excrete.

The plasma drug concentration versus time curve for a drug eliminated by zero order kinetics is linear.

The rate of drug transport across a cell membrane by lipid diffusion depends on all of the following EXCEPT:

Which of the following statement shows “Bioavailability”?

A fundamental characteristic of all first order pharmacokinetic processes is that the rate of the process is proportional to drug concentration: