Pharmacology Sulfa And Tmp

18 Questions | By Jwells488 | Last updated: Mar 21, 2022 | Total Attempts: 1798

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SulfasTMPantibiotics actiing on Folic acid synthesis and DNA synthesis

Questions and Answers

1.

Which of the following are true about sulfadiazine?
- A.
  
  Most potent Sulfa drug
- B.
  
  Commonly used in combination with TMP
- C.
  
  Used parentally only
- D.
  
  Penetrates Blood brain barrier
- E.
  
  Crystalluria common side effects
2.

Which of the following is true regarding the action of sulfonamides?
- A.
  
  Increased PABA concentrations decrease their effectiveness
- B.
  
  Inhibit the dihydrofolate enzyme
- C.
  
  Work synergistically with TMP
- D.
  
  Prevents the formation of folic acid
- E.
  
  Bacteriocidal
3.

Which organisms are affected by sulfonamides?
- A.
  
  Gram negative rods
- B.
  
  Streptococcus
- C.
  
  Staphylococcus
- D.
  
  E Coli.
- E.
  
  Chlamydiae
4.

Which of the following is true about sulfadiazine?
- A.
  
  Excreted by the kidney
- B.
  
  Acetylated in the liver (loss of antimicrobial effect but not toxicity)
- C.
  
  Most Commonly used orally
- D.
  
  Very short halflife
- E.
  
  Binds to serum albumin
5.

What are the two most commonly used sulfonamides?
- A.
  
  Sulfadiazene
- B.
  
  Sulfamethoxazole
- C.
  
  Sulfathalidine
- D.
  
  Sulfasoxazole
- E.
  
  Sulfacetamide
6.

Which of the following is true regarding sulfonamide kinetics?
- A.
  
  Most are given IV
- B.
  
  Excreted by the kidney primarily
- C.
  
  Acetylated in the liver
- D.
  
  Half-life about 6 hours
- E.
  
  Some are used topically and opthallamically
7.

Which adverse effects are associated with Sulfa drugs?
- A.
  
  Crystalluria
- B.
  
  Leukopenia and agranulocytosis
- C.
  
  Cross allergy with furosemide
- D.
  
  Ototoxicity
- E.
  
  Hemolytic anemia (favism)
8.

Long acting sulfonamides are associated with ______
- A.
  
  Steven's Johnson's syndrome
- B.
  
  Inflammation of the airway
- C.
  
  Increased patient tolerance
- D.
  
  Increased used with TMP
9.

Which of the Following are true statements about Mafenide and Silver sulfadiazene?
- A.
  
  They are both used topically for burns
- B.
  
  Mafenide is painless
- C.
  
  They are both absorbed systemically after topical application
- D.
  
  The Silver adds the the antimicrobial effect
10.

Which of the following drugs is used in eye infections because of its high aqueous solubility, and non-irritating nature?
- A.
  
  Sulfamethoxazole
- B.
  
  Sulfazoxazole
- C.
  
  Sulfacetamide
- D.
  
  Salacylazosulfapyridine
- E.
  
  Sulfadiazine
11.

Which drug is notably useful in inflammatory bowel disease?
- A.
  
  Sulfasalazine
- B.
  
  Sulfacetamide
- C.
  
  Sulfadiazene
- D.
  
  Salacylazosulfapyridine
- E.
  
  Sulfasoxazole
12.

Which of the following about Sulfasalazine (salacylazosulfapyridine)
- A.
  
  Effect is caused in bloodstream
- B.
  
  Most of the effect is due to the sulfa drug
- C.
  
  Greatly absorbed from GI tract
- D.
  
  Not used in inflamed bowel disease
- E.
  
  NSAID causes non-inflammatory effect
13.

Which of the following are contraindicated in patients on sulfonamides?
- A.
  
  Oral anticoagulants
- B.
  
  Parenteral anticoagulants
- C.
  
  Oral hypoglycemics
- D.
  
  Parenteral hypoglycemics
- E.
  
  Albumin
14.

Which of the following is true about TMP?
- A.
  
  Penetrates the CNS
- B.
  
  Halflife is about 6 hours
- C.
  
  Used with sulfadiazine in combination often
- D.
  
  Resistant organisms lack dihydrofolate reductase
15.

Why is TMP selective for bacteria?
- A.
  
  Human dyhidrofolate enzyme is much less sensitive to TMP inhibition
- B.
  
  Humans do not metabolize PABA
- C.
  
  Sulfa drugs cause TMP to work on bacteria alone
- D.
  
  Dihydropteroate synthase enzyme is selective for TMP
16.

What are the side effects of TMP?
- A.
  
  Contraindicated in pregnancy
- B.
  
  Leukopenia due to decreased folic acid
- C.
  
  Liver damage
- D.
  
  Renal damage
- E.
  
  Ototoxicity
17.

Typically Adverse effects of Bactrim are more effective in which population?
- A.
  
  Anemic children
- B.
  
  Immunocompromised patients
- C.
  
  AIDS patients
- D.
  
  Elderly
- E.
  
  Infants
18.

Which of the following is NOT treated by Sulfamethoxazole/TMP combination?
- A.
  
  HAemophilus
- B.
  
  UTIs
- C.
  
  Klebsiella Pneumo
- D.
  
  Pneumocystis jurivicii
- E.
  
  Mycoplasma