Pharmacology II Quiz 3

2.

Anhidrosis and hyperactive bowel sounds are associated with serotonin syndrome.

True
False

Correct Answer

A. False

Explanation

Diaphoresis (sweating) not anhidrosis (lack of sweating) is associated with serotonin syndrome.

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3.

Serotonin syndrome is classified as an idiosyncratic drug reaction.

True
False

Correct Answer

A. False

Explanation

Not an idiosyncratic drug reaction.

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4.

Serotonin syndrome caused by the interaction of fentanyl and citalopram would be classified as a pharmacodynamic interaction.

True
False

Correct Answer

A. True

Explanation

When fentanyl and citalopram interact, they can cause serotonin syndrome, which is a potentially life-threatening condition. Serotonin syndrome occurs when there is an excessive accumulation of serotonin in the brain. This interaction is classified as a pharmacodynamic interaction because it involves the effects of the drugs on the body's response, rather than a pharmacokinetic interaction which involves the drugs' absorption, distribution, metabolism, and excretion. Therefore, the given answer that this interaction is a pharmacodynamic interaction is correct.

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5.

Meperidine blocks both serotonin reuptake and potentiates the firing of serotonergic neurons.

True
False

Correct Answer

A. True

Explanation

Meperidine is a medication that belongs to the class of opioids. It is known to have dual effects on serotonin. Firstly, it blocks the reuptake of serotonin, leading to increased levels of serotonin in the synaptic cleft. Secondly, it potentiates the firing of serotonergic neurons, which means it enhances the activity of these neurons. Therefore, the statement that meperidine blocks both serotonin reuptake and potentiates the firing of serotonergic neurons is true.

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6.

St. John's Wort is safe to use with a MAO inhibitor but not safe to use with an SSRI.

True
False

Correct Answer

A. False

Explanation

St. John's Wort not safe with either.

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7.

5-HT2A inhibitors are located on the pre-synaptic terminal.

True
False

Correct Answer

A. False

Explanation

These are receptors on the post synaptic terminal.

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8.

Serotonin syndrome is not fatal.

True
False

Correct Answer

A. False

Explanation

Serotonin syndrome is a potentially life-threatening condition caused by an excess of serotonin in the body. It can occur when certain medications, such as antidepressants, are taken in combination or at high doses. Symptoms of serotonin syndrome include agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, and muscle rigidity. In severe cases, it can lead to seizures, organ failure, and even death. Therefore, the statement "Serotonin syndrome is not fatal" is incorrect.

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9.

Recommending an anti-cholinergic to treat the symptoms of serotonin syndrome is a good choice.

True
False

Correct Answer

A. False

Explanation

It is not a good choice to recommend an anti-cholinergic to treat the symptoms of serotonin syndrome. Serotonin syndrome is caused by an excess of serotonin in the brain, and anti-cholinergic medications work by blocking the effects of acetylcholine, a different neurotransmitter. Therefore, anti-cholinergics would not be effective in treating serotonin syndrome and may even worsen the symptoms.

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10.

Hyperthermia, muscle rigidity, myoclonus, twitching, and tremor are all symptoms of serotonin syndrome.

True
False

Correct Answer

A. True

Explanation

Hyperthermia, muscle rigidity, myoclonus, twitching, and tremor are indeed symptoms of serotonin syndrome. Serotonin syndrome is a potentially life-threatening condition caused by an excess of serotonin in the brain. It can occur when certain medications, such as selective serotonin reuptake inhibitors (SSRIs), are taken in combination or at high doses. These symptoms are indicative of the overstimulation of serotonin receptors in the central nervous system, leading to increased muscle activity and elevated body temperature. Prompt medical attention is necessary if serotonin syndrome is suspected.

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Pharmacology II Quiz 3

If severe symptoms of serotonin syndrome are present, this drug is recommended for therapy.

Quiz Preview

Anhidrosis and hyperactive bowel sounds are associated with serotonin syndrome.

Serotonin syndrome is classified as an idiosyncratic drug reaction.

Serotonin syndrome caused by the interaction of fentanyl and citalopram would be classified as a pharmacodynamic interaction.

Meperidine blocks both serotonin reuptake and potentiates the firing of serotonergic neurons.

St. John's Wort is safe to use with a MAO inhibitor but not safe to use with an SSRI.

5-HT2A inhibitors are located on the pre-synaptic terminal.

Serotonin syndrome is not fatal.

Recommending an anti-cholinergic to treat the symptoms of serotonin syndrome is a good choice.

Hyperthermia, muscle rigidity, myoclonus, twitching, and tremor are all symptoms of serotonin syndrome.