Pharm Practice Exam 2
Antimicrobials, bronchitis, pneumonia, tuberculosis, URI
- 1.A patient's rapid strep test reveals she has group A strep, but you find she has a penicillin allergy. What is an appropriate reaction to this situation?
- A.
Prescribe levofloxacin
- B.
Prescribe cefaclor
- C.
Prescribe gentamicin
- D.
Desensitize her to penicillin
- 2.Which of the following is a gram negative anaerobe?
- A.
Peptostreptococcus
- B.
Moraxella
- C.
Staph aureus
- D.
Bacteroides
- 3.What would be used to treat the organism in question 2?
- A.
A nitroimidazole
- B.
A sulfa
- C.
A glycopeptide
- D.
A fluoroquinolone
- 4.Which of the following does not work by affecting protein synthesis?
- A.
Tetracyclines
- B.
Lincosamides
- C.
Thienamycins
- D.
Macrolides
- 5.Which of the following works by inhibiting the DNA gyrase of bacteria?
- A.
Sulfa drugs
- B.
Fluoroquinolones
- C.
Aminoglycosides
- D.
Cephalosporins
- 6.Which penicillin is incorrectly matched to its subclass?
- A.
Ampicillin - carboxypenicillin
- B.
Benzathine penacillin - natural penicillin
- C.
Nafcillin - penicillinase-resistant penicillins
- D.
Pipercillin - ureidopenicillins
- 7.Which of the following could be used in the case of a pneumonia caused by pseudomonas?
- A.
Oxacillin
- B.
Penicillin G
- C.
Piperacillin
- D.
Amoxicillin
- 8.Which of the following does not require a dose adjustment for renal or hepatic insufficiency?
- A.
Chloramphenicol
- B.
Daptomycin
- C.
Cefclidine
- D.
Linezolid
- 9.In order to treat a nafcillin-resistant strain of staph aureus, you have used the "drug of choice." Which of the following side effects might cause you to change to one of the alternatives, such as trimethoprim-sulfamethaxazole?
- A.
Red Man's Syndrome and ototoxicity
- B.
Torsades de pointes and arthropathy
- C.
Excessive bleeding due to its interaction with warfarin binding proteins
- D.
Pseudomembranous colitis
- 10.Which of the following macrolides is a concern for interactions due to its CYP450 metabolism?
- A.
Clarithromycin
- B.
Azithromycin
- C.
Erythromycin
- D.
Telithromycin
- 11.Which of the following cephalosporins is matched correctly to its generation?
- A.
Cefuroxime - group 2
- B.
Cefoxitin - group 1
- C.
Cefepime - group 4
- D.
Cefmetazole - group 3
- 12.What is the mode of action of the thienamycins?
- A.
Binds to the interface between the 30S and 50S ribosomal subunits, decreasing bacterial protein synthesis
- B.
Binds reversibly to the 30S subunit of the ribosome, preventing protein synthesis
- C.
Inhibit cross-linking enzymes during cell wall formation
- D.
Binds to the D-alanyl-D-alanine terminal residue in the peptidoglycan chain, inhibiting cell wall formation
- 13.Which of the following drugs causes gray-brown tooth discoloration?
- A.
Tetracycline
- B.
Minocycline
- C.
Doxycycline
- D.
Azithromycine
- 14.Which would be a bad choice in fighting an infection caused by gram negative anaerobes?
- A.
Trovafloxacin
- B.
Clindamycin
- C.
Meropenem
- D.
Aztronam
- 15.What class of antibiotics does aztreonam belong to?
- A.
Thienamycins
- B.
Lincosamides
- C.
Monobactams
- D.
Oxalinediones
- 16.Which of the following is very active against gram negative aerobic organisms, including pseudomonas?
- A.
Tetracyclines
- B.
Chloramphenicol
- C.
Streptogramins
- D.
Aminoglycosides
- 17.Which drug works by binding to bacterial cell membranes, causing rapid depolarization of the membrane potential, leading to bacterial cell death?
- A.
Quinupristin/dalfopristin
- B.
Ciprofloxacin
- C.
Daptomycin
- D.
Linezolid
- 18.Which drug does not belong to the broad class of protein-synthesis active drugs?
- A.
Gentamicin
- B.
Vancomycin
- C.
Erythromycin
- D.
Clindamycin
- 19.Although this drug has no activity against gram positive species, it is a good substitute for the aminoglycosides in patients at risk for nephrotoxicity:
- A.
Amoxicillin/clavulanic acid
- B.
Procaine penicillin
- C.
Azetreonam
- D.
Erythromycin
- 20.While you are treating a very sick child with an enterobacter aspiration pneumonia, you find that he is getting Stevens-Johnson Syndrome (cell death causing the epidermis to separate from the dermis). Which is a good alternative treatment?
- A.
Trimethoprim/sulfamethoxazone
- B.
Meropenem
- C.
Cefoxitin
- D.
Dicloxacilin
- 21.Which would not be an appropriate treatment for a bacterial meningitis?
- A.
Ampicillin
- B.
Ceftriaxone
- C.
Amikacin
- D.
Vancomycin
- 22.Formation of crystalluria is a concern in which of the following?
- A.
Glycopeptides
- B.
Sulfas
- C.
Nitroimidazoles
- D.
Fluoroquinolones
- 23.Which of the following does not work by binding to the 50S ribosomal subunit, which inhibits early and late bacterial protein synthesis?
- A.
Streptogramins
- B.
Oxalinedions
- C.
Lincosamides
- D.
Tetracyclines
- 24.Which of the following is correctly matched?
- A.
Lincosamides - clarythromycin
- B.
Lipopeptides - erythromycin
- C.
Glycopeptides - vancomycin
- D.
Lipopetides - clindamycin
- 25.Which of the following is used for urinary tract infections only, since it is not a systemic agent?
- A.
Moxifloxacin
- B.
Norfloxacin
- C.
Ciprofloxacin
- D.
Sparfloxacin
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