Pharmacology Sulfa And Tmp
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SulfasTMPantibiotics actiing on Folic acid synthesis and DNA synthesis
- 1.Which of the following are true about sulfadiazine?
- A.
Most potent Sulfa drug
- B.
Commonly used in combination with TMP
- C.
Used parentally only
- D.
Penetrates Blood brain barrier
- E.
Crystalluria common side effects
- 2.
- A.
Increased PABA concentrations decrease their effectiveness
- B.
Inhibit the dihydrofolate enzyme
- C.
Work synergistically with TMP
- D.
Prevents the formation of folic acid
- E.
Bacteriocidal
- 3.Which organisms are affected by sulfonamides?
- A.
Gram negative rods
- B.
Streptococcus
- C.
Staphylococcus
- D.
E Coli.
- E.
Chlamydiae
- 4.Which of the following is true about sulfadiazine?
- A.
Excreted by the kidney
- B.
Acetylated in the liver (loss of antimicrobial effect but not toxicity)
- C.
Most Commonly used orally
- D.
Very short halflife
- E.
Binds to serum albumin
- 5.What are the two most commonly used sulfonamides?
- A.
Sulfadiazene
- B.
Sulfamethoxazole
- C.
Sulfathalidine
- D.
Sulfasoxazole
- E.
Sulfacetamide
- 6.Which of the following is true regarding sulfonamide kinetics?
- A.
Most are given IV
- B.
Excreted by the kidney primarily
- C.
Acetylated in the liver
- D.
Half-life about 6 hours
- E.
Some are used topically and opthallamically
- 7.Which adverse effects are associated with Sulfa drugs?
- A.
Crystalluria
- B.
Leukopenia and agranulocytosis
- C.
Cross allergy with furosemide
- D.
Ototoxicity
- E.
Hemolytic anemia (favism)
- 8.Long acting sulfonamides are associated with ______
- A.
Steven's Johnson's syndrome
- B.
Inflammation of the airway
- C.
Increased patient tolerance
- D.
Increased used with TMP
- 9.Which of the Following are true statements about Mafenide and Silver sulfadiazene?
- A.
They are both used topically for burns
- B.
Mafenide is painless
- C.
They are both absorbed systemically after topical application
- D.
The Silver adds the the antimicrobial effect
- 10.Which of the following drugs is used in eye infections because of its high aqueous solubility, and non-irritating nature?
- A.
Sulfamethoxazole
- B.
Sulfazoxazole
- C.
Sulfacetamide
- D.
Salacylazosulfapyridine
- E.
Sulfadiazine
- 11.Which drug is notably useful in inflammatory bowel disease?
- A.
Sulfasalazine
- B.
Sulfacetamide
- C.
Sulfadiazene
- D.
Salacylazosulfapyridine
- E.
Sulfasoxazole
- 12.Which of the following about Sulfasalazine (salacylazosulfapyridine)
- A.
Effect is caused in bloodstream
- B.
Most of the effect is due to the sulfa drug
- C.
Greatly absorbed from GI tract
- D.
Not used in inflamed bowel disease
- E.
NSAID causes non-inflammatory effect
- 13.Which of the following are contraindicated in patients on sulfonamides?
- A.
Oral anticoagulants
- B.
Parenteral anticoagulants
- C.
Oral hypoglycemics
- D.
Parenteral hypoglycemics
- E.
Albumin
- 14.Which of the following is true about TMP?
- A.
Penetrates the CNS
- B.
Halflife is about 6 hours
- C.
Used with sulfadiazine in combination often
- D.
Resistant organisms lack dihydrofolate reductase
- 15.Why is TMP selective for bacteria?
- A.
Human dyhidrofolate enzyme is much less sensitive to TMP inhibition
- B.
Humans do not metabolize PABA
- C.
Sulfa drugs cause TMP to work on bacteria alone
- D.
Dihydropteroate synthase enzyme is selective for TMP
- 16.What are the side effects of TMP?
- A.
Contraindicated in pregnancy
- B.
Leukopenia due to decreased folic acid
- C.
Liver damage
- D.
Renal damage
- E.
Ototoxicity
- 17.Typically Adverse effects of Bactrim are more effective in which population?
- A.
Anemic children
- B.
Immunocompromised patients
- C.
AIDS patients
- D.
Elderly
- E.
Infants
- 18.Which of the following is NOT treated by Sulfamethoxazole/TMP combination?
- A.
HAemophilus
- B.
UTIs
- C.
Klebsiella Pneumo
- D.
Pneumocystis jurivicii
- E.
Mycoplasma
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