Ch 40 Antibiotics Affecting Protein Synthesis

41 Questions | Total Attempts: 68

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Ch 40 Antibiotics Affecting Protein Synthesis

Quiz for Ch 40 Antibiotics affecting protein synthesisGSU Fall 2009


Questions and Answers
  • 1. 
    Patients with aminoglycodise therapy should be monitored for
    • A. 

      Cardiotoxicity and nephrotoxicity

    • B. 

      Ototoxicity and nephrotoxicity

    • C. 

      Peripheral neuropathy and cardiotoxicity

    • D. 

      Hepatotoxicity and ototoxicity

  • 2. 
    What is the correct time to obtain a trough level of gentamicin?
    • A. 

      30 min after IM administration

    • B. 

      60 min after IV administration

    • C. 

      2 h before the next dose

    • D. 

      30 min before the next dose

  • 3. 
    Which of the following statements about drug-drug interactions with gentamicin is correct? There are
    • A. 

      Many interactions, and most are very significant

    • B. 

      Many interactions, and most are significant

    • C. 

      Very few interactions, and most are significant

    • D. 

      Very few interactions, and most are insignificant

  • 4. 
    The appropriate route of administration for neomycin is
    • A. 

      PO

    • B. 

      SC

    • C. 

      IM

    • D. 

      IV

  • 5. 
    Clindamycin is reserved for the management of
    • A. 

      Severe systemic gram-positive bacteria

    • B. 

      Severe systemic gram-negative bacteria

    • C. 

      Infections by bacteria with known sensitivity

    • D. 

      Anaerobes only

  • 6. 
    Although clindamycin is reserved for serious infections, topical clindamycin is useful in the treatment of 
    • A. 

      Hives

    • B. 

      Stevens-Johnson syndrome

    • C. 

      Acne vulgaris

    • D. 

      Pruritus

  • 7. 
    Clindamycin is associated with the development of
    • A. 

      Hearing loss

    • B. 

      Pseudomembranous colitis

    • C. 

      Azotemia

    • D. 

      Migraine headaches

  • 8. 
    The antibiotic class of choice for penicillin-allergic patients is
    • A. 

      Cephalosporins

    • B. 

      Macrolides

    • C. 

      Fluoroquinolones

    • D. 

      Aminoglycosides

  • 9. 
    The most common adverse effects of erythromycin affect the _______ system
    • A. 

      Central nervous

    • B. 

      Respiratory

    • C. 

      Hematopoietic

    • D. 

      GI

  • 10. 
    A benefit of clarithromycin therapy is 
    • A. 

      Twice a day dosing

    • B. 

      That it is less expensive than erythromycin

    • C. 

      Alternate-day dosing

    • D. 

      All of the above

  • 11. 
    The pharmacokinetics of linezolid is unusual in that
    • A. 

      The oral formulation has a duration twice as long as the IV formulation

    • B. 

      The oral formulation has 100% bioavailability

    • C. 

      The Iv formulation has 98% bioavailability

    • D. 

      The IV onset is longer than the PO onset

  • 12. 
    The most common adverse effects associated with the use of linezolid include
    • A. 

      Pseudomembranous colitis

    • B. 

      Rebound hypertension

    • C. 

      Diarrhea, headache, nausea, and vomiting

    • D. 

      Constipation

  • 13. 
    Quinupristin/dalfopristin is indicated for the management of
    • A. 

      Brain absesses

    • B. 

      Pseudomembranous colitis

    • C. 

      Trichomoniasis

    • D. 

      VRE

  • 14. 
    Potential serious adverse effects to quinupristin/dalfopristin include all of the following except
    • A. 

      Pseudomembranous colitis

    • B. 

      Superinfection

    • C. 

      Nephrotoxicity

    • D. 

      Hepatotoxicity

  • 15. 
    During quinupristin/dalfopristin therapy, the nurse should arrange for which of the following lab tests?
    • A. 

      Hepatic function and bilirubin

    • B. 

      CBC and renal function

    • C. 

      Hepatic and renal function

    • D. 

      CBC and hepatic function

  • 16. 
    To maximize the absorption of tetracycline, the patient should avoid concurrent administration of 
    • A. 

      Antacids

    • B. 

      Fluids

    • C. 

      Corticosteroids

    • D. 

      All of the above

  • 17. 
    Chloramphenicol is the drug of choice in the treatment of 
    • A. 

      MRSA

    • B. 

      Serious systemic fungal infections

    • C. 

      Brain absesses

    • D. 

      Urinary tract infections

  • 18. 
    A serious adverse effect associated with chloramphenicol therapy in newborn infants is
    • A. 

      Gray baby syndrome

    • B. 

      Red neck syndrome

    • C. 

      Pseudomembranous colitis

    • D. 

      Hypotension

  • 19. 
    In an adult, a common serious adverse effect associated with chloramphenicol therapy is
    • A. 

      Hepatic insufficiency

    • B. 

      Diverticulitis

    • C. 

      CNS depression

    • D. 

      Aplastic anemia

  • 20. 
    Your patient is receiving IV gentamicin therapy. After the blood tech draws a specimen, the patient asks, "Why are they taking so much blood?" Which is the best response?
    • A. 

      "They want to be sure this is the right drug for you"

    • B. 

      "It is important to keep gentamicin levels within a certain range to avoid adverse effects"

    • C. 

      "The lab frequently makes mistakes and has to redraw the specimen"

    • D. 

      "The are really only taking a little bit each time"

  • 21. 
    Your patient has been receiving IV gentamicin for the past 2 days. The patient is scheduled for surgery today. To ensure the patient's safety, you should
    • A. 

      Be sure to tape a note to the front of the chart documenting the administration of gentamicin

    • B. 

      Refrain from giving any benzodiazepine as a preoperative medicine

    • C. 

      Refrain from giving any anticholinergic before surgery

    • D. 

      Ask the anesthesiologist for an increased dose of premedication

  • 22. 
    Your patient is to start PO clindamycin. To maximize the therapeutic effects of the drug, you should administer the first dose
    • A. 

      On an empty stomach

    • B. 

      With a high-fat meal

    • C. 

      With small, frequent meals

    • D. 

      With grapefruit juice

  • 23. 
    Your patient is using clindamycin lotion on her skin. The patient reports that her skin is extremely dry. You would suggest
    • A. 

      Hydration

    • B. 

      Moisturizing cream

    • C. 

      Hydration and moisturizing cream

    • D. 

      Soaking in a bathtub

  • 24. 
    Your patient is hospitalized with a serious infection and is receiving IV clindamycin. This patient should be monitored for which of the following symptoms?
    • A. 

      Rash

    • B. 

      Facial ridgidity

    • C. 

      Resp depression

    • D. 

      Blood tinged diarrhea

  • 25. 
    Your 55 yo patient has had type 1 diabetes since the age of 12 years and experiences diabetic gastroparesis. Which of the following drugs may be helpful in this disorder?
    • A. 

      Cefixime

    • B. 

      Neomycin

    • C. 

      Erythromycin

    • D. 

      Lincomycin

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