Quiz for Ch 40 Antibiotics affecting protein synthesisGSU Fall 2009
Cardiotoxicity and nephrotoxicity
Ototoxicity and nephrotoxicity
Peripheral neuropathy and cardiotoxicity
Hepatotoxicity and ototoxicity
30 min after IM administration
60 min after IV administration
2 h before the next dose
30 min before the next dose
Many interactions, and most are very significant
Many interactions, and most are significant
Very few interactions, and most are significant
Very few interactions, and most are insignificant
PO
SC
IM
IV
Severe systemic gram-positive bacteria
Severe systemic gram-negative bacteria
Infections by bacteria with known sensitivity
Anaerobes only
Hives
Stevens-Johnson syndrome
Acne vulgaris
Pruritus
Hearing loss
Pseudomembranous colitis
Azotemia
Migraine headaches
Cephalosporins
Macrolides
Fluoroquinolones
Aminoglycosides
Central nervous
Respiratory
Hematopoietic
GI
Twice a day dosing
That it is less expensive than erythromycin
Alternate-day dosing
All of the above
The oral formulation has a duration twice as long as the IV formulation
The oral formulation has 100% bioavailability
The Iv formulation has 98% bioavailability
The IV onset is longer than the PO onset
Pseudomembranous colitis
Rebound hypertension
Diarrhea, headache, nausea, and vomiting
Constipation
Brain absesses
Pseudomembranous colitis
Trichomoniasis
VRE
Pseudomembranous colitis
Superinfection
Nephrotoxicity
Hepatotoxicity
Hepatic function and bilirubin
CBC and renal function
Hepatic and renal function
CBC and hepatic function
Antacids
Fluids
Corticosteroids
All of the above
MRSA
Serious systemic fungal infections
Brain absesses
Urinary tract infections
Gray baby syndrome
Red neck syndrome
Pseudomembranous colitis
Hypotension
Hepatic insufficiency
Diverticulitis
CNS depression
Aplastic anemia
"They want to be sure this is the right drug for you"
"It is important to keep gentamicin levels within a certain range to avoid adverse effects"
"The lab frequently makes mistakes and has to redraw the specimen"
"The are really only taking a little bit each time"
Be sure to tape a note to the front of the chart documenting the administration of gentamicin
Refrain from giving any benzodiazepine as a preoperative medicine
Refrain from giving any anticholinergic before surgery
Ask the anesthesiologist for an increased dose of premedication
On an empty stomach
With a high-fat meal
With small, frequent meals
With grapefruit juice
Hydration
Moisturizing cream
Hydration and moisturizing cream
Soaking in a bathtub
Rash
Facial ridgidity
Resp depression
Blood tinged diarrhea
Cefixime
Neomycin
Erythromycin
Lincomycin