1.
Why is it that the cornea is a difficult tissue for drugs to penetrate?
2.
What is the definition for 'volume of distribution of a drug'?
3.
Explain why azithromycin (Z-Pak) can deliver the equivalent of 7-10 days of therapy with 5 days of dosing.
4.
The drug propofol (Diprivan) has a short duration of action due to the rapid re-distribution to other tissues via the ____ system.
A. 
B. 
C. 
D. 
5.
There are substrates, inhibitors, and inducers for oral meds under the OD scope of practice
6.
Check ALL the factors that allow a drug to more easily across plasma membranes.
A. 
Smaller molecular structure
B. 
C. 
7.
Ionization makes a drug molecule _____ lipid-soluble
8.
Which of the following conditions DOES NOT result in hypoalbuinermia (low serum albumin levels)?
A. 
B. 
C. 
Elderly patients with chronic disease states
D. 
E. 
None of the above (they all result in hypoalbumineria)
9.
In general, clinically significant drug interactions are more likely to occur between substrates and either inhibitors and induces of _____ CYP enzyme(s).
10.
Which of the following drugs can result in optic neuritis/neuropathy and can deposit in the cornea and affect vision?
A. 
B. 
Mannitol with cisplatinum
C. 
D. 
Amiodarone (Pacerone, Cordarone)
11.
Which of the following does NOT require energy nor a transport carrier?
A. 
B. 
Carrier-assisted diffusion
C. 
D. 
E. 
More than one of the above
F. 
All of the above require either energy or a transport carrier
12.
ACE Inhibitors are an example of a type of drug that results in a drug becoming ____ active than the parent drug
13.
What percent of patients taking amiodarone present with corneal microdeposits?
A. 
B. 
C. 
D. 
14.
What most commonly occurs in CYP inhibition?
A. 
Inhibitor drug metabolizes to CYP enzyme
B. 
Inhibitor drug prevents absorption of CYP enzyme
C. 
Inhibitor drug competitively binds to active site of enzyme
D. 
15.
Pharmacologic metabolic processes often result in drugs becoming more _____ and more _____-soluble.
16.
What are potential consequences of drug deposition?
A. 
B. 
C. 
D. 
E. 
More than one of the above
17.
What general category of antibiotics can lead to permanent teeth staining when given to a child before the age of 8?
A. 
B. 
C. 
D. 
18.
There is more than one cytochrom P450 enzyme
19.
Where are P450 isoenzymes located specifically in the liver?
A. 
B. 
C. 
Plasma membrane of hepatocytes
D. 
Endoplasmic recticulum of hepatocytes
20.
Which of the following is NOT part of microsomal (P450) oxidation reactions?
A. 
B. 
C. 
D. 
21.
Unbound, or free drugs (aka not bound to serum proteins) will reach __________ between the blood and tissues.
22.
Metabolic reactions can transform an active drug into a less active form or into inactive metabolites. Metabolic reactions can also transform a prodrug into a more active drug or metabolite.
23.
Choose ALL of the reactions that fall under Phase II reactions:
A. 
B. 
C. 
Ethereal sulfate conjugation
D. 
E. 
F. 
24.
In Phase I reactions, drugs are ___________ or ___________. In Phase II reactions, a polar molecular group is __________ to the drug which increases its polarity.
25.
During drug metabolism, what is the general trend that occurs?
A. 
Drugs become more hydrophobic
B. 
Drugs become increasingly less active
C. 
Drugs are deposited more on various tissues
D.