Pharmacology Sulfa And Tmp

18 Questions

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Pharmacology Quizzes & Trivia

SulfasTMPantibiotics actiing on Folic acid synthesis and DNA synthesis


Questions and Answers
  • 1. 
    Which of the following are true about sulfadiazine?
    • A. 

      Most potent Sulfa drug

    • B. 

      Commonly used in combination with TMP

    • C. 

      Used parentally only

    • D. 

      Penetrates Blood brain barrier

    • E. 

      Crystalluria common side effects

  • 2. 
    • A. 

      Increased PABA concentrations decrease their effectiveness

    • B. 

      Inhibit the dihydrofolate enzyme

    • C. 

      Work synergistically with TMP

    • D. 

      Prevents the formation of folic acid

    • E. 

      Bacteriocidal

  • 3. 
    Which organisms are affected by sulfonamides?
    • A. 

      Gram negative rods

    • B. 

      Streptococcus

    • C. 

      Staphylococcus

    • D. 

      E Coli.

    • E. 

      Chlamydiae

  • 4. 
    Which of the following is true about sulfadiazine?
    • A. 

      Excreted by the kidney

    • B. 

      Acetylated in the liver (loss of antimicrobial effect but not toxicity)

    • C. 

      Most Commonly used orally

    • D. 

      Very short halflife

    • E. 

      Binds to serum albumin

  • 5. 
    What are the two most commonly used sulfonamides?
    • A. 

      Sulfadiazene

    • B. 

      Sulfamethoxazole

    • C. 

      Sulfathalidine

    • D. 

      Sulfasoxazole

    • E. 

      Sulfacetamide

  • 6. 
    Which of the following is true regarding sulfonamide kinetics?
    • A. 

      Most are given IV

    • B. 

      Excreted by the kidney primarily

    • C. 

      Acetylated in the liver

    • D. 

      Half-life about 6 hours

    • E. 

      Some are used topically and opthallamically

  • 7. 
    Which adverse effects are associated with Sulfa drugs?
    • A. 

      Crystalluria

    • B. 

      Leukopenia and agranulocytosis

    • C. 

      Cross allergy with furosemide

    • D. 

      Ototoxicity

    • E. 

      Hemolytic anemia (favism)

  • 8. 
    Long acting sulfonamides are associated with ______
    • A. 

      Steven's Johnson's syndrome

    • B. 

      Inflammation of the airway

    • C. 

      Increased patient tolerance

    • D. 

      Increased used with TMP

  • 9. 
    Which of the Following are true statements about Mafenide and Silver sulfadiazene?
    • A. 

      They are both used topically for burns

    • B. 

      Mafenide is painless

    • C. 

      They are both absorbed systemically after topical application

    • D. 

      The Silver adds the the antimicrobial effect

  • 10. 
    Which of the following drugs is used in eye infections because of its high aqueous solubility, and non-irritating nature?
    • A. 

      Sulfamethoxazole

    • B. 

      Sulfazoxazole

    • C. 

      Sulfacetamide

    • D. 

      Salacylazosulfapyridine

    • E. 

      Sulfadiazine

  • 11. 
    Which drug is notably useful in inflammatory bowel disease?
    • A. 

      Sulfasalazine

    • B. 

      Sulfacetamide

    • C. 

      Sulfadiazene

    • D. 

      Salacylazosulfapyridine

    • E. 

      Sulfasoxazole

  • 12. 
    Which of the following about Sulfasalazine (salacylazosulfapyridine)
    • A. 

      Effect is caused in bloodstream

    • B. 

      Most of the effect is due to the sulfa drug

    • C. 

      Greatly absorbed from GI tract

    • D. 

      Not used in inflamed bowel disease

    • E. 

      NSAID causes non-inflammatory effect

  • 13. 
    Which of the following are contraindicated in patients on sulfonamides?
    • A. 

      Oral anticoagulants

    • B. 

      Parenteral anticoagulants

    • C. 

      Oral hypoglycemics

    • D. 

      Parenteral hypoglycemics

    • E. 

      Albumin

  • 14. 
    Which of the following is true about TMP?
    • A. 

      Penetrates the CNS

    • B. 

      Halflife is about 6 hours

    • C. 

      Used with sulfadiazine in combination often

    • D. 

      Resistant organisms lack dihydrofolate reductase

  • 15. 
    Why is TMP selective for bacteria?
    • A. 

      Human dyhidrofolate enzyme is much less sensitive to TMP inhibition

    • B. 

      Humans do not metabolize PABA

    • C. 

      Sulfa drugs cause TMP to work on bacteria alone

    • D. 

      Dihydropteroate synthase enzyme is selective for TMP

  • 16. 
    What are the side effects of TMP?
    • A. 

      Contraindicated in pregnancy

    • B. 

      Leukopenia due to decreased folic acid

    • C. 

      Liver damage

    • D. 

      Renal damage

    • E. 

      Ototoxicity

  • 17. 
    Typically Adverse effects of Bactrim are more effective in which population?
    • A. 

      Anemic children

    • B. 

      Immunocompromised patients

    • C. 

      AIDS patients

    • D. 

      Elderly

    • E. 

      Infants

  • 18. 
    Which of the following is NOT treated by Sulfamethoxazole/TMP combination?
    • A. 

      HAemophilus

    • B. 

      UTIs

    • C. 

      Klebsiella Pneumo

    • D. 

      Pneumocystis jurivicii

    • E. 

      Mycoplasma