Ch 40 Antibiotics Affecting Protein Synthesis
Quiz for Ch 40 Antibiotics affecting protein synthesisGSU Fall 2009
- 1.Patients with aminoglycodise therapy should be monitored for
- A.
Cardiotoxicity and nephrotoxicity
- B.
Ototoxicity and nephrotoxicity
- C.
Peripheral neuropathy and cardiotoxicity
- D.
Hepatotoxicity and ototoxicity
- 2.What is the correct time to obtain a trough level of gentamicin?
- A.
30 min after IM administration
- B.
60 min after IV administration
- C.
2 h before the next dose
- D.
30 min before the next dose
- 3.Which of the following statements about drug-drug interactions with gentamicin is correct? There are
- A.
Many interactions, and most are very significant
- B.
Many interactions, and most are significant
- C.
Very few interactions, and most are significant
- D.
Very few interactions, and most are insignificant
- 4.The appropriate route of administration for neomycin is
- A.
PO
- B.
SC
- C.
IM
- D.
IV
- 5.Clindamycin is reserved for the management of
- A.
Severe systemic gram-positive bacteria
- B.
Severe systemic gram-negative bacteria
- C.
Infections by bacteria with known sensitivity
- D.
Anaerobes only
- 6.Although clindamycin is reserved for serious infections, topical clindamycin is useful in the treatment of
- A.
Hives
- B.
Stevens-Johnson syndrome
- C.
Acne vulgaris
- D.
Pruritus
- 7.Clindamycin is associated with the development of
- A.
Hearing loss
- B.
Pseudomembranous colitis
- C.
Azotemia
- D.
Migraine headaches
- 8.The antibiotic class of choice for penicillin-allergic patients is
- A.
Cephalosporins
- B.
Macrolides
- C.
Fluoroquinolones
- D.
Aminoglycosides
- 9.The most common adverse effects of erythromycin affect the _______ system
- A.
Central nervous
- B.
Respiratory
- C.
Hematopoietic
- D.
GI
- 10.A benefit of clarithromycin therapy is
- A.
Twice a day dosing
- B.
That it is less expensive than erythromycin
- C.
Alternate-day dosing
- D.
All of the above
- 11.The pharmacokinetics of linezolid is unusual in that
- A.
The oral formulation has a duration twice as long as the IV formulation
- B.
The oral formulation has 100% bioavailability
- C.
The Iv formulation has 98% bioavailability
- D.
The IV onset is longer than the PO onset
- 12.The most common adverse effects associated with the use of linezolid include
- A.
Pseudomembranous colitis
- B.
Rebound hypertension
- C.
Diarrhea, headache, nausea, and vomiting
- D.
Constipation
- 13.Quinupristin/dalfopristin is indicated for the management of
- A.
Brain absesses
- B.
Pseudomembranous colitis
- C.
Trichomoniasis
- D.
VRE
- 14.Potential serious adverse effects to quinupristin/dalfopristin include all of the following except
- A.
Pseudomembranous colitis
- B.
Superinfection
- C.
Nephrotoxicity
- D.
Hepatotoxicity
- 15.During quinupristin/dalfopristin therapy, the nurse should arrange for which of the following lab tests?
- A.
Hepatic function and bilirubin
- B.
CBC and renal function
- C.
Hepatic and renal function
- D.
CBC and hepatic function
- 16.To maximize the absorption of tetracycline, the patient should avoid concurrent administration of
- A.
Antacids
- B.
Fluids
- C.
Corticosteroids
- D.
All of the above
- 17.Chloramphenicol is the drug of choice in the treatment of
- A.
MRSA
- B.
Serious systemic fungal infections
- C.
Brain absesses
- D.
Urinary tract infections
- 18.A serious adverse effect associated with chloramphenicol therapy in newborn infants is
- A.
Gray baby syndrome
- B.
Red neck syndrome
- C.
Pseudomembranous colitis
- D.
Hypotension
- 19.In an adult, a common serious adverse effect associated with chloramphenicol therapy is
- A.
Hepatic insufficiency
- B.
Diverticulitis
- C.
CNS depression
- D.
Aplastic anemia
- 20.Your patient is receiving IV gentamicin therapy. After the blood tech draws a specimen, the patient asks, "Why are they taking so much blood?" Which is the best response?
- A.
"They want to be sure this is the right drug for you"
- B.
"It is important to keep gentamicin levels within a certain range to avoid adverse effects"
- C.
"The lab frequently makes mistakes and has to redraw the specimen"
- D.
"The are really only taking a little bit each time"
- 21.Your patient has been receiving IV gentamicin for the past 2 days. The patient is scheduled for surgery today. To ensure the patient's safety, you should
- A.
Be sure to tape a note to the front of the chart documenting the administration of gentamicin
- B.
Refrain from giving any benzodiazepine as a preoperative medicine
- C.
Refrain from giving any anticholinergic before surgery
- D.
Ask the anesthesiologist for an increased dose of premedication
- 22.Your patient is to start PO clindamycin. To maximize the therapeutic effects of the drug, you should administer the first dose
- A.
On an empty stomach
- B.
With a high-fat meal
- C.
With small, frequent meals
- D.
With grapefruit juice
- 23.Your patient is using clindamycin lotion on her skin. The patient reports that her skin is extremely dry. You would suggest
- A.
Hydration
- B.
Moisturizing cream
- C.
Hydration and moisturizing cream
- D.
Soaking in a bathtub
- 24.Your patient is hospitalized with a serious infection and is receiving IV clindamycin. This patient should be monitored for which of the following symptoms?
- A.
Rash
- B.
Facial ridgidity
- C.
Resp depression
- D.
Blood tinged diarrhea
- 25.Your 55 yo patient has had type 1 diabetes since the age of 12 years and experiences diabetic gastroparesis. Which of the following drugs may be helpful in this disorder?
- A.
Cefixime
- B.
Neomycin
- C.
Erythromycin
- D.
Lincomycin
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