Pharm Tech Chapter 10 (Basic Biopharmaceutics)

57 Questions | Total Attempts: 4201

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Pharm Tech Chapter 10 (Basic Biopharmaceutics)

How drugs work, concentration & effect, ADME Processes & diffusion, absorption, distribution, metabolism, excretion, bioequivalence


Questions and Answers
  • 1. 
    The subtstantial degradtion of an orally administered drug caused by enzyme metabolism in the liver before the drug reaches the systemic circulation.
    • A. 

      First-pass metabolism

    • B. 

      Dispostion

    • C. 

      Antagonist

    • D. 

      Hydrophilic

  • 2. 
    The increase in hepatic enzyme activity that results in greater metabolism of drugs
    • A. 

      Bioavailability

    • B. 

      Elimination

    • C. 

      Enzyme

    • D. 

      Enzyme induction

  • 3. 
    The study of the factors associated with drug products and physiological processes, and the resulting systemic concentration of drugs.
    • A. 

      Disposition

    • B. 

      Complexation

    • C. 

      Biopharmaceutics

    • D. 

      Bioavailability

  • 4. 
    The comparison of bioavailability between two dosage forms.
    • A. 

      Bioequivalency

    • B. 

      Bioavailablity

    • C. 

      Biopharmaceutics

    • D. 

      Biological

  • 5. 
    The relative amount of an administered dose that reaches the general circulation and the rate at which this occurs
    • A. 

      Biological

    • B. 

      Bioavailability

    • C. 

      Biopharmaceutics

    • D. 

      Bioequivalency

  • 6. 
    Water repelling; cannot associate with water
    • A. 

      Hydrophilic

    • B. 

      Hydrophobic

    • C. 

      Hydraulic

    • D. 

      Hydrogen

  • 7. 
    Capable of associating with or absorbing water
    • A. 

      Hydrophilic

    • B. 

      Hydrophobic

    • C. 

      Hydrologic

    • D. 

      Hydraulic

  • 8. 
    The blood filitering process of the nephron
    • A. 

      Glomerular filtration

    • B. 

      Disposition

    • C. 

      Complexation

    • D. 

      Enzyme

  • 9. 
    The time a drug will stay in the stomach before it is emptied into the small intestine
    • A. 

      Glomerular filtration

    • B. 

      Gastric emptying time

    • C. 

      Disposition

    • D. 

      Agonist

  • 10. 
    The decrease in hepatic enzyme activity that resutls in reduced metabolism of drugs
    • A. 

      First-pass metabolism

    • B. 

      Hydrophilic

    • C. 

      Gastric emptying time

    • D. 

      Enzyme inhibition

  • 11. 
    A complex protien that catalyzes chemical reactions
    • A. 

      Enzyme

    • B. 

      Enzyme induction

    • C. 

      Enzyme inhibition

    • D. 

      Enzymes from fruit

  • 12. 
    The transfer of drugs and their metabolites from the liver to the bile in the gall bladder, then into the intestine, and then back into circulation
    • A. 

      Enzyme

    • B. 

      Enterohepatic cycling

    • C. 

      First-past metabolism

    • D. 

      Glomerular filtration

  • 13. 
    The porcess of metabolism and excretion
    • A. 

      Elimination

    • B. 

      Disposition

    • C. 

      Antagonists

    • D. 

      Absorption

  • 14. 
    The time the drug concentration is above the MEC.
    • A. 

      Elimination

    • B. 

      Dosposition

    • C. 

      Duration of action

    • D. 

      Absorption

  • 15. 
    A term sometimes used to refer to all the ADME processes together.
    • A. 

      Complexation

    • B. 

      Disposition

    • C. 

      Enzyme inhibition

    • D. 

      Enzyme

  • 16. 
    When different molecules associate or attach to each other
    • A. 

      Biopharmaceutics

    • B. 

      Elimination

    • C. 

      Complexation

    • D. 

      Bio hazzard

  • 17. 
    The movement of drugs from an area of the lower cconcentration to an area of higher concentration; requires cellular energy
    • A. 

      Active transport

    • B. 

      Absorption

    • C. 

      Antagonist

    • D. 

      Agonist

  • 18. 
    The movement of drug from the dosage formulation to the blood
    • A. 

      Absorption

    • B. 

      Active transport

    • C. 

      Hydrate

    • D. 

      First-pass metabolism

  • 19. 
    Drugs that activiate receptors to accelerate or slow normal cellular fuction
    • A. 

      Antagonist

    • B. 

      Agonists

    • C. 

      Disposition

    • D. 

      Lipoidal

  • 20. 
    Drugs that bind with receptors but do not activate them
    • A. 

      Agonists

    • B. 

      Antagonist

    • C. 

      Antiviral

    • D. 

      Antibacteria

  • 21. 
    Fat like sustance
    • A. 

      Grease

    • B. 

      Chicken

    • C. 

      Emulsion

    • D. 

      Lipoidal

  • 22. 
    The attachment of a drug molecule to a protien, effectively making the drug inactive
    • A. 

      Metabolite

    • B. 

      Metabolife

    • C. 

      Protien binding

    • D. 

      None of the above

  • 23. 
    The cellular materila which interacts with the drug
    • A. 

      Selective (action)

    • B. 

      Receptor

    • C. 

      Selective (action)

    • D. 

      Onset of action

  • 24. 
    The movment of drugs from and area of higher concentration to lower concentration
    • A. 

      Pharmaceutical alternative

    • B. 

      Passive diffusion

    • C. 

      Receptor

    • D. 

      Site of action

  • 25. 
    The characteristic of a drug that makes it action specific to certain receptors
    • A. 

      Selective (action)

    • B. 

      Passive diffusion

    • C. 

      Nephron

    • D. 

      Nephrons