Pharm Mt 1 Part III

27 Questions | Total Attempts: 61

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Pharm Mt 1 Part III

Principles of Pharm (Pgs. 19-26)


Questions and Answers
  • 1. 
    Why is it that the cornea is a difficult tissue for drugs to penetrate?
  • 2. 
    What is the definition for 'volume of distribution of a drug'?
  • 3. 
    Explain why azithromycin (Z-Pak) can deliver the equivalent of 7-10 days of therapy with 5 days of dosing.
  • 4. 
    The drug propofol (Diprivan) has a short duration of action due to the rapid re-distribution to other tissues via the ____ system.
    • A. 

      Gastrointestinal

    • B. 

      Respiratory

    • C. 

      Cardiovascular

    • D. 

      CNS

  • 5. 
    There are substrates, inhibitors, and inducers for oral meds under the OD scope of practice
    • A. 

      True

    • B. 

      False

  • 6. 
    Check ALL the factors that allow a drug to more easily across plasma membranes.
    • A. 

      Smaller molecular structure

    • B. 

      Water-soluble

    • C. 

      Ionization

  • 7. 
    Ionization makes a drug molecule _____ lipid-soluble
  • 8. 
    Which of the following conditions DOES NOT result in hypoalbuinermia (low serum albumin levels)?
    • A. 

      Renal dialysis patients

    • B. 

      Burn patients

    • C. 

      Elderly patients with chronic disease states

    • D. 

      Malnourished patients

    • E. 

      None of the above (they all result in hypoalbumineria)

  • 9. 
    In general, clinically significant drug interactions are more likely to occur between substrates and either inhibitors and induces of _____ CYP enzyme(s).
  • 10. 
    Which of the following drugs can result in optic neuritis/neuropathy and can deposit in the cornea and affect vision?
    • A. 

      Phenytoin (Dylantin)

    • B. 

      Mannitol with cisplatinum

    • C. 

      Propofol (Diprivan)

    • D. 

      Amiodarone (Pacerone, Cordarone)

  • 11. 
    Which of the following does NOT require energy nor a transport carrier?
    • A. 

      Passive diffusion

    • B. 

      Carrier-assisted diffusion

    • C. 

      Hydrophillic channels

    • D. 

      Active transport

    • E. 

      More than one of the above

    • F. 

      All of the above require either energy or a transport carrier

  • 12. 
    ACE Inhibitors are an example of a type of drug that results in a drug becoming ____ active than the parent drug
    • A. 

      More

    • B. 

      Less

  • 13. 
    What percent of patients taking amiodarone present with corneal microdeposits?
    • A. 

      1%

    • B. 

      10%

    • C. 

      50%

    • D. 

      90%

  • 14. 
    What most commonly occurs in CYP inhibition?
    • A. 

      Inhibitor drug metabolizes to CYP enzyme

    • B. 

      Inhibitor drug prevents absorption of CYP enzyme

    • C. 

      Inhibitor drug competitively binds to active site of enzyme

    • D. 

      None of the above

  • 15. 
    Pharmacologic metabolic processes often result in drugs becoming more _____ and more _____-soluble.
  • 16. 
    What are potential consequences of drug deposition?
    • A. 

      Faster drug release

    • B. 

      Slower drug release

    • C. 

      Changes in the tissue

    • D. 

      Drug inactivation

    • E. 

      More than one of the above

  • 17. 
    What general category of antibiotics can lead to permanent teeth staining when given to a child before the age of 8?
    • A. 

      Sulfa drugs

    • B. 

      Cephalosporins

    • C. 

      Tetracyclins

    • D. 

      Aminoglycosides

  • 18. 
    There is more than one cytochrom P450 enzyme
    • A. 

      True

    • B. 

      False

  • 19. 
    Where are P450 isoenzymes located specifically in the liver?
    • A. 

      Nucleus of hepatocytes

    • B. 

      Golgi of hepatocytes

    • C. 

      Plasma membrane of hepatocytes

    • D. 

      Endoplasmic recticulum of hepatocytes

  • 20. 
    Which of the following is NOT part of microsomal (P450) oxidation reactions?
    • A. 

      Hydroxylation

    • B. 

      Azo-reduction

    • C. 

      Oxidation

    • D. 

      Polarizing atom exchange

  • 21. 
    Unbound, or free drugs (aka not bound to serum proteins) will reach __________ between the blood and tissues.
  • 22. 
    Metabolic reactions can transform an active drug into a less active form or into inactive metabolites.  Metabolic reactions can also transform a prodrug into a more active drug or metabolite.
    • A. 

      True

    • B. 

      False

  • 23. 
    Choose ALL of the reactions that fall under Phase II reactions:
    • A. 

      Glucuronide conjugation

    • B. 

      Dealkylation

    • C. 

      Ethereal sulfate conjugation

    • D. 

      Acetylation

    • E. 

      Transulfuration

    • F. 

      Glutathion conjugation

  • 24. 
    In Phase I reactions, drugs are ___________ or ___________. In Phase II reactions, a polar molecular group is __________ to the drug which increases its polarity.
  • 25. 
    During drug metabolism, what is the general trend that occurs?
    • A. 

      Drugs become more hydrophobic

    • B. 

      Drugs become increasingly less active

    • C. 

      Drugs are deposited more on various tissues

    • D. 

      Drugs become more polar

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