Pharmacotherapy Antibiotic Review

1. It may be potentially nephrotoxic to administer vanco and gentamicin together.

True

False

2. C. diff is spore producing and one must use special cleaning procedures when dealing with a patient with c. diff.

True

False

3. Which drug causes red "man" syndrome?

Cipro

Gentamicin

Clindamycin

Vanco

4. Oral vanco is used to treat c. diff.

True

False

5. Avoid tigecycline and moxifloxacin in UTIs.

True

False

6. Vanco is good for gram positive organisms only.

True

False

7. Which drugs treat gram positive organisms ONLY?

Vanco, Linezolid, Daptomycin

Vanco, AGs, Daptomycin

Linezolid, Tigecycline, Clindamycin

8. Fluoroquinolones are ____________ dependent killers.

Time

Concentration

9. What is the drug of choice for c diff colitis?

Metronidazole

Clindamycin

Tetracyclines

Daptomycin

10. Which drug's spectrum of activity includes protozoa and anaerobes below the diaphragm?

Clindamycin

Erythromycin

Doxycycline

Tigecycline

Metronidazole

11. Which drug can cause irreversible aplastic anemia and gray baby syndrome?

Daptomycin

Vanco

Chloramphenicol

Rifampin

12. Which drug has a high potential to cause c diff?

Vanco

Daptomycin

Amikacin

Chloramphenicol

Clindamycin

Metronidazole

13. Aminoglycosides are time dependent killers.

True

False

14. Nitrofurantoin is a good choice for UTI prophylaxis in elderly women since no dosage adjustment is needed for renal impairment.

True

False

Bad choice! Dosage adjustment is needed in renal impairment.

Explanation

Bad choice! Dosage adjustment is needed in renal impairment.

15. What is the drug of choice for tickborne pathogens?

Tetracyclines

Tigecycline

FQs

Cephalosporins

16. Tigecycline has good coverage for pseudomonas.

True

False

17. Which drug's spectrum of activity includes aspiration pneumonia, MRSA, mouth flora, and "above the diaphragm anaerobes?"

Daptomycin

Aztreoname

Clindamycin

18. The drug of choice for ESBL producing pathogens...

Macrolides

Daptomycin

Linezolid

Carbapenems

Monobactams

19. What is the drug of choice for Stenotrophomonas maltophilia and pneumocystis jiroveci?

Imipenem

Bactrim

Daptomycin

Aztreonam

Azithromycin

20. Which of the following bugs are atypicals?

Mycoplasma

Legionella pneumophilia

Chlamydia

Submit

21. Tetracyclines can treat CA-MRSA and VRE.

True

False

22. Macrolides, fluconazole, and rifampin are CYP450 inhibitors.

True

False

23. Which of the following bugs are gram positive?

VRE

MRSA

Klebsiella

E coli

Streptococcus pneumoniae

Enterococcus

Staphylococcus aureus

Submit

24. Which is the best choice for lung infections?

FQs and vanco

Macrolides and FQs

Tigecycline and Macrolides

Cephalosporins and FQs

Cephalosporins and Macrolides

25. Monobactams treat ________ organisms only.

Aerobic gram positives

Anaerobic gram positives

Anaerobic gram negatives

Aerobic gram negatives

26. Which of the following is true regarding pencillins?

Time dependent

Concentration dependent

PCN is useful in the treatment of syphilis

Anti-staphylococcal penicillins include dicloxacillin, nafcillin, oxacillin

Submit

27. Which are the drugs of choice for lung tissue penetration?

Quinolones

Macrolides

Daptomycin

Submit

28. Which of the following are true when moving from the 1st to 4th generation cephalosporins?

Increase gram +

Decrease gram +

Increase gram -

Decrease gram -

Reduced susceptibility to destruction by β‐Lactamases

Increased susceptibility to destruction by β‐Lactamases

More chance of cross reactivity with PCNS

Less chance of cross reactivity with PCNS

Submit

29. Rifampin is a CYP450 inhibitor.

True

False

Inducer

Explanation

Inducer

30. Which of the following is true regarding daptomycin?

Good for lung infections

Can cause rhabdomyolysis

Gram positive coverage only

Submit

31. Which of the following are true regarding fluoroquinolones?

Can cause QT prolongation

Can cause tendon rupture

Not recommended for children

Chelates with calcium, magnesium, iron, zinc

Moxifloxacin is good for CAP

Submit

32. Which of the following drugs are static?

Azithromycin

PCNs

Doxycycline

Tigecycline

Submit

33. Which of the following is true regarding tigecycline?

Adjust dosage in hepatic dysfunction

Avoid in bloodstream infections and UTIs

Causes N/V in 30% of patients

Submit

34. Which of the following bugs are anaerobic?

Clostridium

Bacteroides fragilis

Peptostreptococcus

Submit

35. Match the drug with its monitoring parameters.

Daptomycin = WBC / platelets

Daptomycin = CPK (weekly)

Linezolid = WBC / platelets

Clindamycin = WBC / platelets

Aztreoname = WBC / platelets

Submit

36. Which of the following is true regarding cephalosporins?

Time dependent

Concentration dependent

Dosage adjustment in renal failure is needed (except for ceftriaxone)

Cross reactivity with PCNS decreases as the generation increases

Useful for the treatment of enterococcus

"new generation" treats MRSA

Cephalosporins are not useful for the tx of enterococcus!

Explanation

Cephalosporins are not useful for the tx of enterococcus!

Submit

37. Which of the following bugs produce inactivating enzymes?

Penicillinase

Cephalosporinase

MRSA

AmpC

ESBL

Carbapenemase

Submit

38. Which drugs are the best choice for CNS penetration?

Vanco

Ceftriaxone

Metronidazole

Aminoglycosides

Cefepime

Submit

39. Which drugs need to be adjusted in renal dysfunction?

Macrobid

FQs

Rifampin

Daptomycin

Bactrim

Vanco

Penicillin

Ceftriaxone

Submit

40. Which of the following is true regarding carbapenems?

Cilastatin is a beta lactamase inhibitor

Bactericidal like other beta lactams

Allergy of cross reactivity with PCNs around 40% (HIGH!)

Imipenem lowers the seizure threshold

Drugs of choice for ESBL-producing pathogens

Not active against MRSA

Submit

Pharmacotherapy Antibiotic Review

1. It may be potentially nephrotoxic to administer vanco and gentamicin together.

2.

What first name or nickname would you like us to use?

2. C. diff is spore producing and one must use special cleaning procedures when dealing with a patient with c. diff.

3. Which drug causes red "man" syndrome?

4. Oral vanco is used to treat c. diff.

5. Avoid tigecycline and moxifloxacin in UTIs.

6. Vanco is good for gram positive organisms only.

7. Which drugs treat gram positive organisms ONLY?

8. Fluoroquinolones are ____________ dependent killers.

9. What is the drug of choice for c diff colitis?

10. Which drug's spectrum of activity includes protozoa and anaerobes below the diaphragm?

11. Which drug can cause irreversible aplastic anemia and gray baby syndrome?

12. Which drug has a high potential to cause c diff?

13. Aminoglycosides are time dependent killers.

14. Nitrofurantoin is a good choice for UTI prophylaxis in elderly women since no dosage adjustment is needed for renal impairment.

15. What is the drug of choice for tickborne pathogens?

16. Tigecycline has good coverage for pseudomonas.

17. Which drug's spectrum of activity includes aspiration pneumonia, MRSA, mouth flora, and "above the diaphragm anaerobes?"

18. The drug of choice for ESBL producing pathogens...

19. What is the drug of choice for Stenotrophomonas maltophilia and pneumocystis jiroveci?

20. Which of the following bugs are atypicals?

21. Tetracyclines can treat CA-MRSA and VRE.

22. Macrolides, fluconazole, and rifampin are CYP450 inhibitors.

23. Which of the following bugs are gram positive?

24. Which is the best choice for lung infections?

25. Monobactams treat ________ organisms only.

26. Which of the following is true regarding pencillins?

27. Which are the drugs of choice for lung tissue penetration?

28. Which of the following are true when moving from the 1st to 4th generation cephalosporins?

29. Rifampin is a CYP450 inhibitor.

30. Which of the following is true regarding daptomycin?

31. Which of the following are true regarding fluoroquinolones?

32. Which of the following drugs are static?

33. Which of the following is true regarding tigecycline?

34. Which of the following bugs are anaerobic?

35. Match the drug with its monitoring parameters.

36. Which of the following is true regarding cephalosporins?

37. Which of the following bugs produce inactivating enzymes?

38. Which drugs are the best choice for CNS penetration?

39. Which drugs need to be adjusted in renal dysfunction?

40. Which of the following is true regarding carbapenems?